60 6.1. La minimisation de la charge virale initiale du plasma, p.61 ,
61 7.1. La répartition, p.64 ,
69 8.10. La concentration en protéine, p.70 ,
Venoms, antivenoms and immunotherapy, Toxicon, vol.36, issue.6, pp.823-869, 1998. ,
DOI : 10.1016/S0041-0101(97)00160-8
Antidotes against venomous animals: State of the art and prospectives, Journal of Proteomics, vol.72, issue.2, pp.183-99, 2009. ,
DOI : 10.1016/j.jprot.2009.01.020
antivenins de serpent et de scorpion Disponible sur : https://www-biologie-journal-org.docelec.u-bordeaux.fr/articles, Biologie Aujourd'hui [Internet], issue.01, 2010. ,
Albert Calmette 1863?1933 Fondateur de la sérothérapie antivenimeuse Annales de l'Institut Pasteur / Actualités. 1 avr, pp.139-185, 1999. ,
DOI : 10.1016/s0924-4204(99)80029-8
L'oeuvre scientifique de Césaire Phisalix (1852-1906), découvreur du sérum antivenimeux, Bull. Soc. Herp. Fr, vol.123, pp.15-46, 2007. ,
L'immunoth??rapie passive aujourd'hui??: bref historique, Biologie Aujourd'hui, vol.16, issue.1, pp.51-55, 2010. ,
DOI : 10.1055/s-0029-1207589
Estimating the global burden of snakebite : A literature analysis and modelling based on regional estimates of envenoming and deaths, PLoS Medicine, issue.5, p.218, 2008. ,
Les sérums antivenimeux : crise actuelle de leur production et conséquence Annales de l'Académie de Mâcon, p.2012, 2012. ,
The origin of snakes: revealing the ecology, behavior, and evolutionary history of early snakes using genomics, phenomics, and the fossil record, BMC Evolutionary Biology, vol.56, issue.2, p.87, 2015. ,
DOI : 10.1016/j.ympev.2010.04.011
Snakebite mortality in the world, Bull World Health Organ, vol.10, issue.1, pp.35-76, 1954. ,
French Vipera aspis aspis seen in the wild, 2011. ,
Envenimations par les vip??res en France, Archives de P??diatrie, vol.19, issue.6, pp.660-662, 2012. ,
DOI : 10.1016/j.arcped.2012.03.005
Morsures et envenimations ophidiennes, Revue Fran??aise des Laboratoires, vol.2002, issue.342, pp.55-60, 2002. ,
DOI : 10.1016/S0338-9898(02)80062-2
Chemistry and evolution of toxins in snake venoms. Toxicon. 1 janv, pp.1-2, 1974. ,
Effects of snake venom proteins on blood platelets, Toxicon, vol.28, issue.12, pp.1387-422, 1990. ,
DOI : 10.1016/0041-0101(90)90155-Z
Snake venom variability: methods of study, results and interpretation, Toxicon, vol.29, issue.11, pp.1279-1303, 1991. ,
DOI : 10.1016/0041-0101(91)90116-9
Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming, Journal of Proteomics, vol.72, issue.2, pp.165-82, 2009. ,
DOI : 10.1016/j.jprot.2009.01.008
Role of antivenoms in the treatment of snake envenomation, Bull Acad Natl Med, vol.197, issue.4-5, pp.993-1006, 2013. ,
Report of a Consultative Meeting. Geneva, World Health Organization, 2007. ,
Surveillance clinique et biologique des patients envenimés, Bull Soc Pathol Exot, vol.3, pp.95-139, 2002. ,
The efficacy of low-dose antivenom therapy on morbidity and mortality in snakebite cases, The American Journal of Emergency Medicine, vol.26, issue.4, pp.402-409, 2008. ,
DOI : 10.1016/j.ajem.2007.06.017
Envenimations ophidiennes graves. Le Praticien en Anesthésie Réanimation. 1 sept, pp.254-63, 2010. ,
La sérothérapie, entre innovations thérapeutiques et progrès scientifiques à la fin du XIX e s. et au XX e s. La revue du practicien, pp.1177-1181, 2012. ,
1854-1915) [Internet] [cité 9 juill, Disponible sur, 2017. ,
Kuby immunology, p.574, 2007. ,
Les sous classes d'immunoglobulines IgG Aspects biochimiques et cliniques. Revue Française de Transfusion et d'Hémobiologie. 1 oct, pp.357-76, 1989. ,
DOI : 10.1016/s1140-4639(89)80023-1
Vaccine immunology, Perspectives in Vaccinology, vol.1, issue.1, pp.25-59, 2011. ,
DOI : 10.1016/j.pervac.2011.05.002
Production d'immunoglobulines th??rapeutiques hautement purifi??es (ITHP) : analyse d'un proc??d?? de purification, Biologie Aujourd'hui, vol.19, issue.1, pp.55-64, 2010. ,
DOI : 10.1016/S0041-0101(97)00160-8
Immunochemical and biochemical comparisons of equine monovalent and polyvalent snake antivenoms, Toxicon, vol.45, issue.3, pp.369-75, 2005. ,
DOI : 10.1016/j.toxicon.2004.10.019
Report of a WHO workshop on the standardization and control of antivenoms, Toxicon, vol.41, issue.5, pp.541-557, 2003. ,
DOI : 10.1016/S0041-0101(02)00393-8
Recommandations pour la production, le contr??le et l'enregistrement des immunoglobulines antivenimeuses, Biologie Aujourd'hui, vol.41, issue.1, pp.87-91, 2010. ,
DOI : 10.1016/S0041-0101(02)00393-8
Venoms, venomics, antivenomics, FEBS Letters, vol.50, issue.11, pp.1736-1779, 2009. ,
DOI : 10.1016/S0035-9203(97)90219-4
URL : http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2009.03.029/pdf
Farming for venom : Survey of snake venom extraction facilities worldwide Applied Herpetology. 1 janv, pp.1-10, 2006. ,
Production of highly potent horse antivenom against the Thai cobra (Naja kaouthia), Vaccine, vol.15, issue.14, pp.1523-1531, 1997. ,
DOI : 10.1016/S0264-410X(97)00098-4
Antivenoms : A Review of Current Status ans Future Developments, BioDrugs, issue.5, pp.7-366, 1997. ,
Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom, Toxicon, vol.35, issue.1, pp.81-90, 1997. ,
DOI : 10.1016/S0041-0101(96)00077-3
Detoxification of Snake Venoms and Venom Fractions by Formaldehyde., Experimental Biology and Medicine, vol.112, issue.3, pp.595-598, 1963. ,
DOI : 10.3181/00379727-112-28113
The impact of a low dose, low volume, multi-site immunization on the production of therapeutic antivenoms in Thailand, Toxicon, vol.41, issue.1, pp.57-64, 2003. ,
DOI : 10.1016/S0041-0101(02)00209-X
Assessment of the viral safety of antivenoms fractionated from equine plasma, Biologicals, vol.32, issue.3, pp.115-128, 2004. ,
DOI : 10.1016/j.biologicals.2004.07.001
Production of potent polyvalent antivenom against three elapid venoms using a low dose, low volume, multi-site immunization protocol, Toxicon, vol.39, issue.10, pp.1487-1494, 2001. ,
DOI : 10.1016/S0041-0101(01)00108-8
Purification of human immunoglobulins by sequential precipitation with caprylic acid and ammonium sulphate, Journal of Immunological Methods, vol.128, issue.1, pp.9-16, 1990. ,
DOI : 10.1016/0022-1759(90)90458-8
A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia: correlation between safety and biochemical characteristics of antivenoms, Toxicon, vol.37, issue.6, pp.895-908, 1999. ,
DOI : 10.1016/S0041-0101(98)00220-7
Purification of IgG from serum with caprylic acid and ammonium sulphate precipitation is not superior to ammonium sulphate precipitation alone. Comparative Immunology, Microbiology and Infectious Diseases. 1 janv, pp.153-60, 1989. ,
A protocol for ???enhanced pepsin digestion???: a step by step method for obtaining pure antibody fragments in high yield from serum, Journal of Immunological Methods, vol.275, issue.1-2, pp.239-250, 2003. ,
DOI : 10.1016/S0022-1759(03)00005-X
Caprylic acid fractionation of hyperimmune horse plasma: Description of a simple procedure for antivenom production, Toxicon, vol.32, issue.3, pp.351-363, 1994. ,
DOI : 10.1016/0041-0101(94)90087-6
Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.99, issue.6, pp.468-475, 2005. ,
DOI : 10.1016/j.trstmh.2004.09.014
Purification of F(ab???)2 anti-snake venom by caprylic acid: A fast method for obtaining IgG fragments with high neutralization activity, purity and yield, Toxicon, vol.27, issue.3, pp.297-303, 1989. ,
DOI : 10.1016/0041-0101(89)90177-3
Effect of pepsin digestion on the antivenom activity of equine immunoglobulins. Toxicon. 15 déc, pp.876-82, 2005. ,
versus Fab antivenom for pit viper envenomation: A prospective, blinded, multicenter, randomized clinical trial, Clinical Toxicology, vol.6, issue.1, pp.37-45, 2015. ,
DOI : 10.1097/PEC.0b013e3181ea722b
Chromatographic purification of equine immunoglobulin G F(ab)2 from plasma, Journal of Chromatography B, vol.876, issue.1, pp.109-124, 2008. ,
DOI : 10.1016/j.jchromb.2008.10.030
Fractionation of equine antivenom using caprylic acid precipitation in combination with cationic ion-exchange chromatography, Journal of Immunological Methods, vol.282, issue.1-2, pp.63-72, 2003. ,
DOI : 10.1016/j.jim.2003.07.014
Quantitative comparison on the refinement of horse antivenom by salt fractionation and ion-exchange chromatography, Journal of Chromatography B: Biomedical Sciences and Applications, vol.700, issue.1-2, pp.233-239, 1997. ,
DOI : 10.1016/S0378-4347(97)00244-2
Affinity chromatography: A versatile technique for antibody purification, Methods, vol.116, pp.84-94, 2017. ,
DOI : 10.1016/j.ymeth.2016.12.010
Optimised affinity purification of polyclonal antibodies from hyper immunised ovine serum using a synthetic Protein A adsorbent, MAbsorbent?? A2P, Journal of Chromatography B, vol.814, issue.2, pp.209-224, 2005. ,
DOI : 10.1016/j.jchromb.2004.10.027
Chapitre 3 -Opérations pharmaceutiques In : Pharmacie galénique (9e édition) [Internet], 2009. ,
Role of Buffers in Protein Formulations, Journal of Pharmaceutical Sciences, vol.106, issue.3, pp.713-746, 2017. ,
DOI : 10.1016/j.xphs.2016.11.014
Liquid formulation for antibody drugs, Proteins and Proteomics. 1 nov, pp.2041-52, 2014. ,
DOI : 10.1016/j.bbapap.2014.07.016
Low pH formulation of whole IgG antivenom: Impact on quality, safety, neutralizing potency and viral inactivation, Biologicals, vol.40, issue.2, pp.129-162, 2012. ,
DOI : 10.1016/j.biologicals.2011.11.006
Formulation of a liquid ovine Fab-based antivenom for the treatment of envenomation by the Nigerian carpet viper (Echis ocellatus), Toxicon, vol.42, issue.4, pp.399-404, 2003. ,
DOI : 10.1016/S0041-0101(03)00170-3
Pénurie d'anti-venin de vipère dans toute la région PACA ,
Disponible sur : http://france3-regions.francetvinfo.fr/provence-alpes-cote-d-azur/bouches-du- rhone/metropole-aix-marseille/marseille/sante-penurie-anti-venin-vipere-toute- region-paca-1259489, Internet] ,
A multicomponent strategy to improve the availability of antivenom for treating snakebite envenoming, Bulletin of the World Health Organization, vol.92, issue.7, pp.526-532, 2014. ,
DOI : 10.2471/BLT.13.132431
Snake-bites : appraisal of the global situation, Bulletin of the World Health Organization, vol.76, pp.515-524, 1998. ,
Epidemiology of snakebites in Europe: A systematic review of the literature, Toxicon, vol.59, issue.1, pp.86-99, 2012. ,
DOI : 10.1016/j.toxicon.2011.10.008
Producers of antivenomous sera, Toxicon, vol.21, issue.6, pp.739-52, 1983. ,
DOI : 10.1016/0041-0101(83)90063-6
Improving antivenom availability and accessibility : Science, technology, and beyond. Toxicon. 15 sept 2012, pp.676-87 ,
Economic evaluation of snake antivenom production in the public system, Journal of Venomous Animals and Toxins including Tropical Diseases, vol.12, issue.3, pp.497-511, 2006. ,
DOI : 10.1590/S1678-91992006000300012
Consequences of Neglect: Analysis of the Sub-Saharan African Snake Antivenom Market and the Global Context, PLoS Neglected Tropical Diseases, vol.77, issue.6, 2012. ,
DOI : 10.1371/journal.pntd.0001670.t003
Ending the drought: New strategies for improving the flow of affordable, effective antivenoms in Asia and Africa, Journal of Proteomics, vol.74, issue.9, pp.1735-67, 2011. ,
DOI : 10.1016/j.jprot.2011.05.027
Epidemiology of snakebite in Europe: Comparison of data from the literature and case reporting, Toxicon, vol.76, pp.206-219, 2013. ,
DOI : 10.1016/j.toxicon.2013.10.004
Underestimation of snakebite mortality by hospital statistics in the Monaragala District of Sri Lanka, Transactions of the Royal Society of Tropical Medicine and Hygiene, vol.100, issue.7, pp.693-698, 2006. ,
DOI : 10.1016/j.trstmh.2005.09.003
Snake Envenoming : A Disease of Poverty PLoS Negl Trop Dis. 22 déc, 2009. ,
Snakebite envenoming from a global perspective: Towards an integrated approach, Toxicon, vol.56, issue.7, pp.1223-1258, 2010. ,
DOI : 10.1016/j.toxicon.2009.11.020
Research strategies to improve snakebite treatment: Challenges and progress, Journal of Proteomics, vol.74, issue.9, pp.1768-80, 2011. ,
DOI : 10.1016/j.jprot.2011.06.019
Development of process to produce polyvalent IgY antibodies anti-African snake venom, Toxicon, vol.52, issue.2, pp.293-301, 2008. ,
DOI : 10.1016/j.toxicon.2008.05.022
Cat 1 : Elapidae : Dendroaspis jamesoni ; Naja haje (north-east), Naja nigricollis ,
Bitis arietans, Bitis gabonica, Echis ocellatus Cat, vol.2 ,
Atractaspis irregularis ; Colubridae : Dispholidus typus ; Thelotornis kirtlandii ; Elapidae : Naja katiensis, Naja melanoleuca ; Naja senegalensis (north-west) ; Pseudohaje goldii, Pseudohaje nigra ; Viperidae : Atheris squamigera ; Bitis nasicornis ,
Atractaspis irregularis ; Colubridae : Dispholidus typus ; Thelotornis kirtlandii ; Elapidae : Naja melanoleuca ; Pseudohaje nigra ,
Atheris chlorechis ; Bitis nasicornis, Bitis rhinoceros Togo : Cat 1 : Elapidae: Naja nigricollis, Naja senegalensis; Viperidae: Bitis arietans (south) ,
Atractaspis irregularis ; Colubridae : Dispholidus typus ; Thelotornis kirtlandii ; Elapidae : Dendroaspis jamesoni, Dendroaspis viridis ; Naja katiensis, Naja melanoleuca ; Pseudohaje goldii Pseudohaje nigra ,
Atheris chlorechis ; Bitis nasicornis, Bitis rhinoceros Middle East Cyprus : Cat 1 : None Cat 2 : Viperidae : Macrovipera lebetina Azerbaijan ,
Echis carinatus (except Kyrgyzstan); Macrovipera lebetina (except Kazakhstan & Kyrgyzstan); Gloydius halys (throughout) ,
Protobothrops mangshanensis; Vipera berus (Jilin, western Xinjiang); Vipera renardi (western Xinjiang) ,
Special Administrative Region : Cat 1 : Elapidae : Bungarus multicinctus ; Naja atra ; Viperidae : Cryptelytrops albolabris Cat 2 : None Cambodia : Cat 1 : Elapidae : Bungarus candidus ; Naja kaouthia, Naja siamensis ; Viperidae : Calloselasma rhodostoma ; Cryptelytrops albolabris ; Daboia siamensis Cat 2 : Elapidae : Bungarus fasciatus, Bungarus flaviceps ; Ophiophagus hannah ; Viperidae : Cryptelytrops macrops ,
Cat 1 : None Cat 2 : Viperidae : Vipera berus ,
Viperidae : Vipera ammodytes, Vipera berus Belgium ; Denmark ; Finland ; Germany ; The Netherlands ,
Viperidae : Vipera latastei, Vipera seoanei Spain : Cat 1 : None Cat 2 : Viperidae : Vipera aspis, Vipera latastei, Vipera seoanei Sweden ,
Saint Lucia ; Trinidad and Tobago, and offshore islands : Cat 1 : Viperidae : Bothrops cf. atrox (Trinidad), Bothrops caribbaeus, Bothrops lanceolatus (Martinique) ; Crotalus durissus (Aruba) Cat 2 : Elapidae : Micrurus circinalis Micrurus lemniscatus ,
No venomous snakes are naturally occurring in the Falkland Islands ; and no dangerously venomous snakes are naturally occurring in Chile ,
Micrurus corallinus, Micrurus lemniscatus, Micrurus spp. ; Viperidae: Bothrops ammodytoides, Bothrops jararaca, Bothrops jararacussu, Bothrops mattogrossensis, Bothrops neuwiedi, Bothrops pubescens Bolivia ,
Bothrops taeniatus ; Lachesis muta Guyana : Cat 1 : Viperidae : Bothrops atrox, Bothrops bilineatus, Bothrops brazili ; Crotalus durissus Cat 2 : Elapidae : Micrurus lemniscatus ,
Micrurus corallinus, Micrurus lemniscatus, Micrurus spixii, Micrurus spp. ; Viperidae : Bothrops diporus ,
Cat 1 : Viperidae : Bothrops atrox, Bothrops bilineatus, Bothrops pictus ; Crotalus durissus ,
Micrurus lemniscatus, Micrurus mipartitus, Micrurus spixii, Micrurus surinamensis, Micrurus spp. ; Viperidae : Bothriechis schlegelii ; Bothrocophias hyoprora, Bothrocophias microphthalmus ; Bothrops asper ; Bothrops brazili, Bothrops mattogrossensis, Bothrops taeniatus ,
Cat 1 : Viperidae : Bothrops atrox, Bothrops bilineatus, Bothrops brazili ; Crotalus durissus Cat 2 : Elapidae : Micrurus lemniscatus ,