A. Benjdia, A. Guillot, P. Ruffié, J. Leprince, and O. Berteau, Post-translational modification of ribosomally synthesized peptides by a radical SAM epimerase in Bacillus subtilis, Nature Chemistry, vol.8, issue.7, 2017.
DOI : 10.1038/nrmicro2937

E. P. Abraham and S. Robert, Robinson and the early history of penicillin, Natural Product Reports, vol.4, issue.41, 1987.

M. Lobanovska and G. Pilla, Penicillin's discovery and antibiotic resistance : lessons for the future ?

M. Elseviers, M. Ferech, V. Stichele, R. Goossens, and H. , Antibiotic use in ambulatory care in Europe (ESAC data 1997???2002): trends, regional differences and seasonal fluctuations, Pharmacoepidemiology and Drug Safety, vol.1590, issue.1, pp.115-138, 2007.
DOI : 10.1016/S0140-6736(05)17907-0

D. Guillemot and L. R. , Impact de l'exposition des populations sur le risque de r??sistance bact??rienne, M??decine et Maladies Infectieuses, vol.35, issue.3, pp.212-220, 2005.
DOI : 10.1016/S0399-077X(05)83004-5

M. Exner, S. Bhattacharya, B. Christiansen, J. Gebel, P. Goroncy-bermes et al., Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria? GMS Hygiene and Infection Control, p.5, 2017.

J. Davies and D. Davies, Origins and Evolution of Antibiotic Resistance, Microbiology and Molecular Biology Reviews, vol.74, issue.3, pp.417-433, 2010.
DOI : 10.1128/MMBR.00016-10

M. Bergman, S. Nyberg, P. Huovinen, and P. Paakkari, Association between Antimicrobial Consumption and Resistance in Escherichia coli, Antimicrobial Agents and Chemotherapy, vol.53, issue.3, pp.912-917, 2009.
DOI : 10.1128/AAC.00856-08

URL : http://aac.asm.org/content/53/3/912.full.pdf

J. Galland, A. Dazinieras, N. Cohen, C. Blochet, D. Armaingaud et al., Use of antibiotics in nursing homes : a one year retrospective study in 67 French institutions

A. Rosello, A. Hayward, S. Hopkins, C. Horner, D. Ironmonger et al., Impact of long-term care facility residence on the antibiotic resistance of urinary tract Escherichia coli and Klebsiella, Journal of Antimicrobial Chemotherapy, vol.72, issue.4, pp.1184-92, 2017.

L. Nicolle, Urinary infections in the elderly: symptomatic or asymptomatic?, International Journal of Antimicrobial Agents, vol.11, issue.3-4, pp.265-273, 1999.
DOI : 10.1016/S0924-8579(99)00028-X

A. Montoya and L. Mody, Common infections in nursing homes: a review of current issues and challenges, Aging Health, vol.27, issue.6, pp.889-99, 2011.
DOI : 10.1016/S0196-6553(99)70078-7

J. Lim, M. Kwong, R. Stuart, K. Buising, N. Friedman et al., Antibiotic prescribing practice in residential aged care facilities ? health care provider's perspectives
DOI : 10.5694/mja14.01422

S. Walker, A. Mcgeer, A. Simor, M. Armstrong-evans, and M. Loeb, Why are antibiotics prescribed for asymptomatic bacteriuria in institutionalized elderly people ? A qualitative study of physicians' and nurses' perceptions, CMAJ Canadian Medical Association Journal Aug8, vol.163, issue.3, pp.273-277, 2000.

R. Breitenbucher, UTI: managing the most common nursing home infection, Geriatrics, 1990.

J. Warren, F. Palumbo, L. Fitterman, and S. Speedie, Incidence and Characteristics of Antibiotic Use in Aged Nursing Home Patients, Journal of the American Geriatrics Society, vol.37, issue.10, pp.963-72, 1991.
DOI : 10.7326/0003-4819-79-4-555

M. Loeb, A. Simor, L. Landry, S. Walter, M. Mcarthur et al., Antibiotic use in ontario facilities that provide chronic care, Journal of General Internal Medicine, vol.341, issue.6, pp.376-83, 2001.
DOI : 10.1056/NEJM199907223410403

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1495221/pdf

L. Nicolle, Urinary tract infections in long-term?care facilities, American Journal of Infection Control, vol.22, issue.03, pp.167-75, 2001.

L. Nicolle and L. Nicolle, Urinary tract infections in long-term care facilities Asymptomatic bacteriuria in the elderly, American Journal of Infection Control Infectious Disease Clinics of North America, vol.1411, issue.043, pp.220-5647, 1993.

K. Detweiler, D. Mayers, and S. Fletcher, Bacteruria and Urinary Tract Infections in the Elderly, Urologic Clinics of North America, vol.42, issue.4, pp.561-569, 2015.
DOI : 10.1016/j.ucl.2015.07.002

G. Nordenstam, C. Brandberg, A. Odén, S. Edén, C. Svanborg et al., Bacteriuria and Mortality in an Elderly Population, New England Journal of Medicine, vol.314, issue.18, pp.1152-1158, 1986.
DOI : 10.1056/NEJM198605013141804

E. Abrutyn, J. Mossey, J. Berlin, J. Boscia, M. Levison et al., Does Asymptomatic Bacteriuria Predict Mortality and Does Antimicrobial Treatment Reduce Mortality in Elderly Ambulatory Women?, Annals of Internal Medicine, vol.120, issue.10, pp.827-860, 1994.
DOI : 10.7326/0003-4819-120-10-199405150-00003

A. Noreddin and V. Haynes, Use of Pharmacodynamic Principles to Optimise Dosage Regimens for Antibacterial Agents in the Elderly, Drugs & Aging, vol.51, issue.5, pp.275-92, 2007.
DOI : 10.7326/0003-4819-144-6-200503210-00121

S. Walter, Effect of a multifaceted intervention on number of antimicrobial prescriptions for suspected urinary tract infections in residents of nursing homes: cluster randomised controlled trial, British Medical Journal, vol.331, issue.7518, p.669, 2005.

E. Pettersson, A. Vernby, S. Mölstad, and C. Lundborg, Can a multifaceted educational intervention targeting both nurses and physicians change the prescribing of antibiotics to nursing home residents? A cluster randomized controlled trial, Journal of Antimicrobial Chemotherapy, vol.66, issue.11, 2011.
DOI : 10.1093/jac/dkr312

N. Daneman, S. Bronskill, A. Gruneir, A. Newman, H. Fischer et al., Variability in Antibiotic Use Across Nursing Homes and the Risk of Antibiotic-Related Adverse Outcomes for Individual Residents, JAMA Internal Medicine, vol.175, issue.8, pp.1331-1370, 2015.
DOI : 10.1001/jamainternmed.2015.2770

J. Thorpe, C. Thorpe, K. Kennelty, W. Gellad, and R. Schulz, The Impact of Family Caregivers on Potentially Inappropriate Medication Use in Noninstitutionalized Older Adults With Dementia, The American Journal of Geriatric Pharmacotherapy, vol.10, issue.4, pp.230-271, 2012.
DOI : 10.1016/j.amjopharm.2012.05.001

D. Paterson, Resistance in Gram-Negative Bacteria: Enterobacteriaceae, American Journal of Infection Control, vol.19, issue.6, pp.20-28, 2006.
DOI : 10.1016/j.amjmed.2006.03.013

F. Gravey, G. Loggia, D. L. Blanchardière, A. Cattoir, and V. , Bacterial epidemiology and antimicrobial resistance profiles of urinary specimens of the elderly, Médecine et Maladies Infectieuses, pp.271-78, 2017.
DOI : 10.1016/j.medmal.2017.03.002

F. Bruyère, A. Dihn, and A. Sotto, Interest of amoxicillin-clavulanic acid combination in urology: An update, Progrès en Urologie, pp.437-441, 2016.

C. Lee and Y. Doi, Therapy of Infections due to Carbapenem-Resistant Gram-Negative Pathogens, Infection & Chemotherapy, vol.46, issue.3, pp.149-164, 2014.
DOI : 10.3947/ic.2014.46.3.149

I. Stock, . Erkrankungen-durch-carbapenemase-bildende-enterobacteriaceae, and . Mai, Eine besondere Herausforderung für die antibakterielle Therapie. [Maladies infectieuses causées par les Enterobacteriaceae productrices de carbapénémase -un défi particulier pour la thérapie antibactérienne], Medizinische Monatsschrift für Pharmazeuten, vol.37, issue.5, pp.162-172, 2014.