Évaluation de l’effet de pratique du Computerised Speed Cognitive Test et du Symbol Digit Modalities Test : étude chez des patients ayant une sclérose en plaques et des sujets sains

Abstract : Background. Information processing speed (IPS) in Multiple Sclerosis (MS) is assessed by the Symbol Digit Modalities Test (SDMT) or the Computerised Speed Cognitive Test (CSCT). The practice effect is a systematic bias in the repetition of a neuropsychological test. Objective. To compare short-term and long-term practice effect of CSCT and SDMT in the population of relapsing-remitting MS (RRMS) patients and healthy controls. The main secondary objectives are to observe the PE for routine clinical evaluations and to determine the factors influencing PE. Methods. RETEST is a prospective monocentric study. Between January 2016 and February 2017, 28 patients with RRMS were enrolled and 12 healthy controls paired to age, gender and education level. PE was measured using a univariate variance analysis (ANOVA) for repeated measurements with F-statistic calculation for time effect, group effect (SEP or healthy volunteers) and time group, t-tests Student, Cohen's test and calculation of intragroup correlation coefficients (ICC). We used data from the BICAFMS (Brief Cognitive Assessment in French Multiple Sclerosis patients) study to measure effect of PE in routine practice for 6 months of follow-up of 78 patients with MS and 124 heaty controls paired by age, sex and education level. Results. For a period of 12 months, we show a time effect for patients with MS for SDMT (F = 3.569, p <0.05), but no time effect for CSCT (F = 2.765, p> 0.05). For a period of 6 months for MS patients and healthy controls, there was an effect of time for the SDMT (F = 5.176, p=0.005), not found for CSCT (F = 0.503, p>0.05). By calculating Cohen d for 12 months for patients with MS, we found d = -0.03 for CSCT and d = 0.35 for SDMT. Between visits of 6 months and 12 months, there is d = 0.31 for the CSCT and 0.69 for the SDMT. In BICAFMS, there was an improvement in the CSCT score at 1-month intervals, but there isn’t improvement at 5-month intervals. Age and the National Adult Reading Test seem to affect the size of the practice effect. Conclusion. In patients with RRMS, there was no significant practice effect of CSCT on repeated 6-month intervals over a one-year period, unlike SDMT.
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Master Thesis
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Antoine Soulages. Évaluation de l’effet de pratique du Computerised Speed Cognitive Test et du Symbol Digit Modalities Test : étude chez des patients ayant une sclérose en plaques et des sujets sains . Médecine humaine et pathologie. 2017. ⟨dumas-01622922⟩

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