Skip to Main content Skip to Navigation
Master Thesis

Troubles fonctionnels œsophagiens chez les patients avec reflux gastro-œsophagien : résultats d’une étude rétrospective descriptive

Abstract : Rome IV classification identify with pH-metry and/or pH-impedancemetry patients with functional oesophageal disorders particularly functional heartburn and reflux hypersensitivity. Some patients with functional oesophageal disorders have proven gastro-oesophageal reflux desease (GERD). The aim of this study was to describe the characteristics of patients with GERD overlap with functional oesophageal disorders. Methods: Between November 2015 and May 2017, patients with proven GERD (oesophagitis and/or positive pH-metry off PPI) and persistent symptoms on Proton Pump Inhibitor (PPI) were retrospectively and consecutively included. Patients underwent an oesophageal impedance and pH monitoring on PPI at double dose, which leaded to define reflux hypersensitivity (normal acid exposure and significant reflux-symptom association using SI and SAP), functional heartburn (negative reflux-symptom association), and persisting GERD (acid exposure time > 5%). A control group of patients with functional heartburn without GERD at pH-metry off PPI was enlisted. Anxiety and depression scores (HADS), visceral sensitivity (VSI), GERD symptoms (RDQ), and presence of other gastrointestinal functional disorders were evaluated by auto questionnaires. Results: 32 patients with overlap between GERD and oesophageal functional disorders were included (75% were women of mean age 54,8 (14,2) years). 6% of patients had a refractory GERD, 34% a reflux hypersensitivity and 59% a functional heartburn. There was no significative difference between this three groups. Control group with functional heartburn without GERD included 22 patients (95.5% were woman of mean age 52.5 (13.1) years). HADS anxiety scores were similar in both groups (8,4 (4,8) et 8,5 (5,2) respectively for proven GERD and without GERD patients; while depression scores were normal in both groups. Visceral sensitivity index was 58 (17,4) and 53,9 (27,6) respectively. We noted great proportions of patients with functional dyspepsia in both groups: 66.7 % in proven GERD group and 47.6 in control group without GERD. Respectively 25% and 38.1% of patients suffered from irritable bowel syndrome. Symptomatic scores were comparable in both groups. Conclusion: This is the first study describing patients with overlap between GERD and functional oesophageal disorders. Whether or not GERD is proven, patients with functional oesophageal disorders are characterised by high level of anxiety and important prevalence of other functional gastrointestinal disorders.
Document type :
Master Thesis
Complete list of metadatas

Cited literature [90 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01624597
Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Thursday, October 26, 2017 - 3:02:21 PM
Last modification on : Saturday, October 28, 2017 - 1:14:16 AM
Long-term archiving on: : Saturday, January 27, 2018 - 2:28:52 PM

File

Med_spe_2017_Pomarat.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-01624597, version 1

Collections

Citation

Margaux Pomarat. Troubles fonctionnels œsophagiens chez les patients avec reflux gastro-œsophagien : résultats d’une étude rétrospective descriptive. Médecine humaine et pathologie. 2017. ⟨dumas-01624597⟩

Share

Metrics

Record views

349

Files downloads

1043