D. Yvon, The discovery and history of resveratrol

, Articles Factory, 2013.

, The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. WHO MONICA Project Principal Investigators, J Clin Epidemiol, vol.41, issue.2, pp.105-119, 1988.

J. M. Guilford and J. M. Pezzuto, Wine and Health: A Review, Am J Enol Vitic. 1 déc, vol.62, issue.4, pp.471-86, 2011.

I. Ahuja, R. Kissen, and A. M. Bones, Phytoalexins in defense against pathogens, Trends Plant Sci. févr, vol.17, issue.2, pp.73-90, 2012.

W. Wang, K. Tang, H. Yang, P. Wen, P. Zhang et al., Distribution of resveratrol and stilbene synthase in young grape plants (Vitis vinifera L. cv. Cabernet Sauvignon) and the effect of UV-C on its accumulation, Plant Physiol Biochem. févr, vol.48, issue.2-3, pp.142-52, 2010.

M. Iriti and F. Faoro, Bioactivity of grape chemicals for human health, Nat Prod Commun. mai, vol.4, issue.5, pp.611-645, 2009.

G. Malacarne, U. Vrhovsek, L. Zulini, A. Cestaro, M. Stefanini et al., Resistance to Plasmopara viticola in a grapevine segregating population is associated with stilbenoid accumulation and with specific host transcriptional responses, BMC Plant Biol. 12 août, vol.11, p.114, 2011.

M. Polesani, L. Bortesi, A. Ferrarini, A. Zamboni, M. Fasoli et al., General and species-specific transcriptional responses to downy mildew infection in a susceptible (Vitis vinifera) and a resistant (V. riparia) grapevine species, BMC Genomics. 18 févr, vol.11, p.117, 2010.

C. Parage, Génomique fonctionnelle de la biosynthèse des stilbènes chez la vigne (Vitis vinifera

. Disponible,

P. Jeandet, A. Douillet-breuil, R. Bessis, S. Debord, M. Sbaghi et al., Phytoalexins from the Vitaceae: biosynthesis, phytoalexin gene expression in transgenic plants, antifungal activity, and metabolism, J Agric Food Chem. 8 mai, vol.50, issue.10, pp.2731-2772, 2002.

, Showing all polyphenols found in Wine [Red]-Phenol-Explorer

. Histoire-le-vin-en-france-vins-de-france, , 2016.

, Fabrication du vin | Vin | ABC du vin et de l'alcool

S. , , 2016.

. Disponible,

V. L. Singleton, R. Orthofer, and R. M. Lamuela-raventós, Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent, Methods in Enzymology, vol.299, pp.152-78, 1999.

J. D. Everette, Q. M. Bryant, A. M. Green, Y. A. Abbey, G. W. Wangila et al., Thorough Study of Reactivity of Various Compound Classes toward the Folin?Ciocalteu Reagent, J Agric Food Chem. 28 juill, vol.58, issue.14, pp.8139-8183, 2010.

A. I. Romero-pérez, R. M. Lamuela-raventós, C. Andrés-lacueva, and M. C. De-la-torre-boronat, Method for the quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the stilbene content, J Agric Food Chem. janv, vol.49, issue.1, pp.210-215, 2001.

M. Gatti, Evaluation de l'effet du terroir sur la teneur en stilbènes du vin, 2012.

U. Stervbo, O. Vang, and C. Bonnesen, A review of the content of the putative chemopreventive phytoalexin resveratrol in red wine, Food Chem, vol.101, issue.2, pp.449-57, 2007.

I. Garaguso and M. Nardini, Polyphenols content, phenolics profile and antioxidant activity of organic red wines produced without sulfur dioxide/sulfites addition in comparison to conventional red wines, Food Chem. 15 juill, vol.179, pp.336-378, 2015.

J. Mulero, F. Pardo, and P. Zafrilla, Antioxidant activity and phenolic composition of organic and conventional grapes and wines, J Food Compos Anal. 1 sept, vol.23, issue.6, pp.569-74, 2010.

I. V. Vr?ek, M. Boji?, I. ?untar, G. Menda?, and M. Medi?-?ari?, Phenol content, antioxidant activity and metal composition of Croatian wines deriving from organically and conventionally grown grapes, Food Chem. 1 janv, vol.124, issue.1, pp.354-61, 2011.

K. E. Heim, A. R. Tagliaferro, and D. J. Bobilya, Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships, J Nutr Biochem, vol.13, issue.10, pp.572-84, 2002.

M. I. Kaldas, U. K. Walle, and T. Walle, Resveratrol transport and metabolism by human intestinal Caco-2 cells, J Pharm Pharmacol. mars, vol.55, issue.3, pp.307-319, 2003.
DOI : 10.1211/002235702612

T. Ozdal, D. A. Sela, J. Xiao, D. Boyacioglu, F. Chen et al., The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility, vol.6
DOI : 10.3390/nu8020078

URL : http://www.mdpi.com/2072-6643/8/2/78/pdf

A. L. Simons, M. Renouf, S. Hendrich, and P. A. Murphy, Human gut microbial degradation of flavonoids: structure-function relationships, J Agric Food Chem. 18 mai, vol.53, issue.10, pp.4258-63, 2005.

A. R. Rechner, G. Kuhnle, P. Bremner, G. P. Hubbard, K. P. Moore et al., The metabolic fate of dietary polyphenols in humans, Free Radic Biol Med. 15 juill, vol.33, issue.2, pp.220-255, 2002.

C. Manach, A. Scalbert, C. Morand, C. Rémésy, and L. Jiménez, Polyphenols: food sources and bioavailability, Am J Clin Nutr. 1 mai, vol.79, issue.5, pp.727-774, 2004.
DOI : 10.1093/ajcn/79.5.727

URL : https://academic.oup.com/ajcn/article-pdf/79/5/727/23713284/znu00504000727.pdf

D. Su, Y. Cheng, M. Liu, D. Liu, H. Cui et al., Comparision of piceid and resveratrol in antioxidation and antiproliferation activities in vitro, PloS One, vol.8, issue.1, p.54505, 2013.

A. Jennings, A. Macgregor, T. Spector, and A. Cassidy, Higher dietary flavonoid intakes are associated with lower objectively measured body composition in women: evidence from discordant monozygotic twins, Am J Clin Nutr. mars, vol.105, issue.3, pp.626-660, 2017.
DOI : 10.3945/ajcn.116.144394

URL : https://academic.oup.com/ajcn/article-pdf/105/3/626/23800377/ajcn144394.pdf

M. J. Kruger, N. Davies, K. H. Myburgh, and S. Lecour, Proanthocyanidins, anthocyanins and cardiovascular diseases, Food Res Int. 1 mai, vol.59, pp.41-52, 2014.
DOI : 10.1016/j.foodres.2014.01.046

M. Castell, F. J. Pérez-cano, M. Abril-gil, and À. Franch, Flavonoids on allergy, Curr Pharm Des, vol.20, issue.6, pp.973-87, 2014.
DOI : 10.2174/13816128113199990041

E. Middleton, Effect of plant flavonoids on immune and inflammatory cell function, Adv Exp Med Biol, vol.439, pp.175-82, 1998.

K. Beking and A. Vieira, Flavonoid intake and disability-adjusted life years due to Alzheimer's and related dementias: a population-based study involving twenty-three developed countries, Public Health Nutr. sept, vol.13, issue.9, pp.1403-1412, 2010.
DOI : 10.1017/s1368980009992990

URL : https://www.cambridge.org/core/services/aop-cambridge-core/content/view/ECDB83166F5FDAA1C792B73E9E5FBEDC/S1368980009992990a.pdf/div-class-title-flavonoid-intake-and-disability-adjusted-life-years-due-to-alzheimer-s-and-related-dementias-a-population-based-study-involving-twenty-three-developed-countries-div.pdf

S. Renaud and M. De-lorgeril, Wine, alcohol, platelets, and the French paradox for coronary heart disease. The Lancet, juin, vol.20, issue.8808, pp.1523-1529, 1992.
DOI : 10.1016/0140-6736(92)91277-f

URL : https://hal.archives-ouvertes.fr/hal-00395771

C. Faggio, A. Sureda, S. Morabito, A. Sanches-silva, A. Mocan et al., Flavonoids and platelet aggregation: A brief review, Eur J Pharmacol. 15 juill, vol.807, pp.91-101, 2017.
DOI : 10.1016/j.ejphar.2017.04.009

J. Choi, S. Park, S. Kim, and S. Kim, Kaempferol inhibits thrombosis and platelet activation, Biochimie. 1 août, vol.115, pp.177-86, 2015.
DOI : 10.1016/j.biochi.2015.06.001

A. Bub, B. Watzl, D. Heeb, G. Rechkemmer, and K. Briviba, Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice, Eur J Nutr. 1 juin, vol.40, issue.3, pp.113-133, 2001.

D. Ravishankar, A. K. Rajora, F. Greco, and H. Osborn, Flavonoids as prospective compounds for anti-cancer therapy, Int J Biochem Cell Biol. 1 déc, vol.45, issue.12, pp.2821-2852, 2013.
DOI : 10.1016/j.biocel.2013.10.004

Y. C. Xu, S. Leung, G. Leung, and R. Man, Kaempferol enhances endotheliumdependent relaxation in the porcine coronary artery through activation of largeconductance a2+-activated K+ channels, Br J Pharmacol. juin, vol.172, issue.12, pp.3003-3017, 2015.

D. Raffa, B. Maggio, M. V. Raimondi, F. Plescia, and G. Daidone, Recent discoveries of anticancer flavonoids, Eur J Med Chem. 15 déc, vol.142, pp.213-241, 2017.
DOI : 10.1016/j.ejmech.2017.07.034

URL : http://www.elsevier.com/journals/european-journal-of-medicinal-chemistry/0223-5234?generatepdf=true

G. Agullo, L. Gamet-payrastre, S. Manenti, C. Viala, C. Rémésy et al., Relationship between flavonoid structure and inhibition of phosphatidylinositol, pp.3-94

, kinase: A comparison with tyrosine kinase and protein kinase C inhibition, Biochem Pharmacol. 1 juin, vol.53, issue.11, pp.1649-57, 1997.

L. Gamet-payrastre, S. Manenti, M. Gratacap, J. Tulliez, H. Chap et al., Flavonoids and the inhibition of PKC and PI 3-kinase, Gen Pharmacol Vasc Syst. 1 mars, vol.32, issue.3, pp.279-86, 1999.

J. Shay, H. A. Elbaz, I. Lee, S. P. Zielske, M. H. Malek et al., Molecular Mechanisms and Therapeutic Effects of (?)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration

O. Medicine and C. Longevity, , 2015.

M. Kim, G. R. Ryu, J. Kang, S. S. Sim, D. S. Min et al., Inhibitory effects of epicatechin on interleukin-1?-induced inducible nitric oxide synthase expression in RINm5F cells and rat pancreatic islets by down-regulation of NF-?B activation, Biochem Pharmacol, vol.68, issue.9, pp.1775-85, 2004.

I. Bernatova, Biological activities of (?)-epicatechin and (?)-epicatechin-containing foods: Focus on cardiovascular and neuropsychological health, Biotechnol Adv. 1 mai, vol.36, issue.3, pp.666-81, 2018.

, Interactions of epigallo-catechin 3-gallate and ovalbumin, the major allergen of egg white-ScienceDirect

Z. Pons, M. Margalef, F. I. Bravo, A. Arola-arnal, and B. Muguerza, Grape seed flavanols decrease blood pressure via Sirt-1 and confer a vasoprotective pattern in rats, J Funct Foods. 1 juin, vol.24, pp.164-72, 2016.

, EGCG suppresses prostate cancer cell growth modulating acetylation of androgen receptor by anti-histone acetyltransferase activity

. Disponible,

K. Chira, J. Suh, C. Saucier, and P. Teissèdre, Les polyphénols du raisin. Phytothérapie. 1 avr, vol.6, issue.2, pp.75-82, 2008.

H. E. Khoo, A. Azlan, S. T. Tang, and S. M. Lim, Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits, Food Nutr Res, vol.13, issue.2017, p.61

T. Frank, M. Netzel, G. Strass, R. Bitsch, and I. Bitsch, Bioavailability of anthocyanidin-3glucosides following consumption of red wine and red grape juice, Can J Physiol Pharmacol. 1 mai, vol.81, issue.5, pp.423-458, 2003.

C. Czank, A. Cassidy, Q. Zhang, D. J. Morrison, T. Preston et al., Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study, Am J Clin Nutr. mai, vol.97, issue.5, pp.995-1003, 2013.

A. Garcia-brugger, O. Lamotte, E. Vandelle, S. Bourque, D. Lecourieux et al., Early Signaling Events Induced by Elicitors of Plant Defenses, Mol Plant Microbe Interact. 1 juill, vol.19, issue.7, pp.711-735, 2006.

P. Jeandet, B. Delaunois, A. Conreux, D. Donnez, V. Nuzzo et al., Biosynthesis, metabolism, molecular engineering, and biological functions of stilbene phytoalexins in plants, BioFactors Oxf Engl, vol.36, issue.5, pp.331-372, 2010.

W. Wang, K. Tang, H. Yang, P. Wen, P. Zhang et al., Distribution of resveratrol and stilbene synthase in young grape plants (Vitis vinifera L. cv. Cabernet Sauvignon) and the effect of UV-C on its accumulation, Plant Physiol Biochem PPB. mars, vol.48, issue.2-3, pp.142-52, 2010.

, Cours de SVT-Organisation fonctionnelle d'une plante-Maxicours.com

. Maxicours,

. Disponible, Tsp rappels Photosynthèse respiration

M. Svt and C. , , 2017.

, Grain de raisin : la baie-Banque de Schémas-SVT-Académie de Dijon

. Disponible,

, Trans-Resveratrol is found-PhenolExplorer

, Showing details for content value of Trans-Resveratrol in Wine [Red]-PhenolExplorer, p.60

M. Böhmdorfer, A. Szakmary, R. Schiestl, J. Vaquero, J. Riha et al., Involvement of UDP-Glucuronosyltransferases and Sulfotransferases in the Excretion and Tissue Distribution of Resveratrol in Mice, Nutrients. 12 déc, vol.9, issue.12, p.1347, 2017.

H. Piotrowska, M. Kucinska, and M. Murias, Biological activity of piceatannol: Leaving the shadow of resveratrol, Mutat Res Mutat Res. janv, vol.750, issue.1, pp.60-82, 2012.

N. Singh, M. Agrawal, and S. Doré, Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models, ACS Chem Neurosci. 21 août, vol.4, issue.8, pp.1151-62, 2013.

H. Li, N. Xia, and U. Förstermann, Cardiovascular effects and molecular targets of resveratrol, Nitric Oxide Biol Chem. 15 févr, vol.26, issue.2, pp.102-112, 2012.

M. Athar, J. H. Back, L. Kopelovich, D. R. Bickers, and A. L. Kim, Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms, Arch Biochem Biophys. 15 juin, vol.486, issue.2, pp.95-102, 2009.

T. Richard, H. Temsamani, J. Delaunay, S. Krisa, and J. Mérillon, Stilbènes : de la chimie à la neuroprotection, Cah Nutr Diététique. 1 sept, vol.49, issue.4, pp.173-80, 2014.

, World Health Organization, Organization WH. Global Status Report on Alcohol and Health, vol.389, 2014.

F. Santé-publique, Avis d'experts relatif à l'évolution du discours public en matière de consommation d'alcool en France organisé par Santé publique France et l'Institut national du cancer

, Questions & réponses-Comment puis-je boire de l'alcool sans risque ?

S. Belchí-navarro, L. Almagro, D. Lijavetzky, R. Bru, and M. A. Pedreño, Enhanced extracellular production of trans-resveratrol in Vitis vinifera suspension cultured cells by using cyclodextrins and methyljasmonate, Plant Cell Rep. janv, vol.31, issue.1, pp.81-90, 2012.

D. Lijavetzky, L. Almagro, S. Belchi-navarro, J. M. Martínez-zapater, R. Bru et al., Synergistic effect of methyljasmonate and cyclodextrin on stilbene biosynthesis pathway gene expression and resveratrol production in Monastrell grapevine cell cultures, BMC Res Notes. 22 déc, vol.1, p.132, 2008.

A. Belhadj, N. Telef, C. Saigne, S. Cluzet, F. Barrieu et al., Effect of methyl jasmonate in combination with carbohydrates on gene expression of PR proteins, stilbene and anthocyanin accumulation in grapevine cell cultures, Plant Physiol Biochem. avr, vol.46, issue.4, pp.493-502, 2008.

N. El-darra, Les composés phénoliques des raisins : étude du potentiel qualitatif et des procédés émergeants d'extraction, 2013.

. Disponible,

, Fruits et légumes : les Français suivent de moins en moins la recommandation

. Disponible,

, Un petit peu d'extrait de vin pour la santé Santé! | Result In Brief

C. Commission,

. Disponible,

, GAT Food Essentials-wowCAPS (microencapsulation) technology for stabilization of sensitive active ingredients for functional foods and beverages

, Nutrition and Health Claims-European Commission, Directive 2002/46/CE du Parlement européen et du Conseil du 10 juin 2002 relative au rapprochement des législations des États membres concernant les compléments alimentaires (Texte présentant de l'intérêt pour l'EEE), vol.183, 2002.