Skip to Main content Skip to Navigation
Master Thesis

La Tomothérapie hélicoïdale dans le cancer du sein localisé : indications, tolérance, efficacité, expérience d’un centre

Abstract : Purpose: to evaluate progression-free survival (PFS) and tolerance of patients treated with adjuvant helical tomotherapy (TH) for non-metastatic breast cancer. Methods and materials: We conducted a retrospective study in our department. All patients treated between 2009 and 2015 with adjuvant TH for non-metastatic breast cancer were included except those with breast implant. Toxicity was assessed using the Common Terminology Criteria for Adverse Events version 4.0. Results: A total of 179 patients were included. With a median follow-up of 38.1 months (7.4 - 78.2), the 5 years PFS was 90.5% (95% CI 84.2-97.3). Concerning the molecular sub-groups, the PFS was 83.4% (95% CI 69.6-99.9), 85.7% (95% CI 63.3-100) and 92.9 % (95% CI 86-100) for triple negative, overexpressed HER2 and positive hormone receptors (p=0.13). Regarding acute skin toxicity, 57% of patients had grade 0 or 1, 40% grade 2 and 3% grade 3. There was 18% esophagitis (16% grade 1 and 2 % grade 2) but no grade 3. Thirty-one percent of patients had late skin toxicity, limited to grade 1 in 86% of cases. There was no pulmonary and cardiac toxicity. After multivariate analysis, a high BMI was associated with an increased risk of acute (p = 0.04) and late (0.048) skin toxicity. Conclusion: adjuvant TH in non-metastatic breast cancer is an effective and well tolerated treatment for selected patients when conventional techniques are not acceptable. Longer follow-up needed to confirm these results and assess the long-term impact of low doses in healthy tissues.
Document type :
Master Thesis
Complete list of metadatas

Cited literature [114 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01703153
Contributor : Université Paris Descartes - Scd <>
Submitted on : Wednesday, February 7, 2018 - 3:21:22 PM
Last modification on : Friday, March 27, 2020 - 2:30:23 AM
Long-term archiving on: : Friday, May 4, 2018 - 4:42:15 PM

File

ThExe_ARSENE-HENRY_ Alexandre_...
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-01703153, version 1

Citation

Alexandre Arsene-Henry. La Tomothérapie hélicoïdale dans le cancer du sein localisé : indications, tolérance, efficacité, expérience d’un centre. Médecine humaine et pathologie. 2017. ⟨dumas-01703153⟩

Share

Metrics

Record views

38

Files downloads

694