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Master Thesis

Des balles magiques de Paul Ehrlich aux anticorps monoclonaux dans le traitement de la polyarthrite rhumatoïde

Abstract : In the early 20th century, Paul Ehrlich used for the first time the concept of targeted therapy with his “magic bullets”, designed to cure syphilis. In 1975, the discovery of the production of monoclonal antibodies opened new research pathways exploring their potential use as therapeutical agents. Some of these monoclonal antibodies have since been used as biological therapies, in particular for the treatment of autoimmune diseases such as rheumatoid arthritis. This common pathology is characterized by a chronic inflammation of the joints which, without proper treatment, leads to invalidating joints deformities. The traditional symptomatic and longterm treatments usually prescribed are not always efficient, hence the interest of further developing the use of monoclonal antibodies to better address such diseases. Some monoclonal antibodies are already commercialized while others are still in clinical evaluations. In the context of patients dealing with serious symptoms and potentially complex and restrictive treatments, the pharmacist has the important responsibility of counseling about the medications and listening to the patients’ concerns.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01811235
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Submitted on : Friday, June 8, 2018 - 4:47:48 PM
Last modification on : Thursday, July 9, 2020 - 12:30:44 PM

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Marion Rouault. Des balles magiques de Paul Ehrlich aux anticorps monoclonaux dans le traitement de la polyarthrite rhumatoïde. Sciences du Vivant [q-bio]. 2017. ⟨dumas-01811235⟩

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