AEA sont décrites à 08h (T max) avec une valeur de 1,20 [1,02-1,30] pmol/ml, soit 141 % [115-147] de la moyenne individuelle. Les concentrations minimales (Cmin) d'AEA sont décrites à 04h avec une valeur de 0, pp.65-65 ,
La valeur à 8h est de 1,13 [1,01-1,19] pmol/ml. La valeur maximale de Cmin est de 1, pp.89-89 ,
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish, Journal of the American Chemical Society, vol.86, issue.8, pp.1646-1647, 1964. ,
DOI : 10.1021/ja01062a046
Le syst??me endocannabino??de: des effets m??taboliques aux effets neuroendocriniens, Annales d'Endocrinologie, vol.68, issue.1, pp.12-19, 2007. ,
DOI : 10.1016/S0003-4266(07)80004-7
Disponible sur, Handbook of Experimental Pharmacology, vol.2015, issue.231, pp.978-981, 2016. ,
Structure of a cannabinoid receptor and functional expression of the cloned cDNA, Nature, vol.346, issue.6284, pp.561-565, 1990. ,
DOI : 10.1038/346561a0
Molecular characterization of a peripheral receptor for cannabinoids, Nature, vol.365, issue.6441, pp.61-66, 1993. ,
DOI : 10.1038/365061a0
Isolation and structure of a brain constituent that binds to the cannabinoid receptor, Science, vol.258, issue.5090, pp.1946-1955, 1992. ,
DOI : 10.1126/science.1470919
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2, Pharmacological Reviews, vol.62, issue.4, pp.588-631, 2010. ,
DOI : 10.1124/pr.110.003004
Cannabinoid receptor localization in brain., Proceedings of the National Academy of Sciences, vol.87, issue.5, pp.1932-1936, 1990. ,
DOI : 10.1073/pnas.87.5.1932
URL : http://www.pnas.org/content/87/5/1932.full.pdf
Expression and Function of Endocannabinoid Receptors in the Human Adrenal Cortex, Hormone and Metabolic Research, vol.42, issue.02, pp.88-92, 2010. ,
DOI : 10.1055/s-0029-1241860
Normal Human Pituitary Gland and Pituitary Adenomas Express Cannabinoid Receptor Type 1 and Synthesize Endogenous Cannabinoids: First Evidence for a Direct Role of Cannabinoids on Hormone Modulation at the Human Pituitary Level 1, J Clin Endocrinol Metab, vol.86, issue.6, pp.2687-2696, 2001. ,
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance, Endocrine Reviews, vol.27, issue.1, pp.73-100, 2006. ,
DOI : 10.1210/er.2005-0009
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors, Biochemical Pharmacology, vol.50, issue.1, pp.83-90, 1995. ,
DOI : 10.1016/0006-2952(95)00109-D
Role of Endogenous Cannabinoids in Synaptic Signaling, Physiological Reviews, vol.83, issue.3, pp.1017-66, 2003. ,
DOI : 10.1152/physrev.00004.2003
The molecular logic of endocannabinoid signalling N-acylethanolamines, anandamide and food intake, Nat Rev Neurosci. nov Biochem Pharmacol. sept, vol.478, issue.156, pp.553-60, 2003. ,
Hunger and appetite after single doses of marihuana, alcohol, and dextroamphetamine, Clinical Pharmacology & Therapeutics, vol.12, issue.1, pp.44-53, 1971. ,
DOI : 10.1002/cpt197112144
Effects of marijuana and D-amphetamine on the appetite, food consumption and various cardio-respiratory variables in man], Union Med Can. juin, vol.104, issue.6, pp.914-935, 1975. ,
Effect of Dronabinol on Nutritional Status in HIV Infection, Annals of Pharmacotherapy, vol.17, issue.7-8, pp.827-858, 1993. ,
DOI : 10.1038/231260b0
MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future, European Journal of Endocrinology, vol.176, issue.6, pp.309-333, 2017. ,
DOI : 10.1530/EJE-16-1044
URL : http://www.eje-online.org/content/176/6/R309.full.pdf
The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders, Cell Metabolism, vol.17, issue.4, pp.475-90, 2013. ,
DOI : 10.1016/j.cmet.2013.03.001
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats, British Journal of Pharmacology, vol.143, issue.6, pp.1151-1154, 2001. ,
DOI : 10.1097/00024382-200003000-00006
Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol, British Journal of Pharmacology, vol.71, issue.4, pp.550-557, 2002. ,
DOI : 10.1016/S0306-4522(97)00436-3
Bimodal control of stimulated food intake by the endocannabinoid system, Nature Neuroscience, vol.77, issue.3, pp.281-284, 2010. ,
DOI : 10.1038/nn.2494
Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, vol.284, issue.2, pp.345-53, 2003. ,
DOI : 10.1152/ajpregu.00545.2002
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis, Journal of Clinical Investigation, vol.112, issue.3, pp.423-454, 2003. ,
DOI : 10.1172/JCI17725
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC166293/pdf
The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food, Neuroscience Letters, vol.419, issue.3, pp.231-236, 2007. ,
DOI : 10.1016/j.neulet.2007.04.012
The dopamine receptor antagonist SCH 23390 attenuates feeding induced by ??9-tetrahydrocannabinol, Brain Research, vol.1020, issue.1-2, pp.188-95, 2004. ,
DOI : 10.1016/j.brainres.2004.06.033
Cannabinoid facilitation of behavioral and biochemical hedonic taste responses, Neuropharmacology, vol.63, issue.1, pp.161-169, 2012. ,
DOI : 10.1016/j.neuropharm.2011.10.018
CNS Opioid Signaling Separates Cannabinoid Receptor 1-Mediated Effects on Body Weight and Mood-Related Behavior in Mice, Endocrinology, vol.152, issue.10, pp.3661-3668, 2011. ,
DOI : 10.1210/en.2011-1220
Effects of acute low-dose combined treatment with naloxone and AM 251 on food intake, feeding behaviour and weight gain in rats, Pharmacology Biochemistry and Behavior, vol.91, issue.3, pp.358-66, 2009. ,
DOI : 10.1016/j.pbb.2008.08.007
The Cannabinoid CB1 Receptor Antagonist SR141716 Increases Acrp30 mRNA Expression in Adipose Tissue of Obese fa/fa Rats and in Cultured Adipocyte Cells, Molecular Pharmacology, vol.63, issue.4, pp.908-914, 2003. ,
DOI : 10.1124/mol.63.4.908
Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ??-Pancreatic Cells and in Obesity and Hyperglycemia, The Journal of Clinical Endocrinology & Metabolism, vol.91, issue.8, pp.3171-80, 2006. ,
DOI : 10.1210/jc.2005-2679
Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake, International Journal of Obesity, vol.258, pp.7-12, 2006. ,
DOI : 10.1038/nn1457
Anandamide induced PPAR?? transcriptional activation and 3T3-L1 preadipocyte differentiation, European Journal of Pharmacology, vol.517, issue.3, pp.174-81, 2005. ,
DOI : 10.1016/j.ejphar.2005.05.032
Anandamide Increases the Differentiation of Rat Adipocytes and Causes PPAR?? and CB1 Receptor Upregulation, Obesity, vol.131, issue.Suppl 1, pp.1830-1838, 2009. ,
DOI : 10.1038/sj.bjp.0703569
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase, Proceedings of the National Academy of Sciences, vol.5, issue.4, pp.18832-18839, 2013. ,
DOI : 10.1073/pnas.0336351100
URL : http://www.pnas.org/content/110/47/18832.full.pdf
Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity, Journal of Clinical Investigation, vol.115, issue.5, pp.1298-305, 2005. ,
DOI : 10.1172/JCI200523057
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087161/pdf
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice, Journal of Clinical Investigation, vol.118, issue.9, pp.3160-3169, 2008. ,
DOI : 10.1172/JCI34827
Endocannabinoid signal in the gut controls dietary fat intake, Proc Natl Acad Sci. 2 août, pp.12904-12912, 2011. ,
DOI : 10.1016/j.chembiol.2007.10.017
Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats, The FASEB Journal, vol.27, issue.6, pp.2513-2533, 2013. ,
DOI : 10.1096/fj.13-227587
Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release, Journal of Biological Chemistry, vol.29, issue.45, pp.32685-99, 2013. ,
DOI : 10.1113/jphysiol.2008.157107
URL : http://www.jbc.org/content/288/45/32685.full.pdf
Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture, Proceedings of the National Academy of Sciences, vol.34, issue.2, pp.6185-94, 2015. ,
DOI : 10.1038/372686a0
The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice, Disease Models & Mechanisms, vol.9, issue.1, pp.51-61, 2016. ,
DOI : 10.1242/dmm.020750
Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes, Nature Medicine, vol.12, issue.9, pp.1132-1172, 2013. ,
DOI : 10.1074/jbc.M306062200
Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes, Diabetes, vol.66, issue.4, pp.994-1007, 2017. ,
DOI : 10.2337/db16-1199
Effects of in vitro antagonism of endocannabinoid-1 receptors on the glucose transport system in normal and insulin-resistant rat skeletal muscle, Diabetes, Obesity and Metabolism, vol.141, issue.Suppl 2, pp.722-730, 2010. ,
DOI : 10.1007/s00213-002-1384-8
Regulation of MAP Kinase-Directed Mitogenic and Protein Kinase B-Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells, Diabetes, vol.59, issue.2, pp.375-385, 2010. ,
DOI : 10.2337/db09-0979
Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver: The Role of eNOS, p38 MAPK, and AMPK Pathways, Diabetes, vol.59, issue.11, pp.2826-2862, 2010. ,
DOI : 10.2337/db09-1881
Glutamate spillover drives endocannabinoid production and inhibits GABAergic transmission in the Substantia Nigra pars compacta, Neuropharmacology, vol.79, pp.467-75, 2014. ,
DOI : 10.1016/j.neuropharm.2013.12.007
Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader???Willi syndrome, Molecular Metabolism, vol.5, issue.12, pp.1187-99, 2016. ,
DOI : 10.1016/j.molmet.2016.10.004
Psychiatric adverse effects of rimonobant in adults with Prader Willi syndrome, European Journal of Medical Genetics, vol.54, issue.1, pp.14-22, 2011. ,
DOI : 10.1016/j.ejmg.2010.09.015
Simultaneous postprandial deregulation of the orexigenic endocannabinoid anandamide and the anorexigenic peptide YY in obesity, International Journal of Obesity, vol.20, issue.6, p.880, 2012. ,
DOI : 10.1111/j.1365-2826.2008.01693.x
Hedonic Eating Is Associated with Increased Peripheral Levels of Ghrelin and the Endocannabinoid 2-Arachidonoyl-Glycerol in Healthy Humans: A Pilot Study, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.6, pp.917-941, 2012. ,
DOI : 10.1210/jc.2011-3018
Responses of peripheral endocannabinoids and endocannabinoid-related compounds to hedonic eating in obesity, European Journal of Nutrition, vol.4, issue.Suppl 2, pp.1799-805, 2016. ,
DOI : 10.3389/fpsyg.2013.00757
Deranged endocannabinoid responses to hedonic eating in underweight and recently weight-restored patients with anorexia nervosa, American Journal of Clinical Nutrition, vol.101, issue.2, pp.262-271, 2015. ,
DOI : 10.3945/ajcn.114.096164
URL : http://ajcn.nutrition.org/content/101/2/262.full.pdf
Cannabinoid CB1 receptor expression in relation to visceral adipose depots, endocannabinoid levels, microvascular damage, and the presence of the Cnr1 A3813G variant in humans, Metabolism, vol.59, issue.5, pp.734-775, 2010. ,
DOI : 10.1016/j.metabol.2009.09.018
) is associated with derangements in lipid homeostasis, independent of body mass index, Pharmacogenomics, vol.10, issue.11, pp.1647-56, 2008. ,
DOI : 10.1375/twin.10.6.805
Circulating Endocannabinoids and the Polymorphism 385C>A in Fatty Acid Amide Hydrolase (FAAH) Gene May Identify the Obesity Phenotype Related to Cardiometabolic Risk: A Study Conducted in a Brazilian Population of Complex Interethnic Admixture, PLOS ONE, vol.5, issue.1, 4641669. ,
DOI : 10.1371/journal.pone.0142728.t004
Disponible sur Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects, Biomarkers of Endocannabinoid System Activation in Severe Obesity. PLoS ONE [Internet Eur J Endocrinol. 11 janv, vol.5161, issue.15, pp.715-737, 2009. ,
Sleep restriction alters plasma endocannabinoids concentrations before but not after exercise in humans, Psychoneuroendocrinology, vol.74, pp.258-68, 2016. ,
DOI : 10.1016/j.psyneuen.2016.09.014
URL : https://doi.org/10.1016/j.psyneuen.2016.09.014
Activation of the Peripheral Endocannabinoid System in Human Obesity, Diabetes, vol.54, issue.10, pp.2838-2843, 2005. ,
DOI : 10.2337/diabetes.54.10.2838
Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity, Diabetes, vol.55, issue.11, pp.3053-60, 2006. ,
DOI : 10.2337/db06-0812
Endocannabinoids Measurement in Human Saliva as Potential Biomarker of Obesity, PLoS ONE, vol.7, issue.7, p.42399, 2012. ,
DOI : 10.1371/journal.pone.0042399.t001
Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men, International Journal of Obesity, vol.55, issue.Suppl 1, pp.692-66, 2007. ,
DOI : 10.1016/j.ab.2006.10.039
Circulating endocannabinoids in insulin sensitive vs. Insulin resistant obese postmenopausal women. A MONET group study, Obesity, vol.12, issue.1, pp.211-217, 2014. ,
DOI : 10.1111/j.1463-1326.2010.01227.x
URL : http://onlinelibrary.wiley.com/doi/10.1002/oby.20498/pdf
Circulating Endocannabinoids and Insulin Resistance in Patients with Obstructive Sleep Apnea, BioMed Research International, vol.2016, 2016. ,
DOI : 10.1016/j.jsmc.2007.03.009
Circulating anandamide and blood pressure in patients with obstructive sleep apnea, Journal of Hypertension, vol.30, issue.12, pp.2345-51, 2012. ,
DOI : 10.1097/HJH.0b013e3283591595
-acyl-ethanolamides in Patients with Sleep Apnea ??? Specific Role of Oleoylethanolamide, Experimental and Clinical Endocrinology & Diabetes, vol.118, issue.09, pp.591-596, 2010. ,
DOI : 10.1055/s-0030-1253344
Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity, European Heart Journal, vol.32, issue.11, pp.1369-78, 2011. ,
DOI : 10.1093/eurheartj/ehr029
URL : https://academic.oup.com/eurheartj/article-pdf/32/11/1369/7110167/ehr029.pdf
Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease, Obesity, vol.58, issue.1, pp.94-101, 2017. ,
DOI : 10.1016/j.metabol.2009.05.032
URL : http://onlinelibrary.wiley.com/doi/10.1002/oby.21687/pdf
Circadian Integration of Metabolism and Energetics, Science, vol.142, issue.6, pp.1349-54, 2010. ,
DOI : 10.1016/j.cell.2010.08.016
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756146/pdf
Crosstalk between Components of Circadian and Metabolic Cycles in Mammals, Cell Metabolism, vol.13, issue.2, pp.125-162, 2011. ,
DOI : 10.1016/j.cmet.2011.01.006
Endocannabinoid signalling: has it got rhythm?, British Journal of Pharmacology, vol.26, issue.1, pp.530-573, 2010. ,
DOI : 10.1152/ajpregu.90669.2008
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2010.00790.x/pdf
Circadian Rhythm of Circulating Levels of the Endocannabinoid 2-Arachidonoylglycerol Paris: Flammarion médecine-sciences, 220?6. 76. Chanson P, Young J. Traité d'endocrinologie, 2007. ,
Hypothalamic???Pituitary???Adrenocortical Axis Regulation, Endocrinology and Metabolism Clinics of North America, vol.34, issue.2, pp.271-92, 2005. ,
DOI : 10.1016/j.ecl.2005.01.003
Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo???pituitary???adrenocortical responsiveness, Frontiers in Neuroendocrinology, vol.24, issue.3, pp.151-80, 2003. ,
DOI : 10.1016/j.yfrne.2003.07.001
Molecular genetics of hypothalamic?pituitary?adrenal axis activity and function):127?36. 80. Quigley ME, Yen SS. A mid-day surge in cortisol levels The Postprandial Rise in Plasma Cortisol in Men Is Mediated by Macronutrient-Specific Stimulation of Adrenal and Extra-Adrenal Cortisol Production, ):945?7. 81. Stimson RH, pp.160-168, 1979. ,
DOI : 10.1111/j.1749-6632.2010.05902.x
Deconstructing the roles of glucocorticoids in adipose tissue biology and the development of central obesity, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1842, issue.3, pp.473-81, 2014. ,
DOI : 10.1016/j.bbadis.2013.05.029
Food-intake regulation during stress by the hypothalamo-pituitary-adrenal axis, Brain Research Bulletin, vol.95, pp.46-53, 2013. ,
DOI : 10.1016/j.brainresbull.2013.04.002
Glucocorticoids Increase Neuropeptide Y and Agouti-Related Peptide Gene Expression via Adenosine Monophosphate-Activated Protein Kinase Signaling in the Arcuate Nucleus of Rats, Endocrinology, vol.149, issue.9, pp.4544-53, 2008. ,
DOI : 10.1210/en.2008-0229
Corticosterone Regulates Synaptic Input Organization of POMC and NPY, AgRP Neurons in Adult Mice. Endocrinology. 1 nov, vol.151, issue.11, pp.5395-402, 2010. ,
DOI : 10.1210/en.2010-0681
URL : https://academic.oup.com/endo/article-pdf/151/11/5395/9009197/endo5395.pdf
Minireview: Glucocorticoids? Food Intake, Abdominal Obesity, and Wealthy Nations Interaction between Corticosterone and Insulin in Obesity: Regulation of Lard Intake and Fat Stores, Endocrinology. juin Endocrinology. mai, vol.145145, issue.875, pp.2174-85, 2004. ,
Stress-induced obesity and the emotional nervous system, Trends in Endocrinology & Metabolism, vol.21, issue.3, pp.159-65, 2010. ,
DOI : 10.1016/j.tem.2009.10.004
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831158/pdf
The interactions between hypothalamic-pituitary-adrenal axis activity, testosterone, insulin-like growth factor I and abdominal obesity with metabolism and blood pressure in men, International Journal of Obesity, vol.22, issue.12, pp.1184-96, 1998. ,
DOI : 10.1038/sj.ijo.0800745
The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A Hypothesis, The Journal of Clinical Endocrinology & Metabolism, vol.94, issue.8, pp.2692-701, 2009. ,
DOI : 10.1210/jc.2009-0370
Glucocorticoid Regulation of Leptin Synthesis and Secretion in Humans: Elevated Plasma Leptin Levels in Cushing's Syndrome):2542?7. 92. Van Raalte DH, Ouwens DM, Diamant M. Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options? Eur, J Clin Endocrinol Metab. 1 août J Clin Invest. 1 févr, vol.8239, issue.82, pp.81-93, 1997. ,
The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness, The Journal of Steroid Biochemistry and Molecular Biology, vol.165, pp.114-134, 2017. ,
DOI : 10.1016/j.jsbmb.2016.03.023
The cortisol-activating enzyme 11??-hydroxysteroid dehydrogenase type 1 in skeletal muscle in the pathogenesis of the metabolic syndrome, The Journal of Steroid Biochemistry and Molecular Biology, vol.174, 2017. ,
DOI : 10.1016/j.jsbmb.2017.07.030
Tissue-Specific Changes in Peripheral Cortisol Metabolism in Obese Women: Increased Adipose 11??-Hydroxysteroid Dehydrogenase Type 1 Activity, The Journal of Clinical Endocrinology & Metabolism, vol.87, issue.7, pp.3330-3336, 2002. ,
DOI : 10.1210/jcem.87.7.8661
Cushing's syndrome, The Lancet, vol.386, issue.9996, pp.913-940, 2015. ,
DOI : 10.1016/S0140-6736(14)61375-1
MECHANISMS IN ENDOCRINOLOGY: Tissue-specific activation of cortisol in Cushing's syndrome The burden of Cushing's disease: clinical and health-related quality of life aspects, R81?7. 98. Feelders RA, pp.311-337, 2012. ,
Computed tomography assessment of fat distribution in male and female patients with Cushing's syndrome, European Journal of Endocrinology, vol.149, issue.6, pp.561-567, 2003. ,
DOI : 10.1530/eje.0.1490561
Metabolic Syndrome in Cushing???s Syndrome, Neuroendocrinology, vol.92, issue.1, pp.96-101, 2010. ,
DOI : 10.1159/000314272
Metabolic comorbidities in Cushing's syndrome, European Journal of Endocrinology, vol.173, issue.4, pp.133-57, 2015. ,
DOI : 10.1530/EJE-15-0354
Glucose metabolism in patients with subclinical Cushing???s syndrome, Endocrine, vol.95, issue.Suppl 1, pp.415-438, 2012. ,
DOI : 10.1210/jc.2009-2453
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism, Cell Metabolism, vol.1, issue.1, pp.15-25, 2005. ,
DOI : 10.1016/j.cmet.2004.12.003
Changes in Adenosine 5???-Monophosphate-Activated Protein Kinase as a Mechanism of Visceral Obesity in Cushing???s Syndrome, The Journal of Clinical Endocrinology & Metabolism, vol.93, issue.12, pp.4969-73, 2008. ,
DOI : 10.1210/jc.2008-1297
AMP-activated protein kinase mediates glucocorticoid-induced metabolic changes: a novel mechanism in Cushing's syndrome, The FASEB Journal, vol.22, issue.6, pp.1672-83, 2008. ,
DOI : 10.1096/fj.07-094144
Neuropsychiatric Findings in Cushing Syndrome and Exogenous Glucocorticoid Administration, Endocrinology and Metabolism Clinics of North America, vol.42, issue.3, pp.477-88, 2013. ,
DOI : 10.1016/j.ecl.2013.05.010
A systematic review of the effect of oral glucocorticoids on energy intake, appetite, and body weight in humans, Nutrition Research, vol.34, issue.3, pp.179-90, 2014. ,
DOI : 10.1016/j.nutres.2013.12.006
Depressed Mood and Other Psychiatric Manifestations of Cushing??s Syndrome: Relationship to Hormone Levels, Psychosomatic Medicine, vol.43, issue.1, pp.3-18, 1981. ,
DOI : 10.1097/00006842-198102000-00002
A prospective study of appetite and food craving in 30 patients with Cushing???s disease, Pituitary, vol.11, issue.3, pp.117-143, 2016. ,
DOI : 10.1038/nm1201
Effects of glucocorticoids on energy metabolism and food intake in humans, Am J Physiol. août, vol.271, issue.2, pp.317-325, 1996. ,
Glucocorticoid Regulation of Food-Choice Behavior in Humans: Evidence from Cushing's Syndrome, Frontiers in Neuroscience, vol.34, issue.7 ,
DOI : 10.1016/j.psyneuen.2009.03.018
High cardiovascular risk in patients with Cushing's syndrome according to 1999 WHO/ISH guidelines, Clinical Endocrinology, vol.29, issue.6, pp.768-77, 2004. ,
DOI : 10.1046/j.1365-2796.2000.00609.x
Mortality and Morbidity in Cushing's Disease over 50 Years in Stoke-on-Trent, UK: Audit and Meta-Analysis of Literature, The Journal of Clinical Endocrinology & Metabolism, vol.96, issue.3, pp.632-674, 2011. ,
DOI : 10.1210/jc.2010-1942
Outcome of Cushing's Disease following Transsphenoidal Surgery in a Single Center over 20 Years, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.4, pp.1194-201, 2012. ,
DOI : 10.1210/jc.2011-2957
Mortality in Cushing's syndrome: A systematic review and meta-analysis, European Journal of Internal Medicine, vol.23, issue.3, pp.278-82, 2012. ,
DOI : 10.1016/j.ejim.2011.10.013
Mortality in Patients Treated for Cushing???s Disease Is Increased, Compared with Patients Treated for Nonfunctioning Pituitary Macroadenoma, The Journal of Clinical Endocrinology & Metabolism, vol.92, issue.3, pp.976-81, 2007. ,
DOI : 10.1210/jc.2006-2112
Multisystem Morbidity and Mortality in Cushing's Syndrome: A Cohort Study, The Journal of Clinical Endocrinology & Metabolism, vol.98, issue.6, pp.2277-84, 2013. ,
DOI : 10.1210/jc.2012-3582
MANAGEMENT OF ENDOCRINE DISEASE: Mortality remains increased in Cushing's disease despite biochemical remission: a systematic review and meta-analysis, European Journal of Endocrinology, vol.172, issue.4, pp.143-152, 2015. ,
DOI : 10.1530/EJE-14-0556
Predictors of Mortality and Long-term Outcomes in Treated Cushing's Disease: A Study of 346 Patients, The Journal of Clinical Endocrinology & Metabolism, vol.98, issue.3, pp.1022-1052, 2013. ,
DOI : 10.1210/jc.2012-2893
Mortality in patients with Cushing's disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study, The Lancet Diabetes & Endocrinology, vol.4, issue.7, pp.569-76, 2016. ,
DOI : 10.1016/S2213-8587(16)30005-5
Adrenal insufficiency. The Lancet. 31 mai, pp.1881-93, 2003. ,
Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, vol.101, issue.2, pp.364-89, 2016. ,
DOI : 10.1210/jc.2015-1710
URL : https://academic.oup.com/jcem/article-pdf/101/2/364/16607579/jcem0364.pdf
Anorexia after Adrenalectomy in Gold Thioglucose-Treated Obese Mice*, Endocrinology, vol.112, issue.5, pp.1847-51, 1983. ,
DOI : 10.1210/endo-112-5-1847
The Impact of Glucocorticoid Replacement Regimens on Metabolic Outcome and Comorbidity in Hypopituitary Patients, The Journal of Clinical Endocrinology & Metabolism, vol.91, issue.10, pp.3954-61, 2006. ,
DOI : 10.1210/jc.2006-0524
Mortality in Patients with Pituitary Disease, Endocrine Reviews, vol.31, issue.3, pp.301-343, 2010. ,
DOI : 10.1210/er.2009-0033
URL : https://academic.oup.com/edrv/article-pdf/31/3/301/10335111/edrv0301.pdf
Glucocorticoid Replacement and Mortality in Patients with Nonfunctioning Pituitary Adenoma, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.10, pp.1938-1980, 2012. ,
DOI : 10.1210/jc.2012-2432
URL : https://academic.oup.com/jcem/article-pdf/97/10/E1938/10782240/jcem1938.pdf
Higher glucocorticoid replacement doses are associated with increased mortality in patients with pituitary adenoma, European Journal of Endocrinology, vol.177, issue.3, pp.251-257, 2017. ,
DOI : 10.1530/EJE-17-0340
Correction of cortisol overreplacement ameliorates morbidities in patients with hypopituitarism: a pilot study, Pituitary, vol.87, issue.3, pp.279-85, 2008. ,
DOI : 10.7326/0003-4819-133-2-200007180-00010
Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study, European Journal of Endocrinology, vol.161, issue.1, pp.119-149, 2009. ,
DOI : 10.1530/EJE-09-0170
URL : http://www.eje-online.org/content/161/1/119.full.pdf
Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation, The Journal of Clinical Endocrinology & Metabolism, vol.97, issue.2, pp.473-81, 2012. ,
DOI : 10.1210/jc.2011-1926
Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study, Neuroscience, vol.90, issue.3, pp.923-931, 1999. ,
DOI : 10.1016/S0306-4522(98)00524-7
Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations, European Journal of Biochemistry, vol.23, issue.1, pp.54-61, 1995. ,
DOI : 10.1016/0165-3806(93)90124-S
Role of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis, Prog Brain Res. 1 janv, vol.170, pp.397-432, 2008. ,
DOI : 10.1016/S0079-6123(08)00433-0
Corticotrophin and corticosterone secretion following ??1-tetrahydrocannabinol, in intact and in hypothalamic deafferentated male rats, Experimental Brain Research, vol.21, issue.1, pp.85-93, 1982. ,
DOI : 10.1159/000122526
Effect of the Brain Constituent Anandamide, a Cannabinoid Receptor Agonist, on the Hypothalamo-Pituitary-Adrenal Axis in the Rat, Neuroendocrinology, vol.59, issue.2, pp.110-112, 1994. ,
DOI : 10.1159/000126646
Opioid and cannabinoid receptor-mediated regulation of the increase in adrenocorticotropin hormone and corticosterone plasma concentrations induced by central administration of ??9-tetrahydrocannabinol in rats, Brain Research, vol.839, issue.1, pp.173-182, 1999. ,
DOI : 10.1016/S0006-8993(99)01756-4
Characterization of the acute endocrine actions of (???)-11-hydroxy-??8-tetrahydrocannabinol-dimethylheptyl (HU-210), a potent synthetic cannabinoid in rats, European Journal of Pharmacology, vol.344, issue.1, pp.77-86, 1998. ,
DOI : 10.1016/S0014-2999(97)01560-4
Endocrine and other responses to acute administration of cannabinoid compounds to non-stressed male calves, Life Sciences, vol.65, issue.2, pp.125-158, 1999. ,
DOI : 10.1016/S0024-3205(99)00229-5
Endocannabinoid Signaling Negatively Modulates Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis, Endocrinology, vol.145, issue.12, pp.5431-5439, 2004. ,
DOI : 10.1210/en.2004-0638
Requirement of Cannabinoid Receptor Type 1 for the Basal Modulation of Hypothalamic-Pituitary-Adrenal Axis Function, Endocrinology, vol.148, issue.4, pp.1574-81, 2007. ,
DOI : 10.1210/en.2005-1649
The effects of cannabinoids on serum cortisol and prolactin in humans, Psychopharmacology, vol.46, issue.10, p.737, 2009. ,
DOI : 10.1002/j.1552-4604.2002.tb06008.x
The Psychotomimetic Effects of Intravenous Delta-9-Tetrahydrocannabinol in Healthy Individuals: Implications for Psychosis, Neuropsychopharmacology, vol.76, issue.Suppl 3, pp.1558-72, 2004. ,
DOI : 10.1007/BF00432554
Delta-9- tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction, Biol Psychiatry. 15 mars, vol.57, issue.6, pp.594-608, 2005. ,
Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala, European Journal of Pharmacology, vol.528, issue.1-3, pp.99-102, 2005. ,
DOI : 10.1016/j.ejphar.2005.10.058
Prolonged glucocorticoid treatment decreases cannabinoid CB1 receptor density in the hippocampus, Hippocampus, vol.141, issue.2, pp.221-227, 2008. ,
DOI : 10.1002/hipo.20386
Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo, Psychoneuroendocrinology, vol.35, issue.9, pp.1333-1341, 2010. ,
DOI : 10.1016/j.psyneuen.2010.03.005
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914801/pdf
A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome, Proceedings of the National Academy of Sciences, vol.46, issue.2, pp.285-90, 2015. ,
DOI : 10.1021/ac0624086
URL : http://www.pnas.org/content/112/1/285.full.pdf
CB1 receptor mediates the effects of glucocorticoids on AMPK activity in the hypothalamus, Journal of Endocrinology, vol.219, issue.1, pp.79-88, 2013. ,
DOI : 10.1530/JOE-13-0192
Intense exercise increases circulating endocannabinoid and BDNF levels in humans???Possible implications for reward and depression, Psychoneuroendocrinology, vol.37, issue.6, pp.844-51, 2012. ,
DOI : 10.1016/j.psyneuen.2011.09.017
Clinical consequences of Cushing???s syndrome, Pituitary, vol.130, issue.3, pp.319-348, 2012. ,
DOI : 10.7326/0003-4819-130-10-199905180-00015
The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, vol.93, issue.5, pp.1526-1566, 2008. ,
DOI : 10.1210/jc.2008-0125
Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography???tandem electrospray ionization mass spectrometry, Analytical Biochemistry, vol.360, issue.2, pp.216-242, 2007. ,
DOI : 10.1016/j.ab.2006.10.039
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, vol.92, issue.7, pp.412-421, 1985. ,
DOI : 10.1007/BF00280883
Cardiovascular Risk Factors and Common Carotid Artery Caliber and Stiffness in Patients with Cushing???s Disease during Active Disease and 1 Year after Disease Remission, The Journal of Clinical Endocrinology & Metabolism, vol.88, issue.6, pp.2527-2560, 2003. ,
DOI : 10.1210/jc.2002-021558
URL : https://academic.oup.com/jcem/article-pdf/88/6/2527/9149720/jcem2527.pdf
Chronic, noninvasive glucocorticoid administration suppresses limbic endocannabinoid signaling in mice, Neuroscience, vol.204, pp.83-92, 2012. ,
DOI : 10.1016/j.neuroscience.2011.08.048
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697830/pdf
Repeated Stress Impairs Endocannabinoid Signaling in the Paraventricular Nucleus of the Hypothalamus, Journal of Neuroscience, vol.30, issue.33, pp.11188-96, 2010. ,
DOI : 10.1523/JNEUROSCI.1046-10.2010
Effects of General Anesthesia on Anandamide Blood Levels in Humans, Anesthesiology, vol.104, issue.2, pp.273-280, 2006. ,
DOI : 10.1097/00000542-200602000-00012
Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol?, British Journal of Clinical Pharmacology, vol.5, issue.884, pp.54-63, 2012. ,
DOI : 10.1371/journal.pone.0010752