Les nouvelles promesses de la metformine, m??decine/sciences, vol.26, issue.1, pp.82-92, 2014. ,
DOI : 10.1051/medsci/201026121056
URL : http://www.medecinesciences.org/articles/medsci/pdf/2014/01/medsci20143001p82.pdf
Metformin, New England Journal of Medicine, vol.334, issue.9, pp.574-583, 1996. ,
DOI : 10.1056/NEJM199602293340906
Pharmacokinetics of metformin after intravenous and oral administration to man, European Journal of Clinical Pharmacology, vol.16, issue.Suppl. 1, pp.195-202, 1979. ,
DOI : 10.1007/BF00562061
Clinical Pharmacokinetics of Metformin, Clinical Pharmacokinetics, vol.11, issue.4, pp.81-98, 2011. ,
DOI : 10.1111/j.1464-5491.1994.tb00253.x
Clinical Pharmacokinetics of Metformin, Clinical Pharmacokinetics, vol.30, issue.5, pp.359-71, 1996. ,
DOI : 10.2165/00003088-199630050-00003
Accumulation of metformin by tissues of the normal and diabetic mouse, Xenobiotica, vol.37, issue.1, pp.49-57, 1994. ,
DOI : 10.1016/S0168-8227(88)80022-6
Reduced Hepatic Uptake and Intestinal Excretion of Organic Cations in Mice with a Targeted Disruption of the Organic Cation Transporter 1 (Oct1 [Slc22a1]) Gene, Molecular and Cellular Biology, vol.21, issue.16, pp.5471-5478, 2001. ,
DOI : 10.1128/MCB.21.16.5471-5477.2001
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action, Journal of Clinical Investigation, vol.117, issue.5, pp.1422-1453, 2007. ,
DOI : 10.1172/JCI30558DS1
Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin, Molecular Pharmacology, vol.88, issue.1, pp.75-83, 2015. ,
DOI : 10.1124/mol.114.096776
Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I, Journal of Biological Chemistry, vol.1364, issue.2, pp.223-231, 2000. ,
DOI : 10.1002/(SICI)1099-1263(199711/12)17:6<409::AID-JAT462>3.0.CO;2-B
URL : https://hal.archives-ouvertes.fr/inserm-00390049
Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes, European Journal of Biochemistry, vol.119, issue.3, pp.1341-1349, 1993. ,
DOI : 10.1042/bj1190501
URL : https://hal.archives-ouvertes.fr/inserm-00390262
Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure, AJP: Heart and Circulatory Physiology, vol.301, issue.2, pp.459-468, 2011. ,
DOI : 10.1152/ajpheart.00054.2011
Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure, Circulation Research, vol.104, issue.3, pp.403-414, 2009. ,
DOI : 10.1161/CIRCRESAHA.108.190918
Metformin and reduced risk of cancer in diabetic patients, BMJ, vol.330, issue.7503, pp.1304-1309, 2005. ,
DOI : 10.1136/bmj.38415.708634.F7
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTENdeficient mice, Biochem J. 1 juin, vol.412, issue.2, pp.211-232, 2008. ,
Quels b??n??fices antitumoraux attendre de la metformine???, Annales d'Endocrinologie, vol.74, issue.2, pp.137-184, 2013. ,
DOI : 10.1016/j.ando.2013.02.009
Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs, Critical Care, vol.16, issue.3, p.75, 2012. ,
DOI : 10.1186/cc11332
URL : http://doi.org/10.1186/cc11332
Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition, Acta Physiologica, vol.286, issue.Pt 3, pp.171-80, 2015. ,
DOI : 10.1074/jbc.M110.208447
Efficacy of Metformin in Patients with Non-Insulin-Dependent Diabetes Mellitus, New England Journal of Medicine, vol.333, issue.9, pp.541-550, 1995. ,
DOI : 10.1056/NEJM199508313330902
Worldwide Experience of Metformin as an Effective Glucose-lowering Agent: A Meta-analysis, Diabetes/Metabolism Reviews, vol.4, issue.S1, pp.57-62, 1995. ,
DOI : 10.1016/0306-3623(93)90411-P
Metformin in patients with type 2 diabetes mellitus: reconsideration of traditional contraindications, European Journal of Internal Medicine, vol.13, issue.7, p.428, 2002. ,
DOI : 10.1016/S0953-6205(02)00131-0
Pharmacologic Therapy for Type 2 Diabetes Mellitus, Annals of Internal Medicine, vol.131, issue.4, pp.281-303, 1999. ,
DOI : 10.7326/0003-4819-131-4-199908170-00008
Incidence of lactic acidosis in metformin users, Diabetes Care, vol.22, issue.6, pp.925-932, 1999. ,
DOI : 10.2337/diacare.22.6.925
Lactic Acidosis in Patients with Diabetes Treated with Metformin, New England Journal of Medicine, vol.338, issue.4, pp.265-271, 1998. ,
DOI : 10.1056/NEJM199801223380415
Metformin-associated lactic acidosis in Sweden, 1977. ,
Metformin associated lactic acidosis: incidence and clinical correlation with metformin serum concentration measurements, Journal of Clinical Pharmacy and Therapeutics, vol.5, issue.3, pp.376-82, 2011. ,
DOI : 10.1046/j.1463-1326.2003.00241.x
The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis, Drug Safety, vol.180, issue.4, 2013. ,
DOI : 10.1016/j.toxlet.2008.06.793
Lactic acidosis in metformin therapy: searching for a link with metformin in reports of ???metformin-associated lactic acidosis???, Diabetes, Obesity and Metabolism, vol.4, issue.Suppl., pp.195-201, 2001. ,
DOI : 10.2337/diacare.20.2.232b
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus, J Clin Endocrinol Metab. nov, vol.81, issue.11, pp.4059-67, 1996. ,
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. The Cochrane Library, 2010. ,
Lactic Acidosis With Therapeutic Metformin Blood Level in a Low-Risk Diabetic Patient, Diabetes Care, vol.21, issue.8, pp.1364-1369, 1998. ,
DOI : 10.2337/diacare.21.8.1364
Role of Metformin Accumulation in Metformin-Associated Lactic Acidosis, Diabetes Care, vol.18, issue.6, pp.779-84, 1995. ,
DOI : 10.2337/diacare.18.6.779
Metformin and lactic acidosis in diabetic humans, Diabetes, Obesity and Metabolism, vol.21, issue.3, pp.131-138, 2000. ,
DOI : 10.1042/cs0640573
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain, Biochem J. 15 juin, vol.348, issue.3, pp.607-621, 2000. ,
Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I: A Common Mechanism Contributing to Their Antidiabetic Actions?, Diabetes, vol.53, issue.4, pp.1052-1061, 2004. ,
DOI : 10.2337/diabetes.53.4.1052
URL : http://diabetes.diabetesjournals.org/content/diabetes/53/4/1052.full.pdf
Lactic Acidosis in Metformin Therapy: Relationship between plasma metformin concentration and renal function, Diabetes Care, vol.21, issue.8, pp.1366-1373, 1998. ,
DOI : 10.2337/diacare.21.8.1366
Metformin-Associated Lactic Acidosis (MALA): Case Files of the Einstein Medical Center Medical Toxicology Fellowship, Journal of Medical Toxicology, vol.23, issue.1, pp.61-67, 2013. ,
DOI : 10.2337/diacare.19.12.1449
[Metformin-associated lactic acidosis]. Ann Fr Anesthèsie Rèanimation, oct, vol.25, issue.10, pp.1046-52, 2006. ,
Metformin-associated lactic acidosis: A prognostic and therapeutic study*: Crit Care Med, juill, vol.37, issue.7, pp.2191-2197, 2009. ,
DOI : 10.1097/ccm.0b013e3181a02490
Metformin-Associated Lactic Acidosis in Chinese Patients with Type II Diabetes, Pharmacology, vol.40, issue.5-6, pp.260-265, 2011. ,
DOI : 10.1081/CLT-120004407
Metformin-associated lactic acidosis in an intensive care unit, Critical Care, vol.12, issue.6, p.149, 2008. ,
DOI : 10.1186/cc7137
URL : https://ccforum.biomedcentral.com/track/pdf/10.1186/cc7137?site=ccforum.biomedcentral.com
Microassay of plasma and erythrocyte metformin by high performance liquid chromatography], Ann Biol Clin, vol.49, issue.2, pp.98-101, 1991. ,
Measurement of metformin concentration in erythrocytes:clinical implications, Diabetes, Obesity and Metabolism, vol.20, issue.2, pp.93-101, 2003. ,
DOI : 10.1046/j.1463-1326.2000.00053.x
Metformin kinetics in healthy subjects and in patients with diabetes mellitus., British Journal of Clinical Pharmacology, vol.10, issue.2, pp.235-281, 1981. ,
DOI : 10.1002/jps.2600670524
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401849/pdf
Kinetics of plasma and erythrocyte metformin after acute administration in healthy subjects, Diabetes & Metabolism, vol.29, issue.3, pp.279-83, 2003. ,
DOI : 10.1016/S1262-3636(07)70037-X
Erythrocyte metformin levels in patients with type 2 diabetes and varying severity of chronic kidney disease, Clinical Kidney Journal, vol.5, issue.1, pp.65-72, 2012. ,
DOI : 10.1093/ndtplus/sfr134
The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis, BMC Pharmacology and Toxicology, vol.37, issue.1, p.22, 2013. ,
DOI : 10.1097/CCM.0b013e3181a02490
Metformin accumulation: Lactic acidosis and high plasmatic metformin levels in a retrospective case series of 66 patients on chronic therapy, Clinical Toxicology, vol.10, issue.2, pp.129-164, 2014. ,
DOI : 10.1111/j.1365-2710.2010.01192.x
Extracorporeal Treatment for Metformin Poisoning, Critical Care Medicine, vol.43, issue.8, pp.1716-1746, 2015. ,
DOI : 10.1097/CCM.0000000000001002
Bicarbonate haemodialysis: an adequate treatment for lactic acidosis in diabetics treated by metformin, Intensive Care Medicine, vol.13, issue.6, pp.383-390, 1987. ,
DOI : 10.1007/BF00257680
Bicarbonate haemodialysis as a treatment of metformin overdose, Nephrology Dialysis Transplantation, vol.12, issue.5, pp.1046-1053, 1997. ,
DOI : 10.1093/ndt/12.5.1046
Dialysis Rounds???A Dialysis Case Presentation and Discussion???Edited by Roger A. Rodby: Severe Lactic Acidosis Treated with Prolonged Hemodialysis: Recovery After Massive Overdoses of Metformin, Seminars in Dialysis, vol.28, issue.suppl 17, pp.80-83, 2006. ,
DOI : 10.4158/EP.3.6.359
Intoxication par la metformine??: m??canismes de toxicit?? et prise en charge, R??animation, vol.19, issue.6, pp.539-544, 2010. ,
DOI : 10.1016/j.reaurg.2010.05.011
Utility of serum lactate to predict drug-overdose fatality, Clinical Toxicology, vol.59, issue.7, pp.730-736, 2010. ,
DOI : 10.1186/cc7159
URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091774/pdf
Acute Metformin Overdose: Examining Serum pH, Lactate Level, and Metformin Concentrations in Survivors Versus Nonsurvivors: A Systematic Review of the Literature, Annals of Emergency Medicine, vol.54, issue.6, pp.818-841, 2009. ,
DOI : 10.1016/j.annemergmed.2009.04.023
Contraindications to metformin therapy in patients with Type 2 diabetes-a population-based study of adherence to prescribing guidelines, Diabetic Medicine, vol.7, issue.6, pp.483-491, 2001. ,
DOI : 10.1136/bmj.315.7107.524
Contra-indications to metformin therapy are largely disregarded, Diabetic Medicine, vol.21, issue.8, pp.692-698, 1999. ,
DOI : 10.2337/diacare.21.10.1587
Outcome of severe lactic acidosis associated with metformin accumulation, Critical Care, vol.14, issue.6, p.226, 2010. ,
DOI : 10.1186/cc9376
URL : https://ccforum.biomedcentral.com/track/pdf/10.1186/cc9376?site=ccforum.biomedcentral.com
Hyperlactataemia and clinical severity of acute metformin overdose, Internal Medicine Journal, vol.81, issue.4, pp.402-410, 2015. ,
DOI : 10.1038/sj.clpt.6100193
A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study, JAMA: The Journal of the American Medical Association, vol.270, issue.24, pp.2957-63, 1993. ,
DOI : 10.1001/jama.1993.03510240069035
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation*, Critical Care Medicine, vol.37, issue.5, pp.1649-54, 2009. ,
DOI : 10.1097/CCM.0b013e31819def97