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Master Thesis

Aspects qualitatifs de la salive dans le cadre de la radiothérapie cervico-faciale : revue systématique de la littérature

Abstract : Saliva plays a crucial role in the preservation and maintenance of oral health. The hyposialia induced by cervicofacial radiotherapy is well documented but the information concerning the salivary proteome in this context is more sporadic. The aim of our work was to identify salivary proteome modifications during and after radiotherapy and to highlight proteins within the proteome that may be of interest in maintaining good oral health. We conducted a systematic review of qualitative changes in saliva in Head and Neck cancer patients treated with cervicofacial radiotherapy. Our research methodology allowed us to select 17 articles. Modification of salivary proteins during and after radiotherapy as a function of dose and localization of radiation has been observed, especially for certain proteins such as EGF, alpha amylase, IgA and the MMP / TIMP system. The results obtained are still limited and show the need to conduct further studies on the total salivary proteome and these proteins.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01771635
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Submitted on : Thursday, April 19, 2018 - 4:22:34 PM
Last modification on : Wednesday, January 15, 2020 - 9:03:57 AM
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Jocelyn Guibert. Aspects qualitatifs de la salive dans le cadre de la radiothérapie cervico-faciale : revue systématique de la littérature. Chirurgie. 2018. ⟨dumas-01771635⟩

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