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cette dernière active la sérine/thréonine kinase (également connue sous le nom de AKT ou Protein Kinase B (PKB)) afin qu'elle régule divers processus cellulaires ,
activité kinase constitué de deux protéines : une sous unité régulatrice (p85) et une sous unité catalytique (p110) Elle peut donc être activée directement par un récepteur à la tyrosine-kinase (RKT) ou par l'intermédiaire de la protéine Ras ,