.. .. Mesure-de-la-fibrose-hépatique,

M. and .. .. ,

. .. Résultats,

. .. Discussion,

A. , Choix des outils d'évaluation de la fibrose

B. Choix and .. .. , du score METAVIR pour classer les patients dans le groupe cirrhose

.. .. Les,

A. Incidence-de-la-cirrhose and .. .. ,

B. La-cirrhose and .. .. ,

.. .. Les-limites-de-l'étude,

. , C. Les outils d'évaluation de l'atteinte hépatique

. .. Conclusion,

. .. Bibliographie,

. .. Annexes,

. .. Serment-d'hippocrate,

C. Larsen, G. Pialoux, D. Salmon, D. Antona, L. Strat et al., Prevalence of hepatitis C and hepatitis B infection in the HIV-infected population of France, Eurosurveillance, vol.13, pp.4-6, 2004.

R. E. Barth, Q. Huijgen, J. Taljaard, and A. Hoepelman, Hepatitis B/C and HIV in sub-Saharan Africa: an association between highly prevalent infectious diseases, a systematic review and metaanalysis, Intern J Inf Dis, vol.14, pp.1024-1055, 2010.

L. Piroth, S. Pol, K. Lacombe, P. Miailhes, A. Rami et al., Management and treatment of chronic hepatitis B virus infection in HIV positive and negative patients: the EPIB, 2008.

, J Hepatol, vol.53, pp.1006-1012, 2010.

C. Hézode, Histoire naturelle de l'hépatite B, Rev Virologie, vol.14, pp.5-11, 2010.

S. Hughes, H. Wedemeyer, and P. Harisson, Hépatites delta virus, The Lancet, vol.378, pp.73-85, 2011.

R. Romeo, D. Ninno, E. Rumi, M. Russo, A. Sangiovanni et al., A 28-year study of the course of hepatitis Delta infection: a risk factor for cirrhosis and hepatocellular carcinoma, Gastroenterology, vol.136, issue.5, pp.1629-1667, 2009.

J. Colin, D. Cazals-hatem, M. A. Loriot, M. Martinot-peignoux, B. N. Pham et al., Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men, Hepatology, vol.29, issue.4, pp.1306-1316, 1999.

C. L. Thio, E. C. Seaberg, R. Skolasky, J. Phair, B. Visscher et al., HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS), The Lancet, vol.360, pp.1921-1927, 2002.

L. Piroth, S. Pol, P. Miailhes, K. Lacombe, A. Lopes et al., Therapeutic management and evolution of chronic hepatitis B: does HIV still have an impact? The EPIB 2012 study, Liver Int, 2015.

B. Phung, Hepatitis B and human immunodeficiency virus co-infection, World J Gastroenterol, vol.20, issue.46, p.17360, 2014.

D. Konopnicki, A. Mocroft, D. Wit, S. Antunes, F. Ledergerber et al., Hepatitis B and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort, AIDS, vol.19, issue.6, pp.593-601, 2005.

E. Rosenthal, C. Roussillon, D. Salmon-céron, A. Georget, S. Hénard et al., Liver-related deaths in HIV-infected patients between 1995 and 2010 in France: the Mortavic 2010 study in collaboration with the Agence Nationale de Recherche sur le SIDA (ANRS) EN 20 Mortalité 2010 survey: Liver-related causes of death in HIV-infected patients in France, HIV Med, vol.16, issue.4, pp.230-239, 1995.

V. Soriano, D. Grint, D. Monforte, and A. , Hépatitis delta in HIV-infected individuals in Europe, AIDS, vol.25, pp.1987-1992, 2011.

A. Boyd, K. Lacombe, P. Miailhes, J. Gozlan, P. Bonnard et al., Longitudinal evaluation of viral interactions in treated HIV-hepatitis B co-infected patients with additional hepatitis C and D virus, J Viral Hepat, vol.17, pp.65-76, 2010.

, Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach, 2015.

P. Morlat, C. National, and . Sida, Agence Nationale de Recherches sur le Sida et les Hépatites Virales, Ministère des Affaires sociales et de la santé, Prise en charge médicale des personnes vivant avec le VIH : Actualisation 2014 du rapport 2013: recommandations du groupe d'experts. La documentation française, 2014.

J. Sheldon, B. Ramos, and C. Toro, Does treatment of hepatitis B virus (HBV) infection reduce hepatitis delta virus (HDV) replication in HIV-HBV-HDV-coinfected patients?, Antivir Ther, vol.13, issue.1, pp.97-102, 2008.

P. Cacoub, F. Dabis, D. Costagliola, K. Almeida, F. Lert et al., Burden of HIV and hepatitis C co-infection: the changing epidemiology of hepatitis C in HIV-infected patients in France, Liver Int, vol.35, pp.65-70, 2015.

V. De-ledinghen,

, Gastroenterol Clin Biol, vol.26, pp.9-22, 2002.

P. Marcellin, Hepatitis C: the clinical spectrum of the disease, J Hepatol, vol.31, pp.9-16, 1999.

D. Salmon, C. Arvieux, M. Bourliere, P. Cacoub, P. Halfon et al., Use of first generation hcv protease inhibitors in patients coinfected by HIV and HCV genotype 1, Liver Int, vol.34, pp.869-89, 2014.

. I. Poizot-martin, P. Bonnard, and M. Wimmock, Prévalence de la fibrose hépatique F3/F4 au sein de la cohorte ANRS C013-HEPAVIH, Médecine et maladies infectieuses, vol.38, p.110, 2008.

, AFEF, recommandations AFEF pour l'élimination de l'infection par le virus de l'hépatite C en France, 2018.

M. Mandorfer, P. Schwabl, S. Steiner, T. Reiberger, and M. Peck-radosavljevic, Advances in the management of HIV/HCV coinfection, Hepatol Int, vol.10, pp.424-435, 2016.

A. Cohort, Regression of liver stiffness after sustained hepatitis C virus (HCV) virological responses among HIV/HCV-coinfected patients, AIDS, vol.29, issue.14, pp.1821-1830, 2015.

K. Lacombe, V. Massari, P. M. Girard, L. Serfaty, J. Gozlan et al., Major role of hepatitis B genotypes in liver fibrosis during coinfection with HIV, AIDS, vol.20, pp.419-427, 2006.

P. Mathurin, V. Thibault, K. Kadidja, N. Ganne-carrié, J. Moussalli et al., Replication status and histological features of patients with triple (B, C, D) and dual (B, C) hepatic infections, J Viral Hepat, vol.7, pp.15-22, 2000.

J. R. Arribas, J. J. Gonza´les-garc?´a, and A. Lorenzo, Single (B or C), dual (BC or BD) and triple (BCD) viral hepatitis in HIV-infected patients in, AIDS, vol.19, pp.1361-1365, 2005.

C. Wang, J. D. Chen, J. Shao, Q. Li, B. Liu et al., Hepatitis due to Reactivation of Hepatitis B Virus in Endemic Areas Among Patients With Hepatitis C Treated With Direct-acting Antiviral Agents, Clin Gastroenterol Hepatol, vol.15, pp.132-136, 2017.

D. Salmon-ceron, C. Lewden, and P. Morlat, Liver disease as a major cause of death in HIVinfected patients: role of hepatitis C and B viruses and alcohol, J Hepatol, vol.42, pp.799-805, 2005.

K. Lacombe, A. Boyd, M. Desvarieux, L. Serfaty, P. Bonnord et al., Impact of chronic hepatitis C and/or D on liver fibrosis severity in patients co-infected with HIV and hepatitis B virus, AIDS, vol.21, issue.18, pp.2546-2555, 2007.

S. Pol, P. Lebray, and A. Vallet-pichard, HIV infection and hepatic enzyme abnormalities: intricacies of the pathogenic mechanisms, Clin Infect Dis, vol.38, pp.65-72, 2004.

V. Soriano, M. Puoti, P. Garcia-gasco, J. K. Rockstroh, Y. Benhamou et al., Antiretroviral drugs and liver injury, AIDS, vol.22, issue.1, pp.1-13, 2008.

G. Birkus, M. J. Hitchcock, and T. Cihlar, Assessment of mitochondrial toxicity in human cells treated with Ténofovir: comparison with other nucleoside reverse transcriptase inhibitors

, Antimicrob Agents Chemother, vol.46, issue.3, pp.716-739, 2002.

M. V. Machado, A. G. Oliveire, and H. Cortez-pinto, Hepatic steatosis B virus infected patients: metaanalysis of risk factors and comparison with hepatitis C infected patients, J Gastroenterol Hepatol, vol.26, pp.1361-1367, 2011.

D. Neau, M. Winnock, L. Castera, B. L. Bail, M. A. Loko et al., Prevalence of and factors associated with hepatic steatosis in patients coinfected with hepatitis C virus and HIV

, Agence Nationale pour la Recherche contre le SIDA et les hepatites virales CO3 Aquitaine Cohort, J Acquir Immune Defic Syndr, vol.45, pp.168-173, 2007.

P. Bedossa and T. Poynard, An algorithm for the grading of activity in chronic hepatitis C.The METAVIR Cooperative Study Group, Hepatology, vol.24, pp.289-293, 1996.

J. F. Cadranel, P. Rufat, and F. Degos, Practices of liver biopsy in France: results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF), Hepatology, vol.32, pp.477-481, 2000.

L. Castera, J. Vergniol, J. Foucher, L. Bail, B. Chanteloup et al., Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C, Gastroenterology, vol.128, pp.343-350, 2005.

M. Sanchez-conde, M. L. Montes-ramirez, P. Miralles, J. M. Alvarez, J. M. Bellon et al., Comparison of transient elastography and liver biopsy for the assessment of liver fibrosis in HIV/hepatitis C virus-coinfected patients and correlation with noninvasive serum markers, J Viral Hepat, vol.17, pp.280-286, 2010.

V. De-ledinghen, C. Douvin, A. Kettaneh, M. Ziol, D. Roulot et al., Diagnosis of hepatic fibrosis and cirrhosis by transient elastography in HIV/hepatitis C virus-coinfected patients, J Acquir Immune Defic Syndr, vol.41, pp.175-179, 2006.

P. Miailhes, P. Pradat, M. Chevallier, K. Lacombe, F. Bailly et al., Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients, J Viral Hepat, vol.18, pp.61-69, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00851726

M. Friedrich-rust, J. Nierhoff, M. Lupsor, I. Sporea, C. Fierbinteanu-braticevici et al., Performance of Acoustic Radiation Force Impulse imaging for the staging of liver fibrosis: a pooled meta-analysis, J Viral Hepat, vol.19, issue.2, pp.212-221, 2012.

C. Cassinotto, B. Lapuyade, A. Mouries, J. B. Hiriart, J. Vergniol et al., Non-invasive assessment of liver fibrosis with impulse elastography: comparison of Supersonic Shear Imaging with ARFI and FibroScan®, J Hepatol, vol.61, issue.3, pp.550-557, 2014.

P. Cacoub, F. Carrat, P. Bedossa, J. Lambert, G. Penaranda et al., Comparison of noninvasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study-ANRS HC02, J Hepatol, vol.48, pp.765-773, 2008.

J. Bottero, K. Lacombe, and J. Guéchot, Performance of 11 biomarkers for liver fibrosis assessment in HIV/HBV co-infected patients, J Hepatol, vol.50, pp.1074-1083, 2009.

R. K. Sterling, E. Lissen, and N. Clumeck, Development of a simple noninvasive index to predict significant fibrosis patients with HIV/HCV co-infection, Hepatology, vol.43, pp.1317-1325, 2006.

X. Forns, S. Ampurdanès, and J. M. Llovet, Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model, Hepatology, vol.36, pp.986-92, 2002.

C. T. Wai, J. K. Greenson, and R. J. Fontana, A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C, Hepatology, vol.38, issue.2, pp.518-544, 2003.