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Master Thesis

Évaluation des déterminants physiologiques de la capacité d’effort des patients opérés d’une tétralogie de Fallot

Abstract : Purpose: pulmonary valve replacement (PVR) for patients with repaired tetralogy of Fallot (TOF) and pulmonary regurgitation (PR) improves functional status without definitive improvement of peak VO2 despite correction of the haemodynamic lesion. We aim to study the cardio-respiratory and peripheral profils during exercise test before and after PVR to better understand the impact of PVR. Methods and results: patients with TOF and severe PR performed a cardiopulmonary exercise testing (CPET) and a cardiac MRI for the measurement of ventricular volumes and pulmonary regurgitation fraction (FR) before and after PVR. 15 patients (mean age 33±13 years) were included. CPET was performed 6 months before and 25±2 months after PVR. Significant improvement in NYHA functional class (p=0,006) was observed following PVR : without significant improvement in peak VO2 (26±6 to 25±6,9ml/kg/min, p=0,36) nor maximal workload (114±30 to 118 ± 30Watt, p=0,31) with unchanged maximal heart. Patients demonstrated moderate hyperventilation without pejorative criterion (VE/VCO2 nadir 31±3 to 32±7, p=0,61) without pulmonary limitation (maximal breathing reserve 31±23 to 21±17%, p=0,27) despite a restrictive pattern in spirometric results. Nevertheless, we found a significant improvement in peak oxygen pulse (9,9±2,5 to 11±4, p=0,04) and a significant postponed ventilatory anaerobic threshold (VAT) after PVR (05:28±2:00 to 6:57±1:53min, p=0,002; 61±20 to 75±18Watt, p=0,006). PR (FR: 46±14 to 5,6± 9,7%, p<0,001), RV end-diastolic volume (156±39,4 to 92±32ml/m2, p=0,002) and RV end-systolic volume (89±32 to 50±28ml/m2, p=0,004) decreased. Conclusion : despite the lack of improvement in the peak VO2, hemodynamic improvement was observed by the significant improvement in oxygen pulse and peripheral capacity associated with an improvement in functional capacity. It can be assumed that the peak VO2 is not the best marker for the evaluation of aerobic capacity and that our evaluation could be based on the VAT in these patients.
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Master Thesis
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Contributor : Bu Carreire Université de Bordeaux <>
Submitted on : Wednesday, December 6, 2017 - 1:05:17 PM
Last modification on : Saturday, December 9, 2017 - 1:16:55 AM


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Marie-Lou Dinet. Évaluation des déterminants physiologiques de la capacité d’effort des patients opérés d’une tétralogie de Fallot. Médecine humaine et pathologie. 2017. ⟨dumas-01657103⟩



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