R. .. ,

L. 'imagerie-cérébrale-de-la-schizophrénie and .. .. ,

.. .. Diagnostic-de-la-schizophrénie, 4.1. Diagnostic selon la cinquième édition du Diagnostic and Statistical Manual of Mental Disorders (DSM V)

.. .. La-qualité-de-vie-dans-la-schizophrénie, 1. Les bases conceptuelles de la qualité de vie dans la schizophrénie, p.11

. , Modifications cérébrales qui sous-tendent une QV altérée dans la schizophrénie et réseaux neuronaux fonctionnels impliqués : Revue de la littérature

. .. Résultats,

. , Les corrélations entre l'indice S-QoL 18 et les données sociodémographiques et psychiatriques au départ et au suivi de 1 an

, Les corrélations entre l'indice S-QoL 18 et la perfusion SPECT du cerveau, p.22

.. .. Résultats-du-modèle-mixte,

. .. Discussion,

C. .. Et-perspectives, Chapitre, vol.3

B. .. ,

. .. Résumé,

.. .. Résumé,

A. Hofer, S. Baumgartner, M. Edlinger, M. Hummer, G. Kemmler et al., Patient outcomes in schizophrenia I: correlates with sociodemographic variables, psychopathology, and side effects, Eur Psychiatry, vol.20, issue.5, pp.386-394, 2005.

A. G. Awad, L. Voruganti, and R. J. Heslegrave, A conceptual model of quality of life in schizophrenia: description and preliminary clinical validation, Qual Life Res, vol.6, issue.1, 1997.

A. G. Awad and L. N. Voruganti, Measuring quality of life in patients with Schizophrenia, Pharmacoeconomics, vol.30, issue.3, pp.183-195, 2012.

L. Boyer, K. Baumstarck, M. Boucekine, J. Blanc, C. Lançon et al., Measuring quality of life in patients with schizophrenia: an overview, Expert Rev Pharmacoecon Outcomes Res, vol.13, issue.3, pp.343-349, 2013.

S. Priebe, R. Mccabe, U. Junghan, T. Kallert, M. Ruggeri et al., Association between symptoms and quality of life in patients with schizophrenia: a pooled analysis of changes over time, Schizophr Res, vol.133, issue.1, pp.17-21, 2011.

D. Heider, M. C. Angermeyer, I. Winkler, G. Schomerus, P. E. Bebbington et al., A prospective study of quality of life in schizophrenia in three European countries, Schizophr Res, vol.93, issue.1, pp.194-202, 2007.

L. Boyer and P. Auquier, The lack of impact of quality-of-life measures in schizophrenia: a shared responsibility, PharmacoEconomics, vol.30, issue.6, pp.531-532, 2012.

C. Boyer, L. , J. W. Jean-philippe, R. Raphaelle, R. Elisabeth et al., Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study, vol.5
URL : https://hal.archives-ouvertes.fr/hal-01414346

C. Faget-agius, L. Boyer, R. Richieri, P. Auquier, C. Lançon et al., Functional brain substrate of quality of life in patients with schizophrenia: A brain SPECT multidimensional analysis, Psychiatry Res Neuroimaging, vol.249, pp.67-75, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01482504

J. Mcgrath, S. Saha, D. Chant, and J. Welham, Schizophrenia: a concise overview of incidence, prevalence, and mortality, Epidemiol Rev, vol.30, issue.1, pp.67-76, 2008.

D. , T. Saoud, and M. , La schizophrénie de l'adulte, 2006.

D. Robinson, M. G. Woerner, J. Alvir, R. Bilder, R. Goldman et al., Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder, Arch Gen Psychiatry, vol.56, issue.3, pp.241-247, 1999.

K. Alptekin, ?. Erkoç, A. K. Gö?ü?, S. Kültür, L. Mete et al., Disability in schizophrenia: clinical correlates and prediction over 1-year follow-up, Psychiatry Res, vol.135, issue.2, pp.103-111, 2005.
DOI : 10.1016/j.psychres.2004.05.027

J. L. Rapoport, A. M. Addington, S. Frangou, and M. Psych, The neurodevelopmental model of schizophrenia: update, Mol Psychiatry, vol.10, issue.5, p.434, 2005.

D. H. Ingvar and G. Franzen, Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia, Acta Psychiatr Scand, vol.50, issue.4, pp.425-462, 1974.

R. Wake, T. Miyaoka, K. Kawakami, K. Tsuchie, T. Inagaki et al., Characteristic brain hypoperfusion by 99mTc-ECD single photon emission computed tomography (SPECT) in patients with the first-episode schizophrenia, Eur Psychiatry, vol.25, issue.6, pp.361-365, 2010.

N. Kanahara, E. Shimizu, Y. Sekine, Y. Uchida, T. Shibuya et al., Does hypofrontality expand to global brain area in progression of schizophrenia?: a cross-sectional study between first-episode and chronic schizophrenia, Prog Neuropsychopharmacol Biol Psychiatry, vol.33, issue.3, pp.410-415, 2009.

A. Vita, M. Dieci, G. M. Giobbio, A. Caputo, L. Ghiringhelli et al., Language and thought disorder in schizophrenia: brain morphological correlates, Schizophr Res, vol.15, issue.3, pp.243-251, 1995.

R. Erkwoh, O. Sabri, E. M. Steinmeyer, U. Büll, and H. Sass, Psychopathological and SPECT findings in never-treated schizophrenia, Acta Psychiatr Scand, vol.96, issue.1, pp.51-57, 1997.

A. M. Catafau, E. Parellada, F. J. Lomeña, M. Bernardo, J. Pavía et al., Prefrontal and temporal blood flow in schizophrenia: resting and activation technetium-99m-HMPAO SPECT patterns in young neuroleptic-naive patients with acute disease, J Nucl Med Off Publ Soc Nucl Med, vol.35, issue.6, pp.935-941, 1994.

N. C. Andreasen, The American concept of schizophrenia, Schizophr Bull, vol.15, issue.4, p.519, 1989.

B. K. Puri, S. B. Hutton, N. Saeed, A. Oatridge, J. V. Hajnal et al., A serial longitudinal quantitative MRI study of cerebral changes in first-episode schizophrenia using image segmentation and subvoxel registration, Psychiatry Res Neuroimaging, vol.106, issue.2, pp.141-150, 2001.

T. Kohno, T. Shiga, I. Kusumi, T. Matsuyama, H. Kageyama et al., Left temporal perfusion associated with suspiciousness score on the Brief Psychiatric Rating Scale in schizophrenia, Psychiatry Res Neuroimaging, vol.147, issue.2, pp.163-171, 2006.

E. Parellada, A. M. Catafau, M. Bernardo, F. Lomeña, S. Catarineu et al., The resting and activation issue of hypofrontality: a single photon emission computed tomography study in neuroleptic-naive and neuroleptic-free schizophrenic female patients, Biol Psychiatry, vol.44, issue.8, pp.787-790, 1998.

M. T. Strassnig, T. Raykov, C. O'gorman, C. R. Bowie, S. Sabbag et al., Determinants of different aspects of everyday outcome in schizophrenia: the roles of negative symptoms, cognition, and functional capacity, Schizophr Res, vol.165, issue.1, pp.76-82, 2015.

J. Ventura, K. L. Subotnik, M. J. Gitlin, D. Gretchen-doorly, A. Ered et al., Negative symptoms and functioning during the first year after a recent onset of schizophrenia and 8years later, Schizophr Res, vol.161, issue.2, pp.407-413, 2015.

A. F. Lehman, S. Possidente, and F. Hawker, The quality of life of chronic patients in a state hospital and in community residences, Psychiatr Serv, vol.37, issue.9, pp.901-907, 1986.

A. F. Lehman, A quality of life interview for the chronically mentally ill, Eval Program Plann, vol.11, issue.1, pp.51-62, 1988.

A. Zissi, M. M. Barry, and R. Cochrane, A mediational model of quality of life for individuals with severe mental health problems, Psychol Med, vol.28, issue.5, pp.1221-1230, 1998.

M. S. Ritsner, Predicting quality of life impairment in chronic schizophrenia from cognitive variables, Qual Life Res, vol.16, issue.6, pp.929-937, 2007.

P. Auquier, M. C. Simeoni, C. Sapin, R. G. Aghababian, V. Cramer et al., Development and validation of a patient-based health-related quality of life questionnaire in schizophrenia: the SQoL, Schizophr Res, vol.63, issue.1, pp.137-149, 2003.

C. Lançon, G. Reine, M. Simeoni, V. Aghababian, and P. Auquier, Développement et validation d'un instrument d'auto-évaluation de la qualité de vie des patients souffrant de schizophrénie: la SQoL, L'Encéphale, vol.33, issue.3, pp.277-284, 2007.

K. C. Calman, Quality of life in cancer patients-an hypothesis, J Med Ethics, vol.10, issue.3, pp.124-127, 1984.

L. Boyer, M. Simeoni, A. Loundou, D. 'amato, T. et al., The development of the S-QoL 18: a shortened quality of life questionnaire for patients with schizophrenia, Schizophr Res, vol.121, issue.1, pp.241-250, 2010.

J. A. Cramer, R. Rosenheck, W. Xu, J. Thomas, W. Henderson et al., Quality of life in schizophrenia: A comparison of instruments, Schizophr Bull, vol.26, issue.3, p.659, 2000.

C. Chou, M. Ma, and Y. , Determinants of subjective health-related quality of life (HRQoL) for patients with schizophrenia, Schizophr Res, vol.154, issue.1, pp.83-88, 2014.

Y. Xiang, Y. Weng, C. Leung, W. Tang, and G. S. Ungvari, Quality of life of Chinese schizophrenia outpatients in Hong Kong: relationship to sociodemographic factors and symptomatology, Aust N Z J Psychiatry, vol.41, issue.5, pp.442-449, 2007.

S. Marwaha, S. Johnson, P. Bebbington, M. C. Angermeyer, T. Brugha et al., Correlates of subjective quality of life in people with schizophrenia: findings from the EuroSC study, J Nerv Ment Dis, vol.196, issue.2, pp.87-94, 2008.

H. Aki, M. Tomotake, Y. Kaneda, J. Iga, S. Kinouchi et al., Subjective and objective quality of life, levels of life skills, and their clinical determinants in outpatients with schizophrenia, Psychiatry Res, vol.158, issue.1, pp.19-25, 2008.

K. I. Fredriksen-goldsen, H. Kim, C. Shiu, J. Goldsen, and C. A. Emlet, Successful aging among LGBT older adults: Physical and mental health-related quality of life by age group, The Gerontologist, vol.55, issue.1, pp.154-168, 2014.

T. L. Sota and R. W. Heinrichs, Demographic, clinical, and neurocognitive predictors of quality of life in schizophrenia patients receiving conventional neuroleptics, Compr Psychiatry, vol.45, issue.5, pp.415-421, 2004.

V. Aghababian, P. Auquier, K. Baumstarck-barrau, and C. Lancon, Relationship between insight and selfreported quality of life among shizophrenic patients, L'Encephale, vol.37, issue.3, pp.162-171, 2011.

A. Bechdolf, J. Klosterkötter, M. Hambrecht, B. Knost, C. Kuntermann et al., Determinants of subjective quality of life in post acute patients with schizophrenia, Eur Arch Psychiatry Clin Neurosci, vol.253, issue.5, pp.228-235, 2003.

W. W. Ho, M. Y. Chiu, W. T. Lo, and M. G. Yiu, Recovery components as determinants of the health-related quality of life among patients with schizophrenia: structural equation modelling analysis, Aust N Z J Psychiatry, vol.44, issue.1, pp.71-84, 2010.

M. Eklund and M. Bäckström, A model of subjective quality of life for outpatients with schizophrenia and other psychoses, Qual Life Res, vol.14, issue.4, pp.1157-1168, 2005.

J. M. Narvaez, E. W. Twamley, C. L. Mckibbin, R. K. Heaton, and T. L. Patterson, Subjective and objective quality of life in schizophrenia, Schizophr Res, vol.98, issue.1, pp.201-208, 2008.

M. Lambert, A. Karow, S. Leucht, B. G. Schimmelmann, and D. Naber, Remission in schizophrenia: validity, frequency, predictors, and patients' perspective 5 years later, Dialogues Clin Neurosci, vol.12, issue.3, p.393, 2010.

B. Carpiniello, F. Pinna, M. Tusconi, E. Zaccheddu, and F. Fatteri, Gender differences in remission and recovery of schizophrenic and schizoaffective patients: preliminary results of a prospective cohort study, Schizophr Res Treat, 2012.

M. Lambert, D. Naber, A. Schacht, T. Wagner, H. Hundemer et al., Rates and predictors of remission and recovery during 3 years in 392 never-treated patients with schizophrenia, Acta Psychiatr Scand, vol.118, issue.3, pp.220-229, 2008.

G. Fervaha, G. Foussias, O. Agid, and R. G. , Motivational deficits in early schizophrenia: prevalent, persistent, and key determinants of functional outcome, Schizophr Res, vol.166, issue.1, pp.9-16, 2015.

A. Karow, L. Wittmann, D. Schöttle, I. Schäfer, and M. Lambert, The assessment of quality of life in clinical practice in patients with schizophrenia, Dialogues Clin Neurosci, vol.16, issue.2, p.185, 2014.

L. Boyer, A. Millier, E. Perthame, S. Aballea, P. Auquier et al., Quality of life is predictive of relapse in schizophrenia, BMC Psychiatry. 9 janv, vol.13, issue.1, p.15, 2013.

J. M. Haro, D. Novick, E. Perrin, J. Bertsch, and M. Knapp, Symptomatic remission and patient quality of life in an observational study of schizophrenia: is there a relationship?, Psychiatry Res, vol.220, issue.1, pp.163-169, 2014.

A. E. Cancelliere and A. Kertesz, Lesion localization in acquired deficits of emotional expression and comprehension, Brain Cogn, vol.13, issue.2, pp.133-147, 1990.

M. Mesulam and E. J. Mufson, Insula of the old world monkey. III: Efferent cortical output and comments on function, J Comp Neurol, vol.212, issue.1, pp.38-52, 1982.

M. Mesulam, Principles of behavioral and cognitive neurology

. Disponible, books?hl=fr&lr=&id=kezqJb69OlAC&oi=fnd&pg=PR13&dq=(Mesulam,+2000)&ots=EzX0fL0GjN&s ig=yvkusvr3Z6eH6FpUcwFsDiZ2jIA

K. C. Berridge and M. L. Kringelbach, Affective neuroscience of pleasure: reward in humans and animals, Psychopharmacology (Berl), vol.199, issue.3, pp.457-480, 2008.

R. Cunnington, C. Windischberger, S. Robinson, and E. Moser, The selection of intended actions and the observation of others' actions: a time-resolved fMRI study, Neuroimage, vol.29, issue.4, pp.1294-1302, 2006.

P. Cardoso-leite and D. Bavelier, Video game play, attention, and learning: how to shape the development of attention and influence learning?, Curr Opin Neurol, vol.27, issue.2, pp.185-191, 2014.

E. Filevich and P. Haggard, Persistence of internal representations of alternative voluntary actions, Front Psychol, 2013.

A. Duque, D. Coman, B. C. Carlyle, K. A. Bordner, E. D. George et al., Neuroanatomical changes in a mouse model of early life neglect, Brain Struct Funct, vol.217, issue.2, pp.459-472, 2012.

F. Brunelle, A. Saitovitch, N. Boddaert, D. Grevent, J. Cambier et al., Human interaction, social cognition, and the superior temporal sulcus, Bull Acad Natl Med, vol.197, issue.4-5, pp.817-845, 2012.
URL : https://hal.archives-ouvertes.fr/hal-01253346

U. Frith and C. D. Frith, Development and neurophysiology of mentalizing, Philos Trans R Soc Lond B Biol Sci, vol.358, pp.459-473, 1431.

B. A. Völlm, A. N. Taylor, P. Richardson, R. Corcoran, J. Stirling et al., Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task, Neuroimage, vol.29, issue.1, pp.90-98, 2006.

W. Li, X. Mai, and C. Liu, The default mode network and social understanding of others: what do brain connectivity studies tell us. Front Hum Neurosci, vol.8, 2014.

J. Schultz, H. Imamizu, M. Kawato, and C. D. Frith, Activation of the human superior temporal gyrus during observation of goal attribution by intentional objects, J Cogn Neurosci, vol.16, issue.10, pp.1695-1705, 2004.

R. Saxe and N. Kanwisher, People thinking about thinking people: the role of the temporo-parietal junction in "theory of mind, Neuroimage, vol.19, issue.4, pp.1835-1842, 2003.

C. Mcgettigan, E. Walsh, R. Jessop, Z. K. Agnew, D. A. Sauter et al., Individual differences in laughter perception reveal roles for mentalizing and sensorimotor systems in the evaluation of emotional authenticity, Cereb Cortex, vol.25, issue.1, pp.246-257, 2013.

F. Schneider, R. C. Gur, K. Koch, V. Backes, K. Amunts et al., Impairment in the specificity of emotion processing in schizophrenia, Am J Psychiatry, vol.163, issue.3, pp.442-447, 2006.

L. M. Ritter, J. H. Meador-woodruff, and G. W. Dalack, Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia, Schizophr Res, vol.68, issue.1, pp.65-73, 2004.

H. Hori, R. Yoshimura, A. Katsuki, K. Atake, and J. Nakamura, Relationships between brain-derived neurotrophic factor, clinical symptoms, and decision-making in chronic schizophrenia: data from the Iowa Gambling Task. Front Behav Neurosci, vol.8, 2014.

M. Solms and O. Turnbull, The brain and the inner world: An introduction to the neuroscience of subjective experience

, Karnac Books, pp.8-15, 2002.

K. Baumstarck, L. Boyer, M. Boucekine, V. Aghababian, N. Parola et al., Self-reported quality of life measure is reliable and valid in adult patients suffering from schizophrenia with executive impairment, Schizophr Res, vol.147, issue.1, pp.58-67, 2013.

M. Ruggeri, G. Bisoffi, L. Fontecedro, and R. Warner, Subjective and objective dimensions of quality of life in psychiatric patients: a factor analytical approach, Br J Psychiatry, vol.178, issue.3, pp.268-275, 2001.

L. Hansson and T. Björkman, Are factors associated with subjective quality of life in people with severe mental illness consistent over time?-A 6-year follow-up study, Qual Life Res, vol.16, issue.1, pp.9-16, 2007.

M. S. Ritsner, M. Arbitman, A. Lisker, and A. M. Ponizovsky, Ten-year quality of life outcomes among patients with schizophrenia and schizoaffective disorder II. Predictive value of psychosocial factors, Qual Life Res, vol.21, issue.6, pp.1075-1084, 2012.

C. Faget-agius, L. Boyer, R. Padovani, R. Richieri, O. Mundler et al., Schizophrenia with preserved insight is associated with increased perfusion of the precuneus, J Psychiatry Neurosci JPN, vol.37, issue.5, p.297, 2012.

, Association AP, others. Diagnostic and statistical manual of mental disorders (DSM-5®)

G. T. Appelberg and J. W. Fleming, Distributed emergency lighting system having self-testing and diagnostic capabilities, 2004.

D. Addington, J. Addington, and B. Schissel, A depression rating scale for schizophrenics, Schizophr Res, vol.3, issue.4, pp.247-251, 1990.

S. R. Kay, A. Fiszbein, and L. A. Opfer, The positive and negative syndrome scale (PANSS) for schizophrenia, Schizophr Bull, vol.13, issue.2, p.261, 1987.

K. Thompson, J. Kulkarni, and A. A. Sergejew, Reliability and validity of a new Medication Adherence Rating Scale (MARS) for the psychoses, Schizophr Res, vol.42, issue.3, pp.241-247, 2000.

R. Richieri, L. Boyer, J. Farisse, C. Colavolpe, O. Mundler et al., Predictive value of brain perfusion SPECT for rTMS response in pharmacoresistant depression, Eur J Nucl Med Mol Imaging, vol.38, issue.9, pp.1715-1722, 2011.

N. Tzourio-mazoyer, B. Landeau, D. Papathanassiou, F. Crivello, O. Etard et al., Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain, Neuroimage, vol.15, issue.1, pp.273-289, 2002.

E. Guedj, E. J. Barbeau, M. Didic, O. Felician, C. De-laforte et al., Identification of subgroups in amnestic mild cognitive impairment, Neurology, vol.67, issue.2, pp.356-358, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00111068

P. B. Fitzgerald, A. R. De-castella, F. K. Collins, J. Brewer, K. Williams et al., A longitudinal study of patient-and observer-rated quality of life in schizophrenia, Psychiatry Res, vol.119, issue.1, pp.55-62, 2003.

M. Ritsner, A. Gibel, and Y. Ratner, Determinants of changes in perceived quality of life in the course of schizophrenia, Qual Life Res, vol.15, issue.3, pp.515-526, 2006.

S. Priebe, U. Roeder-wanner, and W. Kaiser, Quality of life in first-admitted schizophrenia patients: a follow-up study, Psychol Med, vol.30, issue.1, pp.225-230, 2000.

F. Holloway and J. Carson, Subjective quality of life, psychopathology, satisfaction with care and insight: an exploratory study, Int J Soc Psychiatry, vol.45, issue.4, pp.259-267, 1999.

J. W. Kasckow, E. Twamley, J. J. Mulchahey, B. Carroll, M. Sabai et al., Health-related quality of well-being in chronically hospitalized patients with schizophrenia: comparison with matched outpatients, Psychiatry Res, vol.103, issue.1, pp.69-78, 2001.

S. M. Eack and C. E. Newhill, Psychiatric symptoms and quality of life in schizophrenia: a meta-analysis, Schizophr Bull, vol.33, issue.5, pp.1225-1237, 2007.

E. S. Gardsjord, K. L. Romm, S. Friis, H. E. Barder, J. Evensen et al., Subjective quality of life in first-episode psychosis. A ten year follow-up study, Schizophr Res, vol.172, issue.1, pp.23-28, 2016.

G. Reine, C. Lancon, D. Tucci, S. Sapin, C. Auquier et al., Depression and subjective quality of life in chronic phase schizophrenic patients, Acta Psychiatr Scand, vol.108, issue.4, pp.297-303, 2003.

A. L. Stewart and J. E. Ware, Measuring functioning and well-being: the medical outcomes study approach, 1992.

A. Akinsulore, O. O. Aloba, B. M. Mapayi, I. O. Oloniniyi, F. O. Fatoye et al., Relationship between depressive symptoms and quality of life in Nigerian patients with schizophrenia, Soc Psychiatry Psychiatr Epidemiol, vol.49, issue.8, pp.1191-1198, 2014.

N. A. Shargh, B. Rostami, B. Kosari, Z. Toosi, and G. A. Majelan, Study of relationship between depression and quality of life in patients with chronic schizophrenia, Glob J Health Sci, vol.8, issue.3, p.224, 2016.

J. D. Huppert, K. A. Weiss, R. Lim, S. Pratt, and T. E. Smith, Quality of life in schizophrenia: contributions of anxiety and depression, Schizophr Res, vol.51, issue.2, pp.171-180, 2001.

N. Sönmez, K. L. Romm, O. A. Andreasssen, I. Melle, and J. I. Røssberg, Depressive symptoms in first episode psychosis: a one-year follow-up study, BMC Psychiatry, vol.13, issue.1, p.106, 2013.

Y. Chou, N. Chiu, Y. Feng, J. Chan, C. Lee et al., An early improvement in depressive symptoms predicts symptomatic remission of schizophrenia treated with quetiapine: a multicenter, 4-week case-control study, Int Clin Psychopharmacol, vol.28, issue.5, pp.255-260, 2013.

C. I. Cohen, A. Vengassery, and E. Aracena, A Longitudinal Analysis of Quality of Life and Associated Factors in Older Adults with Schizophrenia Spectrum Disorder, Am J Geriatr Psychiatry, 2017.

. Disponible,

A. Rayan and . Mindfulness, Quality of Life, and Severity of Depressive Symptoms Among Patients With Schizophrenia and Patients With Major Depressive Disorder, J Psychosoc Nurs Ment Health Serv, vol.55, issue.5, pp.40-50, 2017.

T. Behdinan, G. Foussias, A. L. Wheeler, L. Stefanik, D. Felsky et al., Neuroimaging predictors of functional outcomes in schizophrenia at baseline and 6-month follow-up, Schizophr Res, vol.169, issue.1, pp.69-75, 2015.

W. Cahn, H. Pol, E. B. Lems, N. E. Van-haren, H. G. Schnack et al., Brain volume changes in first-episode schizophrenia: a 1-year follow-up study, Arch Gen Psychiatry, vol.59, issue.11, pp.1002-1010, 2002.

T. Kasparek, R. Prikryl, D. Schwarz, H. Kucerova, R. Marecek et al., Gray matter morphology and the level of functioning in one-year follow-up of first-episode schizophrenia patients, Prog Neuropsychopharmacol Biol Psychiatry, vol.33, issue.8, pp.1438-1446, 2009.

D. , A. , C. F. Van-der-linden, M. Laureys, S. et al., Selfreferential reflective activity and its relationship with rest: a PET study, Neuroimage, vol.25, issue.2, pp.616-624, 2005.

R. Herold, A. Feldmann, M. Simon, T. Tenyi, F. Kövér et al., Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia: a voxel-based morphometric study, Acta Psychiatr Scand, vol.119, issue.3, pp.199-208, 2009.

F. Benedetti, A. Bernasconi, M. Bosia, R. Cavallaro, S. Dallaspezia et al., Functional and structural brain correlates of theory of mind and empathy deficits in schizophrenia, Schizophr Res, vol.114, issue.1, pp.154-160, 2009.

I. H. Park, J. Ku, H. Lee, S. Y. Kim, S. I. Kim et al., Disrupted theory of mind network processing in response to idea of reference evocation in schizophrenia, Acta Psychiatr Scand, vol.123, issue.1, pp.43-54, 2011.

K. Jimura, S. Konishi, and Y. Miyashita, Temporal pole activity during perception of sad faces, but not happy faces, correlates with neuroticism trait, Neurosci Lett, vol.453, issue.1, pp.45-48, 2009.

E. Stip, C. Fahim, P. Liddle, A. Mancini-marïe, B. Mensour et al., Neural correlates of sad feelings in schizophrenia with and without blunted affect, Can J Psychiatry, vol.50, issue.14, pp.909-917, 2005.

C. Lamm and T. Singer, The role of anterior insular cortex in social emotions, Brain Struct Funct, vol.214, issue.5-6, pp.579-591, 2010.

X. Gu, P. R. Hof, K. J. Friston, and J. Fan, Anterior insular cortex and emotional awareness, J Comp Neurol, vol.521, issue.15, pp.3371-3388, 2013.

M. L. Phillips, L. Williams, C. Senior, E. T. Bullmore, M. J. Brammer et al., A differential neural response to threatening and non-threatening negative facial expressions in paranoid and non-paranoid schizophrenics, Psychiatry Res Neuroimaging, vol.92, issue.1, pp.11-31, 1999.

P. G. Michalopoulou, S. Surguladze, L. A. Morley, V. P. Giampietro, R. M. Murray et al., Facial fear processing and psychotic symptoms in schizophrenia: functional magnetic resonance imaging study, Br J Psychiatry, vol.192, issue.3, pp.191-196, 2008.

L. Williams, P. Das, B. J. Liddell, G. Olivieri, A. S. Peduto et al., Fronto-limbic and autonomic disjunctions to negative emotion distinguish schizophrenia subtypes, Psychiatry Res Neuroimaging, vol.155, issue.1, pp.29-44, 2007.

K. P. Wylie and J. R. Tregellas, The role of the insula in schizophrenia, Schizophr Res, vol.123, issue.2, pp.93-104, 2010.

T. Liu, Y. Chen, J. Hsieh, and L. Chen, Asymmetric engagement of amygdala and its gamma connectivity in early emotional face processing, PloS One, vol.10, issue.1, p.115677, 2015.

M. Zelikowsky, S. Hersman, M. K. Chawla, C. A. Barnes, and M. S. Fanselow, Neuronal ensembles in amygdala, hippocampus, and prefrontal cortex track differential components of contextual fear, J Neurosci, vol.34, issue.25, pp.8462-8466, 2014.

P. H. Janak and K. M. Tye, From circuits to behaviour in the amygdala, Nature, vol.517, issue.7534, p.284, 2015.

U. Habel, N. Chechko, K. Pauly, K. Koch, V. Backes et al., Neural correlates of emotion recognition in schizophrenia, Schizophr Res, vol.122, issue.1, pp.113-123, 2010.

K. Pauly, T. Kircher, J. Weber, F. Schneider, and U. Habel, Self-concept, emotion and memory performance in schizophrenia, Psychiatry Res, vol.186, issue.1, pp.11-17, 2011.

H. Li, R. C. Chan, G. M. Mcalonan, and Q. Gong, Facial emotion processing in schizophrenia: a metaanalysis of functional neuroimaging data, Schizophr Bull, vol.36, issue.5, pp.1029-1039, 2009.

A. Anticevic, J. X. Van-snellenberg, R. E. Cohen, G. Repovs, E. C. Dowd et al., Amygdala recruitment in schizophrenia in response to aversive emotional material: a meta-analysis of neuroimaging studies, Schizophr Bull, vol.38, issue.3, pp.608-621, 2010.

A. G. Awad and L. N. Voruganti, Impact of atypical antipsychotics on quality of life in patients with schizophrenia, CNS Drugs, vol.18, issue.13, pp.877-893, 2004.

L. Zouari, J. B. Thabet, Z. Elloumi, M. Elleuch, N. Zouari et al., Quality of life in patients with schizophrenia: a study of 100 cases, L'Encephale, vol.38, issue.2, pp.111-117, 2012.