I. I. Annexe, Classification de la néphrite lupique (NL) d'après l'ISN/RPS, vol.50, 2003.

, Classe I : NL mésangiale minime

I. I. Classe, NL proliférative mésangiale

I. Classe, NL proliférative focale (< 50% des glomérules atteints) III (A) : lésions actives III (A/C) : lésions actives et chroniques III (C) : lésions chroniques

I. V. Classe, NL diffuse (? 50% des glomérules atteints

, IV (A) : lésions actives IV (A/C) : lésions actives et chroniques IV (C) : lésions chroniques

, Classe V : NL extra-membraneuse

V. I. Classe, Sclérose avancée (? 90% des glomérules sclérosés sans activité résiduelle) BIBLIOGRAPHIE

L. Arnaud, J. Fagot, A. Mathian, M. Paita, A. Fagot-campagna et al., Prevalence and incidence of systemic lupus erythematosus in France: a 2010 nation-wide population-based study, Autoimmun Rev, vol.13, pp.1082-1091, 2014.

L. Lisnevskaia, G. Murphy, and D. Isenberg, Systemic lupus erythematosus, Lancet Lond Engl, vol.384, pp.1878-88, 2014.

M. Wahren-herlenius and T. Dörner, Immunopathogenic mechanisms of systemic autoimmune disease, The Lancet, vol.382, pp.819-850, 2013.

A. Mathian, L. Arnaud, and Z. Amoura,

, Rev Med Interne, vol.35, pp.503-514, 2014.

M. Martin, J. Leffler, and A. M. Blom, Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells, J Biol Chem, vol.287, pp.33733-33777, 2012.

S. Nagata, R. Hanayama, and K. Kawane, Autoimmunity and the clearance of dead cells, Cell, vol.140, pp.619-649, 2010.

L. A. Casciola-rosen, G. Anhalt, and A. Rosen, Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes, J Exp Med, vol.179, pp.1317-1347, 1994.

Z. Liu and A. Davidson, Taming lupus-a new understanding of pathogenesis is leading to clinical advances, Nat Med, vol.18, pp.871-82, 2012.

G. C. Tsokos, . Systemic-lupus, and . Erythematosus, N Engl J Med, vol.365, pp.2110-2131, 2011.

B. H. Hahn, Antibodies to DNA, N Engl J Med, vol.338, pp.1359-68, 1998.

K. E. Taylor, S. A. Chung, R. R. Graham, W. A. Ortmann, A. T. Lee et al., Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes, PLoS Genet, vol.7, p.1001311, 2011.

R. Cervera, M. A. Khamashta, and G. Hughes, The Euro-lupus project: epidemiology of systemic lupus erythematosus in Europe, Lupus, vol.18, pp.869-74, 2009.

D. Fernandez and K. A. Kirou, What Causes Lupus Flares?, Curr Rheumatol Rep, vol.18, p.14, 2016.

T. Stoll, N. Sutcliffe, J. Mach, R. Klaghofer, and D. A. Isenberg, Analysis of the relationship between disease activity and damage in patients with systemic lupus erythematosus-a 5-yr prospective study, Rheumatol Oxf Engl, vol.43, pp.1039-1083, 2004.

B. Chaigne, C. Chizzolini, T. Perneger, M. Trendelenburg, U. Huynh-do et al., Impact of disease activity on health-related quality of life in systemic lupus erythematosus-a cross-sectional analysis of the Swiss Systemic Lupus Erythematosus Cohort Study (SSCS), BMC Immunol, vol.18, p.17, 2017.

A. Dhanhani, A. M. Gignac, M. Su, J. Fortin, and P. R. , Work disability in systemic lupus erythematosus, Arthritis Rheum, vol.61, pp.378-85, 2009.

M. Mosca, C. Tani, M. Aringer, S. Bombardieri, D. Boumpas et al., European League Against Rheumatism recommendations for monitoring patients with systemic lupus erythematosus in clinical practice and in observational studies, Ann Rheum Dis, vol.69, pp.1269-74, 2010.

F. Conti, F. Ceccarelli, C. Perricone, F. Miranda, S. Truglia et al., Flare, persistently active disease, and serologically active clinically quiescent disease in systemic lupus erythematosus: a 2-year follow-up study, PloS One, vol.7, p.45934, 2012.

S. Soliman and C. Mohan, Lupus nephritis biomarkers, Clin Immunol Orlando Fla, 2016.

H. Wu, J. Zeng, J. Yin, Q. Peng, M. Zhao et al., Organ-specific biomarkers in lupus, Autoimmun Rev, vol.16, pp.391-398, 2017.

N. Bizzaro, D. Villalta, D. Giavarina, and R. Tozzoli, Are anti-nucleosome antibodies a better diagnostic marker than anti-dsDNA antibodies for systemic lupus erythematosus? A systematic review and a study of metanalysis, Autoimmun Rev, vol.12, pp.97-106, 2012.

S. Yung and T. M. Chan, Anti-dsDNA antibodies and resident renal cells-Their putative roles in pathogenesis of renal lesions in lupus nephritis, Clin Immunol Orlando Fla, 2016.

C. Szeto, Urine miRNA in nephrotic syndrome, Clin Chim Acta Int J Clin Chem, vol.436, pp.308-321, 2014.

J. G. Hanly, Diagnosis and management of neuropsychiatric SLE, Nat Rev Rheumatol, vol.10, pp.338-385, 2014.

C. Arriens, J. D. Wren, M. E. Munroe, and C. Mohan, Systemic lupus erythematosus biomarkers: the challenging quest, Rheumatol Oxf Engl, vol.56, pp.32-45, 2017.

F. Cañas, L. Simonin, F. Couturaud, and Y. Renaudineau, Annexin A2 autoantibodies in thrombosis and autoimmune diseases, Thromb Res, vol.135, pp.226-256, 2015.

K. A. Hajjar, A. T. Jacovina, and J. Chacko, An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II, J Biol Chem, vol.269, pp.21191-21198, 1994.

D. Kaczan-bourgois, J. P. Salles, F. Hullin, J. Fauvel, A. Moisand et al., Increased content of annexin II (p36) and p11 in human placenta brush-border membrane vesicles during syncytiotrophoblast maturation and differentiation, Placenta, vol.17, pp.669-76, 1996.

A. B. Deora, G. Kreitzer, A. T. Jacovina, and K. A. Hajjar, An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface, J Biol Chem, vol.279, pp.43411-43419, 2004.

O. Lambert, N. Cavusoglu, J. Gallay, M. Vincent, J. L. Rigaud et al., Novel organization and properties of annexin 2-membrane complexes, J Biol Chem, vol.279, pp.10872-82, 2004.

W. Zhao, D. M. Waisman, and M. Grimaldi, Specific localization of the annexin II heterotetramer in brain lipid raft fractions and its changes in spatial learning, J Neurochem, vol.90, pp.609-629, 2004.

H. Jung, J. S. Kim, W. K. Kim, K. Oh, J. Kim et al., Intracellular annexin A2 regulates NF-?B signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer, Cell Death Dis, vol.6, p.1606, 2015.

Y. Wang, K. Chen, Y. Cai, Y. Cai, X. Yuan et al., Annexin A2 could enhance multidrug resistance by regulating NF-?B signaling pathway in pediatric neuroblastoma, J Exp Clin Cancer Res CR, vol.36, p.111, 2017.

X. Feng, H. Liu, Z. Zhang, Y. Gu, H. Qiu et al., Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells, J Exp Clin Cancer Res CR, vol.36, p.123, 2017.

M. Luo and K. A. Hajjar, Annexin A2 system in human biology: cell surface and beyond, Semin Thromb Hemost, vol.39, pp.338-384, 2013.

G. Cesarman-maus, R. Luna, N. P. Deora, A. B. Huang, B. Villa et al., Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome, Blood, vol.107, pp.4375-82, 2006.

V. Salle, J. C. Mazière, A. Smail, R. Cévallos, C. Mazière et al., Anti-annexin II antibodies in systemic autoimmune diseases and antiphospholipid syndrome, J Clin Immunol, vol.28, pp.291-298, 2008.

S. Miyakis, M. D. Lockshin, T. Atsumi, D. W. Branch, R. L. Brey et al., International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS), J Thromb Haemost JTH, vol.4, pp.295-306, 2006.

K. L. Allen, F. V. Fonseca, V. Betapudi, B. Willard, J. Zhang et al., A novel pathway for human endothelial cell activation by antiphospholipid/anti-?2 glycoprotein I antibodies, Blood, vol.119, pp.884-93, 2012.

M. Petri, Update on anti-phospholipid antibodies in SLE: the Hopkins, Lupus Cohort. Lupus, vol.19, pp.419-442, 2010.

Y. Wu, W. Tang, and J. Zuo, Toll-like receptors: potential targets for lupus treatment, Acta Pharmacol Sin, vol.36, pp.1395-407, 2015.

A. Komatsuda, H. Wakui, K. Iwamoto, M. Ozawa, M. Togashi et al., Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus, Clin Exp Immunol, vol.152, pp.482-489, 2008.

O. Wu, G. P. Chen, H. Chen, X. P. Li, J. H. Xu et al., The expressions of Toll-like receptor 9 and T-bet in circulating B and T cells in newly diagnosed, untreated systemic lupus erythematosus and correlations with disease activity and laboratory data in a Chinese population, Immunobiology, vol.214, pp.392-402, 2009.

W. Ao, H. Zheng, X. Chen, Y. Shen, and C. Yang, Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis, Rheumatol Int, vol.31, pp.865-874, 2011.

S. Yung, K. F. Cheung, Q. Zhang, and T. M. Chan, Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis, J Am Soc Nephrol JASN, vol.21, pp.1912-1939, 2010.

H. Zheng, Y. Chen, W. Ao, Y. Shen, X. Chen et al., Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases, Arthritis Res Ther, vol.11, p.93, 2009.

V. Salle, C. Cordonnier, J. Schmidt, C. Mazière, A. Smail et al., Vascular expression of annexin A2 in lupus nephritis, J Clin Pathol, vol.69, pp.533-539, 2016.

E. M. Tan, A. S. Cohen, J. F. Fries, A. T. Masi, D. J. Mcshane et al., The 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum, vol.25, pp.1271-1278, 1982.

M. C. Hochberg, Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum, vol.40, p.1725, 1997.

J. J. Weening, D. Agati, V. D. Schwartz, M. M. Seshan, S. V. Alpers et al., The classification of glomerulonephritis in systemic lupus erythematosus revisited, J Am Soc Nephrol JASN, vol.15, pp.241-50, 2004.

C. Bombardier, D. D. Gladman, M. B. Urowitz, D. Caron, and C. H. Chang, Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE, Arthritis Rheum, vol.35, pp.630-670, 1992.

J. Yang, F. Yang, J. Nie, X. Zou, H. Tian et al., Evaluation of Annexin A2 as a novel diagnostic serum biomarker for lung cancer, Cancer Biomark Sect Dis Markers, vol.15, pp.205-216, 2015.

M. K. Shaker, A. Fattah, H. I. Sabbour, G. S. Montasser, I. F. Abdelhakam et al., Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients, World J Hepatol, vol.9, pp.469-76, 2017.

A. El-latif, M. Azzam, H. Othman, M. Warda, O. El-sharawy et al., Assessment of annexin A5 and annexin A2 levels as biomarkers for pre-eclampsia: A pilot study, Pregnancy Hypertens, vol.8, pp.65-74, 2017.

S. Chugh, M. Ouzounian, Z. Lu, M. S. Li, W. Bousette et al., Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure, Proteomics, vol.13, pp.2324-2358, 2013.

E. C. Flood and K. A. Hajjar, The Annexin A2 System and Vascular Homeostasis, Vascul Pharmacol, vol.54, p.59, 2011.

G. Cesarman-maus, C. Cantú-brito, F. Barinagarrementeria, R. Villa, E. Reyes et al., Autoantibodies against the Fibrinolytic Receptor, Annexin A2, in Cerebral Venous Thrombosis, Stroke J Cereb Circ, vol.42, p.501, 2011.

J. Zhang and K. R. Mccrae, Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies, Blood, vol.105, pp.1964-1973, 2005.

E. Cockrell, R. G. Espinola, and K. R. Mccrae, Annexin A2: biology and relevance to the antiphospholipid syndrome, Lupus, vol.17, pp.943-51, 2008.

Z. Romay-penabad, M. G. Montiel-manzano, T. Shilagard, E. Papalardo, G. Vargas et al., Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo, Blood, vol.114, pp.3074-83, 2009.

F. Bienaimé, C. Legendre, F. Terzi, and G. Canaud, Antiphospholipid syndrome and kidney disease, Kidney Int, vol.91, pp.34-44, 2017.

R. Silvariño, F. Sant, G. Espinosa, G. Pons-estel, M. Solé et al., Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus erythematosus, Lupus, vol.20, pp.721-730, 2011.

R. Weiss, A. Bitton, B. Shimon, M. , E. Goldman et al., Annexin A2, autoimmunity, anxiety and depression, J Autoimmun, vol.73, pp.92-101, 2016.

L. Sun, L. Min, H. Zhou, M. Li, F. Shao et al., Adolescent social isolation affects schizophrenia-like behavior and astrocyte biomarkers in the PFC of adult rats, Behav Brain Res, vol.333, pp.258-66, 2017.

C. Hu, W. Huang, H. Chen, G. Song, P. Li et al., Autoantibody profiling on human proteome microarray for biomarker discovery in cerebrospinal fluid and sera of neuropsychiatric lupus, PloS One, vol.10, p.126643, 2015.