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Master Thesis

Intérêt de la tomographie par émission de positons dans la prise en charge des carcinomes épidermoïdes des voies aéro-digestives-supérieures

Abstract : Introduction: Cancers of VADS are the fifth most common cancer in France (and second in the world), with more than 16,000 new cases per year. Two thirds of cases are at an advanced stage. PET / CT is not routinely used in the management of VADS cancers. The objective of this study was to evaluate the clinical and therapeutic impact of PET / CT in the initial assessment and follow-up of VADS cancers. Material and method: This retrospective, monocentric and descriptive study focused on exams of the PET / CT patients for VADS cancer from 1 January 2009 to 1 January 2017 at the CHU in Amiens. The therapeutic impact was a change in management, by the discovery of a lesion: the primary tumor, a synchronic or metachronous cancer, a metastasis or an adenopathy. Results: 162 PET-CT exams were analysed in our study. In the initial review, the clinical impact was 13.4% (9 of 67 patients). It was 11.6% (11 out of 95 cases) in post-therapeutic follow-up. In 69% of cases the PET has an interest in post-therapeutic management. The number of tumor cases diagnosed by PET-CT in an asymptomatic patient was 6 out of 44 (14%). The sensitivity was 85% with a positive predictive value of 63%. The specificity of the exam was 88% with a negative predictive value of 96%. Our study confirms the contribution of using PET / CT in the management of VADS cancers.
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https://dumas.ccsd.cnrs.fr/dumas-01873817
Contributor : Thibaud Kientzler <>
Submitted on : Thursday, September 13, 2018 - 3:59:07 PM
Last modification on : Wednesday, February 27, 2019 - 10:04:53 PM

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Delphine Le Nay Pinon. Intérêt de la tomographie par émission de positons dans la prise en charge des carcinomes épidermoïdes des voies aéro-digestives-supérieures. Sciences du Vivant [q-bio]. 2017. ⟨dumas-01873817⟩

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