. On-retrouve-aussi-les-fabricants-suivants, Abysse et herbothicaire, spiruline de Normandie, Alverolife, sephyto, Spiruline d'Orpierre, Spiruline EG

A. Avis, risques liés à la consommation de compléments alimentaires contenant de la spiruline Maisons-Alfort: 2017. Disponible sur https, 2018.

. Antenna, Malnutrition: Spiruline données scientifiques Disponible sur https://www.antenna-france, 2009.

C. Baicus and A. Baicus, Spirulina did not ameliorate idiopathic chronic fatigue in four N-of-1 randomized controlled trials, Phytotherapy Research, vol.5, issue.6, pp.570-573, 2007.
DOI : 10.1002/ptr.2114

P. Bermejo-bescós, E. Piñero-estrada, and Á. M. Villar-del-fresno, Neuroprotection by Spirulina platensis protean extract and phycocyanin against iron-induced toxicity in SH-SY5Y neuroblastoma cells, Toxicology in Vitro, vol.22, issue.6, pp.1496-1502, 2008.
DOI : 10.1016/j.tiv.2008.05.004

C. Bernard, Les cyanobact??ries et leurs toxines, Revue Francophone des Laboratoires, vol.2014, issue.460, pp.53-68, 2014.
DOI : 10.1016/S1773-035X(14)72405-0

M. Bouarfa and A. Pensé-lhéritier, Conception des compléments alimentaires: marché, développement, réglementation et efficacité, 2016.

A. Braakhuis and W. Hopkins, Impact of Dietary Antioxidants on Sport Performance: A Review, Sports Medicine, vol.94, issue.4, pp.939-55, 2015.
DOI : 10.1152/japplphysiol.00884.2002

L. Charpy, M. Langlade, and R. Alliod, La Spiruline peut-elle être un atout pour la santé et le développement en Afrique? Marseille: IRD, 2008.

Y. Chen, J. Chen, C. Tayag, H. Li, D. Putra et al., Spirulina elicits the activation of innate immunity and increases resistance against Vibrio alginolyticus in shrimp, Fish & Shellfish Immunology, vol.55, pp.690-698, 2016.
DOI : 10.1016/j.fsi.2016.06.042

J. Choi, S. Kim, and S. Kim, Spirulan from Blue-Green Algae Inhibits Fibrin and Blood Clots: Its Potent Antithrombotic Effects, Journal of Biochemical and Molecular Toxicology, vol.43, issue.9, pp.240-248, 2015.
DOI : 10.1016/S1056-8719(00)00095-2

L. Colla, T. Bertolin, and J. Costa, Fatty Acids Profile of Spirulina platensis Grown Under Different Temperatures and Nitrogen Concentrations, Zeitschrift f??r Naturforschung C, vol.59, issue.1-2, pp.55-64, 2004.
DOI : 10.1515/znc-2004-1-212

URL : http://www.degruyter.com/downloadpdf/j/znc.2004.59.issue-1-2/znc-2004-1-212/znc-2004-1-212.xml

H. Cruchot, La spiruline: bilan et perspectives, Thèse d'exercice

. Comté, Faculté de médecine et de pharmacie, 2008.

P. Dagnelie, W. Van-staveren, and H. Van-den-berg, Vitamin B-12 from algae appears not to be bioavailable, The American Journal of Clinical Nutrition, vol.53, issue.3, pp.695-702, 1991.
DOI : 10.1093/ajcn/53.3.695

URL : https://academic.oup.com/ajcn/article-pdf/53/3/695/24063618/695.pdf

P. Dartsch, Antioxidant potential of selectedSpirulina platensis preparations, Phytotherapy Research, vol.17, issue.5, pp.627-660, 2008.
DOI : 10.2174/0929867013373011

A. Defranco, R. Locksley, R. Miranda, M. Cunin, R. Masson et al., Immunité: la réponse immunitaire dans les maladies infectieuses et inflammatoires, 2009.

J. Delattre, J. Beaudeux, and D. Bonnefont-rousselot, Radicaux libres et stress oxydant: aspects biologiques et pathologiques, 2005.

F. Agency-response, G. Letter, N. Notice, and . Gnr, Disponible sur http, 2003.

J. Falquet and J. Hurni, Spiruline aspects nutritionnelles Disponible sur https://www.antenna-france, pp.1-41, 2006.

S. M. Farooq, N. B. Boppana, A. Devarajan, S. D. Sekaran, and E. M. Shankar, Cphycocyanin confers protection against oxalate-mediated oxidative stress and mitochondrial dysfunctions in MDCK cells, PLoS ONE, vol.9, issue.7, 2014.
DOI : 10.1371/journal.pone.0093056

URL : https://doi.org/10.1371/journal.pone.0093056

B. Fernández-rojas, O. N. Medina-campos, R. Hernández-pando, M. Negrette-guzmán, S. Huerta-yepez et al., C-Phycocyanin prevents cisplatin-induced nephrotoxicity through inhibition of oxidative stress, Food Funct., vol.20, issue.2, pp.480-490, 2014.
DOI : 10.1016/j.phymed.2012.12.001

R. Fox, La spiruline: technique, pratique et promesse. Aix-en-Provence: Edisud, 1999.

E. Cyanobacterial and G. Arthrospira, Actual State of the Art in Cultivation Methods, Genetics, and Application in Medicine, Front Microbiol, vol.8, p.2541, 2017.

M. Gantar and Z. Svir?ev, MICROALGAE AND CYANOBACTERIA: FOOD FOR THOUGHT, Journal of Phycology, vol.191, issue.Suppl., pp.260-268, 2008.
DOI : 10.3177/jnsv.47.373

G. Gutiérrez-salmeán, L. Fabila-castillo, and G. Chamorro-cevallos, Nutritional and toxicological aspects of spirulina (Arthrospira), Nutr Hosp, vol.32, pp.34-40, 2015.

M. Habib, M. Parvin, T. Huntington, and M. Hasan, Review on culture, production and use of spirulina as food for humans and feeds for domestic animals and fish, 2008.

Y. Hayakawa, Y. Hirashima, H. Yamamoto, M. Kurimoto, T. Hayashi et al., Mechanism of activation of heparin cofactor II by calcium spirulan, Archives of Biochemistry and Biophysics, vol.416, issue.1, pp.47-52, 2003.
DOI : 10.1016/S0003-9861(03)00289-3

T. Hirahashi, M. Matsumoto, K. Hazeki, Y. Saeki, M. Ui et al., Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis, International Immunopharmacology, vol.2, issue.4, pp.423-457, 2002.
DOI : 10.1016/S1567-5769(01)00166-7

L. Hsueh-kuan, H. Chin-cheng, and H. Jen-jung, Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress, Eur J Appl Physiol, vol.98, issue.2, pp.220-226, 2006.

E. Huskisson, S. Maggini, and M. Ruf, The Role of Vitamins and Minerals in Energy Metabolism and Well-Being, Journal of International Medical Research, vol.9, issue.40, pp.277-89, 2007.
DOI : 10.1001/jama.294.3.351

. Inao, Relevé de décision de la séance du comité national de l'agriculture biologique

. Inao, Relevé de décision de la séance du comité national de l'agriculture biologique

G. Jensen, C. Drapeau, M. Lenninger, and K. Benson, : Results from a Randomized, Double-Blind, Placebo-Controlled Study with a Focus on Anticoagulant Activity and Platelet Activation, Journal of Medicinal Food, vol.19, issue.7, pp.645-53, 2016.
DOI : 10.1089/jmf.2015.0143

M. Johnson, L. Hassinger, J. Davis, S. Devor, and R. Disilvestro, A randomized, double blind, placebo controlled study of spirulina supplementation on indices of mental and physical fatigue in men, International Journal of Food Sciences and Nutrition, vol.2, issue.2, pp.203-209, 2016.
DOI : 10.1007/s00421-006-0263-0

J. J. Manuel-de-culture-artisanale-de-la-spiruline, Disponible sur https://www.fichier-pdf.fr, 2014.

M. Kalafati, A. Jamurtas, M. Nikolaidis, V. Paschalis, A. Theodorou et al., Ergogenic and Antioxidant Effects of Spirulina Supplementation in Humans, Medicine & Science in Sports & Exercise, vol.42, issue.1
DOI : 10.1249/MSS.0b013e3181ac7a45

P. Karkos, S. Leong, C. Karkos, N. Sivaji, and D. Assimakopoulos, Spirulina in clinical practice: evidence-based human applications. Evid-Based, Complement Altern Med ECAM, p.531053, 2011.

R. P. Kumari, J. Sivakumar, B. Thankappan, and K. Anbarasu, C-Phycocyanin Modulates Selenite-Induced Cataractogenesis in Rats, Biological Trace Element Research, vol.22, issue.1, pp.59-67, 2013.
DOI : 10.1016/j.tiv.2008.05.004

I. Lavoie, I. Laurion, A. Warren, and V. Warwick, Les fleurs d'eau de cyanobactérieXiii:124p.Québec. Disponible sur https, 2007.

E. Lee, J. Park, Y. Choi, K. Huh, and W. Kim, A randomized study to establish the effects of spirulina in type 2 diabetes mellitus patients, Nutrition Research and Practice, vol.2, issue.4, pp.295-300, 2008.
DOI : 10.4162/nrp.2008.2.4.295

J. Leema, R. Kirubagaran, N. Vinithkumar, P. Dheenan, and S. Karthikayulu, High value pigment production from Arthrospira (Spirulina) platensis cultured in seawater, Bioresource Technology, vol.101, issue.23, pp.9221-9228, 2010.
DOI : 10.1016/j.biortech.2010.06.120

B. Li, X. Chu, M. Gao, and W. Li, Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin, Acta Biochimica et Biophysica Sinica, vol.110, issue.10, pp.80-89, 2010.
DOI : 10.1034/j.1600-0463.2002.1101006.x

B. Li, X. Chu, Y. Xu, F. Yang, C. Lv et al., CD59 Underlines the Antiatherosclerotic Effects of C-Phycocyanin on Mice, BioMed Research International, vol.1830, issue.3, p.15, 2013.
DOI : 10.1016/j.atherosclerosis.2012.04.013

URL : http://doi.org/10.1155/2013/729413

B. J. Lim, J. Y. Jeong, and Y. Chang, C-Phycocyanin Attenuates Cisplatin-Induced Nephrotoxicity in Mice, Renal Failure, vol.289, issue.1, pp.892-900, 2012.
DOI : 10.1152/ajprenal.00401.2004

URL : http://www.tandfonline.com/doi/pdf/10.3109/0886022X.2012.690925?needAccess=true

L. Liping, Q. Li-an, and W. Yiquan, Spirulina platensis extract supplementation attenuates oxidative stress in acute exhaustive exercise: a pilot study, Int J Phys Sci, vol.6, issue.12, pp.2901-2907, 2011.

Q. Liu, Y. Huang, R. Zhang, T. Cai, and Y. Cai, Medical Application of Spirulina platensis Derived C-Phycocyanin. Evid-Based Complement Altern, p.7803846, 2016.

H. Lu, C. Hsieh, J. Hsu, Y. Yang, and H. Chou, Preventive effects of Spirulina platensis on skeletal muscle damage under exercise-induced oxidative stress, European Journal of Applied Physiology, vol.18, issue.3, pp.220-226, 2006.
DOI : 10.1123/ijsn.9.2.166

A. Lupatini, L. Colla, C. Canan, and E. Colla, as a protein source, Journal of the Science of Food and Agriculture, vol.29, issue.3, pp.724-756, 2017.
DOI : 10.1016/j.biotechadv.2010.08.005

C. Magnette and B. Gerard, Recommandations de bonne pratique La plainte fatigue en médecine générale Dispo sur http://www.ssmg.be/images/ssmg/files/Recommandations_de_bonne_pratique/rbp_fatig ue.pdf consult, 2005.

A. Manet, La spiruline: indications thérapeutiques, risques sanitaires et conseils à l'officine. Thèse d'exercice, 2016.

T. Mao, J. Van-de-water, and M. Gershwin, on the Secretion of Cytokines from Peripheral Blood Mononuclear Cells, Journal of Medicinal Food, vol.3, issue.3, pp.135-175, 2000.
DOI : 10.1089/jmf.2000.3.135

J. Marín-prida, G. Pentón-rol, F. Rodrigues, L. Alberici, K. Stringhetta et al., C-Phycocyanin protects SH-SY5Y cells from oxidative injury, rat retina from transient ischemia and rat brain mitochondria from Ca2+/phosphate-induced impairment, Brain Research Bulletin, vol.89, issue.5-6, pp.159-67, 2012.
DOI : 10.1016/j.brainresbull.2012.08.011

R. Marles, M. Barrett, J. Barnes, M. Chavez, P. Gardiner et al., United States Pharmacopeia Safety Evaluation of Spirulina, Critical Reviews in Food Science and Nutrition, vol.69, issue.7, pp.593-604, 2011.
DOI : 10.1007/BF01611001

G. Salmeán and G. Chamorro, Preclinical antitoxic properties of Spirulina (Arthrospira)

M. Mccarty, as a Source of Phycocyanobilin, Journal of Medicinal Food, vol.10, issue.4, pp.566-70, 2007.
DOI : 10.1089/jmf.2007.621

S. Min, J. Park, L. Luo, Y. Kwon, H. Lee et al., Assessment of Cphycocyanin effect on astrocytes-mediated neuroprotection against oxidative brain injury using 2D and 3D astrocyte tissue model, Sci Rep, vol.5, 2015.
DOI : 10.1038/srep14418

URL : http://www.nature.com/articles/srep14418.pdf

S. Mitra, W. A. Siddiqui, and S. Khandelwal, C-Phycocyanin protects against acute tributyltin chloride neurotoxicity by modulating glial cell activity along with its anti-oxidant and anti-inflammatory property: A comparative efficacy evaluation with N-acetyl cysteine in adult rat brain, Chemico-Biological Interactions, vol.238, pp.138-50, 2015.
DOI : 10.1016/j.cbi.2015.06.016

M. Ngo-matip, C. Pieme, M. Azabji-kenfack, B. Moukette, E. Korosky et al., Impact of daily supplementation of Spirulina platensis on the immune system of na??ve HIV-1 patients in Cameroon: a 12-months single blind, randomized, multicenter trial, Nutrition Journal, vol.59, issue.1, p.70, 2015.
DOI : 10.1021/np960017o

C. Nielsen, P. Balachandran, O. Christensen, N. Pugh, H. Tamta et al., Enhancement of Natural Killer Cell Activity in Healthy Subjects by Immulina??, a Spirulina Extract Enriched for Braun Type Lipoproteins, Planta Medica, vol.76, issue.05, pp.1802-1810, 2010.
DOI : 10.1055/s-0030-1251866

E. Ques, /. Sante, and . Pharma, Pharmacies d'officine: portrait de branche 2012 Disponible sur https://www.observatoire-metiers-entreprisesliberales .fr/fichiers_utilisateurs/fichiers/statistiques, OMPL: Observatoire des Métiers dans les Professions Libérales, 2012.

J. Paniagua-michel, E. Dujardin, and C. Sironval, Le tecuiltlatl concentré de spirulines sources de protéines comestibles chez les Aztèques, Cah Agric, pp.283-290, 1993.

H. Park, Y. Lee, H. Ryu, M. Kim, H. Chung et al., A randomized doubleblind , placebo-controlled study to establish the effects of spirulina in elderly Koreans

W. M. Peng, S. T. Shang, Y. L. Fu, and G. Q. Liu, Properties of phycobiliproteins from Spirulina platensis, Journal of China Agricultural University, vol.4, issue.Z1, pp.35-38, 1999.

D. Remirez, V. Fernández, G. Tapia, R. González, and L. Videla, Influence of Cphycocyanin on hepatocellular parameters related to liver oxidative stress and Kupffer cell functioning, Inflamm Res Off J Eur Histamine Res Soc Al, vol.51, pp.351-357, 2002.
DOI : 10.1007/pl00000314

J. Riss, K. Décordé, and T. Sutra, Is Powerfully Responsible for Reducing Oxidative Stress and NADPH Oxidase Expression Induced by an Atherogenic Diet in Hamsters, Journal of Agricultural and Food Chemistry, vol.55, issue.19, pp.7962-7967, 2007.
DOI : 10.1021/jf070529g

C. Selmi, P. Leung, L. Fischer, B. German, C. Yang et al., The effects of Spirulina on anemia and immune function in senior citizens, Cellular & Molecular Immunology, vol.44, issue.3, pp.248-54, 2011.
DOI : 10.1111/j.1753-4887.2009.00218.x

URL : http://www.nature.com/cmi/journal/v8/n3/pdf/cmi201076a.pdf

S. Sguera, Spirulina platensis et ses constituants : intérêts nutritionnels et activités thérapeutiques, Thèse d'exercice. Université de Nancy I. UFR Sciences pharmaceutiques et biologiques, 2008.

M. Sheu, Y. Hsieh, C. Lai, C. Chang, and C. Wu, Antihyperlipidemic and Antioxidant Effects of C-phycocyanin in Golden Syrian Hamsters Fed with a Hypercholesterolemic Diet, Journal of Traditional and Complementary Medicine, vol.3, issue.1, pp.41-47, 2013.
DOI : 10.4103/2225-4110.106545

P. Torres-durán, A. Ferreira-hermosillo, A. Ramos-jiménez, R. Hernández-torres, and M. Juárez-oropeza, on Postprandial Lipemia in Young Runners: A Preliminary Report, Journal of Medicinal Food, vol.15, issue.8, pp.753-760, 2012.
DOI : 10.1089/jmf.2011.0309

B. Vadiraja, N. Gaikwad, and K. Madyastha, Hepatoprotective Effect of C-Phycocyanin: Protection for Carbon Tetrachloride andR-(+)-Pulegone-Mediated Hepatotoxicty in Rats, Biochemical and Biophysical Research Communications, vol.249, issue.2, pp.428-459, 1998.
DOI : 10.1006/bbrc.1998.9149

E. Vardaka, K. Kormas, M. Katsiapi, S. Genitsaris, and M. Moustaka-gouni, Table 1: Commercially available ???Spirulina??? food supplements from the Greek market., PeerJ, vol.42, issue.suppl 1, p.1610, 2016.
DOI : 10.7717/peerj.1610/table-1

URL : https://peerj.com/articles/1610.pdf

J. Vidalo, Spiruline: l'algue bleue de santé et de prévention, Paris: Ed. du Dauphin, 2008.

A. Vonshak, Spirulina platensis (Arthrospira): physiology, cell-biology, and biotechnology, 1997.

F. Watanabe, Sources and Bioavailability, Experimental Biology and Medicine, vol.232, issue.10, pp.1266-74, 2007.
DOI : 10.3177/jnsv.53.183

B. Pseudovitamin, 12) is the predominant cobamide of an algal health food, spirulina tablets, J Agric Food Chem, vol.47, pp.4736-4777, 1999.

F. Winter, F. Emakam, A. Kfutwah, J. Hermann, M. Azabji-kenfack et al., The Effect of Arthrospira platensis Capsules on CD4 T-Cells and Antioxidative Capacity in a Randomized Pilot Study of Adult Women Infected with Human Immunodeficiency Virus Not under HAART in Yaound??, Cameroon, Nutrients, vol.4, issue.7, pp.2973-86, 2014.
DOI : 10.1055/s-0030-1250043

Q. Wu, L. Liu, A. Miron, B. Klímová, D. Wan et al., The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview, Archives of Toxicology, vol.29, issue.2, pp.1817-1857, 2016.
DOI : 10.1111/j.1745-4514.2005.00035.x

J. Zheng, T. Inoguchi, and S. Sasaki, protect against diabetic nephropathy by inhibiting oxidative stress, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.268, issue.2, pp.110-120, 2013.
DOI : 10.1126/science.3029864

URL : http://ajpregu.physiology.org/content/ajpregu/304/2/R110.full.pdf

C. R. Zhou, J. Tang, Y. Jin, and B. J. Guo, Effects of C-phycocyanin from Spirulina platensis on immune function in mice, Journal of Jinan University (Natural Science & Medicine Edition), issue.5, pp.93-97, 1998.

. Site, ?article34 génome : consulté en août 2017. http://www.spiruliniersdefrance.fr/spip.php?article168 carte : consulté en août 2017. http://www.spiruliniersdefrance.fr/spip.php?article32 charte d'engagement : consulté en août 2017, p.2017

. Site, fr/content/les-vitamines-par-le-menu : consulté en Décembre 2017

. Site, com/produit : consulté en Octobre 2017. https://akalfood.com/produit/barre-spirtonic/ : consulté en Octobre 2017. https://akalfood.com/produit/choco-spiru-brownie/ : consulté en Octobre 2017. https://akalfood.com/produit/kissmi-chocolat/ : consulté en Octobre 2017. https://akalfood.com/produit/spirumix/ : consulté en Octobre 2017. https://akalfood.com/produit/spiruline-solidaire-comprimes/ : consulté en Octobre 2017, 2017.

. Site, do?cidTexte=JORFTEXT000000337464&c ategorieLien=id : consulté en janvier 2017