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Master Thesis

Quel est le rôle des Immunoglobulines G dans les exacerbations virales d’asthme ?

Abstract : Introduction. - Asthma is a leading public health problem. Acute asthma exacerbations worsen the quality of life of asthmatic patients and increase the risk of mortality. Viruses are frequently incriminated for these exacerbations. The value of serum immunoglobulin G (IgG) concentrations in asthma exacerbations and the link with viral infections remain unknown. Material and methods. - Patients hospitalized for asthma exacerbation were included in an observational study from 01 January to 31 December 2015. Serum IgG concentrations were compared between patients with a positive upper airway viral sample and those with a negative viral sample. Results. - Among the 82 patients included, those with positive viral nasopharyngeal samples had a lower IgG blood concentration during the exacerbation than those with a negative viral sample (10.1 ± 2.3 g / l vs 11.5 ± 3.6 g / l, p <0.05). The median blood concentration of IgG was lower in patients hospitalized more than 3 days (10.0 g / l [8.2-12.4] vs 11.4 g / l [10.1-12.8], p < 0.05) and in patients who received oral corticosteroid therapy for more than five days (10.1 [8.3-12.2] vs. 11.6 g / l [10-13.8], p <0.05 ). Conclusion. - IgG was significantly lower when exacerbation of asthma was associated with positive viral samples and when exacerbation was more severe. In order to support the hypothesis of a dysfunction in the innate or adaptive response, larger studies are needed.
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Morgane Verduyn. Quel est le rôle des Immunoglobulines G dans les exacerbations virales d’asthme ?. Médecine humaine et pathologie. 2017. ⟨dumas-01655046⟩

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