Biomarqueurs de neuro-imagerie de la dégénérescence dans la maladie d'Alzheimer : les différentes contributions de l'atrophie corticale en IRM structurale et de l'hypométabolisme en TEP-FDG

Abstract : Alzheimer's disease (AD) is the leading cause of neurodegenerative dementia. MA biomarkers are currently divided into biomarkers of amyloid pathology (CSF level of Aβ42, tracer retention on amyloid PET), biomarkers of Tau pathology (CSF level of phosphorylated Tau and tracer retention on PET-Tau) and biomarkers of neurodegeneration (CSF level of total Tau protein, MRI and PET-18FDG). Neurodegeneration biomarkers are commonly used in the diagnosis of AD. The objective of this study was to evaluate the respective contributions of two neuroimaging biomarkers (structural MRI and PET-18FDG) in assessing neurodegeneration, in mild Alzheimer’s type dementia patients. Extent of atrophy on MRI and hypometabolism on PET-18FDG were assessed individually for each patient and compared to healthy subjects, using a voxel-based comparison on a whole-brain approach. Patients were divided into distinct groups based on their extent of atrophy on the one hand and their extent of hypometabolism on the other, then these features were combined and patients were divided based on their imaging profile. They were then compared in terms of demographic, globale cognitive function and CSF biomarkers features, according to each dichotomy. We showed that in AD at the mild dementia stage, structural MRI and PET-18FDG reflected distinct and composite pathological processes involved in neurodegeneration. The extent of hypometabolism in PET-18FDG was associated with the AD pathological processes and clinical severity, while the extent of MRI atrophy seemed to be influenced by factors other than AD processes, such as cognitive reserve via education. These two biomarkers of neurodegeneration are thus not interchangeable but should be considered in combination rather than in isolation.
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https://dumas.ccsd.cnrs.fr/dumas-01940278
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Submitted on : Friday, November 30, 2018 - 10:35:57 AM
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Agnès Benvenutto. Biomarqueurs de neuro-imagerie de la dégénérescence dans la maladie d'Alzheimer : les différentes contributions de l'atrophie corticale en IRM structurale et de l'hypométabolisme en TEP-FDG. Sciences du Vivant [q-bio]. 2018. ⟨dumas-01940278⟩

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