Skip to Main content Skip to Navigation
Master Thesis

Analyse de la performance diagnostique de la cytologie biliaire prélevée par aspiration et brossage au cours d’une cholangiopancréatographie rétrograde endoscopique en comparaison simultanée à la cytoponction pancréatique réalisée au cours d’une échoendoscopie pancréatique dans le diagnostic des sténoses biliaires malignes

Abstract : The purpose of our study covering 124 patients between 01/01/2012 and 01/01/2017 was to evaluate the diagnostic accuracy of the bile duct sample by aspiration before and after brushing + brushing (three sampling method) compared to fine needlze aspiration (FNA) during the same exam and to compare these two sampling techniques in a retrospective cohort of patients with suspected symptoms of pancreatic cancer. We have shown that the diagnostic accuracy of three sampling method was better (Diagnostic accuracy = 63.8%) than FNA (Diagnostic accuracy = 59.6%). The combination of the two techniques, allows a diagnostic accuracy of 79.8% with a sensitivity of 78.4% and a specificity of 100%. The diagnostic performance of the differents samplings was analyzed in subgroups according to the experience of the endoscopist, the existence of diabetis decompensation at the diagnosisf, TNM stage of the tumor and cytology yield. The proportion of positive tests for pancreatic adenocarcinomas (n = 81) increases with the stage of the tumor. There is an improvement in the results with the richness of the bile ducts. A double reading makes it possible to conclude that there is good intra-and inter-observer agreement for the diagnosis of malignancy of the samples. In patients with suspected pancreatic compression cancer, the three sampling method with FNA may contribute to improved diagnostic sensitivity for malignancy.
Document type :
Master Thesis
Complete list of metadatas

Cited literature [71 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-01879821
Contributor : Jean-Hugues Morneau <>
Submitted on : Monday, September 24, 2018 - 12:16:45 PM
Last modification on : Wednesday, July 15, 2020 - 8:58:04 AM
Long-term archiving on: : Tuesday, December 25, 2018 - 2:43:06 PM

File

2018GREA5069_peyret_dismas(1)(...
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-01879821, version 1

Citation

Dysmas Peyret. Analyse de la performance diagnostique de la cytologie biliaire prélevée par aspiration et brossage au cours d’une cholangiopancréatographie rétrograde endoscopique en comparaison simultanée à la cytoponction pancréatique réalisée au cours d’une échoendoscopie pancréatique dans le diagnostic des sténoses biliaires malignes. Médecine humaine et pathologie. 2018. ⟨dumas-01879821⟩

Share

Metrics

Record views

77

Files downloads

779