M. Adeolu and R. S. Gupta, A phylogenomic and molecular marker based proposal for the division of the genus Borrelia into two genera: the emended genus Borrelia containing only the members of the relapsing fever Borrelia, and the genus Borreliella gen. nov. containing the members of the Lyme disease Borrelia (Borrelia burgdorferi sensu lato complex), Antonie Van Leeuwenhoek, vol.105, issue.6, pp.1049-72, 2014.

S. Borréliose-de-lyme, démarches diagnostiques, thérapeutiques et préventives. 16 ème conférence de consensus en thérapeutique anti-infectieuse. Décembre, 2006.

H. Borréliose-de-lyme, État des connaissances. Paris: Haut Conseil de la Santé Publique, 2014.

V. Cairns and G. J. Post, Lyme borreliosis syndrome: a meta-analysis of reported symptoms, Int J Epidemiol, vol.34, issue.6, pp.1340-1345, 2005.

E. Weitzner, D. Mckenna, J. Nowakowski, C. Scavarda, R. Dornbush et al., Long-term Assessment of Post-Treatment Symptoms in Patients With Culture-Confirmed Early Lyme Disease, Clin Infect Dis, vol.61, issue.12, pp.1800-1806, 2015.

H. M. Feder, B. Johnson, S. O'connell, E. D. Shapiro, A. C. Steere et al., A critical appraisal of "chronic Lyme disease, N Engl J Med, vol.357, issue.14, pp.1422-1452, 2007.

, Association France Lyme. Controverses. Média-tiques. Disponible sur

. Invs, Estimation de l'incidence annuelle de la borréliose de Lyme, Disponible sur, 2009.

C. Lenormand, B. Jaulhac, S. Debarbieux, N. Dupin, F. Granel-brocard et al., Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture-and/or polymerase chain reaction (PCR)-documented cases, J Am Acad Dermatol, vol.74, issue.4, pp.685-92, 2016.

J. J. Nocton, B. J. Bloom, B. J. Rutledge, D. H. Persing, E. L. Logigian et al., Detection of Borrelia burgdorferi DNA by polymerase chain reaction in cerebrospinal fluid in Lyme neuroborreliosis, J Infect Dis, vol.174, issue.3, pp.623-630, 1996.

J. J. Nocton, F. Dressler, B. J. Rutledge, P. N. Rys, D. H. Persing et al., Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis, N Engl J Med, vol.330, issue.4, pp.229-263, 1994.

A. T. Borchers, C. L. Keen, A. C. Huntley, and M. E. Gershwin, Lyme disease: a rigorous review of diagnostic criteria and treatment, J Autoimmun, vol.57, pp.82-115, 2015.

A. Chandra, N. Latov, G. P. Wormser, A. R. Marques, and A. Alaedini, Epitope mapping of antibodies to VlsE protein of Borrelia burgdorferi in post-Lyme disease syndrome, Clin Immunol, vol.141, issue.1, pp.103-113, 2011.

A. Chandra, G. P. Wormser, M. S. Klempner, R. P. Trevino, M. K. Crow et al., Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms, Brain Behav Immun, vol.24, issue.6, pp.1018-1042, 2010.

T. A. Rupprecht, U. Koedel, V. Fingerle, and H. Pfister, The pathogenesis of lyme neuroborreliosis: from infection to inflammation, Mol Med, vol.14, issue.3-4, pp.205-217, 2008.

J. Cervantes, Doctor says you are cured, but you still feel the pain. Borrelia DNA persistence in Lyme disease. Microbes Infect, vol.19, pp.459-63, 2017.

S. E. Phillips, J. J. Burrascano, N. S. Harris, L. Johnson, P. V. Smith et al., Chronic infection in "post-Lyme borreliosis syndrome, Int J Epidemiol, vol.34, issue.6, pp.1440-1443, 2005.

M. E. Embers, R. Ramamoorthy, and M. T. Philipp, Survival strategies of Borrelia burgdorferi, the etiologic agent of Lyme disease. Microbes Infect, vol.6, pp.312-320, 2004.

K. Hunfeld, E. Ruzic-sabljic, D. E. Norris, P. Kraiczy, and F. Strle, In vitro susceptibility testing of Borrelia burgdorferi sensu lato isolates cultured from patients with erythema migrans before and after antimicrobial chemotherapy, Antimicrob Agents Chemother, vol.49, issue.4, pp.1294-301, 2005.

R. Iyer, P. Mukherjee, K. Wang, J. Simons, G. P. Wormser et al., Detection of Borrelia burgdorferi nucleic acids after antibiotic treatment does not confirm viability, J Clin Microbiol, vol.51, issue.3, pp.857-62, 2013.
DOI : 10.1128/jcm.02785-12

URL : https://jcm.asm.org/content/51/3/857.full.pdf

L. K. Bockenstedt, J. Mao, E. Hodzic, S. W. Barthold, and D. Fish, Detection of attenuated, noninfectious spirochetes in Borrelia burgdorferi-infected mice after antibiotic treatment, J Infect Dis, vol.186, issue.10, pp.1430-1437, 2002.

T. Papo,

, Med Mal Infect, vol.37, issue.7-8, pp.507-517, 2007.

Y. Hansmann, C. Leyer, N. Lefebvre, M. Revest, C. Rabaud et al., Feedback on difficulties raised by the interpretation of serological tests for the diagnosis of Lyme disease, Med Mal Infect, vol.44, issue.5, pp.199-205, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01491155

C. W. Ang, D. W. Notermans, M. Hommes, A. M. Simoons-smit, and T. Herremans, Large differences between test strategies for the detection of anti-Borrelia antibodies are revealed by comparing eight ELISAs and five immunoblots, Eur J Clin Microbiol Infect Dis, vol.30, issue.8, pp.1027-1059, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00702655

M. Assous,

, Med Mal Infect, vol.37, issue.7-8, pp.487-95, 2007.

S. E. Schutzer, P. K. Coyle, A. L. Belman, M. G. Golightly, and J. Drulle, Sequestration of antibody to Borrelia burgdorferi in immune complexes in seronegative Lyme disease, Lancet, vol.335, issue.8685, pp.312-317, 1990.

, Contrôle du marché d'après les notices des réactifs de sérologie de la borréliose de lyme

M. Karlsson, K. Hovind-hougen, B. Svenungsson, and G. Stiernstedt, Cultivation and characterization of spirochetes from cerebrospinal fluid of patients with Lyme borreliosis, J Clin Microbiol, vol.28, issue.3, pp.473-482, 1990.

I. Bil-lula, P. Matuszek, T. Pfeiffer, and M. Wo?niak, Lyme Borreliosis-the Utility of Improved Real-Time PCR Assay in the Detection of Borrelia burgdorferi Infections, Adv Clin Exp Med, vol.24, issue.4, pp.663-70, 2015.

B. Jaulhac, Performances des méthodes biologiques dans le diagnostic et le suivi de la borréliose de Lyme: Disponible sur

R. B. Dessau, Microscopy of human blood for Borrelia burgdorferi and Babesia without clinical or scientific rationale, Infect Dis (Lond), vol.48, issue.6, pp.420-421, 2016.

M. S. Klempner, P. J. Baker, E. D. Shapiro, A. Marques, R. J. Dattwyler et al., Treatment trials for postLyme disease symptoms revisited, Am J Med, vol.126, issue.8, pp.665-674, 2013.

A. Berende, H. Hofstede, F. J. Vos, H. Van-middendorp, M. L. Vogelaar et al., Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease, N Engl J Med, vol.374, issue.13, pp.1209-1229, 2016.

N. S. Marzec, C. Nelson, P. R. Waldron, B. G. Blackburn, S. Hosain et al., Serious Bacterial Infections Acquired During Treatment of Patients Given a Diagnosis of Chronic Lyme Disease-United States. MMWR Morb Mortal Wkly Rep, vol.66, pp.607-616, 2017.

B. A. Fallon, J. G. Keilp, K. M. Corbera, E. Petkova, C. B. Britton et al., A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy, Neurology, vol.70, issue.13, pp.992-1003, 2008.

L. B. Krupp, L. G. Hyman, R. Grimson, P. K. Coyle, P. Melville et al., Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial, Neurology, vol.60, issue.12, pp.1923-1953, 2003.

, Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease. | National Guideline Clearinghouse

G. P. Wormser, R. J. Dattwyler, E. D. Shapiro, J. J. Halperin, A. C. Steere et al., The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America, Clin Infect Dis, vol.43, issue.9, pp.1089-134, 2006.

, Treatment Guidelines for Lyme Disease from ILADS

P. G. Auwaerter, J. S. Bakken, R. J. Dattwyler, J. S. Dumler, J. J. Halperin et al., Antiscience and ethical concerns associated with advocacy of Lyme disease, Lancet Infect Dis, vol.11, issue.9, pp.713-722, 2011.

. Maladie-de-lyme and . Disponible,

M. De-lyme, Il y a urgence"-29 août 2016-L'Obs

. Maladie-de-lyme, Prise de position de l'Académie nationale de médecine | Académie nationale de médecine

, Les cabinets des généralistes sont remplis de malades de Lyme" | egora

L. Borgermans, C. Perronne, R. Balicer, O. Polasek, V. Obsomer et al., BMJ, vol.351, p.6520, 2015.

, Plan national de lutte contre la maladie de Lyme et les maladies transmissibles par le stiques, Ministère des affaires sociales et de la santé, 2016.

, Cochez d'une croix la réponse OUI ou NON selon votre état actuel. Si vous hésitez, cochez ce qui correspond le mieux à votre état aujourd'hui. Certaines questions ne s'appliquent peut-être pas à vous, mais répondez-y quand même, La liste ci-dessous évoque quelques problèmes rencontrés dans la vie quotidienne

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