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Master Thesis

Évaluation de l'impact d'outils d'aide à la prise en charge vaccinale des patients atteints d'hémopathie maligne sous chimiothérapie : étude HEMAVAC

Abstract : Introduction: Therapeutic advances have changed malignant hemopathy epidemiology and patients’ quality of life. They are especially at risk of infection due to the immunosuppression caused by their pathology and chemotherapy. Vaccination is a key element of prevention, but vaccinal coverage is still insufficient despite the latest guidelines. The study's aim was to identify the existing impediments to vaccination and assess the impact of information tools on vaccinal coverage. Methods: This prospective observational study was based on pre/post analysis carried out in hematology departments of a university hospital and a regional center. Patients with malignant hemopathy under chemotherapy were sampled and surveyed. A flyer was given to patients and a guideline summary on vaccination to hematologists prior to a second assessment of vaccinal coverage. Results: 403 patients were included. Vaccinal coverage did not increase significantly. Only pneumococcal coverage improved according to haematological records. Initial vaccinal coverage was low for influenza (19.3%), pneumococcus (9.7%), DTP (36.2%) and hepatitis B (15%). According to the hematologists, lack of vaccinal anamnesy for patient (75%), lack of vaccination tracability (58.3%) and difficulties to access guidelines (41.6%) were the main obstacles for better vaccinal coverage. Most of the patients considered vaccination as an important part of their treatment (75.4%), but too few were well-informed (24.6%). Discussion: This study confirms vaccine deficit and the low impact of the communication tools provided. It suggests the need for developing online vaccinal booklet and for holding dedicated consultations.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01637288
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Submitted on : Friday, November 17, 2017 - 2:38:20 PM
Last modification on : Wednesday, July 15, 2020 - 8:58:04 AM
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Florian Vaquier, Nicolas Girod. Évaluation de l'impact d'outils d'aide à la prise en charge vaccinale des patients atteints d'hémopathie maligne sous chimiothérapie : étude HEMAVAC. Médecine humaine et pathologie. 2017. ⟨dumas-01637288⟩

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