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Master Thesis

Surveillance des infections de cathéters veineux centraux dans les services de pédiatrie du CHU de Nantes : cohorte prospective sur un an

Abstract : Background: Central venous catheter (CVC) contribute to a better comfort for the treatment of hospitalized children who required prolonged intravenous treatment or multiple blood samples but they expose to risk of severe infection. They are a few data concerning specific paediatric epidemiology and risk factor of catheter-relate bloodstream infection (CRBI). The main objective of this study was to measure the incidence-rate of CRBI in our pediatric university hospital, then subsequently, to characterize the CRBI and to identify risk factors. Matérial and methods: We conduced an epidemiological prospective monocentric study including all the CVC, except Porth-a-Caths and arterial catheters, placed in children, from birth to 18 years old of age, from April 2015 to March 2016 in the pediatric university Hospital of Nantes. Our main outcome was the incidence rate of CRBI defined according to French guidelines and separating infections without bloodstream infection (CRI) and CRBI. We analysed association between infection and potentials risks factors with univariate and multivariate analysis by Cox model. Results: We included 793 CVC which 60 CRBI and 4 CRI. The incidence rate was 4,6/1000 catheter-day and was maximal in neonatal intensive care unit (13,7/1000 catheter-day). Coagulase-negative staphylococci were responsable of 85,9% of CRBI. In multivariate analysis, CRBI was most frequent in children hospitalized for prematurity, orthopedic pathology, traumatology, respiratory or infectious pathology and in children with invasive ventilation. CRBI’s risk decreased with the age of pose. Conclusions: The incidence rate of CRBI in children hospitalised in CHU of Nantes seemed higher than that found in litterature. Perspectives of this work are to develop an automatic tool in order to identify CRBIs from computerized data.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01755808
Contributor : Santé Rennes 1 <>
Submitted on : Wednesday, June 6, 2018 - 12:36:31 PM
Last modification on : Thursday, July 9, 2020 - 12:30:44 PM

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Marion Broudic. Surveillance des infections de cathéters veineux centraux dans les services de pédiatrie du CHU de Nantes : cohorte prospective sur un an. Sciences du Vivant [q-bio]. 2016. ⟨dumas-01755808⟩

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