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Master Thesis

Concordance entre le diagnostic anténatal et le diagnostic post-natal des fentes labiales associées ou non à une fente palatine

Abstract : Objectives: The main objective of our work was to determine the inter-rate agreement between pre-natal screening and post-natal clinical diagnosis of orofacial clefts. The secondary objective was to identify the most common type of error between pre-natal screening and post-natal clinical diagnosis. Methods: We included retrospectively every child born with a cleft lip associated or not with a cleft palate. These children where taken care of at the department for orofacial clefts and facial birth defects at Grenoble Competence Center for Rare Diseases between January 1st 2006 and December 31st 2017. Pre-natal and postnatal data were compared. Results: 167 children had an antenatal cleft diagnosis. Results of prenatal screening were concordant with post-natal diagnosis in 79.6% of cases (133/167). We calculated a kappa coefficient of 0.73 (CI95: 0,65 – 0,81) and a positive predictive value of 0.80 (CI95: 0.73 – 0.85). Conclusion: There is a good inter-rate agreement between pre-natal screening and post-natal clinical diagnosis. Committed errors were most commonly underestimation of cleft types. Improving the quality of screening should provide accurate information to parents.
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https://dumas.ccsd.cnrs.fr/dumas-01882213
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Submitted on : Wednesday, September 26, 2018 - 4:38:17 PM
Last modification on : Wednesday, July 15, 2020 - 9:38:04 AM
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Sunila Kaderbay. Concordance entre le diagnostic anténatal et le diagnostic post-natal des fentes labiales associées ou non à une fente palatine. Gynécologie et obstétrique. 2018. ⟨dumas-01882213⟩

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