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Comparer l'effet de pratique du CSCT et du SDMT à 6 mois d'intervalle, dans des populations de patients suivis pour une SEP rémittente-récurrente (SEP-RR) sous Natalizumab et dans une population de volontaires sains. Les principaux objectifs secondaires sont d'évaluer l'EP pour ces tests en clinique courante ,
Entre janvier 34 patients suivis pour une SEP-RR ont été inclus de façon consécutive ainsi que 12 volontaires sains appariés en âge, en sexe et en niveau éducatif. L'EP a été mesuré au moyen d'analyse de variance univariée (ANOVA) pour mesures répétées avec calcul de la statistique F pour l'effet du temps, l'effet du groupe (SEP ou volontaires sains) et l'interaction temps-groupe, de tests t de Student, du calcul du d de Cohen et du calcul des coefficients de corrélation intragroupe (ICC) Nous avons utilisé les données de l'étude BICAFMS (Brief Cognitive Assessment for French Multiple Sclerosis patients) pour mesurer l, 2016. ,
nos résultats retrouvent chez les patients SEP un effet de temps pour le SDMT (F=3.569, p<0.05) mais pas d'effet du temps pour le CSCT (F=2.765, p>0.05) Sur 6 mois de suivi en étudiant à la fois les patients et les volontaires sains, il existe un effet du temps pour, non retrouvé pour le CSCT (F=0.503, p>0.05). En ,
NEUROLOGIE Mots clés : Effet de pratique, Computerised Speed Cognitive Test, Symbol Digit Modalities Test, Evaluation cognitive ,