B. Doornaert and A. Pichard, Hydrocarbures Aromatiques Polycycliques (HAPs), 2006.

J. P. Meador, J. E. Stein, W. L. Reichert, and U. Varanasi, Bioaccumulation of polycyclic aromatic hydrocarbons by marine organisms, Rev Environ Contam Toxicol, vol.143, pp.79-165, 1995.

G. C. Becking and B. H. Chen, International Programme on Chemical Safety (IPCS) environmental health criteria on boron human health risk assessment, Biol Trace Elem Res, vol.66, issue.1-3, pp.439-52, 1998.
DOI : 10.1007/bf02783154

S. S. Hecht, Tobacco carcinogens, their biomarkers and tobacco-induced cancer, Nat Rev Cancer, vol.3, issue.10, pp.733-777, 2003.
DOI : 10.1038/nrc1190

W. Polynuclear, Aromatic Hydrocarbons : guideline for drinking water quality. WHO, 1998.

, Directive 98/83/CE du Conseil du 3 novembre 1998 relative à la qualité des eaux destinées à la consommation humaine, Journal Officiel des Communautés Européennes

D. H. Phillips, Polycyclic aromatic hydrocarbons in the diet, Mutat Res, vol.443, issue.1-2, pp.139-186, 1999.

H. Benzo,

I. M. Head, D. M. Jones, and W. Röling, Marine microorganisms make a meal of oil, Nat Rev Microbiol, vol.4, issue.3, pp.173-82, 2006.

S. K. Samanta, O. V. Singh, and R. K. Jain, Polycyclic aromatic hydrocarbons: environmental pollution and bioremediation, Trends Biotechnol, vol.20, issue.6, pp.243-251, 2002.
DOI : 10.1016/s0167-7799(02)01943-1

R. J. Grosser, D. Warshawsky, and J. R. Vestal, Indigenous and enhanced mineralization of pyrene, benzo[a]pyrene, and carbazole in soils, Appl Environ Microbiol, vol.57, issue.12, pp.3462-3471, 1991.

M. A. Heitkamp and C. E. Cerniglia, Polycyclic aromatic hydrocarbon degradation by a Mycobacterium sp. in microcosms containing sediment and water from a pristine ecosystem, Appl Environ Microbiol, vol.55, issue.8, pp.1968-73, 1989.

J. Schneider, R. Grosser, K. Jayasimhulu, W. Xue, and D. Warshawsky, Degradation of pyrene, benz[a]anthracene, and benzo[a]pyrene by Mycobacterium sp. strain RJGII-135, isolated from a former coal gasification site, Appl Environ Microbiol, vol.62, issue.1, pp.13-22, 1996.

A. M. Desai, R. L. Autenrieth, P. Dimitriou-christidis, and T. J. Mcdonald, Biodegradation kinetics of select polycyclic aromatic hydrocarbon (PAH) mixtures by Sphingomonas paucimobilis EPA505, Biodegradation, vol.19, issue.2, pp.223-256, 2008.

R. A. Kanaly, S. Harayama, and K. Watanabe, Rhodanobacter sp. strain BPC1 in a benzo[a]pyrene-mineralizing bacterial consortium, Appl Environ Microbiol, vol.68, issue.12, pp.5826-5859, 2002.

A. L. Juhasz, G. A. Stanley, and M. L. Britz, Metabolite repression inhibits degradation of benzo[a]pyrene and dibenz[a,h]anthracene by Stenotrophomonas maltophilia VUN 10,003, J Ind Microbiol Biotechnol, vol.28, issue.2, pp.88-96, 2002.

Z. Chen and J. Boreham, Smoking and cardiovascular disease, Semin Vasc Med, vol.2, issue.3, pp.243-52, 2002.

G. E. Jules, S. Pratap, A. Ramesh, and D. B. Hood, In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life, Toxicology, vol.295, issue.1-3, pp.56-67, 2012.

J. L. Westmaas and T. H. Brandon, Reducing risk in smokers, Curr Opin Pulm Med, vol.10, issue.4, pp.284-292, 2004.

K. Steenland, P. Bertazzi, A. Baccarelli, and M. Kogevinas, Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen, Environ Health Perspect, vol.112, issue.13, pp.1265-1273, 2004.

H. M. Korashy and A. El-kadi, The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases, Drug Metab Rev, vol.38, issue.3, pp.411-50, 2006.

E. Arehart, G. Giasson, M. T. Walsh, and H. Patterson, Dioxin alters the human low-density and very low-density lipoprotein structure with evidence for specific quenching of Trp-48 in apolipoprotein C-II. Biochemistry (Mosc), vol.43, pp.8503-8512, 2004.

N. Podechard, L. Ferrec, E. Rebillard, A. Fardel, O. Lecureur et al., NPC1 repression contributes to lipid accumulation in human macrophages exposed to environmental aryl hydrocarbons, Cardiovasc Res, vol.82, issue.2, pp.361-70, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00673351

D. Curfs, A. M. Knaapen, D. Pachen, M. Gijbels, E. Lutgens et al., Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties, FASEB J Off Publ Fed Am Soc Exp Biol, vol.19, issue.10, pp.1290-1292, 2005.

R. Godschalk, D. Curfs, H. Bartsch, F. Van-schooten, and J. Nair, Benzo[a]pyrene enhances lipid peroxidation induced DNA damage in aorta of apolipoprotein E knockout mice, Free Radic Res, vol.37, issue.12, pp.1299-305, 2003.

A. M. Knaapen, D. M. Curfs, D. M. Pachen, R. W. Gottschalk, M. De-winther et al., Toxicol Appl Pharmacol, vol.91, issue.3, pp.450-60, 1987.

B. Laupeze, L. Amiot, L. Sparfel, L. Ferrec, E. Fauchet et al., Polycyclic aromatic hydrocarbons affect functional differentiation and maturation of human monocytederived dendritic cells, J Immunol Baltim Md, vol.168, issue.6, pp.2652-2660, 1950.

J. Van-grevenynghe, S. Rion, L. Ferrec, E. , L. Vee et al., Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages, J Immunol Baltim Md, vol.170, issue.5, pp.2374-81, 1950.

J. Grevenynghe, L. Sparfel, L. Vee, M. Gilot, D. Drenou et al., Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages, Biochem Biophys Res Commun, vol.317, issue.3, pp.708-724, 2004.

K. Gradin, R. Toftgârd, L. Poellinger, and A. Berghard, Repression of dioxin signal transduction in fibroblasts. Identification Of a putative repressor associated with Arnt, J Biol Chem, vol.274, pp.13511-13519, 1999.

B. Jux, S. Kadow, and C. Esser, Langerhans cell maturation and contact hypersensitivity are impaired in aryl hydrocarbon receptor-null mice, J Immunol Baltim Md, vol.182, issue.11, pp.6709-6726, 1950.
DOI : 10.4049/jimmunol.0713344

URL : http://www.jimmunol.org/content/182/11/6709.full.pdf

C. M. Villano, K. A. Murphy, A. Akintobi, and L. A. White, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces matrix metalloproteinase (MMP) expression and invasion in A2058 melanoma cells, Toxicol Appl Pharmacol, vol.210, issue.3, pp.212-236, 2006.

H. I. Swanson, Cytochrome P450 expression in human keratinocytes: an aryl hydrocarbon receptor perspective, Chem Biol Interact, vol.149, issue.2-3, pp.69-79, 2004.

T. Ikuta and K. Kawajiri, Zinc finger transcription factor Slug is a novel target gene of aryl hydrocarbon receptor, Exp Cell Res, vol.312, issue.18, pp.3585-94, 2006.

O. Yamamoto and Y. Tokura, Photocontact dermatitis and chloracne: two major occupational and environmental skin diseases induced by different actions of halogenated chemicals, J Dermatol Sci, vol.32, issue.2, pp.85-94, 2003.

A. Poland and E. Glover, Variation in the molecular mass of the Ah receptor among vertebrate species and strains of rats, Biochem Biophys Res Commun, vol.146, issue.3, pp.1439-1488, 1987.

K. M. Dolwick, J. V. Schmidt, L. A. Carver, H. I. Swanson, and C. A. Bradfield, Cloning and expression of a human Ah receptor cDNA, Mol Pharmacol, vol.44, issue.5, pp.911-918, 1993.

B. D. Abbott, L. S. Birnbaum, and G. H. Perdew, Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo, Dev Dyn Off Publ Am Assoc Anat, vol.204, issue.2, pp.133-176, 1995.

M. E. Hahn, Aryl hydrocarbon receptors: diversity and evolution, Chem Biol Interact, vol.141, issue.1-2, pp.131-60, 2002.

P. M. Fernandez-salguero, J. M. Ward, J. P. Sundberg, and F. J. Gonzalez, Lesions of arylhydrocarbon receptor-deficient mice, Vet Pathol, vol.34, issue.6, pp.605-619, 1997.
DOI : 10.1177/030098589703400609

G. P. Lahvis, S. L. Lindell, R. S. Thomas, R. S. Mccuskey, C. Murphy et al., Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice, Proc Natl Acad Sci, vol.97, pp.10442-10449, 2000.

T. Baba, J. Mimura, N. Nakamura, N. Harada, M. Yamamoto et al., Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction, Mol Cell Biol, vol.25, issue.22, pp.10040-51, 2005.

P. Fernandez-salguero, T. Pineau, D. M. Hilbert, T. Mcphail, S. S. Lee et al., Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor, Science, vol.268, issue.5211, pp.722-728, 1995.

F. J. Gonzalez, P. Fernandez-salguero, S. S. Lee, T. Pineau, and J. M. Ward, Xenobiotic receptor knockout mice, Toxicol Lett, pp.117-138, 1995.

J. V. Schmidt, G. H. Su, J. K. Reddy, M. C. Simon, and C. A. Bradfield, Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development, Proc Natl Acad Sci, vol.93, issue.13, pp.6731-6737, 1996.

J. R. Petrulis and G. H. Perdew, The role of chaperone proteins in the aryl hydrocarbon receptor core complex, Chem Biol Interact, vol.141, issue.1-2, pp.25-40, 2002.

H. I. Swanson, W. K. Chan, and C. A. Bradfield, DNA binding specificities and pairing rules of the Ah receptor, ARNT, and SIM proteins, J Biol Chem, vol.270, issue.44, pp.26292-302, 1995.

C. Gouédard, R. Barouki, and Y. Morel, Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism, Mol Cell Biol, vol.24, issue.12, pp.5209-5231, 2004.

M. S. Denison, J. M. Rogers, S. R. Rushing, C. L. Jones, S. C. Tetangco et al., Analysis of the aryl hydrocarbon receptor (AhR) signal transduction pathway, 2002.

E. S. Shen and J. P. Whitlock, Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor, J Biol Chem, vol.267, issue.10, pp.6815-6824, 1992.

T. V. Beischlag, L. Morales, J. Hollingshead, B. D. Perdew, and G. H. , The aryl hydrocarbon receptor complex and the control of gene expression, Crit Rev Eukaryot Gene Expr, vol.18, issue.3, pp.207-50, 2008.

D. W. Nebert and F. J. Gonzalez, P450 genes: structure, evolution, and regulation, Annu Rev Biochem, vol.56, pp.945-93, 1987.

D. W. Nebert, T. P. Dalton, A. B. Okey, and F. J. Gonzalez, Role of aryl hydrocarbon receptormediated induction of the CYP1 enzymes in environmental toxicity and cancer, J Biol Chem, vol.279, issue.23, pp.23847-50, 2004.

M. Yueh, Y. Huang, A. Hiller, S. Chen, N. Nguyen et al., Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDPglucuronosyltransferase 1A1, J Biol Chem, vol.278, issue.17, pp.15001-15007, 2003.

P. A. Münzel, T. Lehmköster, M. Brück, J. K. Ritter, and K. W. Bock, Aryl hydrocarbon receptorinducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6, Arch Biochem Biophys, vol.350, issue.1, pp.72-80, 1998.

T. H. Rushmore and C. B. Pickett, Characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants, J Biol Chem, vol.265, issue.24, pp.14648-53, 1990.

A. K. Jaiswal, Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin. Biochemistry (Mosc), vol.30, pp.10647-53, 1991.

M. Lyte and P. H. Bick, Modulation of interleukin-1 production by macrophages following benzo(a)pyrene exposure, Int J Immunopharmacol, vol.8, issue.3, pp.377-81, 1986.

M. S. Jeon and C. Esser, The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family, J Immunol Baltim Md, vol.165, issue.12, pp.6975-83, 1950.

C. Vogel, E. Sciullo, W. Li, P. Wong, G. Lazennec et al., RelB, a new partner of aryl hydrocarbon receptor-mediated transcription, Mol Endocrinol Baltim Md, vol.21, issue.12, pp.2941-55, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00268250

A. Hoffer, C. Y. Chang, and A. Puga, Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and-independent pathways, Toxicol Appl Pharmacol, vol.141, issue.1, pp.238-285, 1996.

J. L. Marlowe, E. S. Knudsen, S. Schwemberger, and A. Puga, The aryl hydrocarbon receptor displaces p300 from E2F-dependent promoters and represses S phase-specific gene expression, J Biol Chem, vol.279, issue.28, pp.29013-29035, 2004.

T. Matikainen, G. I. Perez, A. Jurisicova, J. K. Pru, J. J. Schlezinger et al., Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals, Nat Genet, vol.28, issue.4, pp.355-60, 2001.

W. Miao, L. Hu, P. J. Scrivens, and G. Batist, Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes, J Biol Chem, vol.280, issue.21, pp.20340-20348, 2005.

J. Mimura, M. Ema, K. Sogawa, and Y. Fujii-kuriyama, Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev, vol.13, pp.20-25, 1999.

W. Xue and D. Warshawsky, Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review, Toxicol Appl Pharmacol, vol.206, issue.1, pp.73-93, 2005.

K. P. Miller and K. S. Ramos, Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons, Drug Metab Rev, vol.33, issue.1, pp.1-35, 2001.

R. E. Albert, M. L. Miller, T. Cody, A. Andringa, R. Shukla et al., Benzo[a]pyrene-induced skin damage and tumor promotion in the mouse, Carcinogenesis, vol.12, issue.7, pp.1273-80, 1991.

J. P. Arnould, R. Kubiak, J. Belowski, J. Belegaud, and J. Szczeklik, Detection of benzo[a]pyreneDNA adducts in leukocytes of coke oven workers, Pathol Biol, vol.48, issue.6, pp.548-53, 2000.

G. P. Pfeifer, M. F. Denissenko, M. Olivier, N. Tretyakova, S. S. Hecht et al., Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers, Oncogene, vol.21, issue.48, pp.7435-51, 2002.

A. Dipple, K. Peltonen, S. C. Cheng, H. Ross, and C. A. Bigger, Chemical and mutagenic specificities of polycyclic aromatic hydrocarbon carcinogens, Adv Exp Med Biol, vol.354, pp.101-113, 1994.

Y. Shimizu, Y. Nakatsuru, M. Ichinose, Y. Takahashi, H. Kume et al., Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor, Proc Natl Acad Sci, vol.97, issue.2, pp.779-82, 2000.

T. E. Smithgall, R. G. Harvey, and T. M. Penning, Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism, J Biol Chem, vol.263, issue.4, pp.1814-1834, 1988.

T. M. Penning, S. T. Ohnishi, T. Ohnishi, and R. G. Harvey, Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase, Chem Res Toxicol, vol.9, issue.1, pp.84-92, 1996.

T. M. Penning, M. E. Burczynski, C. F. Hung, K. D. Mccoull, N. T. Palackal et al., Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones, Chem Res Toxicol, vol.12, issue.1, pp.1-18, 1999.

K. Simons and E. Ikonen, Functional rafts in cell membranes, Nature, vol.387, issue.6633, pp.569-72, 1997.

K. Simons and D. Toomre, Lipid rafts and signal transduction, Nat Rev Mol Cell Biol, vol.1, issue.1, pp.31-40, 2000.

E. London, Insights into lipid raft structure and formation from experiments in model membranes, Curr Opin Struct Biol, vol.12, issue.4, pp.480-486, 2002.

A. Rebillard, X. Tekpli, O. Meurette, O. Sergent, G. Lemoigne-muller et al., Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells, Cancer Res, vol.67, issue.16, pp.7865-74, 2007.
URL : https://hal.archives-ouvertes.fr/hal-00690301

P. Nourissat, M. Travert, M. Chevanne, X. Tekpli, A. Rebillard et al., Ethanol induces oxidative stress in primary rat hepatocytes through the early involvement of lipid raft clustering. Hepatol Baltim Md, vol.47, pp.59-70, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00696177

X. Tekpli, M. Rissel, L. Huc, D. Catheline, O. Sergent et al., Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis, Toxicol Appl Pharmacol, vol.243, issue.1, pp.68-76, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00729575

B. Dendelé, X. Tekpli, K. Hardonnière, J. A. Holme, L. Debure et al., Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway, Chem Biol Interact, vol.207, pp.41-51, 2014.

M. Gloerich and J. L. Bos, Epac: defining a new mechanism for cAMP action, Annu Rev Pharmacol Toxicol, vol.50, pp.355-75, 2010.
DOI : 10.1146/annurev.pharmtox.010909.105714

T. C. Rich and J. W. Karpen, Review article: cyclic AMP sensors in living cells: what signals can they actually measure?, Ann Biomed Eng, vol.30, issue.8, pp.1088-99, 2002.
DOI : 10.1114/1.1511242

C. Vogel, E. Sciullo, S. Park, C. Liedtke, C. Trautwein et al., Dioxin increases C/EBPbeta transcription by activating cAMP/protein kinase A, J Biol Chem, vol.279, issue.10, pp.8886-94, 2004.
DOI : 10.1074/jbc.m310190200

URL : http://www.jbc.org/content/279/10/8886.full.pdf

B. Oesch-bartlomowicz and F. Oesch, Role of cAMP in mediating AHR signaling, Biochem Pharmacol, vol.77, issue.4, pp.627-668, 2009.

J. A. Krieger, J. L. Born, and S. W. Burchiel, Persistence of calcium elevation in the HPB-ALL human T cell line correlates with immunosuppressive properties of polycyclic aromatic hydrocarbons, Toxicol Appl Pharmacol, vol.127, issue.2, pp.268-74, 1994.

A. Mayati, L. Ferrec, E. Lagadic-gossmann, D. Fardel, and O. , Aryl hydrocarbon receptorindependent up-regulation of intracellular calcium concentration by environmental polycyclic aromatic hydrocarbons in human endothelial HMEC-1 cells, Environ Toxicol, vol.27, issue.9, pp.556-62, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00680889

D. Kobayashi, S. Ahmed, M. Ishida, S. Kasai, and H. Kikuchi, Calcium/calmodulin signaling elicits release of cytochrome c during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptosis in the human lymphoblastic T-cell line, L-MAT, Toxicology, vol.258, issue.1, pp.25-32, 2009.

L. Ferrec, E. Lagadic-gossmann, D. Rauch, C. Bardiau, C. Maheo et al., Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor-and calcium-dependent, J Biol Chem, vol.277, issue.27, pp.24780-24787, 2002.

Z. Li, J. D. Carter, L. A. Dailey, and Y. Huang, Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor, Environ Health Perspect, vol.102
DOI : 10.1289/ehp.7736

URL : http://europepmc.org/articles/pmc1280341?pdf=render

K. M. Bisset, A. S. Dhopeshwarkar, C. Liao, and R. A. Nicholson, The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro, Neurochem Int, vol.59, issue.5, pp.706-719, 2011.

L. Cui, J. Li, and X. Xie, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C, J Nat Prod, vol.75, issue.6, pp.1058-62, 2012.

K. Mizuo, M. Narita, T. Yoshida, M. Narita, and T. Suzuki, Functional changes in dopamine D3 receptors by prenatal and neonatal exposure to an endocrine disruptor bisphenol-A in mice, Addict Biol, vol.9, issue.1, pp.19-25, 2004.
DOI : 10.1080/13556210410001674059

M. Ishido, M. Morita, S. Oka, and Y. Masuo, Alteration of gene expression of G proteincoupled receptors in endocrine disruptors-caused hyperactive rats. Regul Pept, vol.126, pp.145-53, 2005.

B. K. Kobilka, G protein coupled receptor structure and activation, Biochim Biophys Acta, vol.1768, issue.4, pp.794-807, 2007.

R. Fredriksson and H. B. Schiöth, The repertoire of G-protein-coupled receptors in fully sequenced genomes, Mol Pharmacol, vol.67, issue.5, pp.1414-1439, 2005.

X. Deupi and B. K. Kobilka, Energy landscapes as a tool to integrate GPCR structure, dynamics, and function. Physiol Bethesda Md, vol.25, pp.293-303, 2010.
DOI : 10.1152/physiol.00002.2010

URL : http://europepmc.org/articles/pmc3056154?pdf=render

S. J. Hill, G-protein-coupled receptors: past, present and future, Br J Pharmacol, vol.147, issue.1, pp.27-37, 2006.

P. Ma and R. Zemmel, Value of novelty?, Nat Rev Drug Discov, vol.1, issue.8, pp.571-573, 2002.

W. C. Probst, L. A. Snyder, D. I. Schuster, J. Brosius, and S. C. Sealfon, Sequence alignment of the Gprotein coupled receptor superfamily, DNA Cell Biol, vol.11, issue.1, pp.1-20, 1992.

H. Zheng, E. A. Pearsall, D. P. Hurst, Y. Zhang, J. Chu et al., Palmitoylation and membrane cholesterol stabilize ?-opioid receptor homodimerization and G protein coupling, BMC Cell Biol, vol.13, p.6, 2012.
DOI : 10.1186/1471-2121-13-6

URL : https://bmccellbiol.biomedcentral.com/track/pdf/10.1186/1471-2121-13-6

H. B. Schiöth and R. Fredriksson, The GRAFS classification system of G-protein coupled receptors in comparative perspective, Gen Comp Endocrinol, vol.142, issue.12, pp.94-101, 2005.

R. Fredriksson, M. C. Lagerström, L. Lundin, and H. B. Schiöth, The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints, Mol Pharmacol, vol.63, issue.6, pp.1256-72, 2003.

M. L. Mayer and N. Armstrong, Structure and function of glutamate receptor ion channels, Annu Rev Physiol, vol.66, pp.161-81, 2004.
DOI : 10.1146/annurev.physiol.66.050802.084104

C. B. Felder, R. C. Graul, A. Y. Lee, H. P. Merkle, and W. Sadee, The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors, AAPS PharmSci, vol.1, issue.2, p.2, 1999.

N. Kunishima, Y. Shimada, Y. Tsuji, T. Sato, M. Yamamoto et al., Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor, Nature, vol.407, issue.6807, pp.971-978, 2000.
DOI : 10.1038/35039564

K. Palczewski, T. Kumasaka, T. Hori, C. A. Behnke, H. Motoshima et al., Crystal structure of rhodopsin: A G protein-coupled receptor, Science, vol.289, issue.5480, pp.739-784, 2000.

H. Huang and P. S. Klein, The Frizzled family: receptors for multiple signal transduction pathways, Genome Biol, vol.5, issue.7, p.234, 2004.

C. C. Malbon, Frizzleds: new members of the superfamily of G-protein-coupled receptors, Front Biosci J Virtual Libr, vol.9, pp.1048-58, 2004.

M. Behrens, A. Brockhoff, C. Kuhn, B. Bufe, M. Winnig et al., The human taste receptor hTAS2R14 responds to a variety of different bitter compounds, Biochem Biophys Res Commun, vol.319, issue.2, pp.479-85, 2004.

A. J. Harmar, Family-B G-protein-coupled receptors, Genome Biol, vol.2, issue.12, p.3013, 2001.

G. B. Downes and N. Gautam, The G protein subunit gene families, Genomics, vol.62, issue.3, pp.544-52, 1999.
DOI : 10.1006/geno.1999.5992

G. P. Anderson, Current issues with beta2-adrenoceptor agonists: pharmacology and molecular and cellular mechanisms, Clin Rev Allergy Immunol, vol.31, issue.2-3, pp.119-149, 2006.

D. W. Mcgraw, K. A. Mihlbachler, M. R. Schwarb, F. F. Rahman, K. M. Small et al., Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2adrenergic receptors within a unique heterodimeric complex, J Clin Invest, vol.116, issue.5, pp.1400-1409, 2006.

D. Larue and G. Kato, Reduced number of alpha-and beta-adrenergic receptors in the myocardium of rats exposed to tobacco smoke, Eur J Pharmacol, vol.70, issue.4, pp.519-548, 1981.

K. E. Laustiola, R. Lassila, J. Kaprio, and M. Koskenvuo, Decreased beta-adrenergic receptor density and catecholamine response in male cigarette smokers. A study of monozygotic twin pairs discordant for smoking, Circulation, vol.78, issue.5, pp.1234-1274, 1988.
DOI : 10.1161/01.cir.78.5.1234

URL : http://circ.ahajournals.org/content/circulationaha/78/5/1234.full.pdf

K. E. Laustiola, M. Kotamäki, R. Lassila, O. P. Kallioniemi, and V. Manninen, Cigarette smoking alters sympathoadrenal regulation by decreasing the density of beta 2-adrenoceptors. A study of monitored smoking cessation, J Cardiovasc Pharmacol, vol.17, issue.6, pp.923-931, 1991.
DOI : 10.1097/00005344-199106000-00010

P. Irigaray, V. Ogier, S. Jacquenet, V. Notet, P. Sibille et al., Benzo[a]pyrene impairs beta-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice. A novel molecular mechanism of toxicity for a common food pollutant, FEBS J, vol.273, issue.7, pp.1362-72, 2006.

P. Factor, A. T. Akhmedov, J. D. Mcdonald, A. Qu, J. Wu et al., Polycyclic aromatic hydrocarbons impair function of ?2-adrenergic receptors in airway epithelial and smooth muscle cells, Am J Respir Cell Mol Biol, vol.45, issue.5, pp.1045-1054, 2011.

L. Canga, R. Levi, and A. B. Rifkind, Heart as a target organ in 2,3,7,8-tetrachlorodibenzo-pdioxin toxicity: decreased beta-adrenergic responsiveness and evidence of increased intracellular calcium, Proc Natl Acad Sci, vol.85, issue.3, pp.905-914, 1988.

L. Canga, L. Paroli, T. J. Blanck, R. B. Silver, and A. B. Rifkind, 2,3,7,8-tetrachlorodibenzo-p-dioxin increases cardiac myocyte intracellular calcium and progressively impairs ventricular contractile responses to isoproterenol and to calcium in chick embryo hearts, Mol Pharmacol, vol.44, issue.6, pp.1142-51, 1993.

R. J. Sommer, A. J. Hume, J. M. Ciak, J. J. Vannostrand, M. Friggens et al., Early developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure decreases chick embryo heart chronotropic response to isoproterenol but not to agents affecting signals downstream of the beta-adrenergic receptor, Toxicol Sci Off J Soc Toxicol, vol.83, issue.2, pp.363-71, 2005.

O. E. Brodde and M. C. Michel, Adrenergic and muscarinic receptors in the human heart, Pharmacol Rev, vol.51, issue.4, pp.651-90, 1999.

R. P. Xiao, X. Ji, and E. G. Lakatta, Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes, Mol Pharmacol, vol.47, issue.2, pp.322-331, 1995.

R. Xiao, S. Zhang, K. Chakir, P. Avdonin, W. Zhu et al., Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)-but not beta1-ARmediated positive inotropic effect in myocytes from failing rat hearts, Circulation, vol.108, issue.13, pp.1633-1642, 2003.

K. Pönicke, F. Gröner, I. Heinroth-hoffmann, and O. Brodde, Agonist-specific activation of the beta2-adrenoceptor/Gs-protein and beta2-adrenoceptor/Gi-protein pathway in adult rat ventricular cardiomyocytes, Br J Pharmacol, vol.147, issue.7, pp.714-723, 2006.

R. Begonha, D. Moura, and S. Guimarães, Vascular beta-adrenoceptor-mediated relaxation and the tone of the tissue in canine arteries, J Pharm Pharmacol, vol.47, issue.6, pp.510-513, 1995.

A. Ferro, L. R. Queen, R. M. Priest, B. Xu, J. M. Ritter et al., Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro, Br J Pharmacol, vol.126, issue.8, pp.1872-80, 1999.

D. W. Gray and I. Marshall, Novel signal transduction pathway mediating endotheliumdependent beta-adrenoceptor vasorelaxation in rat thoracic aorta, Br J Pharmacol, vol.107, issue.3, pp.684-90, 1992.
DOI : 10.1111/j.1476-5381.1992.tb14507.x

URL : https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1992.tb14507.x

M. Johnson, Beta2-adrenoceptors: mechanisms of action of beta2-agonists, Paediatr Respir Rev, vol.2, issue.1, pp.57-62, 2001.
DOI : 10.1053/prrv.2000.0102

I. J. Arinze and Y. Kawai, Adrenergic regulation of glycogenolysis in isolated guinea-pig hepatocytes: evidence that beta 2-receptors mediate catecholamine stimulation of glycogenolysis, Arch Biochem Biophys, vol.225, issue.1, pp.196-202, 1983.

Y. Kawai and I. J. Arinze, beta-Adrenergic receptors in rabbit liver plasma membranes. Predominance of beta 2-receptors and mediation of adrenergic regulation of hepatic glycogenolysis, J Biol Chem, vol.258, issue.7, pp.4364-71, 1983.

J. Carron, C. Morel, J. W. Blum, and H. M. Hammon, Effects of dexamethasone and colostrum feeding on mRNA levels and binding capacities of beta-adrenergic receptors in the liver of neonatal calves, Domest Anim Endocrinol, vol.28, issue.3, pp.257-71, 2005.

L. K. Mccorry, Physiology of the autonomic nervous system, Am J Pharm Educ, vol.71, issue.4, p.78, 2007.

Y. Daaka, L. M. Luttrell, and R. J. Lefkowitz, Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A, Nature, vol.390, issue.6655, pp.88-91, 1997.

S. Offermanns and M. I. Simon, G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C, J Biol Chem, vol.270, issue.25, pp.15175-80, 1995.

D. Wu, Y. Kuang, Y. Wu, and H. Jiang, Selective coupling of beta 2-adrenergic receptor to hematopoietic-specific G proteins, J Biol Chem, vol.270, issue.27, pp.16008-16018, 1995.
DOI : 10.1074/jbc.270.27.16008

URL : http://www.jbc.org/content/270/27/16008.full.pdf

X. Zhu, S. Gilbert, M. Birnbaumer, and L. Birnbaumer, Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density, Mol Pharmacol, vol.46, issue.3, pp.460-469, 1994.

S. B. Liggett, Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling, J Allergy Clin Immunol, vol.110, issue.6, pp.223-230, 2002.

J. A. Brzostowski and A. R. Kimmel, Signaling at zero G: G-protein-independent functions for 7-TM receptors, Trends Biochem Sci, vol.26, issue.5, pp.291-298, 2001.

C. Heuss and U. Gerber, G-protein-independent signaling by G-protein-coupled receptors, Trends Neurosci, vol.23, issue.10, pp.469-75, 2000.

K. Rajagopal, R. J. Lefkowitz, and H. A. Rockman, When 7 transmembrane receptors are not G protein-coupled receptors, J Clin Invest, vol.115, issue.11, pp.2971-2975, 2005.

R. A. Hall, R. T. Premont, C. W. Chow, J. T. Blitzer, J. A. Pitcher et al., The beta2adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange, Nature, vol.392, issue.6676, pp.626-656, 1998.
DOI : 10.1038/33458

Y. Sun, D. Mcgarrigle, and X. Huang, When a G protein-coupled receptor does not couple to a G protein, Mol Biosyst, vol.3, issue.12, pp.849-54, 2007.

R. J. Lefkowitz and S. K. Shenoy, Transduction of receptor signals by beta-arrestins, Science, vol.308, issue.5721, pp.512-519, 2005.
DOI : 10.1126/science.1109237

L. M. Luttrell and R. J. Lefkowitz, The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals, J Cell Sci, vol.115, pp.455-65, 2002.

S. K. Shenoy, M. T. Drake, C. D. Nelson, D. A. Houtz, X. K. Madabushi et al., beta-arrestindependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor, J Biol Chem, vol.281, issue.2, pp.1261-73, 2006.

M. Azzi, P. G. Charest, S. Angers, G. Rousseau, T. Kohout et al., Beta-arrestinmediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors, Proc Natl Acad Sci, vol.100, issue.20, pp.11406-11417, 2003.
DOI : 10.1073/pnas.1936664100

URL : http://www.pnas.org/content/100/20/11406.full.pdf

L. M. Luttrell, S. S. Ferguson, Y. Daaka, W. E. Miller, S. Maudsley et al., Betaarrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes, Science, vol.283, issue.5402, pp.655-61, 1999.

G. Romero, M. Von-zastrow, and P. A. Friedman, Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity, Adv Pharmacol San Diego Calif, vol.62, pp.279-314, 2011.

E. J. Weinman, D. Steplock, K. Tate, R. A. Hall, R. F. Spurney et al., Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF), J Clin Invest, vol.101, issue.10, pp.2199-206, 1998.
DOI : 10.1172/jci204

URL : http://www.jci.org/articles/view/204/files/pdf

D. Wheeler, W. B. Sneddon, B. Wang, P. A. Friedman, and G. Romero, NHERF-1 and the cytoskeleton regulate the traffic and membrane dynamics of G protein-coupled receptors, J Biol Chem, vol.282, issue.34, pp.25076-87, 2007.

A. Mayati, N. Levoin, H. Paris, N. 'diaye, M. Courtois et al., Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a ?2adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells, J Biol Chem, vol.287, issue.6, pp.4041-52, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00682497

M. Schmidt, S. Evellin, P. A. Weernink, F. Von-dorp, H. Rehmann et al., A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase, Nat Cell Biol, vol.3, issue.11, pp.1020-1024, 2001.
DOI : 10.1038/ncb1101-1020

M. Keiper, M. B. Stope, D. Szatkowski, A. Böhm, K. Tysack et al., Epac-and Ca2+-controlled activation of Ras and extracellular signal-regulated kinases by Gscoupled receptors, J Biol Chem, vol.279, issue.45, pp.46497-508, 2004.
DOI : 10.1074/jbc.m403604200

URL : http://www.jbc.org/content/279/45/46497.full.pdf

M. Bouvier, W. P. Hausdorff, D. Blasi, A. , O. Dowd et al., Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization, Nature, vol.333, issue.6171, pp.370-373, 1988.

W. P. Hausdorff, M. Bouvier, O. Dowd, B. F. Irons, G. P. Caron et al., Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization, J Biol Chem, vol.264, issue.21, pp.12657-65, 1989.

R. J. Lefkowitz, G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization, J Biol Chem, vol.273, issue.30, pp.18677-80, 1998.

J. A. Pitcher, N. J. Freedman, and R. J. Lefkowitz, G protein-coupled receptor kinases, Annu Rev Biochem, vol.67, pp.653-92, 1998.

R. B. Penn, A. N. Pronin, and J. L. Benovic, Regulation of G protein-coupled receptor kinases, Trends Cardiovasc Med, vol.10, issue.2, pp.81-90, 2000.

J. L. Benovic, R. H. Strasser, M. G. Caron, and R. J. Lefkowitz, Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor, Proc Natl Acad Sci, vol.83, issue.9, pp.2797-801, 1986.

X. Li, E. Huston, M. J. Lynch, M. D. Houslay, and G. S. Baillie, Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes, Biochem J, vol.394, pp.427-462, 2006.

N. M. Tepe and S. B. Liggett, Functional receptor coupling to Gi is a mechanism of agonistpromoted desensitization of the beta2-adrenergic receptor, J Recept Signal Transduct Res, vol.20, issue.1, pp.75-85, 2000.

A. Ruiz-gómez and F. Mayor, Beta-adrenergic receptor kinase (GRK2) colocalizes with betaadrenergic receptors during agonist-induced receptor internalization, J Biol Chem, vol.272, issue.15, pp.9601-9605, 1997.

J. Zhang, L. S. Barak, P. H. Anborgh, S. A. Laporte, M. G. Caron et al., Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes, J Biol Chem, vol.274, issue.16, pp.10999-1006, 1999.

O. B. Goodman, J. G. Krupnick, F. Santini, V. V. Gurevich, R. B. Penn et al., Betaarrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor, Nature, vol.383, issue.6599, pp.447-50, 1996.

S. A. Laporte, R. H. Oakley, J. Zhang, J. A. Holt, S. S. Ferguson et al., The beta2adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis, Proc Natl Acad Sci, vol.96, issue.7, pp.3712-3719, 1999.

P. H. Anborgh, J. L. Seachrist, L. B. Dale, and S. S. Ferguson,

, formation and the differential trafficking and resensitization of beta2-adrenergic and angiotensin II type 1A receptors, Mol Endocrinol Baltim Md, vol.14, issue.12, pp.2040-53, 2000.

L. Kallal, A. W. Gagnon, R. B. Penn, and J. L. Benovic, Visualization of agonist-induced sequestration and down-regulation of a green fluorescent protein-tagged beta2adrenergic receptor, J Biol Chem, vol.273, issue.1, pp.322-330, 1998.

S. S. Yu, R. J. Lefkowitz, and W. P. Hausdorff, Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization, J Biol Chem, vol.268, issue.1, pp.337-378, 1993.

E. Hermans, M. A. Vanisberg, M. Geurts, and J. M. Maloteaux, Down-regulation of neurotensin receptors after ligand-induced internalization in rat primary cultured neurons, Neurochem Int, vol.31, issue.2, pp.291-300, 1997.

P. I. Tsao and M. Von-zastrow, Type-specific sorting of G protein-coupled receptors after endocytosis, J Biol Chem, vol.275, issue.15, pp.11130-11170, 2000.

K. M. Krueger, Y. Daaka, J. A. Pitcher, and R. J. Lefkowitz, The role of sequestration in G proteincoupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification, J Biol Chem, vol.272, issue.1, pp.5-8, 1997.

B. G. Tholanikunnel and C. C. Malbon, A 20-nucleotide (A + U)-rich element of beta2adrenergic receptor (beta2AR) mRNA mediates binding to beta2AR-binding protein and is obligate for agonist-induced destabilization of receptor mRNA, J Biol Chem, vol.272, issue.17, pp.11471-11479, 1997.

C. Barreau, L. Paillard, and H. B. Osborne, AU-rich elements and associated factors: are there unifying principles?, Nucleic Acids Res, vol.33, issue.22, pp.7138-50, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00292935

S. Danner, M. Frank, and M. J. Lohse, Agonist regulation of human beta2-adrenergic receptor mRNA stability occurs via a specific AU-rich element, J Biol Chem, vol.273, issue.6, pp.3223-3232, 1998.

A. Pende, K. D. Tremmel, C. T. Demaria, B. C. Blaxall, W. A. Minobe et al., Regulation of the mRNA-binding protein AUF1 by activation of the beta-adrenergic receptor signal transduction pathway, J Biol Chem, vol.271, issue.14, pp.8493-501, 1996.

M. Bouvier, S. Collins, O. Dowd, B. F. Campbell, P. T. De-blasi et al., Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level, J Biol Chem, vol.264, issue.28, pp.16786-92, 1989.

S. Collins, M. Bouvier, M. A. Bolanowski, M. G. Caron, and R. J. Lefkowitz, cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure, Proc Natl Acad Sci, vol.86, issue.13, pp.4853-4860, 1989.

S. Pippig, S. Andexinger, and M. J. Lohse, Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization, Mol Pharmacol, vol.47, issue.4, pp.666-76, 1995.

S. K. Shenoy, P. H. Mcdonald, T. A. Kohout, and R. J. Lefkowitz, Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin, Science, vol.294, issue.5545, pp.1307-1320, 2001.

S. K. Shenoy, K. Xiao, V. Venkataramanan, P. M. Snyder, N. J. Freedman et al., Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor, J Biol Chem, vol.283, issue.32, pp.22166-76, 2008.
DOI : 10.1074/jbc.m709668200

URL : http://www.jbc.org/content/283/32/22166.full.pdf

M. Berthouze, V. Venkataramanan, Y. Li, and S. K. Shenoy, The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization, EMBO J, vol.17, issue.12, pp.1684-96, 2009.
DOI : 10.1038/emboj.2009.128

URL : http://embojnl.embopress.org/content/embojnl/28/12/1684.full.pdf

A. Monopoli, A. Conti, A. Forlani, and E. Ongini, Beta 1 and beta 2 adrenoceptors are involved in mediating vasodilation in the human coronary artery, Pharmacol Res, vol.27, issue.3, pp.273-282, 1993.

A. Bouskine, M. Nebout, F. Brücker-davis, M. Benahmed, and P. Fenichel, Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor. Environ Health Perspect, vol.117, pp.1053-1061, 2009.

S. A. Lahousse, S. A. Beall, and K. J. Johnson, Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1, Toxicol Sci Off J Soc Toxicol, vol.91, issue.1, pp.255-64, 2006.
DOI : 10.1093/toxsci/kfj135

URL : https://academic.oup.com/toxsci/article-pdf/91/1/255/10955311/kfj135.pdf

P. D. Brown-woodman, W. S. Webster, K. Picker, and F. Huq, In vitro assessment of individual and interactive effects of aromatic hydrocarbons on embryonic development of the rat, Reprod Toxicol Elmsford N, vol.8, issue.2, pp.121-156, 1994.

R. Slama, O. Thiebaugeorges, V. Goua, L. Aussel, P. Sacco et al., Maternal personal exposure to airborne benzene and intrauterine growth. Environ Health Perspect, vol.117, pp.1313-1334, 2009.
DOI : 10.1289/ehp.0800465

URL : https://hal.archives-ouvertes.fr/inserm-00410224

I. Bos, D. Boever, P. Vanparijs, J. Pattyn, N. Panis et al., Subclinical effects of aerobic training in urban environment, Med Sci Sports Exerc, vol.45, issue.3, pp.439-486, 2013.

M. Nukaya, J. A. Walisser, S. M. Moran, G. D. Kennedy, and C. A. Bradfield, Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver, Toxicol Sci Off J Soc Toxicol, vol.118, issue.2, pp.554-63, 2010.
DOI : 10.1093/toxsci/kfq305

URL : https://academic.oup.com/toxsci/article-pdf/118/2/554/16683027/kfq305.pdf

R. F. Jacob, M. D. Aleo, Y. Self-medlin, C. M. Doshna, and R. P. Mason, 1,2-naphthoquinone stimulates lipid peroxidation and cholesterol domain formation in model membranes, Invest Ophthalmol Vis Sci, vol.54, issue.12, pp.7189-97, 2013.
DOI : 10.1167/iovs.13-12793

URL : http://iovs.arvojournals.org/data/journals/iovs/932980/i1552-5783-54-12-7189.pdf

B. K. Kobilka, G protein coupled receptor structure and activation, Biochim Biophys Acta. avr, vol.1768, issue.4, pp.794-807, 2007.

S. J. Hill, G-protein-coupled receptors: past, present and future, Br J Pharmacol. janv, vol.147, issue.1, pp.27-37, 2006.
DOI : 10.1038/sj.bjp.0706455

URL : https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1038/sj.bjp.0706455

G. E. Jules, S. Pratap, A. Ramesh, and D. B. Hood, In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life, Toxicology. 16 mai, vol.295, issue.1-3, pp.56-67, 2012.

D. Curfs, A. M. Knaapen, D. Pachen, M. Gijbels, E. Lutgens et al., Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties, FASEB J Off Publ Fed Am Soc Exp Biol. août, vol.19, issue.10, pp.1290-1292, 2005.
DOI : 10.1096/fj.04-2269fje

A. M. Knaapen, D. M. Curfs, D. M. Pachen, R. W. Gottschalk, M. De-winther et al., The environmental carcinogen benzo[a]pyrene induces expression of monocytechemoattractant protein-1 in vascular tissue: a possible role in atherogenesis, Mutat Res. 1 août, vol.621, issue.1-2, pp.31-41, 2007.

V. Lecureur, E. L. Ferrec, N. 'diaye, M. Vee, M. L. Gardyn et al., ERK-dependent induction of TNFalpha expression by the environmental contaminant benzo(a)pyrene in primary human macrophages, FEBS Lett. 28 mars, vol.579, issue.9, pp.1904-1914, 2005.

N. 'diaye, M. , L. Ferrec, E. Lagadic-gossmann, D. Corre et al., Aryl hydrocarbon receptor-and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene, J Biol Chem. 21 juill, vol.281, issue.29, pp.19906-19921, 2006.

M. Nukaya, J. A. Walisser, S. M. Moran, G. D. Kennedy, and C. A. Bradfield, Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver, Toxicol Sci Off J Soc Toxicol. déc, vol.118, issue.2, pp.554-63, 2010.
DOI : 10.1093/toxsci/kfq305

URL : https://academic.oup.com/toxsci/article-pdf/118/2/554/16683027/kfq305.pdf

A. Mayati, N. Levoin, H. Paris, N. 'diaye, M. Courtois et al., Induction of intracellular calcium concentration by environmental benzo(a)pyrene involves a ?2adrenergic receptor/adenylyl cyclase/Epac-1/inositol 1,4,5-trisphosphate pathway in endothelial cells, J Biol Chem. 3 févr, vol.287, issue.6, pp.4041-52, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00682497

P. Irigaray, V. Ogier, S. Jacquenet, V. Notet, P. Sibille et al., Benzo[a]pyrene impairs beta-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice. A novel molecular mechanism of toxicity for a common food pollutant, FEBS J. avr, vol.273, issue.7, pp.1362-72, 2006.

K. E. Laustiola, R. Lassila, J. Kaprio, and M. Koskenvuo, Decreased beta-adrenergic receptor density and catecholamine response in male cigarette smokers. A study of monozygotic twin pairs discordant for smoking. Circulation, vol.78, pp.1234-1274, 1988.

K. E. Laustiola, M. Kotamäki, R. Lassila, O. P. Kallioniemi, and V. Manninen, Cigarette smoking alters sympathoadrenal regulation by decreasing the density of beta 2-adrenoceptors. A study of monitored smoking cessation, J Cardiovasc Pharmacol. juin, vol.17, issue.6, pp.923-931, 1991.

D. Larue and G. Kato, Reduced number of alpha-and beta-adrenergic receptors in the myocardium of rats exposed to tobacco smoke, Eur J Pharmacol. 9 avr, vol.70, issue.4, pp.519-548, 1981.

P. Factor, A. T. Akhmedov, J. D. Mcdonald, A. Qu, J. Wu et al., Polycyclic aromatic hydrocarbons impair function of ?2-adrenergic receptors in airway epithelial and smooth muscle cells, Am J Respir Cell Mol Biol, vol.45, issue.5, pp.1045-1054, 2011.

A. Monopoli, A. Conti, A. Forlani, and E. Ongini, Beta 1 and beta 2 adrenoceptors are involved in mediating vasodilation in the human coronary artery, Pharmacol Res. avr, vol.27, issue.3, pp.273-282, 1993.

I. J. Arinze and Y. Kawai, Adrenergic regulation of glycogenolysis in isolated guinea-pig hepatocytes: evidence that beta 2-receptors mediate catecholamine stimulation of glycogenolysis, Arch Biochem Biophys. août, vol.225, issue.1, pp.196-202, 1983.

Y. Kawai and I. J. Arinze, beta-Adrenergic receptors in rabbit liver plasma membranes. Predominance of beta 2-receptors and mediation of adrenergic regulation of hepatic glycogenolysis, J Biol Chem. 10 avr, vol.258, issue.7, pp.4364-71, 1983.

J. Carron, C. Morel, J. W. Blum, and H. M. Hammon, Effects of dexamethasone and colostrum feeding on mRNA levels and binding capacities of beta-adrenergic receptors in the liver of neonatal calves, Domest Anim Endocrinol. avr, vol.28, issue.3, pp.257-71, 2005.

X. Tekpli, M. Rissel, L. Huc, D. Catheline, O. Sergent et al., Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis, Toxicol Appl Pharmacol. 15 févr, vol.243, issue.1, pp.68-76, 2010.
URL : https://hal.archives-ouvertes.fr/hal-00729575

B. Dendelé, X. Tekpli, K. Hardonnière, J. A. Holme, L. Debure et al., Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway, Chem Biol Interact. 25 janv, vol.207, pp.41-51, 2014.

R. F. Jacob, M. D. Aleo, Y. Self-medlin, C. M. Doshna, and R. P. Mason, 1,2-naphthoquinone stimulates lipid peroxidation and cholesterol domain formation in model membranes, Invest Ophthalmol Vis Sci, vol.54, issue.12, pp.7189-97, 2013.

J. Sikkema, J. A. De-bont, and B. Poolman, Interactions of cyclic hydrocarbons with biological membranes, J Biol Chem. 18 mars, vol.269, issue.11, pp.8022-8030, 1994.

A. Bouskine, M. Nebout, F. Brücker-davis, M. Benahmed, and P. Fenichel, Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor, Environ Health Perspect. juill, vol.117, issue.7, pp.1053-1061, 2009.

S. A. Lahousse, S. A. Beall, and K. J. Johnson, Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1, Toxicol Sci Off J Soc Toxicol. mai, vol.91, issue.1, pp.255-64, 2006.

K. M. Bisset, A. S. Dhopeshwarkar, C. Liao, and R. A. Nicholson, The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro, Neurochem Int, vol.59, issue.5, pp.706-719, 2011.

K. Mizuo, M. Narita, T. Yoshida, M. Narita, and T. Suzuki, Functional changes in dopamine D3 receptors by prenatal and neonatal exposure to an endocrine disruptor bisphenol-A in mice, Addict Biol. mars, vol.9, issue.1, pp.19-25, 2004.

M. Ishido, M. Morita, S. Oka, and Y. Masuo, Alteration of gene expression of G proteincoupled receptors in endocrine disruptors-caused hyperactive rats, Regul Pept. 15 mars, vol.126, issue.1-2, pp.145-53, 2005.

U. F. De, . De, . N°-déséchalliers, and . Thomas, Rôle des récepteurs couplés aux protéines G adrénergiques dans la toxicité des hydrocarbures aromatiques polycycliques 119 feuilles, 17 illustrations, 5 tableaux, 30 cm-Thèse : Pharmacie, Rennes, vol.1, 2016.