M. Alizadeh, M. Bernard, B. Danic, C. Dauriac, B. Birebent et al., Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real-time quantitative polymerase chain reaction, Blood, vol.99, issue.12, pp.4618-4625, 2002.
DOI : 10.1182/blood.V99.12.4618

M. Alizadeh, M. Bernard, B. Danic, C. Dauriac, B. Birebent et al., Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real-time quantitative polymerase chain reaction, Blood, vol.99, issue.12, pp.4618-4625, 2002.
DOI : 10.1182/blood.V99.12.4618

M. Aloisio, D. Licastro, L. Caenazzo, V. Torboli, A. Eustacchio et al., A technical application of quantitative next generation sequencing for chimerism evaluation, Molecular Medicine Reports, vol.14, issue.4, 2016.
DOI : 10.3892/mmr.2016.5593

M. Aloisio, B. Bortot, I. Gandin, G. M. Severini, and E. Athanasakis, A semi-nested real-time PCR method to detect low chimerism percentage in small quantity of hematopoietic stem cell transplant DNA samples, Genome, vol.146, issue.15, pp.183-192, 2017.
DOI : 10.1038/sj.leu.2403719

M. Aoudjhane, M. Labopin, N. C. Gorin, A. Shimoni, T. Ruutu et al., Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT), Leukemia, vol.18, issue.12, pp.2304-2312, 2005.
DOI : 10.1016/S0140-6736(00)02137-1

P. Bader, W. Hölle, T. Klingebiel, R. Handgretinger, D. Niethammer et al., Quantitative assessment of mixed hematopoietic chimerism by polymerase chain reaction after allogeneic BMT, 1996.

P. Bader, J. Beck, A. Frey, P. G. Schlegel, H. Hebarth et al., Serial and quantitative analysis of mixed hematopoietic chimerism by PCR in patients with acute leukemias allows the prediction of relapse after allogeneic BMT, Bone Marrow Transplantation, vol.21, issue.5, pp.487-495, 1998.
DOI : 10.1038/sj.bmt.1701119

P. Bader, K. Stoll, S. Huber, A. Geiselhart, R. Handgretinger et al., Characterization of lineage-specific chimaerism in patients with acute leukaemia and myelodysplastic syndrome after allogeneic stem cell transplantation before and after relapse, British Journal of Haematology, vol.77, issue.1, pp.761-768, 2000.
DOI : 10.1016/0145-2126(95)00026-K

P. Bader, H. Kreyenberg, W. Hoelle, G. Dueckers, R. Handgretinger et al., Increasing Mixed Chimerism Is an Important Prognostic Factor for Unfavorable Outcome in Children With Acute Lymphoblastic Leukemia After Allogeneic Stem-Cell Transplantation: Possible Role For Pre-Emptive Immunotherapy?, Journal of Clinical Oncology, vol.22, issue.9, pp.1696-1705, 2004.
DOI : 10.1200/JCO.2004.05.198

P. Bader, D. Niethammer, A. Willasch, H. Kreyenberg, and T. Klingebiel, How and when should we monitor chimerism after allogeneic stem cell transplantation?, Bone Marrow Transplantation, vol.7, issue.2, pp.107-119, 2005.
DOI : 10.1038/sj.leu.2403087

URL : http://www.nature.com/bmt/journal/v35/n2/pdf/1704715a.pdf

J. N. Barker, D. J. Weisdorf, T. E. Defor, B. R. Blazar, P. B. Mcglave et al., Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy, Blood, vol.105, issue.3, pp.1343-1347, 2005.
DOI : 10.1182/blood-2004-07-2717

F. Baron and B. M. Sandmaier, Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning, Leukemia, vol.262, issue.10, pp.1690-1700, 2006.
DOI : 10.1016/S0022-1759(02)00017-0

URL : http://www.nature.com/leu/journal/v20/n10/pdf/2404335a.pdf

F. Baron and R. Storb, Allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning as treatment for hematologic malignancies and inherited blood disorders, Molecular Therapy, vol.13, issue.1, pp.26-41, 2006.
DOI : 10.1016/j.ymthe.2005.09.011

URL : https://doi.org/10.1016/j.ymthe.2005.09.011

F. Baron, J. E. Baker, R. Storb, T. A. Gooley, B. M. Sandmaier et al., Kinetics of engraftment in patients with hematologic malignancies given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning, Blood, vol.104, issue.8, pp.2254-2262, 2004.
DOI : 10.1182/blood-2004-04-1506

M. Barrios, A. Jiménez-velasco, J. Román-gómez, M. E. Madrigal, J. A. Castillejo et al., Chimerism status is a useful predictor of relapse after allogeneic stem cell transplantation for acute leukemia, Haematologica, vol.88, pp.801-810, 2003.

F. Beckerich, Analyse du suivi de la maladie résiduelle chez les patients suivis pour leucémie aiguë au troisième mois de l'allogreffe: une étude lyonnaise de 212 cas, 2013.

W. A. Bethge, U. Hegenbart, M. J. Stuart, B. E. Storer, M. B. Maris et al., Adoptive immunotherapy with donor lymphocyte infusions after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning, Blood, vol.103, issue.3, pp.790-795, 2004.
DOI : 10.1182/blood-2003-07-2344

URL : http://www.bloodjournal.org/content/bloodjournal/103/3/790.full.pdf

B. R. Blazar, H. T. Orr, D. C. Arthur, J. H. Kersey, and A. H. Filipovich, Restriction fragment length polymorphisms as markers of engraftment in allogeneic marrow transplantation, Blood, vol.66, pp.1436-1444, 1985.

M. Bleakley and S. R. Riddell, Molecules and mechanisms of the graft-versus-leukaemia effect, Nature Reviews Cancer, vol.4, issue.5, 2004.
DOI : 10.1038/nrc1365

W. Blum, R. Brown, H. S. Lin, B. Zehnbauer, H. Khoury et al., Low-dose (550 cGy), single-exposure total body irradiation and cyclophosphamide: Consistent, durable engraftment of related-donor peripheral blood stem cells with low treatment-related mortality and fatal organ toxicity, Biology of Blood and Marrow Transplantation, vol.8, issue.11, pp.608-618, 2002.
DOI : 10.1053/bbmt.2002.v8.abbmt080608

M. Bornhauser, U. Oelschlaegel, U. Platzbecker, G. Bug, K. Lutterbeck et al., Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation, Haematologica, vol.94, issue.11, pp.1613-1617, 2009.
DOI : 10.3324/haematol.2009.007765

S. Bretagne, M. Vidaud, M. Kuentz, C. Cordonnier, T. Henni et al., Mixed blood chimerism in T cell-depleted bone marrow transplant recipients: evaluation using DNA polymorphisms, Blood, vol.70, pp.1692-1695, 1987.

M. Van-der-burg, H. Kreyenberg, A. Willasch, B. H. Barendregt, S. Preuner et al., Standardization of DNA isolation from low cell numbers for chimerism analysis by PCR of short tandem repeats, Leukemia, vol.12, issue.9, pp.1467-1470, 2011.
DOI : 10.1038/sj.leu.2401246

C. Carvallo, N. Geller, R. Kurlander, R. Srinivasan, O. Mena et al., Prior chemotherapy and allograft CD34+ dose impact donor engraftment following nonmyeloablative allogeneic stem cell transplantation in patients with solid tumors, Blood, vol.103, issue.4, pp.1560-1563, 2004.
DOI : 10.1182/blood-2003-04-1170

L. Casarino, C. Carbone, M. A. Capucci, T. Izzi, and G. B. Ferrara, Analysis of chimerism after bone marrow transplantation using specific oligonucleotide probes, Bone Marrow Transplant, vol.10, pp.165-170, 1992.

D. Chen, C. Tseng, W. Wang, M. Wang, S. Tsai et al., Real-time biallelic polymorphism???polymerase chain reaction for chimerism monitoring of hematopoietic stem cell transplantation relapsed patients, Clinica Chimica Acta, vol.412, issue.7-8, pp.625-630, 2011.
DOI : 10.1016/j.cca.2010.12.018

R. Childs, E. Clave, N. Contentin, D. Jayasekera, N. Hensel et al., Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses, Blood, vol.94, pp.3234-3241, 1999.

S. J. Choi, K. H. Lee, J. H. Lee, S. Kim, H. J. Chung et al., Prognostic value of hematopoietic chimerism in patients with acute leukemia after allogeneic bone marrow transplantation: a prospective study, Bone Marrow Transplantation, vol.26, issue.3, pp.327-332, 2000.
DOI : 10.1038/sj.bmt.1702504

S. J. Choi, K. H. Lee, J. H. Lee, S. Kim, H. J. Chung et al., Prognostic value of hematopoietic chimerism in patients with acute leukemia after allogeneic bone marrow transplantation: a prospective study, Bone Marrow Transplantation, vol.26, issue.3, pp.327-332, 2000.
DOI : 10.1038/sj.bmt.1702504

R. A. Clift, C. D. Buckner, E. D. Thomas, E. Bryant, C. Anasetti et al., Marrow transplantation for patients in accelerated phase of chronic myeloid leukemia, Blood, vol.84, pp.4368-4373, 1994.

C. Cutler, K. Stevenson, H. T. Kim, J. Brown, S. Mcdonough et al., Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis, Bone Marrow Transplantation, vol.100, issue.5, pp.659-667, 2011.
DOI : 10.1038/leu.2008.343

URL : http://www.nature.com/bmt/journal/v46/n5/pdf/bmt2010192a.pdf

J. Dausset, J. Colombani, L. Legrand, N. Feingold, R. et al., Genetic and biological aspects of the HL-A system of human histocompatibility, Blood, vol.35, pp.591-612, 1970.

R. Duléry, O. Nibourel, J. Gauthier, V. Elsermans, H. Behal et al., Impact of Wilms' tumor 1 expression on outcome of patients undergoing allogeneic stem cell transplantation for AML, Bone Marrow Transplantation, vol.62, issue.4, pp.539-543, 2017.
DOI : 10.1016/j.patbio.2014.05.011

D. M. Durnam, K. R. Anders, L. Fisher, J. O-'quigley, E. M. Bryant et al., Analysis of the origin of marrow cells in bone marrow transplant recipients using a Y-chromosome-specific in situ hybridization assay, Blood, vol.74, pp.2220-2226, 1989.

E. Elkaim, Facteurs prédictifs du chimérisme après greffe non apparentée de cellules souches de sang placentaire chez l'enfant, Th D Med, 2014.

E. Elkaim, C. Picard, C. Galambrun, V. Barlogis, A. Loundou et al., Peripheral blood cells chimerism after unrelated cord blood transplantation in children: kinetics, predictive factors and impact on post-transplant outcome, British Journal of Haematology, vol.100, issue.4, pp.557-565, 2014.
DOI : 10.1038/bmt.2009.82

URL : https://hal.archives-ouvertes.fr/hal-01054157

J. L. Ferrara and P. Reddy, Pathophysiology of Graft-Versus-Host Disease, Seminars in Hematology, vol.43, issue.1, pp.3-10, 2006.
DOI : 10.1053/j.seminhematol.2005.09.001

N. Gardiner, M. Lawler, J. O-'riordan, M. Dearce, P. Humphries et al., Persistent donor chimaerism is consistent with disease-free survival following BMT for chronic myeloid leukaemia, Bone Marrow Transplantation, vol.20, issue.3, pp.235-241, 1997.
DOI : 10.1038/sj.bmt.1700861

D. George, J. Czech, B. John, M. Yu, J. et al., Detection and quantification of chimerism by droplet digital PCR, Chimerism, vol.13, issue.3, pp.102-108, 2013.
DOI : 10.1016/j.ymeth.2010.01.003

E. Gineikiene, M. Stoskus, and L. Griskevicius, Single Nucleotide Polymorphism-Based System Improves the Applicability of Quantitative PCR for Chimerism Monitoring, The Journal of Molecular Diagnostics, vol.11, issue.1, pp.66-74, 2009.
DOI : 10.2353/jmoldx.2009.080039

D. Ginsburg, J. H. Antin, B. R. Smith, S. H. Orkin, R. et al., Origin of cell populations after bone marrow transplantation. Analysis using DNA sequence polymorphisms., Journal of Clinical Investigation, vol.75, issue.2, pp.596-603, 1985.
DOI : 10.1172/JCI111736

M. Girgis, C. Hallemeier, W. Blum, R. Brown, H. Lin et al., Chimerism and clinical outcomes of 110 recipients of unrelated donor bone marrow transplants who underwent conditioning with low-dose, single-exposure total body irradiation and cyclophosphamide, Blood, vol.105, issue.8, pp.3035-3041, 2005.
DOI : 10.1182/blood-2003-07-2346

M. Guimond, L. Busque, C. Baron, Y. Bonny, R. Bélanger et al., Relapse after bone marrow transplantation: evidence for distinct immunological mechanisms between adult and paediatric populations, British Journal of Haematology, vol.80, issue.1, pp.130-137, 2000.
DOI : 10.1038/nm1296-1361

URL : http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2000.01961.x/pdf

U. Hegenbart, D. Niederwieser, B. M. Sandmaier, M. B. Maris, J. A. Shizuru et al., Treatment for Acute Myelogenous Leukemia by Low-Dose, Total-Body, Irradiation-Based Conditioning and Hematopoietic Cell Transplantation From Related and Unrelated Donors, Journal of Clinical Oncology, vol.24, issue.3, pp.444-453, 2006.
DOI : 10.1200/JCO.2005.03.1765

R. S. Hill, F. B. Petersen, R. Storb, F. R. Appelbaum, K. Doney et al., Mixed hematologic chimerism after allogeneic marrow transplantation for severe aplastic anemia is associated with a higher risk of graft rejection and a lessened incidence of acute graft-versushost disease, Blood, vol.67, pp.811-816, 1986.

W. Hoelle, J. F. Beck, G. Dueckers, H. Kreyenberg, P. Lang et al., Clinical relevance of serial quantitative analysis of hematopoietic chimerism after allogeneic stem cell transplantation in children for severe aplastic anemia, Bone Marrow Transplantation, vol.21, issue.Suppl 2, pp.219-223, 2004.
DOI : 10.1038/sj.bmt.1701154

M. M. Horowitz, R. P. Gale, P. M. Sondel, J. M. Goldman, J. Kersey et al., Graft-versus-leukemia reactions after bone marrow transplantation, Blood, vol.75, pp.555-562, 1990.

R. Huss, H. J. Deeg, T. Gooley, E. Bryant, W. Leisenring et al., Effect of mixed chimerism on graft-versus-host disease, disease recurrence and survival after HLA-identical marrow transplantation for aplastic anemia or chronic myelogenous leukemia, Bone Marrow Transplant, vol.18, pp.767-776, 1996.

A. J. Jeffreys, V. Wilson, and S. L. Thein, Individual-specific ???fingerprints??? of human DNA, Nature, vol.8, issue.6023, pp.316-76, 1985.
DOI : 10.1002/ijc.2910080312

A. Jiménez-velasco, M. Barrios, J. Román-gómez, G. Navarro, I. Buño et al., Reliable quantification of hematopoietic chimerism after allogeneic transplantation for acute leukemia using amplification by real-time PCR of null alleles and insertion/deletion polymorphisms, Leukemia, vol.26, issue.3, pp.336-343, 2005.
DOI : 10.1038/sj.bmt.1702504

F. Keil, E. Prinz, K. Moser, C. Mannhalter, P. Kalhs et al., RAPID ESTABLISHMENT OF LONG-TERM CULTURE-INITIATING CELLS OF DONOR ORIGIN AFTER NONMYELOABLATIVE ALLOGENEIC HEMATOPOIETIC STEM-CELL TRANSPLANTATION, AND SIGNIFICANT PROGNOSTIC IMPACT OF DONOR T-CELL CHIMERISM ON STABLE ENGRAFTMENT AND PROGRESSION-FREE SURVIVAL, Transplantation, vol.76, issue.1, pp.230-236, 2003.
DOI : 10.1097/01.TP.0000071862.42835.76

F. Khan, A. Agarwal, and S. Agrawal, Significance of chimerism in hematopoietic stem cell transplantation: new variations on an old theme, Bone Marrow Transplantation, vol.34, issue.1, pp.1-12, 2004.
DOI : 10.1038/sj.bmt.1704525

R. G. Knowlton, V. A. Brown, J. C. Braman, D. Barker, J. W. Schumm et al., Use of highly polymorphic DNA probes for genotypic analysis following bone marrow transplantation, Blood, vol.68, pp.378-385, 1986.

G. Kögler, H. H. Wolf, A. Heyll, G. Arkesteijn, and P. Wernet, Detection of mixed chimerism and leukemic relapse after allogeneic bone marrow transplantation in subpopulations of leucocytes by fluorescent in situ hybridization in combination with the simultaneous immunophenotypic analysis of interphase cells, Bone Marrow Transplant, vol.15, pp.41-48, 1995.

H. J. Kolb, Donor Leukocyte Transfusions for Treatment of Leukemic Relapse after Bone Marrow Transplantation, Vox Sanguinis, vol.345, issue.Suppl 1, pp.321-329, 1998.
DOI : 10.1016/S0140-6736(95)91150-2

H. J. Kolb, A. Schattenberg, J. M. Goldman, B. Hertenstein, N. Jacobsen et al., Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients, Blood, vol.86, pp.2041-2050, 1995.

R. Korngold and J. Sprent, Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow, Journal of Experimental Medicine, vol.148, issue.6, 1978.
DOI : 10.1084/jem.148.6.1687

N. Kröger, A. Shimoni, T. Zabelina, H. Schieder, J. Panse et al., Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS), Bone Marrow Transplantation, vol.35, issue.4, pp.339-344, 2006.
DOI : 10.1038/sj.bmt.1704859

M. Kwon, C. Martínez-laperche, M. Infante, F. Carretero, P. Balsalobre et al., Evaluation of Minimal Residual Disease by Real-Time Quantitative PCR of Wilms??? Tumor 1 Expression in Patients with Acute Myelogenous Leukemia after Allogeneic Stem Cell Transplantation: Correlation with Flow Cytometry and Chimerism, Biology of Blood and Marrow Transplantation, vol.18, issue.8, pp.1235-1242, 2012.
DOI : 10.1016/j.bbmt.2012.01.012

T. Lange, M. Hubmann, R. Burkhardt, G. Franke, M. Cross et al., Monitoring of WT1 expression in PB and CD34+ donor chimerism of BM predicts early relapse in AML and MDS patients after hematopoietic cell transplantation with reduced-intensity conditioning, Leukemia, vol.114, issue.3, pp.498-505, 2011.
DOI : 10.1182/blood-2009-03-208298

M. Lawler, P. Humphries, and S. R. Mccann, Evaluation of mixed chimerism by in vitro amplification of dinucleotide repeat sequences using the polymerase chain reaction, Blood, vol.77, pp.2504-2514, 1991.

J. E. Van-leeuwen, M. J. Van-tol, B. G. Bodzinga, J. T. Wijnen, M. Van-der-keur et al., Detection of mixed chimaerism in flow-sorted cell subpopulations by PCR-amplified VNTR markers after allogeneic bone marrow transplantation, British Journal of Haematology, vol.77, issue.2, pp.218-225, 1991.
DOI : 10.1097/00007890-198703000-00016

J. E. Van-leeuwen, M. J. Van-tol, A. M. Joosten, J. T. Wijnen, P. J. Verweij et al., Persistence of host-type hematopoiesis after allogeneic bone marrow transplantation for leukemia is significantly related to the recipient's age and/or the conditioning regimen, but it is not associated with an increased risk of relapse, Blood, vol.83, pp.3059-3067, 1994.

M. De-lima, S. Giralt, P. F. Thall, L. De-padua-silva, R. B. Jones et al., Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome, Cancer, vol.110, issue.23, pp.5420-5431, 2010.
DOI : 10.1182/blood-2007-06-096966

T. Lion, Summary: Reports on quantitative analysis of chimerism after allogeneic stem cell transplantation by PCR amplification of microsatellite markers and capillary electrophoresis with fluorescence detection, Leukemia, vol.15, issue.1, pp.252-254, 2003.
DOI : 10.1038/sj.leu.2401953

T. Lion, H. Daxberger, J. Dubovsky, P. Filipcik, G. Fritsch et al., Analysis of chimerism within specific leukocyte subsets for detection of residual or recurrent leukemia in pediatric patients after allogeneic stem cell transplantation, Leukemia, vol.15, issue.2, pp.307-310, 2001.
DOI : 10.1038/sj.leu.2402017

T. Lion, F. Watzinger, S. Preuner, H. Kreyenberg, M. Tilanus et al., The EuroChimerism concept for a standardized approach to chimerism analysis after allogeneic stem cell transplantation, Leukemia, vol.49, issue.8, pp.1821-1828, 2012.
DOI : 10.1159/000022855

G. Lucarelli, M. Andreani, and E. Angelucci, The cure of thalassemia by bone marrow transplantation, Blood Reviews, vol.16, issue.2, pp.81-85, 2002.
DOI : 10.1054/blre.2002.0192

F. Maas, N. Schaap, S. Kolen, A. Zoetbrood, I. Buño et al., Quantification of donor and recipient hemopoietic cells by real-time PCR of single nucleotide polymorphisms, Leukemia, vol.83, issue.3, pp.621-629, 2003.
DOI : 10.1038/ng0997-21

S. Mackinnon, L. Barnett, J. H. Bourhis, P. Black, G. Heller et al., Myeloid and lymphoid chimerism after T-cell-depleted bone marrow transplantation: evaluation of conditioning regimens using the polymerase chain reaction to amplify human minisatellite regions of genomic DNA, Blood, vol.80, pp.3235-3241, 1992.

S. Mackinnon, E. B. Papadopoulos, M. H. Carabasi, L. Reich, N. H. Collins et al., Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease, Blood, vol.86, pp.1261-1268, 1995.

S. Mangioni, A. Balduzzi, A. Rivolta, A. Rovelli, F. Nesi et al., Long-term persistence of hemopoietic chimerism following sex-mismatched bone marrow transplantation, Bone Marrow Transplantation, vol.20, issue.11, pp.969-973, 1997.
DOI : 10.1038/sj.bmt.1701011

S. Matthes-martin, T. Lion, O. A. Haas, F. Frommlet, H. Daxberger et al., Lineage-specific chimaerism after stem cell transplantation in children following reduced intensity conditioning: potential predictive value of NK cell chimaerism for late graft rejection, Leukemia, vol.50, issue.10, pp.1934-1942, 2003.
DOI : 10.1007/s002620100217

J. Mattsson, M. Uzunel, M. Remberger, and O. And-ringdén, T CELL MIXED CHIMERISM IS SIGNIFICANTLY CORRELATED TO A DECREASED RISK OF ACUTE GRAFT-VERSUS-HOST DISEASE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION 1, Transplantation, vol.71, issue.3, pp.433-439, 2001.
DOI : 10.1097/00007890-200102150-00017

J. Mattsson, M. Uzunel, L. Tammik, J. Aschan, and O. And-ringdén, Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic stem cell transplantation, Leukemia, vol.15, issue.12, pp.1976-1985, 2001.
DOI : 10.1038/sj.leu.2402311

S. Maury, F. M. Lemoine, Y. Hicheri, M. Rosenzwajg, C. Badoual et al., CD4+CD25+ regulatory T cell depletion improves the graft-versustumor effect of donor lymphocytes after allogeneic hematopoietic stem cell transplantation, Sci. Transl. Med, vol.2, pp.41-52, 2010.

P. A. Mcsweeney, D. Niederwieser, J. A. Shizuru, B. M. Sandmaier, A. J. Molina et al., Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects, Blood, vol.97, issue.11, pp.3390-3400, 2001.
DOI : 10.1182/blood.V97.11.3390

M. Michallet, Allogreffes de cellules souches h??matopo????tiques, Transfusion Clinique et Biologique, vol.18, issue.2, pp.235-245, 2011.
DOI : 10.1016/j.tracli.2011.02.021

G. L. Min, J. Hibbin, C. Arthur, J. Apperley, A. Jeffreys et al., Use of minisatellite DNA probes for recognition and characterization of relapse after allogeneic bone marrow transplantation, British Journal of Haematology, vol.53, issue.2, 1988.
DOI : 10.1038/bjc.1986.73

Y. Miura, J. Tanaka, T. Toubai, Y. Tsutsumi, N. Kato et al., Analysis of donor-type chimerism in lineage-specific cell populations after allogeneic myeloablative and nonmyeloablative stem cell transplantation, Bone Marrow Transplantation, vol.128, issue.9, pp.837-843, 2006.
DOI : 10.1111/j.1365-2141.2005.05372.x

M. Mohty, O. Avinens, C. Faucher, P. Viens, D. Blaise et al., Predictive factors and impact of full donor T-cell chimerism after reduced intensity conditioning allogeneic stem cell transplantation, Haematologica, vol.92, issue.7, pp.1004-1006, 2007.
DOI : 10.3324/haematol.10971

I. Mollet, C. Giannoli, D. Rigal, M. Michallet, and V. Dubois, Suivi de chim??risme des populations cellulaires my??lo??des chez des patients allogreff??s atteints de leuc??mie aigu?? my??lo??de??: ??tude lyonnaise, Pathologie Biologie, vol.60, issue.2, pp.106-111, 2012.
DOI : 10.1016/j.patbio.2010.07.001

A. P. Monaco, Chimerism in organ transplantation: conflicting experiments and clinical observations, Transplantation, vol.75, issue.Supplement, pp.13-16, 2003.
DOI : 10.1097/01.TP.0000067945.90241.F4

E. Nikolousis, S. Robinson, S. Nagra, C. Brookes, F. Kinsella et al., Post-transplant T cell chimerism predicts graft versus host disease but not disease relapse in patients undergoing an alemtuzumab based reduced intensity conditioned allogeneic transplant, Leukemia Research, vol.37, issue.5, pp.561-565, 2013.
DOI : 10.1016/j.leukres.2013.01.010

A. Odriozola, J. A. Riancho, M. Colorado, and M. T. Zarrabeitia, Evaluation of the sensitivity of two recently developed STR multiplexes for the analysis of chimerism after haematopoietic stem cell transplantation, International Journal of Immunogenetics, vol.15, issue.2, pp.88-92, 2013.
DOI : 10.1093/nar/24.14.2807

K. Offit, J. P. Burns, I. Cunningham, S. C. Jhanwar, P. Black et al., Cytogenetic analysis of chimerism and leukemia relapse in chronic myelogenous leukemia patients after T cell-depleted bone marrow transplantation, Blood, vol.75, pp.1346-1355, 1990.

J. P. Panse, S. Heimfeld, K. A. Guthrie, M. B. Maris, D. G. Maloney et al., Allogeneic peripheral blood stem cell graft composition affects early T-cell chimaerism and later clinical outcomes after non-myeloablative conditioning, British Journal of Haematology, vol.106, issue.5, pp.659-667, 2005.
DOI : 10.1182/blood.V98.12.3221

URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05363.x/pdf

J. A. Pérez-simón, D. Caballero, M. Diez-campelo, R. Lopez-pérez, G. Mateos et al., Chimerism and minimal residual disease monitoring after reduced intensity conditioning (RIC) allogeneic transplantation, Leukemia, vol.16, issue.8, pp.1423-1431, 2002.
DOI : 10.1038/sj.leu.2402550

L. D. Petz, P. Yam, R. B. Wallace, A. D. Stock, G. De-lange et al., Mixed hematopoietic chimerism following bone marrow transplantation for hematologic malignancies, Blood, vol.70, pp.1331-1337, 1987.

K. Rezvani, S. Mielke, M. Ahmadzadeh, Y. Kilical, B. N. Savani et al., High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT, Blood, vol.108, issue.4, pp.1291-1297, 2006.
DOI : 10.1182/blood-2006-02-003996

J. Román, J. Serrano, A. Jiménez, J. A. Castillejo, M. L. Reina et al., Myeloid mixed chimerism is associated with relapse in bcr-abl positive patients after unmanipulated allogeneic bone marrow transplantation for chronic myelogenous leukemia, Haematologica, vol.85, pp.173-180, 2000.

G. Rossi, A. M. Carella, M. M. Minervini, L. Savino, A. Fontana et al., Minimal residual disease after allogeneic stem cell transplant: a comparison among multiparametric flow cytometry, Wilms tumor 1 expression and chimerism status (Complete chimerism versus Low Level Mixed Chimerism) in acute leukemia, Leukemia & Lymphoma, vol.1, issue.12, pp.2660-2666, 2013.
DOI : 10.3324/haematol.2009.005801

A. Ruggeri, M. Labopin, G. Sanz, S. Piemontese, W. Arcese et al., Comparison of outcomes after unrelated cord blood and unmanipulated haploidentical stem cell transplantation in adults with acute leukemia, Leukemia, vol.90, issue.9, pp.1891-1900, 2015.
DOI : 10.1182/blood-2008-02-140095

A. Sahota, S. Gao, J. Hayes, and R. M. Jindal, Microchimerism and rejection: a meta-analysis, 2000.
DOI : 10.1097/00007890-199904150-00616

R. Sanders, J. F. Huggett, C. A. Bushell, S. Cowen, D. J. Scott et al., Evaluation of Digital PCR for Absolute DNA Quantification, Analytical Chemistry, vol.83, issue.17, pp.6474-6484, 2011.
DOI : 10.1021/ac103230c

A. Santurtún, J. A. Riancho, J. Arozamena, M. López-duarte, and M. T. Zarrabeitia, Indel analysis by droplet digital PCR: a sensitive method for DNA mixture detection and chimerism analysis, International Journal of Legal Medicine, vol.407, issue.7, pp.67-72, 2017.
DOI : 10.1007/s00216-015-8458-z.

N. Schaap, A. Schattenberg, B. Bär, E. Mensink, A. De-man et al., Red blood cell phenotyping is a sensitive technique for monitoring chronic myeloid leukaemia patients after T-cell-depleted bone marrow transplantation and after donor leucocyte infusion, British Journal of Haematology, vol.83, issue.1, pp.116-125, 2000.
DOI : 10.1097/00007890-198711000-00011

C. Schmid, M. Schleuning, G. Ledderose, J. Tischer, and H. Kolb, Sequential Regimen of Chemotherapy, Reduced-Intensity Conditioning for Allogeneic Stem-Cell Transplantation, and Prophylactic Donor Lymphocyte Transfusion in High-Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome, Journal of Clinical Oncology, vol.23, issue.24, 2005.
DOI : 10.1200/JCO.2005.07.061

C. Schmid, M. Labopin, A. Nagler, M. Bornhäuser, J. Finke et al., Donor Lymphocyte Infusion in the Treatment of First Hematological Relapse After Allogeneic Stem-Cell Transplantation in Adults With Acute Myeloid Leukemia: A Retrospective Risk Factors Analysis and Comparison With Other Strategies by the EBMT Acute Leukemia Working Party, Journal of Clinical Oncology, vol.25, issue.31, 2007.
DOI : 10.1200/JCO.2007.11.6053

C. Schmid, M. Schleuning, M. Hentrich, G. E. Markl, A. Gerbitz et al., High antileukemic efficacy of an intermediate intensity conditioning regimen for allogeneic stem cell transplantation in patients with high-risk acute myeloid leukemia in first complete remission, Bone Marrow Transplantation, vol.20, issue.8, pp.721-727, 2008.
DOI : 10.1038/sj.bmt.1705965

E. Schütz, A. Fischer, J. Beck, M. Harden, M. Koch et al., Graft-derived cell-free DNA, a noninvasive early rejection and graft damage marker in liver transplantation: A prospective, observational, multicenter cohort study, PLOS Medicine, vol.41, issue.1, p.1002286, 2017.
DOI : 10.1371/journal.pmed.1002286.s016

J. Serrano, J. Roman, J. Sanchez, A. Jimenez, J. A. Castillejo et al., Molecular analysis of lineage-specific chimerism and minimal residual disease by RT-PCR of p210(BCR-ABL) and p190(BCR-ABL) after allogeneic bone marrow transplantation for chronic myeloid leukemia: increasing mixed myeloid chimerism and p190(BCR-ABL) detection precede cytogenetic relapse, Blood, vol.95, pp.2659-2665, 2000.

W. D. Shlomchik, Graft-versus-host disease, Nature Reviews Immunology, vol.171, issue.5, pp.340-352, 2007.
DOI : 10.4049/jimmunol.171.3.1272

S. Slavin, A. Nagler, E. Naparstek, Y. Kapelushnik, M. Aker et al., Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases, Blood, vol.91, pp.756-763, 1998.

G. Socié, R. A. Clift, D. Blaise, A. Devergie, O. Ringden et al., Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia: long-term follow-up of 4 randomized studies, Blood, vol.98, issue.13, pp.3569-3574, 2001.
DOI : 10.1182/blood.V98.13.3569

T. Stahl, M. U. Böhme, N. Kröger, and B. Fehse, Digital PCR to assess hematopoietic chimerism after allogeneic stem cell transplantation, Experimental Hematology, vol.43, issue.6, pp.462-468, 2015.
DOI : 10.1016/j.exphem.2015.02.006

A. Stikvoort, J. Gertow, M. Sundin, M. Remberger, J. Mattsson et al., Chimerism Patterns of Long-Term Stable Mixed Chimeras Posthematopoietic Stem Cell Transplantation in Patients with Nonmalignant Diseases: Follow-Up of Long-Term Stable Mixed Chimerism Patients, Biology of Blood and Marrow Transplantation, vol.19, issue.5, pp.838-844, 2013.
DOI : 10.1016/j.bbmt.2013.02.015

P. J. Sykes, S. H. Neoh, M. J. Brisco, E. Hughes, J. Condon et al., Quantitation of targets for PCR by use of limiting dilution, BioTechniques, vol.13, pp.444-449, 1992.

C. Taira, K. Matsuda, A. Yamaguchi, M. Uehara, M. Sugano et al., Rapid single nucleotide polymorphism based method for hematopoietic chimerism analysis and monitoring using high-speed droplet allele-specific PCR and allele-specific quantitative PCR, Clinica Chimica Acta, vol.445, pp.101-106, 2015.
DOI : 10.1016/j.cca.2015.03.018

A. Thannberger, Etude rétrospective du suivi de chimérisme dans l'allogreffe de cellules souches hématopoïétiques: vers une optimisation de la procédure de surveillance, 2007.

S. L. Thein, A. J. Jeffreys, and H. A. Blacklock, IDENTIFICATION OF POST-TRANSPLANT CELL POPULATION BY DNA FINGERPRINT ANALYSIS, The Lancet, vol.328, issue.8497, p.37, 1986.
DOI : 10.1016/S0140-6736(86)92577-8

C. Thiede, Diagnostic Chimerism Analysis After Allogeneic Stem Cell Transplantation, American Journal of PharmacoGenomics, vol.4, issue.4, pp.177-187, 2004.
DOI : 10.2165/00129785-200404030-00005

E. Thomas, R. Storb, R. A. Clift, A. Fefer, F. L. Johnson et al., Bone-Marrow Transplantation, New England Journal of Medicine, vol.292, issue.16, pp.832-843, 1975.
DOI : 10.1056/NEJM197504172921605

E. D. Thomas, R. Storb, R. A. Clift, A. Fefer, L. Johnson et al., Bone-Marrow Transplantation, New England Journal of Medicine, vol.292, issue.17, pp.895-902, 1975.
DOI : 10.1056/NEJM197504242921706

E. D. Thomas, C. D. Buckner, R. A. Clift, A. Fefer, F. L. Johnson et al., Marrow Transplantation for Acute Nonlymphoblastic Leukemia in First Remission, New England Journal of Medicine, vol.301, issue.11, pp.597-599, 1979.
DOI : 10.1056/NEJM197909133011109

Y. Tsutsumi, J. Tanaka, Y. Miura, T. Toubai, N. Kato et al., Molecular Analysis of T-Cell Repertoire in Patients with Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation, Leukemia & Lymphoma, vol.29, issue.3, pp.481-488, 2004.
DOI : 10.1046/j.1365-2141.2000.02080.x

D. Valcárcel, R. Martino, D. Caballero, M. V. Mateos, J. A. Pérez-simón et al., Chimerism analysis following allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning, Bone Marrow Transplantation, vol.95, issue.5, pp.387-392, 2003.
DOI : 10.1056/NEJM197905103001902

P. S. Walsh, N. J. Fildes, R. , and R. , Sequence Analysis and Characterization of Stutter Products at the Tetranucleotide Repeat Locus VWA, Nucleic Acids Research, vol.24, issue.14, pp.2807-2812, 1996.
DOI : 10.1093/nar/24.14.2807

M. C. Walters, M. Patience, W. Leisenring, Z. R. Rogers, V. M. Aquino et al., Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia, Biology of Blood and Marrow Transplantation, vol.7, issue.12, pp.665-673, 2001.
DOI : 10.1053/bbmt.2001.v7.pm11787529

URL : https://doi.org/10.1053/bbmt.2001.v7.pm11787529

F. Watzinger, T. Lion, C. Steward, and E. Consortium, The RSD code: proposal for a nomenclature of allelic configurations in STR-PCR-based chimerism testing after allogeneic stem cell transplantation, Leukemia, vol.17, issue.8, pp.1448-1452, 2006.
DOI : 10.1038/sj.leu.2402755

J. B. Whitlam, L. Ling, M. Swain, T. Harrington, O. Mirochnik et al., Use of ubiquitous, highly heterozygous copy number variants and digital droplet polymerase chain reaction to monitor chimerism after allogeneic haematopoietic stem cell transplantation, Experimental Hematology, vol.49, pp.39-47, 2017.
DOI : 10.1016/j.exphem.2017.01.004

R. Zeiser, A. Spyridonidis, R. Wäsch, G. Ihorst, C. Grüllich et al., Evaluation of immunomodulatory treatment based on conventional and lineage-specific chimerism analysis in patients with myeloid malignancies after myeloablative allogeneic hematopoietic cell transplantation, Leukemia, vol.90, issue.5, pp.814-821, 2005.
DOI : 10.1111/j.1423-0410.1998.tb05438.x

H. Zetterquist, J. Mattsson, M. Uzunel, I. Näsman-björk, P. Svenberg et al., Mixed chimerism in the B cell lineage is a rapid and sensitive indicator of minimal residual disease in bone marrow transplant recipients with pre-B cell acute lymphoblastic leukemia, Bone Marrow Transplantation, vol.91, issue.8, pp.843-851, 2000.
DOI : 10.1038/sj.bmt.1700831