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Master Thesis

Prédiction in silico de l'absorption intestinale et de la pénétration cérébrale des pesticides chez l'homme

Abstract : Pesticides are chemicals widely used in agriculture and domestic sphere for their insecticidal, fungicidal or herbicidal properties. There is a growing evidence that exposure to pesticide is linked to impaired human health and may cause neurological, metabolic or hormonal dysfunctions. Those adverse effects are tributary to the ability of ingered pesticides to cross a serie of selective barriers: gastro-intestinal barrier to access the blood stream and then blood brain barrier to access central nervous system and exert neurotoxicity. These key steps of gastro-intestinal and blood brain barriers crossing are poorly described for pesticides contrary to drugs. The objective of this study was to predict gastrointestinal absorption and brain blood barrier permeation of 338 pesticides (including pyrethroid, organophosphorus, organochlorine, carbamate, triazine and miscellaneous pesticides) using the online available tool SwissADME. Our results show that a large proportion of pesticides (81%) is predicted to cross gastro-intestinal barrier. A lower (but substantial) part of pesticides (about 39%) are predicted to cross blood brain barrier thus supporting their toxic effects for human health, including neurotoxic ones.
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Master Thesis
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https://dumas.ccsd.cnrs.fr/dumas-01812006
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Submitted on : Monday, June 11, 2018 - 10:23:41 AM
Last modification on : Thursday, July 9, 2020 - 12:30:44 PM

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Lisa Chedik. Prédiction in silico de l'absorption intestinale et de la pénétration cérébrale des pesticides chez l'homme. Sciences du Vivant [q-bio]. 2017. ⟨dumas-01812006⟩

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