. Afssaps, Prise en charge thérapeutique du patient dyslipidémique -recommandations, 2005.

. Afssaps, Prise en charge thérapeutique du patient dyslipidémique -argumentaire, 2005.

S. Akoudad, M. L. Portegies, P. J. Koudstaal, A. Hofman, A. Van-der-lugt et al., « Cerebral Microbleeds Are Associated With an Increased Risk of Stroke: The Rotterdam Study, Circulation. 2015, vol.132, pp.6-509

S. Alamowitch and G. Grateau, « Angiopathies amyloïdes cérébrales ». Sang Thrombose Vaisseaux, pp.367-373, 2007.

S. Allan and M. Brett, « Aspirin/Dipyridamole vs Clopidogrel to Prevent Recurrent Stroke: A Toss- Up? ». Medscape, 2008.

N. C. Alonzo, B. T. Hyman, G. W. Rebeck, and S. M. Greenberg, Progression of Cerebral Amyloid Angiopathy: Accumulation of Amyloid-??40 in Affected Vessels, Journal of Neuropathology and Experimental Neurology, vol.57, issue.4, pp.4-353, 1998.
DOI : 10.1097/00005072-199804000-00008

P. Amarenco, J. Labreuche, P. Lavallée, and P. «. Touboul, Statins in Stroke Prevention and Carotid Atherosclerosis: Systematic Review and Up-to-Date Meta-Analysis, Stroke, vol.35, issue.12, pp.12-2902, 2004.
DOI : 10.1161/01.STR.0000147965.52712.fa

J. Attems, F. Lauda, and K. A. Jellinger, Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy, Journal of Neurology, vol.5, issue.1, pp.1-70, 2008.
DOI : 10.1161/01.STR.14.6.924

E. Bakker, C. Van-broeckhoven, J. Haan, E. Voorhoeve, W. Van-hul et al., « DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type) », Am. J. Hum. Genet, vol.49, pp.3-518, 1991.

A. Barrera-ocampo and F. Lopera, « Amyloid-beta immunotherapy: the hope for Alzheimer disease? », Colomb Med, vol.47, pp.4-203, 2016.

P. J. Barter and K. Rye, « Cardioprotective Properties of Fibrates ». Circulation, pp.12-1553, 2006.

A. Baurand, A. Eckly, B. Hechler, G. Kauffenstein, J. Galzi et al., Differential Regulation and Relocalization of the Platelet P2Y Receptors after Activation: A Way to Avoid Loss of Hemostatic Properties?, Molecular Pharmacology, vol.67, issue.3, pp.3-721, 2005.
DOI : 10.1124/mol.104.004846

A. Biffi and S. M. Greenberg, Cerebral Amyloid Angiopathy: A Systematic Review, Journal of Clinical Neurology, vol.7, issue.1, pp.1-1, 2011.
DOI : 10.3988/jcn.2011.7.1.1

URL : http://synapse.koreamed.org/Synapse/Data/PDFData/0145JCN/jcn-7-1.pdf

M. Bifulco and A. M. Malfitano, Regulation of platelet function by statins », Journal of Blood Disorders. 2014, vol.1, pp.1-2

K. Blennow and D. Galasko, Cerebrospinal Fluid Biomarkers for Alzheimer's Disease, Journal of Alzheimer's Disease, vol.18, issue.2, 2001.
DOI : 10.3233/JAD-2009-1177

K. Blennow and H. Hampel, CSF markers for incipient Alzheimer's disease, The Lancet Neurology, vol.2, issue.10, pp.10-605, 2003.
DOI : 10.1016/S1474-4422(03)00530-1

M. Bornebroek, C. De-jonghe, J. Haan, S. Kumar-singh, S. Younkin et al., « Hereditary cerebral hemorrhage with amyloidosis Dutch type (AbetaPP 693): decreased plasma amyloid-beta 42 concentration, Neurobiol. Dis, vol.14, pp.3-619, 2003.
DOI : 10.1016/j.nbd.2003.08.019

G. Boulouis, A. Charidimou, and S. M. Greenberg, Sporadic Cerebral Amyloid Angiopathy: Pathophysiology, Neuroimaging Features, and Clinical Implications, Seminars in Neurology, vol.36, issue.03, pp.3-233, 2016.
DOI : 10.1055/s-0036-1581993

P. A. Boyle, L. Yu, S. Nag, S. Leurgans, R. S. Wilson et al., Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons, Neurology, vol.85, issue.22, pp.22-1930, 2015.
DOI : 10.1212/WNL.0000000000002175

S. A. Braksick, J. P. Klaas, R. D. Brown, A. A. Rabinstein, S. E. Hocker et al., Influence of Antithrombotics on the Etiology of Intracerebral Hemorrhage, Journal of Stroke and Cerebrovascular Diseases, vol.24, issue.3, pp.3-699
DOI : 10.1016/j.jstrokecerebrovasdis.2014.11.009

J. T. Brandt, C. D. Payne, S. D. Wiviott, G. Weerakkody, N. A. Farid et al., A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation, American Heart Journal, vol.153, issue.1, pp.1-66, 2007.
DOI : 10.1016/j.ahj.2006.10.010

P. «. Brugières, Comprendre le signal de l'hémorragie cérébro-méningée en IRM ». Act, « An Italian type of HCHWA ». Neurobiology of Aging, p.238, 1998.

J. W. Burch, N. Stanford, and P. W. Majerus, Inhibition of platelet prostaglandin synthetase by oral aspirin., Journal of Clinical Investigation, vol.61, issue.2, pp.2-314, 1978.
DOI : 10.1172/JCI108941

C. L. Campbell, S. Smyth, G. Montalescot, and S. R. Steinhubl, Aspirin Dose for the Prevention of Cardiovascular Disease, JAMA, vol.297, issue.18, pp.18-2018, 2007.
DOI : 10.1001/jama.297.18.2018

C. Steering and C. , « A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE), CAPRIE Steering Committee ». Lancet, vol.348, pp.9038-1329, 1996.

A. De-la-chapelle, R. Tolvanen, G. Boysen, J. Santavy, L. Bleeker-wagemakers et al., Gelsolin???derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187, Nature Genetics, vol.19, issue.2, pp.2-157, 1992.
DOI : 10.1101/gr.1.4.255

C. Collaborators, B. Mihaylova, J. Emberson, L. Blackwell, A. Keech et al., « The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials, Cholesterol Treatment Trialists, vol.380, pp.9841-581

A. T. Collaboration, ATT) « Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials ». The Lancet, pp.9678-1849, 2009.

B. S. Coller and S. J. Shattil, The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend, Blood, vol.112, pp.8-3011, 2008.

R. Collins, J. Armitage, S. Parish, P. Sleight, and R. Peto, Heart Protection Study Collaborative Group. « Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions, Lancet, vol.363, pp.9411-757, 2004.

C. Cordonnier, R. Al-shahi-salman, and J. Wardlaw, Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting, Brain, vol.130, issue.8, pp.1988-2003, 2007.
DOI : 10.1093/brain/awl387

C. Cordonnier and W. M. Flier, Van der. « Brain microbleeds and Alzheimer's disease: innocent observation or key player? ». Brain, pp.2-335, 2011.

S. R. Coughlin, Protease-activated receptors in hemostasis, thrombosis and vascular biology, Journal of Thrombosis and Haemostasis, vol.77, issue.3, pp.8-1800, 2005.
DOI : 10.1074/jbc.271.25.14910

A. J. Coull, J. K. Lovett, and P. M. Rothwell, Oxford Vascular Study. « Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services », BMJ, vol.328, pp.7435-326, 2004.

J. K. Damås, L. Puccetti, and P. Aukrust, « Early anti-thrombotic and anti-inflammatory actions of statins and fibrates--time for adjuvant therapy in acute coronary syndromes?, Thromb. Haemost, vol.94, pp.1-1, 2005.

J. S. Day, B. A. Policeni, W. R. Smoker, M. C. Dobre, Y. Zhang et al., Previous Statin Use Is Not Associated With an Increased Prevalence or Degree of Gradient-Echo Lesions in Patients With Acute Ischemic Stroke or Transient Ischemic Attack, Stroke, vol.42, issue.2, pp.2-354, 2011.
DOI : 10.1161/STROKEAHA.110.594101

E. Delvalee, Effets pléiotropes et perspectives thérapeutiques des statines dans le domaine cardiovasculaire, 2012.

H. C. Diener, L. Cunha, C. Forbes, J. Sivenius, P. Smets et al., European Stroke Prevention Study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke, Journal of the Neurological Sciences, vol.143, issue.1-2, pp.1-2, 1996.
DOI : 10.1016/S0022-510X(96)00308-5

H. Diener, J. Bogousslavsky, L. M. Brass, C. Cimminiello, L. Csiba et al., MATCH investigators. « Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial ». Lancet, pp.9431-331, 2004.

P. «. Duriez, Mechanisms of actions of statins and fibrates], Therapie, vol.58, pp.1-5, 2003.

R. J. Ellis, J. M. Olichney, L. J. Thal, S. S. Mirra, J. C. Morris et al., Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV, Neurology, vol.46, issue.6, pp.6-1592, 1996.
DOI : 10.1212/WNL.46.6.1592

M. Endres and U. Laufs, « Effects of Statins on Endothelium and Signaling Mechanisms ». Stroke, pp.2708-2711, 2004.

M. Félétou, P. M. Vanhoutte, and T. J. Verbeuren, The thromboxane/endoperoxide receptor (TP): the common villain, J. Cardiovasc. Pharmacol, vol.55, pp.4-317, 2010.

D. S. Fredrickson and R. S. Lees, « a system for phenotyping hyperlipoproteinemia ». Circulation, pp.321-327, 1965.

C. «. Gachet, Les mécanismes moléculaires de l'activation plaquettaire, Bull. Acad. Natle Méd. 2013, pp.2-361

C. «. Gachet, REGULATION OF PLATELET FUNCTIONS BY P2 RECEPTORS, Annual Review of Pharmacology and Toxicology, vol.46, issue.1, pp.277-300, 2006.
DOI : 10.1146/annurev.pharmtox.46.120604.141207

C. Gachet, P2 receptors, platelet function and pharmacological implications, Thrombosis and Haemostasis, vol.99, pp.3-466, 2008.
DOI : 10.1160/TH07-11-0673

URL : https://www.schattauer.de/index.php?id=5236&mid=9466

B. Ghetti, P. Piccardo, M. G. Spillantini, Y. Ichimiya, M. Porro et al., Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP., Proceedings of the National Academy of Sciences, vol.93, issue.2, pp.2-744, 1996.
DOI : 10.1073/pnas.93.2.744

M. Goedert, R. Jakes, R. A. Crowther, J. Six, U. Lübke et al., The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development., Proceedings of the National Academy of Sciences, vol.90, issue.11, pp.11-5066, 1993.
DOI : 10.1073/pnas.90.11.5066

I. Goldenberg, M. Benderly, and U. Goldbourt, « Update on the use of fibrates: focus on bezafibrate ». Vasc Health Risk Manag, pp.1-131, 2008.

T. J. Grabowski, H. S. Cho, J. P. Vonsattel, G. W. Rebeck, and S. M. Greenberg, Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy, Annals of Neurology, vol.5, issue.6, pp.6-697, 2001.
DOI : 10.1006/neur.1996.0017

S. M. Greenberg, Cerebral amyloid angiopathy: Prospects for clinical diagnosis and treatment, Neurology, vol.51, issue.3, pp.3-690, 1998.
DOI : 10.1212/WNL.51.3.690

S. M. Greenberg, J. A. Eng, M. Ning, E. E. Smith, and J. Rosand, « Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage ». Stroke, pp.6-1415, 2004.
DOI : 10.1161/01.str.0000126807.69758.0e

URL : http://stroke.ahajournals.org/content/strokeaha/35/6/1415.full.pdf

S. M. Gregoire, H. R. Jäger, T. A. Yousry, C. Kallis, M. M. Brown et al., Brain microbleeds as a potential risk factor for antiplatelet-related intracerebral haemorrhage: hospital-based, case-control study, Journal of Neurology, Neurosurgery & Psychiatry, vol.81, issue.6, pp.6-679, 2010.
DOI : 10.1136/jnnp.2009.198994

URL : https://hal.archives-ouvertes.fr/hal-00557436

P. Gresele, S. Momi, and E. Falcinelli, Anti-platelet therapy: phosphodiesterase inhibitors, British Journal of Clinical Pharmacology, vol.21, issue.2, pp.4-634, 2011.
DOI : 10.1053/euhj.2000.2458

T. Hamaguchi, S. Okino, N. Sodeyama, Y. Itoh, A. Takahashi et al., Association of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy, J. Neurol. Neurosurg. Psychiatr, vol.76, pp.5-696, 2005.

J. R. Hamilton, Protease-activated receptors as targets for antiplatelet therapy ». Blood Rev, pp.2-61, 2009.

H. C. Hanger, T. J. Wilkinson, N. Fayez?iskander, and R. Sainsbury, The risk of recurrent stroke after intracerebral haemorrhage, Journal of Neurology, Neurosurgery & Psychiatry, vol.78, issue.8, pp.8-836, 2007.
DOI : 10.1136/jnnp.2006.106500

G. J. Hankey, C. L. Sudlow, and D. W. Dunbabin, Thienopyridines or Aspirin to Prevent Stroke and Other Serious Vascular Events in Patients at High Risk of Vascular Disease? : A Systematic Review of the Evidence From Randomized Trials, Stroke, vol.31, issue.7, pp.7-1779, 2000.
DOI : 10.1161/01.STR.31.7.1779

D. C. Haussen, N. Henninger, S. Kumar, and M. Selim, « Statin use and microbleeds in patients with spontaneous intracerebral hemorrhage ». Stroke, pp.10-2677, 2012.

R. A. Hayward, T. P. Hofer, and S. Vijan, Narrative Review: Lack of Evidence for Recommended Low-Density Lipoprotein Treatment Targets: A Solvable Problem, Annals of Internal Medicine, vol.145, issue.7, pp.7-520, 2006.
DOI : 10.7326/0003-4819-145-7-200610030-00010

J. He, P. K. Whelton, B. Vu, and M. J. Klag, Aspirin and risk of hemorrhagic stroke: a metaanalysis of randomized controlled trials, JAMA, vol.280, pp.22-1930, 1998.

L. Hendriks, C. M. Van-duijn, P. Cras, M. Cruts, W. Van-hul et al., Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene, Nat. Genet, vol.1, pp.3-218, 1992.

M. D. Hill, F. L. Silver, P. C. Austin, and J. V. Tu, Rate of Stroke Recurrence in Patients With Primary Intracerebral Hemorrhage, Stroke, vol.31, issue.1, pp.1-123, 2000.
DOI : 10.1161/01.STR.31.1.123

T. Ibbotson, J. K. Mcgavin, and K. L. Goa, Abciximab, Drugs, vol.19, issue.2, pp.11-1121, 2003.
DOI : 10.1161/01.CIR.102.2.149

H. Iso, D. R. Jacobs, D. Wentworth, J. D. Neaton, and J. D. Cohen, Serum Cholesterol Levels and Six-Year Mortality from Stroke in 350,977 Men Screened for the Multiple Risk Factor Intervention Trial, New England Journal of Medicine, vol.320, issue.14, pp.14-904, 1989.
DOI : 10.1056/NEJM198904063201405

T. Jayakumar, C. Yang, P. Geraldine, T. Yen, and J. «. Sheu, The pharmacodynamics of antiplatelet compounds in thrombosis treatment, Expert Opinion on Drug Metabolism & Toxicology, vol.3, issue.1, pp.6-615
DOI : 10.1097/MJT.0b013e318187de4f

S. C. Johnston, D. R. Gress, W. S. Browner, S. Sidney, and . ». Tia, Short-term Prognosis After Emergency Department Diagnosis of TIA, JAMA, vol.284, issue.22, pp.22-2901, 2000.
DOI : 10.1001/jama.284.22.2901

E. Jouvent, D. Hervé, and H. Chabriat, « Partie 2 : angiopathie amyloïde cérébrale et formes génétiques de maladies des petites artères cérébrales ». Pratique Neurologique -FMC, pp.4-289, 2012.

J. Kang, H. G. Lemaire, A. Unterbeck, J. M. Salbaum, C. L. Masters et al., Müller-Hill B. « The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor ». Nature, pp.6106-733, 1987.

H. A. Keage, R. O. Carare, R. P. Friedland, P. G. Ince, S. Love et al., Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review, BMC Neurology, vol.31, issue.6, p.3, 2009.
DOI : 10.1111/j.1365-2990.2005.00678.x

W. T. Kimberly, A. Gilson, N. S. Rost, J. Rosand, A. Viswanathan et al., Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy, Neurology, vol.72, issue.14, pp.14-1230, 2009.
DOI : 10.1212/01.wnl.0000345666.83318.03

R. H. Knopp, M. D-'emden, J. G. Smilde, and S. J. Pocock, « Efficacy and safety of atorvastatin in the prevention of cardiovascular end points in subjects with type 2 diabetes: the Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in non-insulin-dependent diabetes mellitus (ASPEN) ». Diabetes Care, pp.7-1478, 2006.

K. A. Knudsen, J. Rosand, D. Karluk, and S. M. Greenberg, Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria, Neurology, vol.56, issue.4, pp.4-537, 2001.
DOI : 10.1212/WNL.56.4.537

H. «. Koennecke, Cerebral microbleeds on MRI: Prevalence, associations, and potential clinical implications, Neurology, vol.66, issue.2, pp.2-165, 2006.
DOI : 10.1212/01.wnl.0000194266.55694.1e

E. Kövari, F. R. Herrmann, P. R. Hof, and C. Bouras, The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer's disease, Neuropathology and Applied Neurobiology, vol.977, issue.5, pp.5-498
DOI : 10.1111/j.1749-6632.2002.tb04794.x

M. R. Law, N. J. Wald, and A. R. Rudnicka, Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis, BMJ, vol.326, issue.7404, p.1423, 2003.
DOI : 10.1136/bmj.326.7404.1423

S. Lee, H. Bae, B. Yoon, H. Kim, D. Kim et al., Low Concentration of Serum Total Cholesterol Is Associated With Multifocal Signal Loss Lesions on Gradient-Echo Magnetic Resonance Imaging: Analysis of Risk Factors for Multifocal Signal Loss Lesions, Stroke, vol.33, issue.12, pp.12-2845, 2002.
DOI : 10.1161/01.STR.0000036092.23649.2E

J. Linn, A. Halpin, P. Demaerel, J. Ruhland, A. D. Giese et al., « Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy(CME), Neurology, vol.74, pp.17-1346, 2010.

J. Linn, J. Herms, M. Dichgans, H. Brückmann, G. Fesl et al., Subarachnoid Hemosiderosis and Superficial Cortical Hemosiderosis in Cerebral Amyloid Angiopathy, American Journal of Neuroradiology, vol.29, issue.1, pp.1-184, 2008.
DOI : 10.3174/ajnr.A0783

J. Maclouf, S. Bellucci, and A. Thromboxane, Prostacycline ou le duel plaquettes-vaisseaux ». m/s. 1986. n°2, pp.552-557
DOI : 10.4267/10608/3425

S. Mead, M. James-galton, T. Revesz, R. B. Doshi, G. Harwood et al., Familial British dementia with amyloid angiopathy, Brain, vol.123, issue.5, pp.975-991, 2000.
DOI : 10.1093/brain/123.5.975

URL : https://academic.oup.com/brain/article-pdf/123/5/975/17864280/1230975.pdf

P. Mehndiratta, S. Manjila, T. Ostergard, S. Eisele, M. L. Cohen et al., Cerebral amyloid angiopathy???associated intracerebral hemorrhage: pathology and management, Neurosurgical Focus, vol.32, issue.4, pp.4-7, 2012.
DOI : 10.3171/2012.1.FOCUS11370

URL : http://thejns.org/doi/pdf/10.3171/2012.1.FOCUS11370

J. V. Mitsios, A. I. Papathanasiou, J. A. Goudevenos, and A. D. Tselepis, The Antiplatelet and Antithrombotic Actions of Statins, Current Pharmaceutical Design, vol.16, issue.34, pp.34-3808, 2010.
DOI : 10.2174/138161210794455120

M. Moussouttas, R. Malhotra, L. Fernandez, M. Maltenfort, M. Holowecki et al., Role of antiplatelet agents in hematoma expansion during the acute period of intracerebral hemorrhage ». Neurocrit Care, pp.1-24, 2010.

A. Muñiz-lozano, F. Rollini, F. Franchi, and D. J. Angiolillo, « Update on platelet glycoprotein IIb/IIIa inhibitors: recommendations for clinical practice ». Ther Adv Cardiovasc Dis, pp.4-197, 2013.

H. Naka, E. Nomura, J. Kitamura, E. Imamura, S. Wakabayashi et al., Antiplatelet Therapy as a Risk Factor for Microbleeds in Intracerebral Hemorrhage Patients: Analysis Using Specific Antiplatelet Agents, Journal of Stroke and Cerebrovascular Diseases, vol.22, issue.6, pp.6-834
DOI : 10.1016/j.jstrokecerebrovasdis.2012.06.001

R. N. Nandigam, A. Viswanathan, P. Delgado, M. E. Skehan, E. E. Smith et al., MR Imaging Detection of Cerebral Microbleeds: Effect of Susceptibility-Weighted Imaging, Section Thickness, and Field Strength, American Journal of Neuroradiology, vol.30, issue.2, pp.2-338, 2009.
DOI : 10.3174/ajnr.A1355

M. A. Neumann, Combined Amyloid Vascular Changes and Argyrophilic Plaques in the Central Nervous System, Journal of Neuropathology & Experimental Neurology, vol.19, issue.3, pp.370-382, 1960.
DOI : 10.1097/00005072-196007000-00005

G. Nicolas, D. Wallon, C. Goupil, A. Richard, C. Pottier et al., Rovelet-Lecrux A. « Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy, Eur. J. Hum. Genet. 2016, vol.24, pp.1-92

K. Niwa, V. A. Porter, K. Kazama, D. Cornfield, G. A. Carlson et al., « A beta-peptides enhance vasoconstriction in cerebral circulation, Am. J. Physiol. Heart Circ. Physiol, vol.281, pp.6-2417, 2001.

J. Octave, A. Macq, and B. Philippe, « Le précurseur du peptide amyloïde dans la maladie d'Alzheimer ». médecine/sciences, pp.9-1251, 1995.

O. Donnell, H. C. Rosand, J. Knudsen, K. A. Furie, K. L. Segal et al., « Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage, N. Engl. J. Med, vol.342, pp.4-240, 2000.

H. Okazaki, T. J. Reagan, and R. J. Campbell, Clinicopathologic studies of primary cerebral amyloid angiopathy, Mayo Clin. Proc, vol.54, pp.1-22, 1979.

J. M. Olichney, L. A. Hansen, D. Galasko, T. Saitoh, C. R. Hofstetter et al., The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant, Neurology, vol.47, issue.1, pp.1-190, 1996.
DOI : 10.1212/WNL.47.1.190

D. N. Orken, G. Kenangil, E. Uysal, L. Gundogdu, E. Erginoz et al., Lack of association between cerebral microbleeds and low serum cholesterol in patients with acute intracerebral hemorrhage, Clinical Neurology and Neurosurgery, vol.112, issue.8, pp.8-668, 2010.
DOI : 10.1016/j.clineuro.2010.05.004

A. Palsdottir, M. Abrahamson, L. Thorsteinsson, A. Arnason, I. Olafsson et al., MUTATION IN CYSTATIN C GENE CAUSES HEREDITARY BRAIN HAEMORRHAGE, The Lancet, vol.332, issue.8611, pp.8611-603, 1988.
DOI : 10.1016/S0140-6736(88)90641-1

A. Palsdottir, A. O. Snorradottir, and L. Thorsteinsson, « Hereditary cystatin C amyloid angiopathy: genetic, clinical, and pathological aspects, Brain Pathol, vol.16, pp.1-55, 2006.

S. «. Pantelakis, A particular type of senile angiopathy of the central nervous system: congophilic angiopathy, topography and frequency] ». Monatsschr Psychiatr Neurol, pp.4-219, 1954.

D. Paris, T. Town, T. Mori, T. A. Parker, J. Humphrey et al., « Soluble beta-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway », Neurobiol. Aging, vol.21, pp.2-183, 2000.

F. Pasquier and D. Leys, Why are stroke patients prone to develop dementia?, Journal of Neurology, vol.244, issue.3, pp.3-135, 1997.
DOI : 10.1007/s004150050064

S. Passero, L. Burgalassi, P. D-'andrea, and N. Battistini, « Recurrence of bleeding in patients with primary intracerebral hemorrhage ». Stroke, pp.7-1189, 1995.

C. Patrono, B. Coller, G. A. Fitzgerald, J. Hirsh, and G. Roth, « Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy ». Chest, pp.3-234, 2004.

T. Paunio, H. Kangas, O. Heinonen, M. H. Buc-caron, J. J. Robert et al., Cells of the Neuronal Lineage Play a Major Role in the Generation of Amyloid Precursor Fragments in Gelsolin-related Amyloidosis, Journal of Biological Chemistry, vol.66, issue.26, pp.26-16319, 1998.
DOI : 10.1038/323455a0

A. Pezzini, D. Zotto, E. Volonghi, I. Giossi, A. Costa et al., « New insights into the pleiotropic effects of statins for stroke prevention ». Mini Rev Med Chem, pp.7-794, 2009.

R. P. Phipps and N. Blumberg, Statin Islands and PPAR Ligands in Platelets, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.29, issue.5, pp.5-620, 2009.
DOI : 10.1161/ATVBAHA.109.184648

G. T. Plant, T. Révész, R. O. Barnard, A. E. Harding, and P. C. Gautier-smith, FAMILIAL CEREBRAL AMYLOID ANGIOPATHY WITH NONNEURITIC AMYLOID PLAQUE FORMATION, Brain, vol.113, issue.3, pp.721-747, 1990.
DOI : 10.1093/brain/113.3.721

O. M. Pontes-neto, E. Auriel, and S. M. Greenberg, Advances in our Understanding of the Pathophysiology, Detection and Management of Cerebral Amyloid Angiopathy, European Neurological Review, vol.7, issue.2, pp.2-134
DOI : 10.17925/ENR.2012.07.02.134

D. R. Premkumar, D. L. Cohen, P. Hedera, R. P. Friedland, and R. N. Kalaria, « Apolipoprotein E- epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease », Am. J. Pathol, vol.148, pp.6-2083, 1996.

R. Prior, G. Wihl, and B. Urmoneit, Apolipoprotein E, Smooth Muscle Cells and the Pathogenesis of Cerebral Amyloid Angiopathy: the Potential Role of Impaired Cerebrovascular Abeta Clearance, Annals of the New York Academy of Sciences, vol.70, issue.1 VASCULAR FACT, pp.180-186, 2000.
DOI : 10.1006/abbi.1995.1345

L. Puccetti, F. Bruni, G. Bova, M. Cercignani, G. Pompella et al., Role of platelets in tissue factor expression by monocytes in normal and hypercholesterolemic subjects, In vitro effect of cerivastatin ». Int. J. Clin. Lab. Res, vol.30, pp.3-147, 2000.

K. Rannikmäe, N. Samarasekera, N. A. Martînez-gonzâlez, R. Al-shahi-salman, and C. L. Sudlow, Genetics of cerebral amyloid angiopathy: systematic review and meta-analysis, Journal of Neurology, Neurosurgery & Psychiatry, vol.70, issue.8, pp.8-901
DOI : 10.1212/01.wnl.0000308819.43401.87

N. Raposo, A. Viguier, V. Cuvinciuc, L. Calviere, C. Cognard et al., Cortical subarachnoid haemorrhage in the elderly: a recurrent event probably related to cerebral amyloid angiopathy, European Journal of Neurology, vol.23, issue.4, pp.4-597, 2011.
DOI : 10.1046/j.1440-1789.2003.00506.x

T. Revesz, J. Ghiso, T. Lashley, G. Plant, A. Rostagno et al., Cerebral Amyloid Angiopathies: A Pathologic, Biochemical, and Genetic View, Journal of Neuropathology & Experimental Neurology, vol.62, issue.9, pp.9-885, 2003.
DOI : 10.1093/jnen/62.9.885

URL : https://academic.oup.com/jnen/article-pdf/62/9/885/9553478/62-9-885.pdf

P. M. Ridker, E. Danielson, F. A. Fonseca, J. Genest, A. M. Gotto et al., JUPITER Study Group. « Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein », N. Engl. J. Med, vol.359, pp.21-2195, 2008.

R. López, J. , M. Montero, J. L. , F. Fontanillo et al., Lobar intracerebral haemorrhage: analysis of a series and characteristics of patients receiving antiplatelet or anticoagulation treatment, Neurologia. 2012, vol.27, pp.7-387

Z. M. Ruggeri, The role of von Willebrand factor in thrombus formation, Thrombosis Research, vol.120, pp.5-9, 2007.
DOI : 10.1016/j.thromres.2007.03.011

Z. M. Ruggeri, A. Zarpellon, J. R. Roberts, R. A. Mc-clintock, H. Jing et al., Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib, Thrombosis and Haemostasis, vol.104, issue.5, pp.5-894, 2010.
DOI : 10.1160/TH10-09-0578

J. «. Rutishauser, Effets pléiotropes des statines ». Forum Med Suisse, pp.187-190, 2008.

M. Schachter, Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update, Fundamental and Clinical Pharmacology, vol.14, issue.1, pp.1-117, 2005.
DOI : 10.1016/S0378-4274(03)90352-3

V. L. Serebruany, M. Miller, A. N. Pokov, A. I. Malinin, D. R. Lowry et al., Effect of Statins on Platelet PAR-1 Thrombin Receptor in Patients With the Metabolic Syndrome (From the PAR-1 Inhibition by Statins [PARIS] Study), The American Journal of Cardiology, vol.97, issue.9, pp.9-1332, 2006.
DOI : 10.1016/j.amjcard.2005.11.058

J. Shepherd, S. M. Cobbe, I. Ford, C. G. Isles, A. R. Lorimer et al., « Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group, N. Engl. J. Med, vol.333, pp.20-1301, 1995.

E. E. Smith and S. M. Greenberg, Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston Criteria, Current Atherosclerosis Reports, vol.56, issue.4, pp.4-260, 2003.
DOI : 10.1212/WNL.56.4.537

S. Steiner, D. Seidinger, K. Huber, C. Kaun, E. Minar et al., Effect of Glycoprotein IIb/IIIa Antagonist Abciximab on Monocyte-Platelet Aggregates and Tissue Factor Expression, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.23, issue.9, pp.9-1697, 2003.
DOI : 10.1161/01.ATV.0000087035.46547.89

R. F. Storey, D. J. Angiolillo, S. B. Patil, B. Desai, R. Ecob et al., Inhibitory Effects of Ticagrelor Compared With Clopidogrel on Platelet Function in Patients With Acute Coronary Syndromes, Journal of the American College of Cardiology, vol.56, issue.18, pp.18-1456, 2010.
DOI : 10.1016/j.jacc.2010.03.100

M. Tanskanen, M. Mäkelä, L. Myllykangas, I. Notkola, T. Polvikoski et al., Prevalence and severity of cerebral amyloid angiopathy: a population-based study on very elderly Finns (Vantaa 85+), Neuropathology and Applied Neurobiology, vol.153, issue.4, pp.4-329
DOI : 10.1016/S0002-9440(10)65616-7

J. «. Thachil, Antiplatelet therapy - a summary for the general physicians, Lond). 2016, pp.2-152
DOI : 10.7861/clinmedicine.16-2-152

D. R. Thal, W. S. Griffin, D. Vos, R. A. Ghebremedhin, and E. , Cerebral amyloid angiopathy and its relationship to Alzheimer???s disease, Acta Neuropathologica, vol.28, issue.Suppl., pp.6-599, 2008.
DOI : 10.1161/01.STR.27.7.1155

S. The and . Group, « Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. The SALT Collaborative Group, Lancet, vol.338, pp.8779-1345, 1991.

K. A. Tong, S. Ashwal, B. A. Holshouser, L. A. Shutter, G. Herigault et al., Hemorrhagic Shearing Lesions in Children and Adolescents with Posttraumatic Diffuse Axonal Injury: Improved Detection and Initial Results, Radiology, vol.227, issue.2, pp.2-332, 2003.
DOI : 10.1148/radiol.2272020176

K. Toyoda, M. Yasaka, K. Nagata, T. Nagao, J. Gotoh et al., Bleeding with Antithrombotic Therapy Study Group. « Antithrombotic therapy influences location, enlargement, and mortality from intracerebral hemorrhage. The Bleeding with Antithrombotic Therapy (BAT) Retrospective Study, Cerebrovasc. Dis, vol.27, pp.2-151, 2009.

R. J. Uitti, J. R. Donat, B. Rozdilsky, R. J. Schneider, and A. H. Koeppen, Report of a new family with unusual features, Arch. Neurol, vol.45, pp.10-1118, 1988.

P. B. Verghese, J. M. Castellano, and D. M. Holtzman, Apolipoprotein E in Alzheimer's disease and other neurological disorders, The Lancet Neurology, vol.10, issue.3, pp.3-241, 2011.
DOI : 10.1016/S1474-4422(10)70325-2

M. W. Vernooij, M. D. Haag, A. Van-der-lugt, A. Hofman, G. P. Krestin et al., Use of Antithrombotic Drugs and the Presence of Cerebral Microbleeds, Archives of Neurology, vol.66, issue.6, pp.6-714, 2009.
DOI : 10.1001/archneurol.2009.42

H. H. Versteeg, J. W. Heemskerk, M. Levi, and P. H. Reitsma, New Fundamentals in Hemostasis, Physiological Reviews, vol.93, issue.1, pp.1-327
DOI : 10.1152/physrev.00016.2011

R. Vidal, T. Revesz, A. Rostagno, E. Kim, J. L. Holton et al., A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred, Proceedings of the National Academy of Sciences, vol.45, issue.1, pp.9-4920, 2000.
DOI : 10.1111/j.1440-1827.1995.tb03373.x

H. V. Vinters, A critical review ». Stroke, pp.2-311, 1987.

H. V. Vinters and J. J. Gilbert, Cerebral amyloid angiopathy, pp.6-924, 1983.
DOI : 10.1017/CBO9780511570216.041

V. Durand, D. Le-jeunne, and C. , Dorosz Guide pratique des médicaments 2017, 36e éd. 36 e éd, p.2017

J. P. Vonsattel, R. H. Myers, E. T. Hedley-whyte, A. H. Ropper, E. D. Bird et al., Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study, Annals of Neurology, vol.29, issue.5, pp.5-637, 1991.
DOI : 10.1111/j.1532-5415.1981.tb01229.x

L. «. Wallentin and . P2y, 12) inhibitors: differences in properties and mechanisms of action and potential consequences for clinical use, Eur. Heart J, vol.30, pp.16-1964, 2009.

L. Wallentin, C. Varenhorst, S. James, D. Erlinge, O. O. Braun et al., Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease, European Heart Journal, vol.29, issue.1, pp.1-21, 2008.
DOI : 10.1093/eurheartj/ehm545

K. J. Winters and A. Siegbahn, « Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease, Eur. Heart J, vol.29, pp.1-21, 2008.

D. Wang, B. Liu, W. Tao, Z. Hao, and M. Liu, « Fibrates for secondary prevention of cardiovascular disease and stroke, Cochrane Database of Systematic Reviews, 2015.

Z. Z. Wang, O. Jensson, L. Thorsteinsson, and H. V. Vinters, Microvascular degeneration in hereditary cystatin C amyloid angiopathy of the brain, APMIS, vol.57, issue.Suppl. 177, pp.1-41, 1997.
DOI : 10.1161/01.STR.21.3.397

A. R. Wattendorff, G. T. Bots, L. N. Went, and L. J. Endtz, Familial cerebral amyloid angiopathy presenting as recurrent cerebral haemorrhage, Journal of the Neurological Sciences, vol.55, issue.2, pp.2-121, 1982.
DOI : 10.1016/0022-510X(82)90094-6

S. D. Wiviott and P. G. Steg, « Clinical evidence for oral antiplatelet therapy in acute coronary syndromes ». The Lancet, pp.9990-292, 2015.

K. S. Wong, Y. L. Chan, J. Y. Liu, S. Gao, and W. W. Lam, Asymptomatic microbleeds as a risk factor for aspirin-associated intracerebral hemorrhages, Neurology. 11 février 2003, pp.3-511
DOI : 10.1212/01.WNL.0000046583.40125.20

K. S. Wong, V. Mok, W. W. Lam, R. Kay, A. Tang et al., Aspirin-associated intracerebral hemorrhage: Clinical and radiologic features, Neurology, vol.54, issue.12, pp.12-2298, 2000.
DOI : 10.1212/WNL.54.12.2298

D. Woo, L. R. Sauerbeck, B. M. Kissela, J. C. Khoury, J. P. Szaflarski et al., « Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study ». Stroke, pp.5-1190, 2002.

D. «. Yacoub, Rôle de l'axe CD40/CD40L dans la régulation de la fonction paquettaire, 2011.

M. «. Yamada, Brain Hemorrhages in Cerebral Amyloid Angiopathy, Seminars in Thrombosis and Hemostasis, vol.39, issue.08, pp.8-955
DOI : 10.1055/s-0033-1357489

S. Zhang, M. Rahman, S. Zhang, Z. Qi, and H. Thorlacius, Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis, Journal of Leukocyte Biology, vol.89, issue.5, pp.5-735, 2011.
DOI : 10.1189/jlb.0510279

L. Zhao, M. Arbel-ornath, X. Wang, R. A. Betensky, S. M. Greenberg et al., Matrix metalloproteinase 9???mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy, Neurobiology of Aging, vol.36, issue.11, pp.11-2963
DOI : 10.1016/j.neurobiolaging.2015.07.016

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609585/pdf