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Master Thesis

Symptomatologie psychiatrique précoce dans la cohorte française des patients atteints d’encéphalite à anticorps anti-NMDA

Abstract : Anti-NMDA receptor antibodies encephalitis (NMDARE) is an autoimmune disease of recent discovery. Its initial clinical presentation is characterized by psychiatric-like symptoms. The objective of this study was to better describe these symptoms, in order to allow earlier identification and diagnosis. All 111 patients studied had a NMDARE confirmed in the reference center, in Lyon. All were evaluated in an emergency department, and 45 were hospitalized in psychiatry for a median of 9 days. All patients had neurological symptoms, sometimes discreet, and 21 patients had a severe neuroleptic intolerance, justifying their transfer to an appropriate department. Psychiatric symptomatology is probably not enough contributing, being especially nonspecific. Particular attention should be given during a first psychiatric episode, especially in young women, to the existence of neurological signs (amnesia, disorientation, dyskinesia). An EEG should be part of systematic check-up for a first psychiatric episode. The neuroleptic malignant syndrome or severe intolerance should question the diagnosis. The 'perfect' resemblance between certain psychiatric disorders and NMDARE question the role of anti-NMDA antibodies in the pathogenesis of these disorders outside the strict framework of encephalitis. It is a path of innovative research in the field of immuno-psychiatry.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01623774
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Florian Lejuste. Symptomatologie psychiatrique précoce dans la cohorte française des patients atteints d’encéphalite à anticorps anti-NMDA. Médecine humaine et pathologie. 2016. ⟨dumas-01623774⟩

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