.. Et-tau, La Glycogène Synthase Kinase-3? A?, p.99

. Aboutkidshealth, ca, n.d. Traitement de l'épilepsie par l'alimentation - AboutKidsHealth [WWW Document

K. G. Alberti, D. G. Johnston, A. Gill, A. J. Barnes, and H. Orskov, Hormonal regulation of ketone-body metabolism in man, Biochem. Soc. Symp, pp.163-182, 1978.

B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts et al., Biologie moléculaire de la cellule, Brigitte Peyrot, 2011.

B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts et al., Biologie moléculaire de la cellule, Chapitre, vol.15, issue.11, 2011.

B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts et al., Biologie moléculaire de la cellule Chapitre 14 : Conversion énergétique, mitochondries et chloroplastes, 2011.

B. Alberts, A. Johnson, J. Lewis, M. Raff, K. Roberts et al., Biologie moléculaire de la cellule, Chapitre, vol.18, issue.11

N. D. Alzheimer-articles-epidémiologie, http:www.fondation-Alzheimer.org. URL http://www.fondationalzheimer .org/0-Articles, p.60

M. C. Amoureux, D. Van-gool, M. T. Herrero, R. Dom, F. C. Colpaert et al., Regulation of metallothionein-III (GIF) mRNA in the brain of patients with Alzheimer disease is not impaired, Molecular and Chemical Neuropathology, vol.28, issue.1-3, pp.101-121, 1997.
DOI : 10.1016/B978-0-08-057132-4.50006-X

E. Aronica and P. B. Crino, Inflammation in epilepsy: Clinical observations, Epilepsia, vol.134, issue.suppl 2, 2011.
DOI : 10.1093/brain/awr032

URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2011.03033.x/pdf

N. Arslan, O. Guzel, E. Kose, U. Y?lmaz, P. Kuyum et al., Is ketogenic diet treatment hepatotoxic for children with intractable epilepsy?, Seizure, vol.43, pp.32-38, 2016.
DOI : 10.1016/j.seizure.2016.10.024

Z. Arvanitakis, R. S. Wilson, J. L. Bienias, D. A. Evans, and D. A. Bennett, Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function, Archives of Neurology, vol.61, issue.5, pp.661-666, 2004.
DOI : 10.1001/archneur.61.5.661

P. Azevedo-de-lima, M. Baldini-prudêncio, D. K. Murakami, L. Pereira-de-brito-sampaio, F. Neto et al., Effect of classic ketogenic diet treatment on lipoprotein subfractions in children and adolescents with refractory epilepsy. Nutr, N.R, 2016.

L. D. Baker, D. J. Cross, S. Minoshima, D. Belongia, G. S. Watson et al., Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes, Archives of Neurology, vol.68, issue.1, pp.51-57, 2011.
DOI : 10.1001/archneurol.2010.225

M. Bélanger, I. Allaman, and P. J. Magistretti, Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation, Cell Metabolism, vol.14, issue.6, pp.724-738, 2011.
DOI : 10.1016/j.cmet.2011.08.016

B. Sghier and A. , Les épilepsies pharmacorésistantes (à propos de 25 cas), 2014.

E. Beurel and R. S. Jope, The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways, Progress in Neurobiology, vol.79, issue.4, 2006.
DOI : 10.1016/j.pneurobio.2006.07.006

P. G. Bittar, Y. Charnay, L. Pellerin, C. Bouras, and P. J. Magistretti, Selective Distribution of Lactate Dehydrogenase Isoenzymes in Neurons and Astrocytes of Human Brain, Journal of Cerebral Blood Flow & Metabolism, vol.263, issue.6, pp.1079-1089, 1996.
DOI : 10.1056/NEJM196009152631102

T. M. Bliss, M. Ip, E. Cheng, M. Minami, L. Pellerin et al., Dual-Gene, Dual-Cell Type Therapy against an Excitotoxic Insult by Bolstering Neuroenergetics, Journal of Neuroscience, vol.24, issue.27, pp.6202-6208, 2004.
DOI : 10.1523/JNEUROSCI.0805-04.2004

URL : http://www.jneurosci.org/content/jneuro/24/27/6202.full.pdf

K. J. Bough, J. Wetherington, B. Hassel, J. F. Pare, J. W. Gawryluk et al., Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet, Annals of Neurology, vol.39, issue.2, pp.223-235, 2006.
DOI : 10.1001/archpedi.153.9.946

J. M. Bourre, Roles of unsaturated fatty acids (especially omega-3 fatty acids) in the brain at various ages and during ageing, J. Nutr. Health Aging, vol.8, pp.163-174, 2004.

A. F. Branco, A. Ferreira, R. F. Simões, S. Magalhães-novais, C. Zehowski et al., Ketogenic diets: from cancer to mitochondrial diseases and beyond, European Journal of Clinical Investigation, vol.100, issue.Suppl. 1, pp.285-298, 2016.
DOI : 10.1016/j.eplepsyres.2011.05.020

URL : http://onlinelibrary.wiley.com/doi/10.1111/eci.12591/pdf

P. Bubber, V. Haroutunian, G. Fisch, J. P. Blass, and G. E. Gibson, Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications, Annals of Neurology, vol.36, issue.5, pp.695-703, 2005.
DOI : 10.1111/j.1532-5415.1976.tb03247.x

J. Burkhalter, H. Fiumelli, I. Allaman, J. Chatton, and J. Martin, Brain-derived neurotrophic factor stimulates energy metabolism in developing cortical neurons, J. Neurosci. Off. J. Soc. Neurosci, vol.23, pp.8212-8220, 2003.

G. F. Cahill, Fuel Metabolism in Starvation, Annual Review of Nutrition, vol.26, issue.1, 2006.
DOI : 10.1146/annurev.nutr.26.061505.111258

N. Calderón, L. Betancourt, L. Hernández, and P. Rada, A ketogenic diet modifies glutamate, gammaaminobutyric acid and agmatine levels in the hippocampus of rats: A microdialysis study, 2017.

J. Cambier, M. Masson, C. Masson, and H. Dehen, Neurologie -13 ème édition, 2012.

A. Cangemi, D. Fanale, G. Rinaldi, V. Bazan, A. Galvano et al., Dietary restriction: could it be considered as speed bump on tumor progression road?, Tumor Biology, vol.69, issue.3, pp.7109-7118, 2016.
DOI : 10.1002/pros.20878

C. Castellano, S. Nugent, N. Paquet, S. Tremblay, C. Bocti et al., Lower brain 18F-fluorodeoxyglucose uptake but normal 11C- acetoacetate metabolism in mild Alzheimer's disease dementia, J. Alzheimers Dis. JAD, vol.43, pp.1343-135310, 2015.

P. Chang, K. Augustin, K. Boddum, S. Williams, M. Sun et al., Seizure control by decanoic acid through direct AMPA receptor inhibition, Brain, vol.139, issue.2, pp.431-44310, 1093.
DOI : 10.1093/brain/awv325

URL : https://academic.oup.com/brain/article-pdf/139/2/431/17348230/awv325.pdf

Z. Chen and C. Zhong, Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies, Progress in Neurobiology, vol.108, 2013.
DOI : 10.1016/j.pneurobio.2013.06.004

URL : https://doi.org/10.1016/j.pneurobio.2013.06.004

A. Cheng, R. Wan, J. Yang, N. Kamimura, T. G. Son et al., Involvement of PGC-1?? in the formation and maintenance of neuronal dendritic spines, Nature Communications, vol.100, 2012.
DOI : 10.1073/pnas.1232352100

B. Cheng, X. Yang, L. An, B. Gao, X. Liu et al., Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease, Brain Research, vol.1286, 2009.
DOI : 10.1016/j.brainres.2009.06.060

C. M. Cheng, K. Hicks, J. Wang, D. A. Eagles, and C. A. Bondy, Caloric restriction augments brain glutamic acid decarboxylase-65 and -67 expression, Journal of Neuroscience Research, vol.66, issue.2, pp.270-276, 2004.
DOI : 10.1042/bj3260573

R. M. Clanton, G. Wu, G. Akabani, and R. Aramayo, Control of seizures by ketogenic diet-induced modulation of metabolic pathways, Amino Acids, vol.49, issue.Suppl 8, pp.10-1007, 2016.
DOI : 10.1111/j.1528-1167.2008.01841.x

K. Clarke, K. Tchabanenko, R. Pawlosky, E. Carter, T. King et al., Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects, Regulatory Toxicology and Pharmacology, vol.63, issue.3, pp.401-408, 2012.
DOI : 10.1016/j.yrtph.2012.04.008

R. J. Colman, R. M. Anderson, S. C. Johnson, E. K. Kastman, K. J. Kosmatka et al., Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys, Science, vol.42, issue.8, pp.201-204, 2009.
DOI : 10.1016/j.exger.2007.03.009

G. Coppola, A. D-'aniello, T. Messana, D. Pasquale, F. Della-corte et al., Low glycemic index diet in children and young adults with refractory epilepsy: First Italian experience, Seizure, vol.20, issue.7, pp.526-528, 2011.
DOI : 10.1016/j.seizure.2011.03.008

URL : https://doi.org/10.1016/j.seizure.2011.03.008

A. Courchesne-loyer, E. Croteau, C. Castellano, V. St-pierre, M. Hennebelle et al., Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study Blood Flow Metab. doi:10 Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes, J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Cell Metab, vol.24, pp.256-268, 1177.

S. Craft, B. J. Neth, A. Mintz, K. Sai, N. Shively et al., KETOGENIC DIET EFFECTS ON BRAIN KETONE METABOLISM AND ALZHEIMER'S DISEASE CSF BIOMARKERS, Alzheimer's & Dementia, vol.12, issue.7, pp.342-343, 2016.
DOI : 10.1016/j.jalz.2016.06.633

T. E. Cullingford, C. T. Dolphin, and H. Sato, The peroxisome proliferator-activated receptor ??-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain, Neuropharmacology, vol.42, issue.5, pp.724-730, 2002.
DOI : 10.1016/S0028-3908(02)00014-X

S. C. Cunnane, A. Courchesne-loyer, V. St-pierre, C. Vandenberghe, T. Pierotti et al., Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease, Annals of the New York Academy of Sciences, vol.18, issue.Pt 3, pp.12-20, 2016.
DOI : 10.2337/diab.18.2.96

S. C. Cunnane and M. A. Crawford, Energetic and nutritional constraints on infant brain development: Implications for brain expansion during human evolution, Journal of Human Evolution, vol.77, pp.88-98, 2014.
DOI : 10.1016/j.jhevol.2014.05.001

M. Dahlin, A. Elfving, U. Ungerstedt, and P. Amark, The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy, Epilepsy Research, vol.64, issue.3, pp.115-125, 2005.
DOI : 10.1016/j.eplepsyres.2005.03.008

M. Damiano, Rôle de la dysfonction mitochondriale dans deux maladies neurodégénératives, 2014.

N. N. Danial, A. L. Hartman, C. E. Stafstrom, and L. L. Thio, How Does the Ketogenic Diet Work? Four Potential Mechanisms, Journal of Child Neurology, vol.54, issue.20, pp.1027-1033, 2013.
DOI : 10.1016/j.neuron.2010.09.002

P. Daniela, S. Orazio, P. Alessandro, N. F. Mariano, I. Leonardo et al., A Survey of FDG- and Amyloid-PET Imaging in Dementia and GRADE Analysis, BioMed Research International, vol.12, issue.4, p.785039, 2014.
DOI : 10.1016/j.jalz.2013.06.001

D. Darnis, Le régime cétogène, une approche diététique de l'Epilepsie. Elaboration d'un outil pour l'utilisation des médicaments aux excipients sucrés, NANTES, 2012.

D. Groot, S. Vreeswijk, M. P. Welters, M. J. Gravesteijn, G. Boei et al., The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study, BMC Cancer, vol.22, issue.21, p.652, 2015.
DOI : 10.1016/j.cmet.2015.05.012

S. M. De-la-monte, Insulin resistance and Alzheimer's disease, BMB Reports, vol.42, issue.8, pp.475-481, 2009.
DOI : 10.5483/BMBRep.2009.42.8.475

N. De-roos, E. Schouten, and M. Katan, Consumption of a solid fat rich in lauric acid results in a more favorable serum lipid profile in healthy men and women than consumption of a solid fat rich in trans-fatty acids, J. Nutr, vol.131, pp.242-245, 2001.

D. 'ercole, A. J. Ye, P. Calikoglu, A. S. Gutierrez-ospina, and G. , The role of the insulin-like growth factors in the central nervous system, Mol. Neurobiol, vol.13, pp.227-255, 1996.

L. Devi, B. M. Prabhu, D. F. Galati, N. G. Avadhani, and H. K. Anandatheerthavarada, Accumulation of Amyloid Precursor Protein in the Mitochondrial Import Channels of Human Alzheimer's Disease Brain Is Associated with Mitochondrial Dysfunction, Journal of Neuroscience, vol.26, issue.35, pp.9057-9068, 2006.
DOI : 10.1523/JNEUROSCI.1469-06.2006

D. C. Devivo, M. P. Leckie, H. C. Agrawal, . Major, . Of et al., d-?-HYDROXYBUTYRATE: A MAJOR PRECURSOR OF AMINO ACIDS IN DEVELOPING RAT BRAIN, Journal of Neurochemistry, vol.32, issue.2, pp.161-170, 1975.
DOI : 10.1111/j.1471-4159.1972.tb01271.x

E. Elliott, R. Atlas, A. Lange, and I. Ginzburg, Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3Kinase signalling mechanism, European Journal of Neuroscience, vol.65, issue.5, pp.1081-1089, 2004.
DOI : 10.1091/mbc.9.6.1495

T. D. Filippatos, D. B. Panagiotakos, E. N. Georgousopoulou, E. Pitaraki, G. Kouli et al., Mediterranean Diet and 10-year (2002-2012) Incidence of Diabetes and Cardiovascular Disease in Participants with Prediabetes: The ATTICA study, The Review of Diabetic Studies, vol.13, issue.4, pp.226-23510226, 1900.
DOI : 10.1900/RDS.2016.13.226

R. S. Fisher, C. Acevedo, A. Arzimanoglou, A. Bogacz, J. H. Cross et al., ILAE Official Report: A practical clinical definition of epilepsy, Epilepsia, vol.18, issue.4, pp.475-482, 2014.
DOI : 10.1159/000079256

W. Fong, H. Tsai, Y. Chen, J. Wu, and T. Lin, Anti-apoptotic Actions of PPAR-?? Against Ischemic Stroke, Molecular Neurobiology, vol.26, issue.2-3, pp.180-186, 2010.
DOI : 10.1038/bjc.1972.33

F. Fouque, C. Marsac, and C. Benelli, Le complexe pyruvate d??shydrog??nase : de l'organisation mol??culaire ?? la pathologie., m??decine/sciences, vol.14, issue.12, pp.1366-1375, 1998.
DOI : 10.4267/10608/975

E. Freemantle, M. Vandal, J. Tremblay-mercier, M. Plourde, J. Poirier et al., Metabolic response to a ketogenic breakfast in the healthy elderly, The Journal of Nutrition, Health and Aging, vol.42, issue.Suppl1, pp.293-298, 2009.
DOI : 10.1016/j.patbio.2006.07.002

F. Levi, Y. Vedin, I. Cederholm, T. Basun, H. et al., Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study, Journal of Internal Medicine, vol.33, issue.4, pp.428-436, 2014.
DOI : 10.1016/j.neurobiolaging.2011.12.014

M. Gasior, J. Yankura, A. L. Hartman, A. French, and M. A. Rogawski, Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation, Epilepsia J. Alzheimers Dis. JAD, vol.51, issue.9, pp.1385-1394, 2006.

L. C. Gormsen, M. Svart, H. H. Thomsen, E. Søndergaard, M. H. Vendelbo et al., Ketone Body Infusion With 3???Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study, Journal of the American Heart Association, vol.6, issue.3, 2017.
DOI : 10.1161/JAHA.116.005066

S. L. Gray, M. L. Anderson, S. Dublin, J. T. Hanlon, R. Hubbard et al., Cumulative Use of Strong Anticholinergics and Incident Dementia, JAMA Internal Medicine, vol.175, issue.3, pp.401-407, 2015.
DOI : 10.1001/jamainternmed.2014.7663

URL : http://archinte.jamanetwork.com/data/journals/intemed/932778/ioi140138.pdf

T. Greco, T. C. Glenn, D. A. Hovda, and M. L. Prins, Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity, Journal of Cerebral Blood Flow & Metabolism, vol.11, issue.9, pp.1603-161310, 1177.
DOI : 10.1016/j.micron.2009.08.010

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012517/pdf

É. W. Griffin, S. Mullally, C. Foley, S. A. Warmington, S. M. O-'mara et al., Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males, Physiology & Behavior, vol.104, issue.5, pp.934-941, 2011.
DOI : 10.1016/j.physbeh.2011.06.005

C. A. Grillo, G. G. Piroli, R. M. Hendry, and L. P. Reagan, Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent, Brain Research, vol.1296, pp.35-45, 2009.
DOI : 10.1016/j.brainres.2009.08.005

B. Grygiel-górniak, Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review, Nutrition Journal, vol.374, issue.9684, pp.10-1186, 2014.
DOI : 10.1016/S0140-6736(09)60870-9

Y. Gu, A. M. Brickman, Y. Stern, C. G. Habeck, Q. R. Razlighi et al., Mediterranean diet and brain structure in a multiethnic elderly cohort, Neurology, vol.85, issue.20, pp.1744-1751100000000000002121, 1212.
DOI : 10.1212/WNL.0000000000002121

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653103/pdf

K. Gudala, D. Bansal, F. Schifano, and A. Bhansali, Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies, Journal of Diabetes Investigation, vol.3, issue.6, pp.640-650, 2013.
DOI : 10.1111/j.2040-1124.2012.00234.x

S. Hallan and K. Sharma, The Role of Mitochondria in Diabetic Kidney Disease, Current Diabetes Reports, vol.444, issue.7117, p.61, 2016.
DOI : 10.1038/nature05354

G. E. Hardingham and H. Bading, Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders, Nature Reviews Neuroscience, vol.39, issue.10, pp.682-696, 2010.
DOI : 10.1016/S1570-9639(02)00455-7

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948541/pdf

A. L. Hartman, M. Lyle, M. A. Rogawski, M. S. Gasior, I. Scherping et al., Efficacy of the ketogenic diet in the 6-Hz seizure test Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice, Epilepsia Neurobiol. Aging, vol.4912, issue.30, pp.334-339, 2007.

C. B. Henderson, F. M. Filloux, S. C. Alder, J. L. Lyon, and D. A. Caplin, Efficacy of the Ketogenic Diet as a Treatment Option for Epilepsy: Meta-analysis, J. Child Neurol, vol.21, pp.193-19810701000044, 2006.

S. T. Henderson, J. L. Vogel, L. J. Barr, F. Garvin, J. J. Jones et al., Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial, Nutrition & Metabolism, vol.6, issue.1, pp.31-41, 2009.
DOI : 10.1186/1743-7075-6-31

L. Hertz, Y. Chen, and H. S. Waagepetersen, Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, ??-amyloid toxicity, and astrocyte function, Journal of Neurochemistry, vol.24, issue.Suppl 1, pp.7-20, 2015.
DOI : 10.1002/ana.410240210

R. M. Holsinger, J. Schnarr, P. Henry, V. T. Castelo, and M. Fahnestock, Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease, Molecular Brain Research, vol.76, issue.2, pp.347-354, 2000.
DOI : 10.1016/S0169-328X(00)00023-1

C. Hooper, R. Killick, and S. Lovestone, The GSK3 hypothesis of Alzheimer???s disease, Journal of Neurochemistry, vol.24, issue.3, pp.1433-1439, 2008.
DOI : 10.1523/JNEUROSCI.2860-04.2004

M. Hoshi, A. Takashima, K. Noguchi, M. Murayama, M. Sato et al., Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain., Proc. Natl. Acad. Sci. U. S. A. 93, pp.2719-2723, 1996.
DOI : 10.1073/pnas.93.7.2719

Z. G. Hu, H. D. Wang, W. Jin, and H. X. Yin, Ketogenic Diet Reduces Cytochrome c Release and Cellular Apoptosis Following Traumatic Brain Injury in Juvenile Rats, Ann. Clin. Lab. Sci, vol.39, pp.76-83, 2009.

Z. Hu, H. Wang, L. Qiao, W. Yan, Q. Tan et al., The protective effect of the ketogenic diet on traumatic brain injury-induced cell death in juvenile rats, Brain Injury, vol.134, issue.5, pp.459-4651002699050902788469, 1080.
DOI : 10.1016/j.autneu.2007.02.002

P. R. Huttenlocher, Ketonemia and Seizures: Metabolic and Anticonvulsant Effects of Two Ketogenic Diets in Childhood Epilepsy, Pediatric Research, vol.10, issue.5, pp.536-540, 1976.
DOI : 10.1203/00006450-197605000-00006

M. R. Hynd, H. L. Scott, and P. R. Dodd, Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease, Neurochem. Int, vol.45, 2004.

J. Janson, T. Laedtke, J. E. Parisi, P. O-'brien, R. C. Petersen et al., Increased Risk of Type 2 Diabetes in Alzheimer Disease, Diabetes, vol.53, issue.2, pp.474-481, 2004.
DOI : 10.2337/diabetes.53.2.474

S. G. Jarrett, J. B. Milder, L. Liang, and M. Patel, The ketogenic diet increases mitochondrial glutathione levels, Journal of Neurochemistry, vol.28, issue.3, 2008.
DOI : 10.1016/j.biochi.2007.11.010

N. Juge, J. A. Gray, H. Omote, T. Miyaji, T. Inoue et al., Metabolic Control of Vesicular Glutamate Transport and Release, Neuron, vol.68, issue.1, pp.99-112, 2010.
DOI : 10.1016/j.neuron.2010.09.002

R. R. Kalyani, R. Varadhan, C. O. Weiss, L. P. Fried, and A. R. Cappola, Frailty Status and Altered Glucose-Insulin Dynamics, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol.67, issue.12, pp.1300-1306, 2012.
DOI : 10.1093/gerona/glr141

URL : https://academic.oup.com/biomedgerontology/article-pdf/67/12/1300/1659418/glr141.pdf

K. Kanamori, B. D. Ross, and R. W. Kondrat, Rate of Glutamate Synthesis from Leucine in Rat Brain Measured In Vivo by 15N NMR, Journal of Neurochemistry, vol.70, issue.3, pp.1304-1315, 1998.
DOI : 10.1046/j.1471-4159.1998.70031304.x

H. C. Kang, D. E. Chung, D. W. Kim, and H. D. Kim, Early- and Late-onset Complications of the Ketogenic Diet for Intractable Epilepsy, Epilepsia, vol.49, issue.6, 2004.
DOI : 10.1056/NEJM199806113382402

P. Karimzadeh, M. Sedighi, M. Beheshti, E. Azargashb, M. Ghofrani et al., Low Glycemic Index Treatment in pediatric refractory epilepsy: The first Middle East report, Seizure, vol.23, issue.7, pp.570-572, 2014.
DOI : 10.1016/j.seizure.2014.03.012

Y. Kashiwaya, T. Takeshima, N. Mori, K. Nakashima, K. Clarke et al., D-beta -Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease, Proc. Natl, 2000.
DOI : 10.1038/9843

S. L. Kesl, A. M. Poff, N. P. Ward, T. N. Fiorelli, C. Ari et al., Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague???Dawley rats, Nutrition & Metabolism, vol.13, issue.3, 2016.
DOI : 10.1016/S0899-9007(96)00409-1

D. Y. Kim, K. A. Simeone, T. A. Simeone, J. D. Pandya, J. C. Wilke et al., Ketone bodies mediate antiseizure effects through mitochondrial permeability transition, Annals of Neurology, vol.8, issue.pt 7, pp.77-87, 2015.
DOI : 10.1371/journal.pone.0077131

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480159/pdf

J. Klepper, V. Engelbrecht, H. Scheffer, M. S. Van-der-knaap, and A. Fiedler, GLUT1 Deficiency With Delayed Myelination Responding to Ketogenic Diet, Pediatric Neurology, vol.37, issue.2, pp.130-133, 2007.
DOI : 10.1016/j.pediatrneurol.2007.03.009

E. H. Kossoff, B. A. Zupec-kania, P. E. Amark, K. R. Ballaban-gil, C. Bergqvist et al., Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group, Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group, pp.304-317, 2009.
DOI : 10.1212/WNL.49.6.1655

M. Krautwald and G. Münch, Advanced glycation end products as biomarkers and gerontotoxins ??? A basis to explore methylglyoxal-lowering agents for Alzheimer???s disease?, Experimental Gerontology, vol.45, issue.10, pp.744-751, 2010.
DOI : 10.1016/j.exger.2010.03.001

R. Krikorian, M. D. Shidler, K. Dangelo, S. C. Couch, S. C. Benoit et al., Dietary ketosis enhances memory in mild cognitive impairment, Neurobiology of Aging, vol.33, issue.2, pp.19-27, 2012.
DOI : 10.1016/j.neurobiolaging.2010.10.006

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116949/pdf

L. Kukreja, G. C. Kujoth, T. A. Prolla, F. Van-leuven, and R. Vassar, Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer???s disease, Molecular Neurodegeneration, vol.9, issue.1, pp.1750-1326, 2014.
DOI : 10.2174/156720505774330573

P. Kwan and M. J. Brodie, Early Identification of Refractory Epilepsy, New England Journal of Medicine, vol.342, issue.5, pp.314-319, 2000.
DOI : 10.1056/NEJM200002033420503

H. Kwon, B. L. Sabatini, C. Lee, L. Raffaghello, S. Brandhorst et al., Glutamate induces de novo growth of functional spines in developing cortex Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy, Nature Sci. Transl. Med, vol.474, pp.100-104, 2011.

R. L. Leino, D. Z. Gerhart, and L. R. Drewes, Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats: a quantitative electron microscopic immunogold study, Developmental Brain Research, vol.113, issue.1-2, pp.47-54, 1999.
DOI : 10.1016/S0165-3806(98)00188-6

R. L. Leino, D. Z. Gerhart, R. Duelli, B. E. Enerson, and L. R. Drewes, Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain, Neurochemistry International, vol.38, issue.6, pp.519-527, 2001.
DOI : 10.1016/S0197-0186(00)00102-9

G. Leuba, C. Büla, and F. Schenk, Du vieillissement cérébral à la maladie d'Alzheimer. Vulnérabilité et plasticité, 2013.

X. Lian, F. A. Khan, and J. L. Stringer, Fructose-1,6-Bisphosphate Has Anticonvulsant Activity in Models of Acute Seizures in Adult Rats, Journal of Neuroscience, vol.27, issue.44, pp.12007-12011, 2007.
DOI : 10.1523/JNEUROSCI.3163-07.2007

A. Lin, W. Zhang, X. Gao, and L. Watts, Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain, Neurobiology of Aging, vol.36, issue.7, 2015.
DOI : 10.1016/j.neurobiolaging.2015.03.012

URL : https://doi.org/10.1016/j.neurobiolaging.2015.03.012

Y. Liu, F. Liu, K. Iqbal, I. Grundke-iqbal, and C. Gong, Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease, FEBS Letters, vol.41, issue.2, pp.359-364, 2008.
DOI : 10.1242/jcs.01192

M. Llorens-marítin, J. Jurado, F. Hernández, and J. Ávila, GSK-3?, a pivotal kinase in Alzheimer disease, Front. Mol. Neurosci, 2014.

A. Loaiza, O. H. Porras, and L. F. Barros, Glutamate Triggers Rapid Glucose Transport Stimulation in Astrocytes as Evidenced by Real-Time Confocal Microscopy, J. Neurosci, vol.23, pp.7337-7342, 2003.

Q. Ma, Role of Nrf2 in Oxidative Stress and Toxicity, Annual Review of Pharmacology and Toxicology, vol.53, issue.1, pp.401-426, 2013.
DOI : 10.1146/annurev-pharmtox-011112-140320

M. Maalouf, J. M. Rho, and M. P. Mattson, The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies, Brain Research Reviews, vol.59, issue.2, 2009.
DOI : 10.1016/j.brainresrev.2008.09.002

P. Magistretti, Chaire internationale. L'annuaire Collège Fr. Cours Trav, 2008.
DOI : 10.4000/annuaire-cdf.118

A. Mandel, M. Ballew, J. E. Pina-garza, V. Stalmasek, and L. H. Clemens, Medical Costs are Reduced when Children with Intractable Epilepsy are Successfully Treated with the Ketogenic Diet, Journal of the American Dietetic Association, vol.102, issue.3, pp.396-398, 2002.
DOI : 10.1016/S0002-8223(02)90091-X

A. H. Manninen, Very-low-carbohydrate diets and preservation of muscle mass, Nutr. Metab, vol.3, issue.9, pp.10-1186, 2006.
DOI : 10.1111/j.1467-789x.2006.00271.x

K. Marosi, S. W. Kim, K. Moehl, M. Scheibye-knudsen, A. Cheng et al., 3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons, Journal of Neurochemistry, vol.5, issue.5
DOI : 10.1038/nrneurol.2009.54

K. Marosi and M. P. Mattson, BDNF mediates adaptive brain and body responses to energetic challenges, Trends in Endocrinology & Metabolism, vol.25, issue.2, 2014.
DOI : 10.1016/j.tem.2013.10.006

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915771/pdf

M. Martin, K. Rehani, R. S. Jope, and S. M. Michalek, Toll-like receptor???mediated cytokine production is differentially regulated by glycogen synthase kinase 3, Nature Immunology, vol.165, issue.8, pp.777-78410, 1038.
DOI : 10.4049/jimmunol.165.10.5780

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933525/pdf

S. A. Masino, M. Kawamura-jr, and D. N. Ruskin, Adenosine Receptors in Neurology and Psychiatry ; Chapitre 11 adenosine receptors and epilepsie : curent evidence and futur potential, 2014.

S. A. Masino, T. Li, P. Theofilas, U. S. Sandau, D. N. Ruskin et al., A ketogenic diet suppresses seizures in mice through adenosine A1 receptors, Journal of Clinical Investigation, vol.121, issue.7, pp.2679-2683, 2011.
DOI : 10.1172/JCI57813

J. A. Mattison, M. A. Lane, G. S. Roth, and D. K. Ingram, Calorie restriction in rhesus monkeys, Experimental Gerontology, vol.38, issue.1-2, pp.35-46, 2003.
DOI : 10.1016/S0531-5565(02)00146-8

M. P. Mattson, Interventions that Improve Body and Brain Bioenergetics for Parkinson's Disease Risk Reduction and Therapy, J. Park. Dis, vol.4, pp.1-13, 2014.

M. P. Mattson and R. Wan, Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems, The Journal of Nutritional Biochemistry, vol.16, issue.3, pp.129-137, 2005.
DOI : 10.1016/j.jnutbio.2004.12.007

M. Mazzuferi, G. Kumar, J. Van-eyll, B. Danis, P. Foerch et al., Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy, Annals of Neurology, vol.63, issue.suppl 4, pp.560-568, 2013.
DOI : 10.1016/B978-0-12-398339-8.00002-1

M. F. Mccarty and J. J. Dinicolantonio, Lauric acid-rich medium-chain triglycerides can substitute for other oils in cooking applications and may have limited pathogenicity, Open Heart, vol.3, issue.2, pp.467-477, 2016.
DOI : 10.1136/openhrt-2016-000467

K. A. Meckling, M. Gauthier, R. Grubb, and J. Sanford, Effects of a hypocaloric, low-carbohydrate diet on weight loss, blood lipids, blood pressure, glucose tolerance, and body composition in free-living overweight women, Canadian Journal of Physiology and Pharmacology, vol.82, issue.11, pp.1095-1105, 2002.
DOI : 10.1042/bj0820090

T. M. Melø, A. Nehlig, and U. Sonnewald, Neuronal???glial interactions in rats fed a ketogenic diet, Neurochemistry International, vol.48, issue.6-7, pp.498-507, 2006.
DOI : 10.1016/j.neuint.2005.12.037

R. P. Mensink, P. L. Zock, A. D. Kester, and M. B. Katan, Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a metaanalysis of 60 controlled trials, Am. J. Clin. Nutr, vol.77, pp.1146-1155, 2003.

A. T. Michael-titus and J. V. Priestley, Omega-3 fatty acids and traumatic neurological injury: from neuroprotection to neuroplasticity? Trends Neurosci, 2014.
DOI : 10.1016/j.tins.2013.10.005

J. B. Milder, L. Liang, and M. Patel, Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet, Neurobiology of Disease, vol.40, issue.1, 2010.
DOI : 10.1016/j.nbd.2010.05.030

B. Moreno, D. Bellido, I. Sajoux, A. Goday, D. Saavedra et al., Comparison of a very low-calorie-ketogenic diet with a standard low-calorie diet in the treatment of obesity, Endocrine, vol.97, issue.7, pp.793-805, 2014.
DOI : 10.3945/ajcn.112.050310

S. Mudaliar, S. Alloju, and R. R. Henry, Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis, Diabetes Care, vol.39, issue.7, pp.1115-1122, 2016.
DOI : 10.2337/dc16-0542

S. G. Mueller, A. H. Trabesinger, P. Boesiger, and H. G. Wieser, Brain glutathione levels in patients with epilepsy measured by in vivo 1H-MRS, Neurology, vol.57, issue.8, pp.1422-1427, 2001.
DOI : 10.1212/WNL.57.8.1422

K. S. Nair, S. L. Welle, D. Halliday, and R. G. Campbell, Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans., Journal of Clinical Investigation, vol.82, issue.1, pp.198-205, 1988.
DOI : 10.1172/JCI113570

A. Nehlig, Brain uptake and metabolism of ketone bodies in animal models, Prostaglandins, Leukotrienes and Essential Fatty Acids, vol.70, issue.3, pp.265-275, 2004.
DOI : 10.1016/j.plefa.2003.07.006

A. Nehlig, Age-dependent pathways of brain energy metabolism: the suckling rat, a natural model of the ketogenic diet Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapy, Epilepsy Res. J. Mol. Psychiatry, vol.3799, issue.4, pp.211-221, 1999.

M. Nei, L. Ngo, J. I. Sirven, and M. R. Sperling, Ketogenic diet in adolescents and adults with epilepsy, Seizure, vol.23, issue.6, 2014.
DOI : 10.1016/j.seizure.2014.02.015

URL : https://doi.org/10.1016/j.seizure.2014.02.015

. Nutripro, Aperçu sur l'Alimentation des Enfants de 3 à 12 ans | Nutripro [WWW Document], n.d. URL https://www.nutripro.nestle.fr/dossier/nutrition-moments-de-vie/enfants-de-3-12- ans/articles/un-apercu-sur-lalimentation-des-enfants-de, pp.3-12, 2017.

. Nutripro, Apports nutritionels conseillés : nourrissons et enfants en bas âge | Nutripro [WWW Document], n.d. URL https://www.nutripro.nestle.fr/dossier/nutrition-moments-de-vie/nourrissonsenfants-en-bas-age, 2017.

D. Omodei and L. Fontana, Calorie restriction and prevention of age-associated chronic disease, FEBS Letters, vol.280, issue.11, pp.1537-1542, 2011.
DOI : 10.1001/jama.280.23.2001

K. A. Page, A. Williamson, N. Yu, E. C. Mcnay, J. Dzuira et al., Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia, Diabetes, vol.58, issue.5, pp.1237-124410, 2009.
DOI : 10.2337/db08-1557

L. Pasca, V. D. Giorgis, J. A. Macasaet, C. Trentani, A. Tagliabue et al., The changing face of dietary therapy for epilepsy, European Journal of Pediatrics, vol.95, issue.10, pp.1267-1276, 2016.
DOI : 10.1016/j.eplepsyres.2011.04.003

J. Pei, T. Tanaka, Y. Tung, E. Braak, K. Iqbal et al., Distribution, Levels, and Activity of Glycogen Synthase Kinase-3 in the Alzheimer Disease Brain, Journal of Neuropathology and Experimental Neurology, vol.56, issue.1, pp.70-78, 1997.
DOI : 10.1097/00005072-199701000-00007

. Pharmacomedicale and . Org, Anti-épileptiques : Les Points essentiels

H. S. Phillips, J. M. Hains, M. Armanini, G. R. Laramee, S. A. Johnson et al., BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease, Neuron, vol.7, issue.5, pp.695-702, 1991.
DOI : 10.1016/0896-6273(91)90273-3

K. Pierre and L. Pellerin, Monocarboxylate transporters in the central nervous system: distribution, regulation and function, Journal of Neurochemistry, vol.50, issue.2, pp.1-14, 2005.
DOI : 10.1006/bbrc.1997.6588

R. A. Polin, S. H. Abman, D. Rowitch, and W. E. Benitz, Fetal and Neonatal Physiology, 2016.

N. Porta, L. Vallée, C. Lecointe, E. Bouchaert, B. Staels et al., Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties, Processus morphogénétiques. L'annuaire Collège Fr. Cours Trav, pp.331-353, 2009.
DOI : 10.1111/j.1528-1167.2008.01901.x

URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2008.01901.x/pdf

M. A. Puchowicz, J. L. Zechel, J. Valerio, D. S. Emancipator, K. Xu et al., Neuroprotection in Diet-Induced Ketotic Rat Brain after Focal Ischemia, Journal of Cerebral Blood Flow & Metabolism, vol.7, issue.2, pp.1907-191679, 2008.
DOI : 10.1186/1471-2202-7-29

URL : http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2008.79

W. Qin, V. Haroutunian, P. Katsel, C. P. Cardozo, L. Ho et al., PGC-1?? Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia, Archives of Neurology, vol.66, issue.3, pp.352-361588, 2008.
DOI : 10.1001/archneurol.2008.588

X. Qin, C. Cao, N. X. Cawley, T. Liu, J. Yuan et al., Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer???s disease: a meta-analysis study (N=7277), Molecular Psychiatry, vol.19, issue.2, 2017.
DOI : 10.3233/JAD-150799

M. A. Reger, S. T. Henderson, C. Hale, B. Cholerton, L. D. Baker et al., Effects of ??-hydroxybutyrate on cognition in memory-impaired adults, Neurobiology of Aging, vol.25, issue.3, pp.311-314, 2004.
DOI : 10.1016/S0197-4580(03)00087-3

B. Ren, L. Deng, J. Wang, Y. Zhu, L. Wei et al., R??gulation par l???hypoxie des prot??ines de transport facilit?? du glucose GLUT-1 et GLUT-3 dans les chondrocytes de souris, par l???interm??diaire du HIF-1alpha, Revue du Rhumatisme, vol.75, issue.3, 2008.
DOI : 10.1016/j.rhum.2007.05.022

M. A. Rogawski, W. Löscher, and J. M. Rho, Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet. Cold Spring Harb, 2016.

S. Rowley and M. Patel, Mitochondrial Involvement and Oxidative Stress in Temporal Lobe Epilepsy. Free Radic, Biol. Med, vol.62, pp.121-131, 2013.
DOI : 10.1016/j.freeradbiomed.2013.02.002

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043127/pdf

M. Roy, Étude du métabolisme cérébral au cours du vieillissement sain chez le rat : impact de la diète cétogène et de la restriction calorique. The study of brain metabolism during aging in rats: the effect of the ketogenic diet and calorie restriction, p.170, 2014.

M. Roy, Implication de la protéine UCP2 dans la réponse au stress, 2014.

L. Rui, C. Samieri, C. Féart, C. Proust-lima, E. Peuchant et al., Energy metabolism in the liver Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study, Compr. Physiol. Neurology, vol.4, issue.77, pp.177-197, 2011.

A. Sánchez-villegas, C. Galbete, M. Á. Martinez-gonzález, J. A. Martinez, C. Razquin et al., The effect of the Mediterranean diet on plasma brain-derived neurotrophic factor (BDNF) levels: The PREDIMED-NAVARRA randomized trial, Nutritional Neuroscience, vol.15, issue.7, pp.195-201, 2011.
DOI : 10.1001/jama.2009.1146

D. W. Seccombe, P. G. Harding, and F. Possmayer, Fetal utilization of maternally derived ketone bodies for lipogenesis in the rat, Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol.488, issue.3, pp.402-416, 1977.
DOI : 10.1016/0005-2760(77)90199-0

L. A. Sena and N. S. Chandel, Physiological Roles of Mitochondrial Reactive Oxygen Species, Molecular Cell, vol.48, issue.2, pp.158-167, 2012.
DOI : 10.1016/j.molcel.2012.09.025

T. N. Seyfried, R. E. Flores, A. M. Poff, and D. P. Agostino, Cancer as a metabolic disease: implications for novel therapeutics Role of Medium Chain Triglycerides (Axona®) in the Treatment of Mild to Moderate Alzheimer's Disease, Carcinogenesis Am. J. Alzheimers Dis. Dementias®, vol.35, issue.29, pp.515-527, 1177.

T. Shimazu, M. D. Hirschey, J. Newman, W. He, K. Shirakawa et al., Suppression of Oxidative Stress by ??-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor, Science, vol.376, issue.2, pp.211-214, 2013.
DOI : 10.1016/j.ab.2008.02.022

T. A. Simeone, S. A. Matthews, K. K. Samson, and K. A. Simeone, Regulation of brain PPARgamma2 contributes to ketogenic diet anti-seizure efficacy, Experimental Neurology, vol.287, 2016.
DOI : 10.1016/j.expneurol.2016.08.006

I. A. Simpson, A. Carruthers, and S. J. Vannucci, Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient Transporters, Journal of Cerebral Blood Flow & Metabolism, vol.89, issue.2, pp.1766-1791, 2007.
DOI : 10.1079/BJN2002763

I. A. Simpson, K. R. Chundu, T. Davies-hill, W. G. Honer, and P. Davies, Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease, Annals of Neurology, vol.23, issue.5, pp.546-551, 1994.
DOI : 10.1038/jcbfm.1991.65

M. Sirerol-piquer, P. Gomez-ramos, F. Hernández, M. Perez, M. A. Morán et al., GSK3?? overexpression induces neuronal death and a depletion of the neurogenic niches in the dentate gyrus, Hippocampus, vol.132, pp.910-922, 2011.
DOI : 10.1016/j.cell.2008.01.033

S. F. Sleiman, J. Henry, R. Haddad, L. E. Hayek, E. A. Haidar et al., Author response, eLife, vol.5, 2016.
DOI : 10.7554/eLife.15092.012

C. E. Stafstrom, J. C. Ockuly, L. Murphree, M. T. Valley, A. Roopra et al., Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models, Annals of Neurology, vol.35, issue.4, pp.435-447, 2009.
DOI : 10.1016/S0360-3016(96)85017-6

E. Steen, B. M. Terry, E. J. Rivera, J. L. Cannon, T. R. Neely et al., Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease ??? is this type 3 diabetes?, Journal of Alzheimer's Disease, vol.7, issue.1, pp.63-80, 2005.
DOI : 10.3233/JAD-2005-7107

D. P. Stiehl, W. Jelkmann, R. H. Wenger, and T. Hellwig-bürgel, Normoxic induction of the hypoxia-inducible factor 1?? by insulin and interleukin-1?? involves the phosphatidylinositol 3-kinase pathway, FEBS Letters, vol.12, issue.1-3, pp.157-162, 2002.
DOI : 10.3109/08977199509028967

P. G. Sullivan, C. Dubé, K. Dorenbos, O. Steward, and T. Z. Baram, Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death, Annals of Neurology, vol.13, issue.suppl 2, pp.711-717, 2003.
DOI : 10.1016/0887-8994(95)00185-I

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930774/pdf

P. G. Sullivan, N. A. Rippy, K. Dorenbos, R. C. Concepcion, A. K. Agarwal et al., The ketogenic diet increases mitochondrial uncoupling protein levels and activity, Annals of Neurology, vol.53, issue.4, pp.576-580, 2004.
DOI : 10.1002/ana.20062

M. Suzuki, M. Suzuki, Y. Kitamura, S. Mori, K. Sato et al., ??-Hydroxybutyrate, a Cerebral Function Improving Agent, Protects Rat Brain Against Ischemic Damage Caused by Permanent and Transient Focal Cerebral Ischemia, The Japanese Journal of Pharmacology, vol.89, issue.1, pp.36-43, 2002.
DOI : 10.1254/jjp.89.36

URL : https://www.jstage.jst.go.jp/article/jjp/89/1/89_1_36/_pdf

M. Suzuki, M. Suzuki, K. Sato, S. Dohi, T. Sato et al., Effect of .BETA.-Hydroxybutyrate, a Cerebral Function Improving Agent, on Cerebral Hypoxia, Anoxia and Ischemia in Mice and Rats., The Japanese Journal of Pharmacology, vol.87, issue.2, pp.143-150, 2001.
DOI : 10.1254/jjp.87.143

URL : https://hal.archives-ouvertes.fr/jpa-00218648

R. H. Swerdlow and S. M. Khan, A ???mitochondrial cascade hypothesis??? for sporadic Alzheimer's disease, Medical Hypotheses, vol.63, issue.1, 2004.
DOI : 10.1016/j.mehy.2003.12.045

G. S. Tejeda and M. Díaz-guerra, Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies, International Journal of Molecular Sciences, vol.20, issue.2, 2017.
DOI : 10.1038/cddis.2015.307

S. Tenoutasse, T. Mouraux, and H. Dorchy, L'acidocétose Diabétique, Diagnostic, prise en charge, prévention. Rev. Médicale Brux, pp.71-76, 2010.

K. Tieu, C. Perier, C. Caspersen, P. Teismann, D. Wu et al., D-??-Hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson disease, Journal of Clinical Investigation, vol.112, issue.6, pp.892-901, 2003.
DOI : 10.1172/JCI200318797

C. Tranchant and J. Azulay, Le livre de l'interne, 2012.

R. Valdebenito, I. Ruminot, P. Garrido-gerter, I. Fernández-moncada, L. Forero-quintero et al., Targeting of astrocytic glucose metabolism by beta-hydroxybutyrate, Journal of Cerebral Blood Flow & Metabolism, vol.36, issue.10, pp.1813-1822, 2015.
DOI : 10.1016/j.neuron.2010.09.002

T. B. Vanitallie, C. Nonas, D. Rocco, A. Boyar, K. Hyams et al., Treatment of Parkinson disease with diet-induced hyperketonemia: A feasibility study, Neurology, vol.64, issue.4, pp.728-730, 2005.
DOI : 10.1212/01.WNL.0000152046.11390.45

M. Varghese, W. Zhao, J. Wang, A. Cheng, X. Qian et al., Abstract, Translational Neuroscience, vol.440, issue.1, pp.1-5, 2011.
DOI : 10.1038/nature04533

F. O. Vehmeijer, E. J. Van-der-louw, W. F. Arts, C. E. Catsman-berrevoets, and R. F. Neuteboom, Can we predict efficacy of the ketogenic diet in children with refractory epilepsy?, European Journal of Paediatric Neurology, vol.19, issue.6, pp.701-705, 2015.
DOI : 10.1016/j.ejpn.2015.06.004

B. Vellas and P. Robert, Traité sur la maladie d'Alzheimer. Avec la collaboration de la Fédération nationale des Centres Mémoire de Ressources et de Recherche, Vellas et Robert, 2013.
DOI : 10.1016/s0248-8663(03)80682-3

B. Vellas and P. Robert, Traité sur la maladie d'Alzheimer. Avec la collaboration de la Fédération nationale des Centres Mémoire de Ressources et de Recherche, Vellas et Robert, 2013.
DOI : 10.1016/s0248-8663(03)80682-3

A. Verrotti, C. D-'egidio, S. Agostinelli, and G. Gobbi, Glut1 deficiency: When to suspect and how to diagnose?, European Journal of Paediatric Neurology, vol.16, issue.1, pp.3-9, 2012.
DOI : 10.1016/j.ejpn.2011.09.005

A. Vidal-puig, M. Jimenez-liñan, B. B. Lowell, A. Hamann, E. Hu et al., Regulation of PPAR gamma gene expression by nutrition and obesity in rodents., Proc. Natl. Acad. Sci. U. S. A. 99, pp.2553-2561, 1996.
DOI : 10.1172/JCI118703

A. F. Vizuete, D. F. De-souza, M. C. Guerra, C. Batassini, M. F. Dutra et al., Brain changes in BDNF and S100B induced by ketogenic diets in Wistar rats, Life Sciences, vol.92, issue.17-19, pp.923-928, 2013.
DOI : 10.1016/j.lfs.2013.03.004

W. Wang, A. H. Iyo, J. Miguel-hidalgo, S. Regunathan, and M. Zhu, Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons, Brain Research, vol.1084, issue.1, pp.210-216, 2006.
DOI : 10.1016/j.brainres.2006.02.024

X. Wang, Q. Liu, J. Zhou, X. Wu, and Q. Zhu, 2017. ? hydroxybutyrate levels in serum and cerebrospinal fluid under ketone body metabolism in rats, Exp. Anim
URL : https://hal.archives-ouvertes.fr/hal-01533163

A. Ward, S. Crean, C. J. Mercaldi, J. M. Collins, D. Boyd et al., Prevalence of Apolipoprotein E4 Genotype and Homozygotes (APOE e4/4) among Patients Diagnosed with Alzheimer???s Disease: A Systematic Review and Meta-Analysis, Neuroepidemiology, vol.6, issue.1, pp.1-17, 2012.
DOI : 10.1016/S1474-4422(07)70178-3

J. W. Wheless, M. Berezi?ska, and J. Z. Nowak, History and Origin of the Ketogenic Diet Epilepsy and the Ketogenic Diet, Nutrition and Health, PUFAs: Structures, Metabolism and Functions. Adv. Clin. Exp. Med. Off. Organ Wroclaw Med. Univ, vol.24, pp.31-50, 2004.

E. A. Winkler, Y. Nishida, A. P. Sagare, S. V. Rege, R. D. Bell et al., GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration, Nature Neuroscience, vol.4, issue.4, pp.521-530, 2015.
DOI : 10.7150/ijms.4.232

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734893/pdf

A. V. Witte, M. Fobker, R. Gellner, S. Knecht, and A. Flöel, Caloric restriction improves memory in elderly humans, Proc. Natl. Acad. Sci, pp.1255-1260, 2009.
DOI : 10.3109/00207459608986690

URL : http://www.pnas.org/content/106/4/1255.full.pdf

S. Xie, N. Jin, J. Gu, J. Shi, J. Sun et al., O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease, Aging Cell, vol.12, issue.3, pp.455-464, 2016.
DOI : 10.1038/nn.2405

Y. Xu, K. K. Kiningham, M. N. Devalaraja, C. Yeh, H. Majima et al., An Intronic NF-kappaB Element Is Essential for Induction of the Human Manganese Superoxide Dismutase Gene by Tumor Necrosis Factor-alpha and Interleukin-1beta, DNA and Cell Biology, vol.18, issue.9, pp.709-722, 1999.
DOI : 10.1089/104454999314999

X. Yu, X. Shao, H. Sun, Y. Li, J. Yang et al., Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by inhibiting oxidative stress following pilocarpine-induced status epilepticus, Brain Research, vol.1200, pp.146-158, 2008.
DOI : 10.1016/j.brainres.2008.01.047

M. Yudkoff, Y. Daikhin, I. Nissim, O. Horyn, A. Lazarow et al., Response of brain amino acid metabolism to ketosis, Neurochemistry International, vol.47, issue.1-2, pp.119-128, 2005.
DOI : 10.1016/j.neuint.2005.04.014

E. Zelzer, Y. Levy, C. Kahana, B. Z. Shilo, M. Rubinstein et al., Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha /ARNT, The EMBO Journal, vol.17, issue.17, pp.5085-5094, 1998.
DOI : 10.1093/emboj/17.17.5085

X. Zhang, Y. Zhang, Y. Liu, J. Wang, Q. Xu et al., Medium-chain triglycerides promote macrophage reverse cholesterol transport and improve atherosclerosis in ApoE-deficient mice fed a high-fat diet, Nutrition Research, vol.36, issue.9, pp.964-973, 2016.
DOI : 10.1016/j.nutres.2016.06.004

M. Zilberter, A. Ivanov, S. Ziyatdinova, M. Mukhtarov, A. Malkov et al., Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease, Journal of Neurochemistry, vol.31, issue.Suppl 1, pp.157-171, 2013.
DOI : 10.1016/j.tips.2010.06.005