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Master Thesis

Diagnostic précoce des troubles du spectre autistique chez l’enfant d’âge préscolaire : étude rétrospective de cohorte

Abstract : Objectives: the purpose of our study was to describe the demographic and phenotypic profiles of a French cohort of toddlers with social communication disorders. We also aimed to estimate if the cumulative effect of risk factors know to be associated with ASD increases the probability to receive a final diagnosis of ASD. Methods: we retrospectively collected and analyzed the clinical data of children aged <36 months with social communication disorders, referred to a tertiary care child psychiatry unit dedicated to ASD (Robert Debré hospital, Paris, France). Four groups of RF for ASD were considered: genetic, maternal, perinatal risk factors and birth parameters below or over the 10th centile. We used a logistic model to estimate the influence of the cumulative effect of Risk factors on ASD diagnosis. With a linear model, we finally tested the effect of these RF on the severity of core ASD symptoms, measured with the ADOS-2. Results: out of a total of 162 children included, 138 met DSM-5 criteria for ASD. The probability to receive a diagnosis of ASD increased with the number of RF (p<0.01). However, no association was found between ASD severity scores and RF (or their accumulation). Conclusions: in our cohort, the association of RF increased the probability to receive an ASD diagnosis. This finding could help to reinforce health policies aiming to improve early detection of toddlers with ASD by primary care including early childhood professionals.
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https://dumas.ccsd.cnrs.fr/dumas-01735378
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  • HAL Id : dumas-01735378, version 1

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Lucile Huard. Diagnostic précoce des troubles du spectre autistique chez l’enfant d’âge préscolaire : étude rétrospective de cohorte . Sciences du Vivant [q-bio]. 2017. ⟨dumas-01735378⟩

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