B. Prakken, S. Albani, and A. Martini, Juvenile idiopathic arthritis, Lancet Lond Engl, vol.377, issue.9783, pp.2138-2187, 2011.

M. S. Diamantberger, Du rhumatisme noueux (Polyarthrite déformante) chez les enfants. Thèse pour le doctoral en médecine, p.1891

G. F. Still, On a form of chronic joint disease in children, Medico-Chir Transcations, vol.80, p.47, 1897.

R. E. Petty, T. R. Southwood, P. Manners, J. Baum, D. N. Glass et al., International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, J Rheumatol, vol.31, issue.2, pp.390-392, 2001.

K. Oen, P. N. Malleson, D. A. Cabral, A. M. Rosenberg, R. E. Petty et al., Disease course and outcome of juvenile rheumatoid arthritis in a multicenter cohort, J Rheumatol, vol.29, issue.9, pp.1989-99, 2002.

M. Batthish and R. Schneider, Systemic Juvenile Idiopathic Arthritis, Handbook of Systemic Autoimmune Diseases, pp.53-84, 2016.

L. Berntson, A. Gäre, B. Fasth, A. Herlin, T. Kristinsson et al., Incidence of juvenile idiopathic arthritis in the Nordic countries. A population based study with special reference to the validity of the ILAR and EULAR criteria, J Rheumatol, vol.30, issue.10, pp.2275-82, 2003.

E. M. Behrens, T. Beukelman, L. Gallo, J. Spangler, M. Rosenkranz et al., Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR), J Rheumatol, vol.35, issue.2, pp.343-351, 2008.

P. Woo, T. R. Southwood, A. M. Prieur, C. J. Doré, J. Grainger et al., Randomized, placebocontrolled, crossover trial of low-dose oral methotrexate in children with extended oligoarticular or systemic arthritis, Arthritis Rheum, vol.43, issue.8, pp.1849-57, 2000.

F. De-benedetti, M. Massa, P. Robbioni, A. Ravelli, G. R. Burgio et al., Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis, Arthritis Rheum, vol.34, issue.9, pp.1158-63, 1991.

M. A. Muzaffer, J. Dayer, B. M. Feldman, W. Pruzanski, P. Roux-lombard et al., Differences in the profiles of circulating levels of soluble tumor necrosis factor receptors 40 and interleukin 1 receptor antagonist reflect the heterogeneity of the subgroups of juvenile rheumatoid arthritis, J Rheumatol, vol.29, issue.5, pp.1071-1079, 2002.

P. Quartier, P. Taupin, F. Bourdeaut, I. Lemelle, P. Pillet et al., Efficacy of etanercept for the treatment of juvenile idiopathic arthritis according to the onset type, Arthritis Rheum, vol.48, issue.4, pp.1093-101, 2003.

F. Prince, M. Twilt, R. Ten-cate, .. J. Van-rossum-m-a, W. Armbrust et al., Long-term follow-up on effectiveness and safety of etanercept in juvenile idiopathic arthritis: the Dutch national register, Ann Rheum Dis, vol.68, issue.5, pp.635-676, 2009.

M. H. Otten, F. Prince, W. Armbrust, R. Ten-cate, E. Hoppenreijs et al., Factors associated with treatment response to etanercept in juvenile idiopathic arthritis, JAMA, vol.306, issue.21, pp.2340-2347, 2011.

S. Yokota, T. Miyamae, T. Imagawa, S. Katakura, R. Kurosawa et al., Clinical study of tocilizumab in children with systemic-onset juvenile idiopathic arthritis, Clin Rev Allergy Immunol, vol.28, issue.3, pp.231-239, 2005.

S. Yokota, T. Imagawa, M. Mori, T. Miyamae, Y. Aihara et al., Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial, Lancet Lond Engl, vol.371, issue.9617, pp.998-1006, 2008.

P. Quartier, F. Allantaz, R. Cimaz, P. Pillet, C. Messiaen et al., A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial), Ann Rheum Dis, vol.70, issue.5, pp.747-54, 2011.

N. Ruperto, H. I. Brunner, P. Quartier, T. Constantin, N. Wulffraat et al., Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis, N Engl J Med, vol.367, issue.25, pp.2396-406, 2012.

D. Benedetti, F. Brunner, H. I. , R. N. Kenwright, A. Wright et al., Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis, N Engl J Med, vol.367, issue.25, pp.2385-95, 2012.

M. H. Otten, J. Anink, F. Prince, M. Twilt, S. J. Vastert et al., Trends in prescription of biological agents and outcomes of juvenile idiopathic arthritis: results of the Dutch national Arthritis and Biologics in Children Register, Ann Rheum Dis, vol.74, issue.7, pp.1379-86, 2015.

C. Modesto, P. Woo, J. García-consuegra, R. Merino, M. García-granero et al., Systemic onset juvenile chronic arthritis, polyarticular pattern and hip involvement as markers for a bad prognosis, Clin Exp Rheumatol, vol.19, issue.2, pp.211-218, 2001.

R. Russo and M. M. Katsicas, Patients with very early-onset systemic juvenile idiopathic arthritis exhibit more inflammatory features and a worse outcome, J Rheumatol, vol.40, issue.3, pp.329-363, 2013.

C. Lomater, V. Gerloni, M. Gattinara, J. Mazzotti, R. Cimaz et al., Systemic onset juvenile idiopathic arthritis: a retrospective study of 80 consecutive patients followed for 10 years, J Rheumatol, vol.27, issue.2, pp.491-497, 2000.

F. Fantini, V. Gerloni, M. Gattinara, R. Cimaz, C. Arnoldi et al., Remission in juvenile chronic arthritis: a cohort study of 683 consecutive cases with a mean 10 year followup, J Rheumatol, vol.30, issue.3, pp.579-84, 2003.

L. R. Spiegel, R. Schneider, B. A. Lang, N. Birdi, E. D. Silverman et al., Early predictors of poor functional outcome in systemic-onset juvenile rheumatoid arthritis: a multicenter cohort study, Arthritis Rheum, vol.43, issue.11, pp.2402-2411, 2000.

W. P. Bekkering, C. R. Van-suijlekom-smit, L. W. Mul, D. Van-der-velde, E. A. Van-den-ende et al., The relationship between impairments in joint function and disabilities in independent function in children with systemic juvenile idiopathic arthritis, J Rheumatol, vol.28, issue.5, pp.1099-105, 2001.

R. N. Hensinger, P. D. Devito, and C. G. Ragsdale, Changes in the cervical spine in juvenile rheumatoid arthritis, J Bone Joint Surg Am, vol.68, issue.2, pp.189-98, 1986.

J. C. Packham and M. A. Hall, Long-term follow-up of 246 adults with juvenile idiopathic arthritis: education and employment. Rheumatol Oxf Engl, vol.41, pp.1436-1445, 2002.

T. Odent, P. Journeau, A. Prieur, P. Touzet, J. Pouliquen et al., Cementless hip arthroplasty in juvenile idiopathic arthritis, J Pediatr Orthop, vol.25, issue.4, pp.465-70, 2005.

C. Mertelsmann-voss, S. Lyman, T. J. Pan, S. M. Goodman, M. P. Figgie et al., US trends in rates of arthroplasty for inflammatory arthritis including rheumatoid arthritis, juvenile idiopathic arthritis, and spondyloarthritis. Arthritis Rheumatol Hoboken NJ, vol.66, pp.1432-1441, 2014.

J. Cabane, A. Michon, J. M. Ziza, P. Bourgeois, O. Blétry et al., Comparison of long term evolution of adult onset and juvenile onset Still's disease, both followed up for more than 10 years, Ann Rheum Dis, vol.49, issue.5, pp.283-288, 1990.

M. Zak, C. Hassager, D. J. Lovell, S. Nielsen, C. J. Henderson et al., Assessment of bone mineral density in adults with a history of juvenile chronic arthritis: a cross-sectional longterm followup study, Arthritis Rheum, vol.42, issue.4, pp.790-798, 1999.

S. Stagi, L. Masi, S. Capannini, R. Cimaz, G. Tonini et al., Cross-sectional and longitudinal evaluation of bone mass in children and young adults with juvenile 42 idiopathic arthritis: the role of bone mass determinants in a large cohort of patients, J Rheumatol, vol.37, issue.9, pp.1935-1978, 2010.

R. Cimaz, Osteoporosis in childhood rheumatic diseases: prevention and therapy, Best Pract Res Clin Rheumatol, vol.16, issue.3, pp.397-409, 2002.

M. Batthish, B. M. Feldman, P. S. Babyn, P. N. Tyrrell, and R. Schneider, Predictors of hip disease in the systemic arthritis subtype of juvenile idiopathic arthritis, J Rheumatol, vol.38, issue.5, pp.954-962, 2011.

K. Oen, M. Reed, P. N. Malleson, D. A. Cabral, R. E. Petty et al., Radiologic outcome and its relationship to functional disability in juvenile rheumatoid arthritis, J Rheumatol, vol.30, issue.4, pp.832-872, 2003.

C. H. Spencer and B. H. Bernstein, Hip disease in juvenile rheumatoid arthritis, Curr Opin Rheumatol, vol.14, issue.5, pp.536-577, 2002.

M. S. Fedrizzi, M. V. Ronchezel, M. O. Hilario, H. M. Lederman, S. Sawaya et al., Ultrasonography in the early diagnosis of hip joint involvement in juvenile rheumatoid arthritis, J Rheumatol, vol.24, issue.9, pp.1820-1825, 1997.

P. B. Kitsoulis, K. S. Stafilas, A. Siamopoulou, P. N. Soucacos, and T. A. Xenakis, Total hip arthroplasty in children with juvenile chronic arthritis: long-term results, J Pediatr Orthop, vol.26, issue.1, pp.8-12, 2006.

C. Aoki, Y. Inaba, H. Choe, U. Kaneko, R. Hara et al., Discrepancy between clinical and radiological responses to tocilizumab treatment in patients with systemic-onset juvenile idiopathic arthritis, J Rheumatol, vol.41, issue.6, pp.1171-1178, 2014.

C. Malattia, A. Consolaro, S. Pederzoli, A. Madeo, A. Pistorio et al., MRI versus conventional measures of disease activity and structural damage in evaluating treatment efficacy in juvenile idiopathic arthritis, Ann Rheum Dis, vol.72, issue.3, pp.363-371, 2013.

R. E. Petty, T. R. Southwood, P. Manners, J. Baum, D. N. Glass et al., International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, J Rheumatol, vol.31, issue.2, pp.390-392, 2001.

C. Modesto, P. Woo, J. García-consuegra, R. Merino, M. García-granero et al., Systemic onset juvenile chronic arthritis, polyarticular pattern and hip involvement as markers for a bad prognosis, Clin Exp Rheumatol, vol.19, issue.2, pp.211-218, 2001.

R. Russo and M. M. Katsicas, Patients with very early-onset systemic juvenile idiopathic arthritis exhibit more inflammatory features and a worse outcome, J Rheumatol, vol.40, issue.3, pp.329-363, 2013.

S. Yokota, T. Miyamae, T. Imagawa, S. Katakura, R. Kurosawa et al., Clinical study of tocilizumab in children with systemic-onset juvenile idiopathic arthritis, Clin Rev Allergy Immunol, vol.28, issue.3, pp.231-239, 2005.

S. Yokota, T. Imagawa, M. Mori, T. Miyamae, Y. Aihara et al., Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial, Lancet Lond Engl, vol.371, issue.9617, pp.998-1006, 2008.

P. Quartier, F. Allantaz, R. Cimaz, P. Pillet, C. Messiaen et al., A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial), Ann Rheum Dis, vol.70, issue.5, pp.747-54, 2011.

N. Ruperto, H. I. Brunner, P. Quartier, T. Constantin, N. Wulffraat et al., Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis, N Engl J Med, vol.367, issue.25, pp.2396-406, 2012.

P. Woo, T. R. Southwood, A. M. Prieur, C. J. Doré, J. Grainger et al., Randomized, placebocontrolled, crossover trial of low-dose oral methotrexate in children with extended oligoarticular or systemic arthritis, Arthritis Rheum, vol.43, issue.8, pp.1849-57, 2000.

P. Quartier, P. Taupin, F. Bourdeaut, I. Lemelle, P. Pillet et al., Efficacy of etanercept for the treatment of juvenile idiopathic arthritis according to the onset type, Arthritis Rheum, vol.48, issue.4, pp.1093-101, 2003.

F. Prince, M. Twilt, R. Ten-cate, .. J. Van-rossum-m-a, W. Armbrust et al., Long-term follow-up on effectiveness and safety of etanercept in juvenile idiopathic arthritis: the Dutch national register, Ann Rheum Dis, vol.68, issue.5, pp.635-676, 2009.

M. H. Otten, F. Prince, W. Armbrust, R. Ten-cate, E. Hoppenreijs et al., Factors associated with treatment response to etanercept in juvenile idiopathic arthritis, JAMA, vol.306, issue.21, pp.2340-2347, 2011.

D. Benedetti, F. Brunner, H. I. , R. N. Kenwright, A. Wright et al., Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis, N Engl J Med, vol.367, issue.25, pp.2385-95, 2012.

M. H. Otten, J. Anink, F. Prince, M. Twilt, S. J. Vastert et al., Trends in prescription of biological agents and outcomes of juvenile idiopathic arthritis: results of the Dutch national Arthritis and Biologics in Children Register, Ann Rheum Dis, vol.74, issue.7, pp.1379-86, 2015.

R. N. Hensinger, P. D. Devito, and C. G. Ragsdale, Changes in the cervical spine in juvenile rheumatoid arthritis, J Bone Joint Surg Am, vol.68, issue.2, pp.189-98, 1986.

L. R. Spiegel, R. Schneider, B. A. Lang, N. Birdi, E. D. Silverman et al., Early predictors of poor functional outcome in systemic-onset juvenile rheumatoid arthritis: a multicenter cohort study, Arthritis Rheum, vol.43, issue.11, pp.2402-2411, 2000.

J. C. Packham and M. A. Hall, Long-term follow-up of 246 adults with juvenile idiopathic arthritis: education and employment. Rheumatol Oxf Engl, vol.41, pp.1436-1445, 2002.

T. Odent, P. Journeau, A. Prieur, P. Touzet, J. Pouliquen et al., Cementless hip arthroplasty in juvenile idiopathic arthritis, J Pediatr Orthop, vol.25, issue.4, pp.465-70, 2005.

C. Mertelsmann-voss, S. Lyman, T. J. Pan, S. M. Goodman, M. P. Figgie et al., US trends in rates of arthroplasty for inflammatory arthritis including rheumatoid arthritis, juvenile idiopathic arthritis, and spondyloarthritis. Arthritis Rheumatol Hoboken NJ, vol.66, pp.1432-1441, 2014.

J. Cabane, A. Michon, J. M. Ziza, P. Bourgeois, O. Blétry et al., Comparison of long term evolution of adult onset and juvenile onset Still's disease, both followed up for more than 10 years, Ann Rheum Dis, vol.49, issue.5, pp.283-288, 1990.

M. Zak, C. Hassager, D. J. Lovell, S. Nielsen, C. J. Henderson et al., Assessment of bone mineral density in adults with a history of juvenile chronic arthritis: a cross-sectional longterm followup study, Arthritis Rheum, vol.42, issue.4, pp.790-798, 1999.

S. Stagi, L. Masi, S. Capannini, R. Cimaz, G. Tonini et al., Cross-sectional and longitudinal evaluation of bone mass in children and young adults with juvenile idiopathic arthritis: the role of bone mass determinants in a large cohort of patients, J Rheumatol, vol.37, issue.9, pp.1935-1978, 2010.

R. Cimaz, Osteoporosis in childhood rheumatic diseases: prevention and therapy, Best Pract Res Clin Rheumatol, vol.16, issue.3, pp.397-409, 2002.

M. Batthish, B. M. Feldman, P. S. Babyn, P. N. Tyrrell, and R. Schneider, Predictors of hip disease in the systemic arthritis subtype of juvenile idiopathic arthritis, J Rheumatol, vol.38, issue.5, pp.954-962, 2011.

K. Oen, M. Reed, P. N. Malleson, D. A. Cabral, R. E. Petty et al., Radiologic outcome and its relationship to functional disability in juvenile rheumatoid arthritis, J Rheumatol, vol.30, issue.4, pp.832-872, 2003.

C. H. Spencer and B. H. Bernstein, Hip disease in juvenile rheumatoid arthritis, Curr Opin Rheumatol, vol.14, issue.5, pp.536-577, 2002.

M. S. Fedrizzi, M. V. Ronchezel, M. O. Hilario, H. M. Lederman, S. Sawaya et al., Ultrasonography in the early diagnosis of hip joint involvement in juvenile rheumatoid arthritis, J Rheumatol, vol.24, issue.9, pp.1820-1825, 1997.

P. B. Kitsoulis, K. S. Stafilas, A. Siamopoulou, P. N. Soucacos, and T. A. Xenakis, Total hip arthroplasty in children with juvenile chronic arthritis: long-term results, J Pediatr Orthop, vol.26, issue.1, pp.8-12, 2006.

C. Aoki, Y. Inaba, H. Choe, U. Kaneko, R. Hara et al., Discrepancy between clinical and radiological responses to tocilizumab treatment in patients with systemic-onset juvenile idiopathic arthritis, J Rheumatol, vol.41, issue.6, pp.1171-1178, 2014.

C. Malattia, A. Consolaro, S. Pederzoli, A. Madeo, A. Pistorio et al., MRI versus conventional measures of disease activity and structural damage in evaluating treatment efficacy in juvenile idiopathic arthritis, Ann Rheum Dis, vol.72, issue.3, pp.363-371, 2013.