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Master Thesis

Liens entre troubles du sommeil et des rythmes circadiens et composantes du syndrome métabolique dans les troubles bipolaires

Abstract : Introduction: sleep and circadian rhythms abnormalities are frequently observed in bipolar disorders (BD), and have an important impact on patient’s health. On the other hand, the prevalence of metabolic syndrome in BD is higher than in the general population, and multiple factors are involved. Our hypothesis in this thesis is that there might be a link between sleep and circadian abnormalities, and the components of the metabolic syndrome in BD. Such associations have already been shown, but studies in this field are rare. This links have been studied in the general population, and hormonal and inflammation mechanisms may be involved. Aim of the study: to study the association between sleep efficiency (SE) and M10 onset and the components of the metabolic syndrome and BMI in a population of 67 bipolar inpatients in remission. Then we also explore associations with fragmentation index of sleep (IF) and amplitude of the circadian rhythm. Results: we showed that there was a significant association between SE and triglycerides levels, and between M10 onset and systolic blood pressure (PAS). Furthermore, we found a significant association between FI and PAS. The impact of some potential confounding factors such as obstructive sleep apnea or treatments might not explained the associations we observed. Conclusion: this exploratory results should be further investigated in larger studies, because it might shed some light on the physiopathology of the metabolic syndrome in this vulnerable population and lead to new ways to treat BP comorbidities.
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Master Thesis
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Héléna Brochard. Liens entre troubles du sommeil et des rythmes circadiens et composantes du syndrome métabolique dans les troubles bipolaires. Médecine humaine et pathologie. 2017. ⟨dumas-01739588⟩

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