index!de!perturbations!des!hubs!étaient!fortement!altérés!chez!les!patients! pour! tous! ces! paramètres!:! CI! (? CI =_0,68!;! p<0,0001)! ;! BC! (? BC =_0, pp.76-77 ,
71!;!p<0,0001) ,
,
IRMf)! et! simulées!(TVB)!n'était!pas!différente!chez!les!patients!ni!les!témoins!(CI!TVB_IRMf témoins =0,01! ;!p=0,9!;!CI!TVB_IRMf patients =_0,007;!p=0,9)!Il!n'existait!pas!de!relation!significative!entre!la!CI! empirique!et!simulée!, CI!R 2 témoins =0,003!;!p=0 ,
groupes! (BC! TVB_IRMf témoins =17,3!;! p<0,0001! ;! BC! TVB_ IRMf patients =18,6!;!p<!0,001) ,
, R 2 patients =0,06!;! p=0,0012)! Les! mBC! entre! patients! et! témoins! n
,
Eloc! R 2 témoins =0,037!;! p=0,01! ;! Eloc! R 2 patients =0,05!;! p=0,004).! A! nouveau! les! mEloc! entre! patients! et! témoins! n'étaient! pas! différentes! en! IRMf! (IRMf! Eloc témoins! ?! patients =_0 ,
,
groupes! (Eglob! TVB_fMRI témoins =_0,0172!;! p=0,002! ;! Eglob! TVB_ La!position!relative!du!point!de!travail!par!rapport!au!point!critique!est!donc!conditionnée!en! partie!par!la!valeur!, 2013. ,
,
! Dans! notre! étude! la! variance! du! signal! BOLD! entre! les! patients! et! les! témoins! n'était! pas! significativement!différente, !!!!!, 2007. ,
! 2017)! que! la! réorganisation! fonctionnelle! observée! aux! stades! précoces! de! la! SEP! serait! un! processus! bénéfique! pour! limiter! le! handicap! cognitif! secondaire! à! l'atteinte! de! la! substance! blanche.! Cette! réorganisation! précoce, !!!, 2010. ,
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altération!;! 1.! Toute! autre! perturbation! neurologique! attribuable! à! la! SEP! (à! spécifier ,
Nom'raccourcit' Nom'Complet'' 1! G_and_S_frontomargin! Fronto_marginal!gyrus!(of!Wernicke)!and!sulcus! 2! G_and_S_occipital_inf! Inferior!occipital!gyrus!(O3)!and!sulcus! 3! G_and_S_paracentral! Paracentral!lobule!and!sulcus! 4! G_and_S_subcentral! Subcentral!gyrus!(central!operculum)!and!sulci! 5! G_and_S_transv_frontopol! Transverse!frontopolar!gyri! ,
! isthmus! of! the! cingulate! gyrus)! 11! G_cuneus! Cuneus!(O6)! 12! G_front_inf_Opercular! Opercular!part!of!the!inferior!frontal!gyrus! 13! G_front_inf_Orbital! Orbital!part!of!the!inferior!frontal!gyrus! 14! G_front_inf_Triangul! Triangular!part!of!the!inferior!frontal!gyrus! 15! G_front_middle! Middle!frontal!gyrus!(F2)! 16! G_front_sup! Superior!frontal!gyrus!(F1)! 17! G_Ins_lg_and_S_cent_ins! Long!insular!gyrus!and!central!sulcus!of!the!insula! 18! G_insular_short! Short!insular!gyri! 19! G_occipital_middle! Middle!occipital!gyrus!(O2,!lateral!occipital!gyrus)! 20! G_occipital_sup! Superior!occipital!gyrus!(O1)! 21! G_oc_temp_lat_fusifor! Lateral!occipito_temporal!gyrus!(fusiform!gyrus,!O4_T4)! 22! G_oc_temp_med_Lingual! Lingual!gyrus,!ligual!part!of!the!medial!occipito_temporal!gyrus,!(O5)! 23! G_oc_temp_med_Parahip! Parahippocampal!gyrus,!parahippocampal!part!of!the!medial!occipito_temporal! gyrus,!(T5)! 24! G_orbital! Orbital!gyri! 25! G_pariet_inf_Angular! Angular!gyrus! 26! G_pariet_inf_Supramar! Supramarginal!gyrus! 27! G_parietal_sup! Superior!parietal!lobule!(lateral!part!of!P1)! 28! G_postcentral! Postcentral!gyrus! 29! G_precentral! Precentral!gyrus! 30! G_precuneus! Precuneus!(medial!part!of!P1)! 31! G_rectus! Straight!gyrus,!Gyrus!rectus! 32! G_subcallosal! Subcallosal!area,!subcallosal!gyrus! 33! G_temp_sup_G_T_transv! Anterior!transverse!temporal!gyrus!(of!Heschl)! 34! G_temp_sup_Lateral! Lateral!aspect!of!the!superior!temporal!gyrus! 35! G_temp_sup_Plan_polar! Planum!polare!of!the!superior!temporal!gyrus! 36! G_temp_sup_Plan_tempo! Planum!temporale!or!temporal!plane!of!the!superior!temporal!gyrus! 37! G_temporal_inf! Inferior!temporal!gyrus!(T3)! 38! G_temporal_middle! Middle!temporal!gyrus!(T2)! 39! Lat_Fis_ant_Horizont! Horizontal!ramus!of!the!anterior!segment!of!the!lateral!sulcus!(or!fissure)! 40! Lat_Fis_ant_Vertical! Vertical!ramus!of!the!anterior!segment!of!the!lateral!sulcus!(or!fissure)! 41! Lat_Fis_post! Posterior!ramus!(or!segment)!of!the!lateral!sulcus!(or!fissure)! 42! Pole_occipital! Occipital!pole! 43! Pole_temporal! Temporal!pole! 44! S_calcarine! Calcarine!sulcus! 45! S_central! Central!sulcus!(Rolando's!fissure)! 46! S_cingul_Marginalis! Marginal!branch!(or!part)!of!the!cingulate!sulcus! 47! S_circular_insula_ant! Anterior!segment!of!the!circular!sulcus!of!the!insula! 48! S_circular_insula_inf! Inferior!segment!of!the!circular!sulcus!of!the!insula! 49! S_circular_insula_sup! Superior!segment!of!the!circular!sulcus!of!the!insula! 50! S_collat_transv_ant! Anterior!transverse!collateral!sulcus! 51! S_collat_transv_post! Posterior!transverse!collateral!sulcus! 52! S_front_inf! Inferior!frontal!sulcus! 53! S_front_middle! Middle!frontal!sulcus! 54! S_front_sup! Superior!frontal!sulcus! 55! S_interm_prim_Jensen! Sulcus!intermedius!primus!(of!Jensen)! 56! S_intrapariet_and_P_trans! Intraparietal!sulcus!(interparietal!sulcus) ,
, Schéma!de!la!parcellisation!corticale!selon!l'Atlas!de!Destrieux, p.84
, ADC':!Coefficient!Apparent!de!Diffusion!
, BC
, BOLD!:!Blood!Oxygen!Level!Dependant!
, CI!:! index! de! connectivité!:! correspond! au! nombre! de! connexion! d'un! noeud! CIS':!Syndrome!cliniquement!isolé! DMN':!Default!Mode!Network
, DTI':!Diffusion!Tensor!Imaging!
, EDSS':!Expanded!Disability!Status!Score!
, Eglob':!Efficience!globale!
, Eloc':!Efficience!locale!
, FA':!Fraction!d'Anisotropie! FLAIR':!Fluid!
, FOV':!Field!Of!View! Hub':'noeud!du!réseau!très!connecté
, ICA':!Analyse!en!composantes!indépendantes!!
, IgG
, IRM':!Imagerie!par!Résonnance!Magnétique!
!index!de!perturbation!des!hubs! ? Eglob':! Indice!de!perturbation!de!l'efficience!globale!des!hubs!! ? Eloc!:! Indice!de!perturbation!de!l'efficience!locale!des!hubs!! ? CI!:! Indice ,
, MPRAGE':!Magnetization!Prepared!Rapid!Acquisition!Gradient
, MSFC':!MultipleSclerosis!Functional!Composite!! NHPT':!Nine!Hole!Peg!Test!
, ROI':!région!d'intérêt!
,
, SEP!:!Sclérose!en!Plaques!
,
, SEP'SP!:!SEP!secondairement!progressive!
,
, SNC':'Système!nerveux!central!
, TE':!temps!d'écho!
, TI':'temps!d'inversion!!
,
, TR':!temps!de!relaxation!