M. Pugliatti, G. Rosati, H. Carton, T. Riise, J. Drulovic et al., The epidemiology of multiple sclerosis in Europe, European Journal of Neurology, vol.51, issue.2, pp.700-722, 2006.
DOI : 10.1093/heapol/16.3.326

S. Vukusic, V. Bockstael, V. Gosselin, S. Confavreux, and C. , Regional variations in the prevalence of multiple sclerosis in French farmers, Journal of Neurology, Neurosurgery & Psychiatry, vol.78, issue.7, pp.707-709, 2007.
DOI : 10.1136/jnnp.2006.101196

D. Pivot, M. Debouverie, M. Grzebyk, D. Brassat, M. Clanet et al., Geographical Heterogeneity of Multiple Sclerosis Prevalence in France, PLOS ONE, vol.8, issue.Pt 1, 2016.
DOI : 10.1371/journal.pone.0167556.s001

URL : https://hal.archives-ouvertes.fr/inserm-01576154

S. Foulon, G. Maura, M. Dalichampt, A. F. Debouverie, M. Moreau et al., Prevalence and mortality of patients with multiple sclerosis in France in 2012: a study based on French health insurance data, Journal of Neurology, vol.31, issue.5, pp.1185-92, 2017.
DOI : 10.1185/03007995.2015.1014029

A. Scalfari, A. Neuhaus, A. Degenhardt, G. Rice, P. Muraro et al., The natural history of multiple sclerosis, a geographically based study 10: relapses and long-term disability, Brain, vol.133, issue.7, pp.1914-1943, 2010.
DOI : 10.1093/brain/awq118

D. Miller, D. Chard, and O. Ciccarelli, Clinically isolated syndromes, The Lancet Neurology, vol.11, issue.2, pp.157-69, 2012.
DOI : 10.1016/S1474-4422(11)70274-5

URL : https://hal.archives-ouvertes.fr/hal-00552764

R. Beck, D. Chandler, S. Cole, J. Simon, L. Jacobs et al., Interferon ?-1a for early multiple sclerosis: CHAMPS trial subgroup analyses, Annals of Neurology, vol.52, issue.4, pp.481-90, 2002.
DOI : 10.1212/WNL.52.3.599

B. Ford, D. Tampieri, and G. Francis, Long-term follow-up of acute partial transverse myelopathy, Neurology, vol.42, issue.1, pp.250-252, 1992.
DOI : 10.1212/WNL.42.1.250

D. Miller, B. Weinshenker, M. Filippi, B. Banwell, J. Cohen et al., Differential diagnosis of suspected multiple sclerosis: a consensus approach, Multiple Sclerosis Journal, vol.53, issue.9, 2008.
DOI : 10.1136/jnnp.53.2.146

C. Polman, S. Reingold, G. Edan, M. Filippi, H. Hartung et al., Diagnostic criteria for multiple sclerosis: 2005 revisions to the ???McDonald Criteria???, Annals of Neurology, vol.6, issue.6, pp.840-846, 2005.
DOI : 10.1212/WNL.53.6.1184

M. Tintoré, A. Rovira, J. Río, C. Nos, E. Grivé et al., Baseline MRI predicts future attacks and disability in clinically isolated syndromes, Neurology, vol.67, issue.6, pp.968-72, 2006.
DOI : 10.1212/01.wnl.0000237354.10144.ec

D. Miller, F. Barkhof, X. Montalban, A. Thompson, and M. Filippi, Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis, The Lancet Neurology, vol.4, issue.5, pp.281-88, 2005.
DOI : 10.1016/S1474-4422(05)70071-5

J. Hyun, S. Huh, W. Kim, M. Park, S. Ahn et al., Evaluation of 2016 MAGNIMS MRI criteria for dissemination in space in patients with a clinically isolated syndrome, Multiple Sclerosis Journal, vol.1352458517706744, 2017.
DOI : 10.1016/S1474-4422(07)70176-X

C. Polman, S. Reingold, B. Banwell, M. Clanet, J. Cohen et al., Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria, Annals of Neurology, vol.64, issue.suppl 2, pp.292-302, 2011.
DOI : 10.1002/ana.21464

M. Tintoré, A. Rovira, J. Río, C. Tur, R. Pelayo et al., Do oligoclonal bands add information to MRI in first attacks of multiple sclerosis? Neurology, pp.1079-83

E. Mowry, M. Pesic, B. Grimes, S. Deen, P. Bacchetti et al., Clinical predictors of early second event in patients with clinically isolated syndrome, Journal of Neurology, vol.56, issue.7, pp.10-66, 2009.
DOI : 10.1212/WNL.56.3.422

C. Polman, L. Kappos, M. Freedman, G. Edan, H. Hartung et al., Subgroups of the BENEFIT study: Risk of developing MS and treatment effect of interferon beta-1b, Journal of Neurology, vol.11, issue.4, pp.480-487, 2008.
DOI : 10.1177/135245850100700603

R. Dobson, S. Ramagopalan, and G. Giovannoni, The eff ect of gender in CIS: a meta-analysis, Mult Scler J, 2011.

V. Zipoli, B. Goretti, B. Hakiki, G. Siracusa, S. Sorbi et al., Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromes, Multiple Sclerosis Journal, vol.5, issue.2, pp.62-69, 2010.
DOI : 10.1177/135245859900500205

M. Amato, The diagnostic dilemma of multiple sclerosis presenting with isolated cognitive and behavioral disorders, Multiple Sclerosis Journal, vol.23, issue.11, p.1352458517705002, 2017.
DOI : 10.1016/S1474-4422(14)70250-9

L. Hamel, D. Deloire, M. Ruet, A. Charré-morin, J. Saubusse et al., Deciphering Depressive Mood in Relapsing-Remitting and Progressive Multiple Sclerosis and Its Consequence on Quality of Life, PloS One, vol.10, pp.11-0142152, 2015.

A. Ruet, M. Deloire, D. Hamel, J. Ouallet, K. Petry et al., Cognitive impairment, health-related quality of life and vocational status at early stages of multiple sclerosis: a 7-year longitudinal study, Journal of Neurology, vol.257, issue.6, pp.776-84, 2013.
DOI : 10.1007/s00415-009-5441-7

G. Apolone, D. Carli, G. Brunetti, M. Garattini, and S. , Health-Related Quality of Life (HR-QOL) and Regulatory Issues, PharmacoEconomics, vol.279, issue.6, pp.187-95, 2001.
DOI : 10.2165/00019053-200119020-00005

L. Berrigan, J. Lefevre, L. Rees, J. Berard, M. Freedman et al., Cognition in Early Relapsing-Remitting Multiple Sclerosis: Consequences May Be Relative to Working Memory, Journal of the International Neuropsychological Society, vol.10, issue.08, pp.938-987, 2013.
DOI : 10.1136/jnnp.2004.045872

L. Ruano, E. Portaccio, B. Goretti, C. Niccolai, M. Severo et al., Age and disability drive cognitive impairment in multiple sclerosis across disease subtypes, Multiple Sclerosis Journal, vol.49, issue.9, pp.1258-67, 2017.
DOI : 10.1177/1352458512442438

A. Ruet, M. Deloire, J. Ouallet, S. Molinier, and B. Brochet, Predictive factors for multiple sclerosis in patients with clinically isolated spinal cord syndrome, Multiple Sclerosis Journal, vol.16, issue.2, pp.312-320, 2011.
DOI : 10.1177/1352458509353650

S. Morrow, A. Drake, R. Zivadinov, F. Munschauer, B. Weinstock-guttman et al., Predicting loss of employment over three years in multiple sclerosis: clinically meaningful cognitive decline, The Clinical Neuropsychologist, vol.58, issue.7, pp.1131-1176, 2010.
DOI : 10.1016/j.acn.2005.07.006

J. Kurtzke, Patterns of neurologic involvement in multiple sclerosis, Neurology, vol.39, issue.9, pp.1235-1243, 1989.
DOI : 10.1212/WNL.39.9.1235

R. Benedict, D. Ramasamy, F. Munschauer, B. Weinstock-guttman, R. Zivadinov et al., Mémory impairment in MS : correlation with deep grey matter and mesial temporal atrophy Cognitive function and quality of life in multiple sclerosis patients: a cross-sectional study, J Neurol Neurosurg Psychiatry BMC Neurol, vol.8011, pp.201-1617, 2009.

N. Lincoln and K. Radford, Cognitive abilities as predictors of safety to drive in people with multiple sclerosis, Multiple Sclerosis Journal, vol.18, issue.1, pp.123-131, 2008.
DOI : 10.1037/0894-4105.18.1.85

M. Schultheis, V. Weisser, J. Ang, E. Elovic, R. Nead et al., Examining the Relationship Between Cognition and Driving Performance in Multiple Sclerosis, Archives of Physical Medicine and Rehabilitation, vol.91, issue.3, pp.465-73, 2010.
DOI : 10.1016/j.apmr.2009.09.026

A. Ruet, M. Deloire, J. Charré-morin, D. Hamel, and B. Brochet, A new computerised cognitive test for the detection of information processing speed impairment in multiple sclerosis, Multiple Sclerosis Journal, vol.19, issue.12, pp.1665-72, 2013.
DOI : 10.1177/135245850100700409

E. Hubsky and J. Sears, Fatigue in Multiple Sclerosis: Guidelines for Nursing Care, Rehabilitation Nursing, vol.17, issue.4, pp.176-81, 1992.
DOI : 10.1002/j.2048-7940.1992.tb01542.x

J. Freal, G. Kraft, and J. Coryell, Symptomatic fatigue in multiple sclerosis, Arch Phys Med Rehabil, vol.65, issue.3, pp.135-143, 1984.

D. Kos, E. Kerckhofs, G. Nagels, D. 'hooghe, M. Ilsbroukx et al., Origin of Fatigue in Multiple Sclerosis: Review of the Literature, Neurorehabilitation and Neural Repair, vol.21, issue.11, pp.91-100, 2008.
DOI : 10.1002/(SICI)1097-4598(199808)21:8<1068::AID-MUS12>3.0.CO;2-Q

L. Krupp, L. Alvarez, N. Larocca, and L. Scheinberg, Fatigue in Multiple Sclerosis, Archives of Neurology, vol.45, issue.4, pp.435-442, 1988.
DOI : 10.1001/archneur.1988.00520280085020

J. Fisk, A. Pontefract, P. Ritvo, C. Archibald, and T. Murray, ABSTRACT:, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, vol.33, issue.01, pp.9-14, 1994.
DOI : 10.1016/0304-3959(85)90078-8

F. Khan, B. Amatya, and M. Galea, Management of Fatigue in Persons with Multiple Sclerosis, Frontiers in Neurology, vol.84, issue.10, p.177, 2014.
DOI : 10.1136/jnnp-2012-303816

I. Higginson, S. Hart, E. Silber, R. Burman, and P. Edmonds, Symptom prevalence and severity in people severely affected by multiple sclerosis, J Palliat Care, vol.22, issue.3, pp.158-65, 2006.

M. Bonnet, M. Deloire, E. Salort, V. Dousset, K. Petry et al., Evidence of cognitive compensation associated with educational level in early relapsing???remitting multiple sclerosis, Journal of the Neurological Sciences, vol.251, issue.1-2, pp.23-31, 200621.
DOI : 10.1016/j.jns.2006.08.002

M. Bonnet, M. Allard, B. Dilharreguy, M. Deloire, K. Petry et al., Cognitive compensation failure in multiple sclerosis, Neurology, vol.75, issue.14, pp.1241-1249, 2010.
DOI : 10.1212/WNL.0b013e3181f612e3

E. Patrick, C. Christodoulou, and L. Krupp, Longitudinal correlates of fatigue in multiple sclerosis, Multiple Sclerosis Journal, vol.37, issue.2, pp.258-61, 2009.
DOI : 10.1007/s00415-006-0247-3

L. Chwastiak, L. Gibbons, D. Ehde, M. Sullivan, J. Bowen et al., Fatigue and psychiatric illness in a large community sample of persons with multiple sclerosis, Journal of Psychosomatic Research, vol.59, issue.5, pp.291-299, 2005.
DOI : 10.1016/j.jpsychores.2005.06.001

E. Stenager, N. Koch-henriksen, and E. Stenager, Risk Factors for Suicide in Multiple Sclerosis, Psychotherapy and Psychosomatics, vol.65, issue.2, pp.86-90, 1996.
DOI : 10.1159/000289052

E. Stenager, E. Stenager, and N. Koch-henriksen, Suicide and multiple sclerosis: an epidemiological investigation., Journal of Neurology, Neurosurgery & Psychiatry, vol.55, issue.7, pp.542-545, 1992.
DOI : 10.1136/jnnp.55.7.542

A. Sadovnick, K. Eisen, G. Ebers, and D. Paty, Cause of death in patients attending multiple sclerosis clinics, Neurology, vol.41, issue.8, pp.1193-1199, 1991.
DOI : 10.1212/WNL.41.8.1193

E. Hakim, A. Bakheit, T. Bryant, M. Roberts, S. Mcintosh-michaelis et al., The social impact of multiple sclerosis - a study of 305 patients and their relatives, Disability and Rehabilitation, vol.22, issue.6, pp.288-93, 2000.
DOI : 10.1080/096382800296755

C. Even, C. Laffite, B. Etain, and R. Dardennes, Les déterminants de la dépression dans la SEP. Revue de la littérature, pp.78-85, 1999.

T. Dubayova, M. Krokavcova, I. Nagyova, J. Rosenberger, Z. Gdovinova et al., Type D, anxiety and depression in association with quality of life in patients with Parkinson???s disease and patients with multiple sclerosis, Quality of Life Research, vol.15, issue.5, pp.1353-1360, 2013.
DOI : 10.1111/j.1468-1331.2008.02103.x

A. Feinstein, An examination of suicidal intent in patients with multiple sclerosis, Neurology, vol.59, issue.5, pp.674-678, 2002.
DOI : 10.1212/WNL.59.5.674

D. Nunnari, D. Cola, M. , D. 'aleo, G. Rifici et al., Impact of Depression, Fatigue, and Global Measure of Cortical Volume on Cognitive Impairment in Multiple Sclerosis, BioMed Research International, vol.69, issue.6, 2015.
DOI : 10.1212/wnl.0b013e3182918c6f

P. A. Arnett, C. I. Higginson, and J. J. Randolph, Depression in multiple sclerosis: Relationship to planning ability, Journal of the International Neuropsychological Society, vol.7, issue.6, pp.665-674, 2001.
DOI : 10.1017/S1355617701766027

A. Feinstein, S. Magalhaes, J. Richard, B. Audet, and C. Moore, The link between multiple sclerosis and depression, Nature Reviews Neurology, vol.4, issue.9, pp.507-524, 2014.
DOI : 10.1176/jnp.4.2.145

N. Tellez, J. Rio, M. Tintore, C. Nos, I. Galan et al., Fatigue in multiple sclerosis persists over time, Journal of Neurology, vol.46, issue.11, pp.1466-70, 2006.
DOI : 10.1212/WNL.46.2.552

M. Korostil and A. Feinstein, Anxiety disorders and their clinical correlates in multiple sclerosis patients, Multiple Sclerosis Journal, vol.51, issue.27, pp.67-72, 2007.
DOI : 10.1001/archpsyc.1994.03950090072010

K. H. Jones, A Large-Scale Study of Anxiety and Depression in People with Multiple Sclerosis: A Survey via the Web Portal of the UK MS Register, PLoS ONE, vol.7, issue.7, p.2012, 41910.
DOI : 10.1371/journal.pone.0041910.s001

E. Fernandez-jimenez and P. Arnett, Impact of neurological impairment, depression, cognitive function and coping on quality of life of people with multiple sclerosis: A relative importance analysis, Multiple Sclerosis Journal, vol.21, issue.11, pp.1468-1472, 2015.
DOI : 10.1093/arclin/15.3.185

A. C. Garfield and N. B. Lincoln, Factors affecting anxiety in multiple sclerosis, Disability and Rehabilitation, vol.62, issue.11, pp.2047-2052, 2012.
DOI : 10.1080/13854040802665808

A. Feinstein, O. Connor, P. Gray, T. Feinstein, and K. , The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis, Multiple Sclerosis, vol.5, issue.5, pp.323-329, 1999.
DOI : 10.1191/135245899678846348

S. Quesnel and A. Feinstein, Multiple sclerosis and alcohol: a study of problem drinking. Mult Scler, pp.197-201

S. Pittion-vouyovitch, M. Debouverie, F. Guillemin, N. Vandenberghe, R. Anxionnat et al., Fatigue in multiple sclerosis is related to disability, depression and quality of life, Journal of the Neurological Sciences, vol.243, issue.1-2, pp.39-45, 2006.
DOI : 10.1016/j.jns.2005.11.025

V. Janardhan and R. Bakshi, Quality of life in patients with multiple sclerosis, Journal of the Neurological Sciences, vol.205, issue.1, pp.51-58, 2002.
DOI : 10.1016/S0022-510X(02)00312-X

F. Mattioli, C. Stampatori, F. Bellomi, C. Scarpazza, and R. Capra, Natalizumab Significantly Improves Cognitive Impairment over Three Years in MS: Pattern of Disability Progression and Preliminary MRI Findings, PLOS ONE, vol.21, issue.2, p.131803, 2015.
DOI : 10.1371/journal.pone.0131803.t003

F. Patti, V. Morra, M. Amato, M. Trojano, S. Bastianello et al., Subcutaneous Interferon ??-1a May Protect against Cognitive Impairment in Patients with Relapsing???Remitting Multiple Sclerosis: 5-Year Follow-up of the COGIMUS Study, PLoS ONE, vol.364, issue.8, p.74111, 2013.
DOI : 10.1371/journal.pone.0074111.t002

F. Reuter, W. Zaaraoui, L. Crespy, A. Faivre, A. Rico et al., Frequency of cognitive impairment dramatically increases during the first 5 years of multiple sclerosis, Journal of Neurology, Neurosurgery & Psychiatry, vol.82, issue.10, pp.1157-91, 2011.
DOI : 10.1136/jnnp.2010.213744

M. Deloire, E. Salort, M. Bonnet, Y. Arimone, and M. Boudineau, Amieva H et al Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis, JNNP, vol.76, pp.519-526, 2005.

A. Giordano, F. Granella, A. Lugaresi, V. Martinelli, M. Trojano et al., Anxiety and depression in multiple sclerosis patients around diagnosis, Journal of the Neurological Sciences, vol.307, issue.1-2, pp.86-91, 2011.
DOI : 10.1016/j.jns.2011.05.008

J. Lovera, B. Bagert, K. Smoot, K. Wild, R. Frank et al., Correlations of Perceived Deficits Questionnaire of Multiple Sclerosis Quality of Life Inventory with Beck Depression Inventory and neuropsychological tests, The Journal of Rehabilitation Research and Development, vol.43, issue.1, p.73, 2006.
DOI : 10.1682/JRRD.2004.09.0118

K. Baumstarck-barrau, M. Simeoni, F. Reuter, I. Klemina, V. Aghababian et al., Cognitive function and quality of life in multiple sclerosis patients: a cross-sectional study, BMC Neurology, vol.267, issue.Pt 7, p.17, 2011.
DOI : 10.1016/j.jns.2007.10.002

A. Janssens, P. Van-doorn, J. De-boer, F. Van-der-meché, J. Passchier et al., Impact of recently diagnosed multiple sclerosis on quality of life, anxiety, depression and distress of patients and partners, Acta Neurologica Scandinavica, vol.44, issue.6, pp.389-95, 2003.
DOI : 10.1007/s004150050204

A. Mitchell, J. Benito-leo´n, M. Gonza´lez, J. Riveranavarro, and J. , Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing, The Lancet Neurology, vol.4, issue.9, pp.556-566, 2005.
DOI : 10.1016/S1474-4422(05)70166-6

L. Fisniku, P. Brex, D. Altmann, K. Miszkiel, C. Benton et al., Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis, Brain, vol.131, issue.3, pp.808-825, 2008.
DOI : 10.1093/brain/awm329

L. Kappos, Effect of drugs in secondary disease progression in patients with multiple sclerosis, Multiple Sclerosis Journal, vol.337, issue.2, pp.46-54, 2004.
DOI : 10.1016/S0301-0082(02)00105-3

B. Borchet, Place de l'EDSS dans l'évaluation précoce du handicap EM-Consulte

F. Barkhof, M. Filippi, D. Miller, P. Scheltens, A. Campi et al., Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis, Brain, vol.120, issue.11, pp.2059-69, 1997.
DOI : 10.1093/brain/120.11.2059

M. Deloire, M. Bonnet, E. Salort, Y. Arimone, M. Boudineau et al., How to detect cognitive dysfunction at early stages of multiple sclerosis? Mult Scler, pp.445-52, 2006.

A. Ruet, Cognitive impairment in MS Neuropsychiatric symtpoms of inflammatory demyelinating diseases, pp.227-274

N. Chiaravalloti and J. Deluca, Cognitive impairment in multiple sclerosis, The Lancet Neurology, vol.7, issue.12, pp.1139-51, 2008.
DOI : 10.1016/S1474-4422(08)70259-X

N. Sicotte, K. Kern, B. Giesser, A. Arshanapalli, A. Schultz et al., Regional hippocampal atrophy in multiple sclerosis, Brain, vol.131, issue.4, pp.1134-1175, 2008.
DOI : 10.1093/brain/awn030

L. Pelosi, J. Geesken, M. Holly, M. Hayward, and L. Blumhardt, Working memory impairment in early multiple sclerosis. Evidence from an event-related potential study of patients with clinically isolated myelopathy, Brain, vol.120, issue.11, p.203958, 1997.
DOI : 10.1093/brain/120.11.2039

M. Auduong, B. Audoin, K. Boulanouar, D. Ibarrola, I. Malikova et al., Altered functional connectivity related to white matter changes inside the work memory network at very early stage of MS, J Vereb Blood Flow Metab, vol.25, issue.10, pp.1245-53, 2005.

L. Feuillet, F. Reuter, B. Audoin, I. Malikova, K. Barrau et al., Early cognitive impairment in patients with clinically isolated syndrome suggestive of multiple sclerosis, Multiple Sclerosis Journal, vol.76, issue.1, pp.124-131, 2007.
DOI : 10.1136/jnnp.2004.045518

URL : https://hal.archives-ouvertes.fr/hal-00169069

C. Lebrun, F. Blanc, D. Brassat, H. Zephir, D. Seze et al., Cognitive function in radiologically isolated syndrome, Multiple Sclerosis Journal, vol.72, issue.8, pp.919-944, 2010.
DOI : 10.1177/1352458508096878

URL : https://hal.archives-ouvertes.fr/hal-00617782

A. Archiron and Y. Barak, Cognitive impairment in probable multiple sclerosis, Journal of Neurology, Neurosurgery & Psychiatry, vol.74, issue.4, pp.443-446, 2003.
DOI : 10.1136/jnnp.74.4.443

J. Deluca, G. Chelune, D. Tulsky, J. Lengenfelder, and N. Chiaravalloti, Is Speed of Processing or Working Memory the Primary Information Processing Deficit in Multiple Sclerosis?, Journal of Clinical and Experimental Neuropsychology, vol.26, issue.4, pp.550-562, 2004.
DOI : 10.1080/13803390490496641

K. Zakzanis, Distinct Neurocognitive Profiles in Multiple Sclerosis Subtypes, Archives of Clinical Neuropsychology, vol.15, issue.2, pp.115-151, 2000.
DOI : 10.1093/arclin/15.2.115

A. Ruet, M. Deloire, J. Charré-morin, D. Hamel, and B. Brochet, Cognitive impairment differs between primary progressive and relapsing-remitting MS, Neurology, vol.80, issue.16, pp.1501-1509, 2013.
DOI : 10.1212/WNL.0b013e31828cf82f

J. Macniven, C. Davis, C. Bradshaw, E. Szabadi, and C. Constaniscu, Stroop performance in MS information processing speech, selective aatention or executive function, J Intern Neuropsychol Soc, vol.14, pp.805-819, 2008.

J. Fisk and C. Archibald, Limitations of the Paced Auditory Serial Addition Test as a measure of working memory in patients with multiple sclerosis, Journal of the International Neuropsychological Society, vol.7, issue.3, pp.363-72, 2001.
DOI : 10.1017/S1355617701733103

M. Summers, J. Swanton, K. Fernando, C. Dalton, D. Miller et al., Cognitive impairment in multiple sclerosis can be predicted by imaging early in the disease, Journal of Neurology, Neurosurgery & Psychiatry, vol.79, issue.8, pp.955-963, 2008.
DOI : 10.1136/jnnp.2007.138685

R. Prakash, E. Snook, J. Lewis, R. Motl, and A. Kramer, Cognitive impairments in relapsing-remitting multiple sclerosis: a meta-analysis, Multiple Sclerosis Journal, vol.12, issue.9, pp.1250-61, 2008.
DOI : 10.1080/01688639008401002

D. Denney, L. Sworowski, and S. Lynch, Cognitive impairment in three subtypes of multiple sclerosis, Archives of Clinical Neuropsychology, vol.20, issue.8, pp.967-81, 2005.
DOI : 10.1016/j.acn.2005.04.012

D. Denney, S. Lynch, and B. Parmenter, A 3-year longitudinal study of cognitive impairment in patients with primary progressive multiple sclerosis: Speed matters, Journal of the Neurological Sciences, vol.267, issue.1-2, pp.129-165, 2008.
DOI : 10.1016/j.jns.2007.10.007

M. Guidelines, Fatigue and multiple sclerosis: evidence-based management strategies for fatigue in multiple sclerosis]; Available from: https://www.scholars.northwestern.edu/en/publications/fatigue-and-multiple-sclerosis- evidence-based-management-strategi, 1998.

M. Debouverie, S. Pittion-vouyovitch, S. Louis, and F. Guillemin, Validity of a French version of the fatigue impact scale in multiple sclerosis, Multiple Sclerosis Journal, vol.8, issue.1, pp.1026-1058, 2007.
DOI : 10.1191/1352458505ms1148oa

L. Krupp and C. Christodoulou, Fatigue in multiple sclerosis, Current Neurology and Neuroscience Reports, vol.42, issue.suppl 1, pp.294-302, 2001.
DOI : 10.1212/WNL.42.8.1468

H. Zéphir and M. Fatigue, Fatigue et scl??rose en plaques, Pratique Neurologique - FMC, vol.5, issue.1, pp.49-56, 2014.
DOI : 10.1016/j.praneu.2013.12.004

A. Leplège, E. Ecosse, J. Coste, J. Pouchot, and T. Perneger, Le questionnaire MOS SF-36: manuel de l'utilisateur et guide d'interprétation des scores, Editions Estem, 2001.

J. Bouyer, P. Flachenecker, T. Kümpfel, B. Kallmann, M. Gottschalk et al., Fatigue in multiple sclerosis: a comparison of different rating scales and correlation to clinical parameters, Méthodes statistiques Médecine-Biologie Inserm. 1996 Edition De Boeck 103, pp.523-529, 2002.

S. Rao, G. Leo, L. Bernardin, and F. Unverzagt, Cognitive dysfunction in multiple sclerosis.: I. Frequency, patterns, and prediction, Neurology, vol.41, issue.5, pp.685-91, 1991.
DOI : 10.1212/WNL.41.5.685

S. L. Minden, Evidence-based guideline: Assessment and management of psychiatric disorders in individuals with MS: Report of the Guideline Development Subcommittee of the American Academy of Neurology, Neurology, vol.82, issue.2, pp.174-181, 2014.
DOI : 10.1212/WNL.0000000000000013

G. Santangelo, R. Sacco, M. Siciliano, A. Bisecco, G. Muzzo et al., Anxiety in Multiple Sclerosis: psychometric properties of the State-Trait Anxiety Inventory, Acta Neurologica Scandinavica, vol.132, issue.Suppl 20, pp.458-66, 2016.
DOI : 10.1111/ane.12385

M. Amato, G. Ponziani, G. Siracusa, and S. Sorbi, Cognitive Dysfunction in Early-Onset Multiple Sclerosis, Archives of Neurology, vol.58, issue.10, pp.1602-1608, 2001.
DOI : 10.1001/archneur.58.10.1602

G. Deluca, R. Yates, H. Beale, and S. Morrow, Cognitive Impairment in Multiple Sclerosis: Clinical, Radiologic and Pathologic Insights, Brain Pathology, vol.15, issue.Pt 2, pp.79-98, 2015.
DOI : 10.1016/S0887-6177(98)00157-7

B. Duque, J. Sepulcre, B. Bejarano, L. Samaranch, P. Pastor et al., Memory decline evolves independently of disease activity in MS, Multiple Sclerosis Journal, vol.255, issue.7, pp.947-53, 2008.
DOI : 10.1016/j.jns.2007.01.070

A. Labiano-fontcuberta, M. Martínez-ginés, Y. Aladro, L. Ayuso, A. Mitchell et al., A comparison study of cognitive deficits in radiologically and clinically isolated syndromes, Multiple Sclerosis Journal, vol.22, issue.2, pp.250-253, 2016.
DOI : 10.1177/1352458509350311

B. Glanz, B. Healy, D. Rintell, S. Jaffin, R. Bakshi et al., The association between cognitive impairment and quality of life in patients with early multiple sclerosis, Journal of the Neurological Sciences, vol.290, issue.1-2, pp.75-84
DOI : 10.1016/j.jns.2009.11.004

D. Langdon, Cognition in multiple sclerosis, Current Opinion in Neurology, vol.24, issue.3, pp.244-253, 2011.
DOI : 10.1097/WCO.0b013e328346a43b

M. Debouverie, S. Pittion-vouyovitch, and F. Guillemin, Reconsid??rer l???apparition du handicap d??s le d??but de la SEP : la fatigue, Revue Neurologique, vol.165, issue.4, pp.135-144, 2009.
DOI : 10.1016/S0035-3787(09)72125-3

C. Anhoque, S. Domingues, A. Teixeira, and R. Domingues, Cognitive impairment in clinically isolated syndrome: a systematic review, Dementia & Neuropsychologia, vol.63, issue.35-36, pp.86-90, 2010.
DOI : 10.1001/archneur.63.8.1175

J. Hanna, J. Santo, M. Blair, K. Smolewska, E. Warriner et al., Comparing depression screening tools in persons with multiple sclerosis (MS)., Rehabilitation Psychology, vol.62, issue.1, pp.20-24, 2017.
DOI : 10.1037/rep0000115

S. Johansson, K. Gottberg, M. Kierkegaard, and C. Ytterberg, Variations in and predictors of the occurrence of depressive symptoms and mood symptoms in multiple sclerosis: a longitudinal two-year study, BMC Neurology, vol.85, issue.Suppl 2, p.32, 2016.
DOI : 10.1002/14651858.CD007256.pub2

L. Krupp, C. Christodoulou, P. Melville, W. Scherl, W. Macallister et al., Donepezil improved memory in multiple sclerosis in a randomized clinical trial, Neurology, vol.63, issue.9, pp.1579-85, 2004.
DOI : 10.1212/01.WNL.0000142989.09633.5A

S. B. Patten, C. A. Beck, J. V. Williams, C. Barbui, and L. M. Metz, Major depression in multiple sclerosis: A population-based perspective, Neurology, vol.61, issue.11, pp.61-1524, 2003.
DOI : 10.1212/01.WNL.0000095964.34294.B4

I. Penner, N. Bechtek, C. Raselli, M. Stöckin, K. Opwis et al., Fatigue in multiple sclerosis: relation to depression, physical impairment, personality and action control, Multiple Sclerosis Journal, vol.64, issue.9, pp.1161-1168, 2007.
DOI : 10.1136/jnnp.64.2.262

R. Kessler, P. Berglund, O. Demler, J. R. Merikangas, K. Walters et al., Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication, Archives of General Psychiatry, vol.62, issue.6, pp.593-602, 2005.
DOI : 10.1001/archpsyc.62.6.593

K. Hornarmand and A. Feinstein, Validation of the Hospital Anxiety and Depression Scale for use with multiple sclerosis patients, Multiple Sclerosis Journal, vol.15, issue.12, pp.1518-1524, 2009.
DOI : 10.1177/1352458508099143

M. N. Burns, E. Nawacki, J. Siddique, D. Pelletier, and D. C. Mohr, Prospective Examination of Anxiety and Depression Before and During Confirmed and Pseudoexacerbations in Patients With Multiple Sclerosis, Psychosomatic Medicine, vol.75, issue.1, pp.76-82, 2013.
DOI : 10.1097/PSY.0b013e3182757b2b

W. Group and . Development, Rationale and current status, International Journal of Mental Health, issue.23, pp.24-56, 1994.

L. Jacobs, R. Beck, and J. Simon, Intramuscular Interferon Beta-1A Therapy Initiated during a First Demyelinating Event in Multiple Sclerosis, New England Journal of Medicine, vol.343, issue.13, pp.898-904, 2000.
DOI : 10.1056/NEJM200009283431301

R. Kinkel, G. Laforet, and X. You, Disease-Related Determinants of Quality of Life 10 Years After Clinically Isolated Syndrome, International Journal of MS Care, vol.17, issue.1, pp.26-34, 2015.
DOI : 10.7224/1537-2073.2013-041

M. Amato, V. Zipoli, and E. Portaccio, Multiple sclerosis-related cognitive changes: A review of cross-sectional and longitudinal studies, Journal of the Neurological Sciences, vol.245, issue.1-2, pp.41-47, 2006.
DOI : 10.1016/j.jns.2005.08.019

M. Amato, V. Zipoli, B. Goretti, E. Portaccio, D. Caro et al., Benign multiple sclerosis, Journal of Neurology, vol.53, issue.suppl 87, 2006.
DOI : 10.1212/WNL.53.8.1622

G. Defer, B. Brochet, and J. Pelletier, Neuropsychologie de la sclérose en plaques, p.209, 2011.