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Master Thesis

Rôle des récepteurs couplés aux protéines G adrénergiques dans la toxicité des hydrocarbures aromatiques polycycliques

Abstract : Polycyclic aromatic hydrocarbons (PAHs) constitute a major family of widely-distributed environmental contaminants. They have a large influence on human health. Indeed, they have many toxic effects, such as carcinogenic properties and cardiovascular toxicity. Most of these effects are caused by the activation of a cytosolic receptor, called aryl hydrocarbon receptor (AhR). Besides, environmental contaminants are probably in contact with G protein-coupled receptors (GPCRs), a large family of transmembrane receptors that control many functions of the human body. Thus, studies have shown that among GPCRs, the beta2-adrenergic receptor is a PAHs likely target. The aim of this thesis is to review the beta2-adrenergic receptor roles in PAHs toxicity.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01758160
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Thomas Déséchalliers. Rôle des récepteurs couplés aux protéines G adrénergiques dans la toxicité des hydrocarbures aromatiques polycycliques. Sciences du Vivant [q-bio]. 2016. ⟨dumas-01758160⟩

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