R. E. , , 2015.

J. A. Chazan, M. R. London, and L. M. Pono, Long-term survival of vascular accesses in a large chronic hemodialysis population, Nephron, vol.69, issue.3, pp.228-261, 1995.

L. D. Browne, K. Bashar, P. Griffin, E. G. Kavanagh, S. R. Walsh et al., The Role of Shear Stress in Arteriovenous Fistula Maturation and Failure: A Systematic Review. Aliseda A, editor. PLOS ONE, vol.10, p.145795, 2015.

M. Franzoni, I. Cattaneo, L. Longaretti, M. Figliuzzi, B. Ene-iordache et al., Endothelial cell activation by hemodynamic shear stress derived from arteriovenous fistula for hemodialysis access

, Am J Physiol-Heart Circ Physiol, vol.310, issue.1, pp.49-59, 2016.

J. Lutz, J. Menke, D. Sollinger, H. Schinzel, and K. Thürmel, Haemostasis in chronic kidney disease, Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc-Eur Ren Assoc, vol.29, issue.1, pp.29-40, 2014.

H. I. Horowitz, I. M. Stein, B. D. Cohen, and J. G. White, Further studies on the platelet-inhibitory effect of guanidinosuccinic acid and its role in uremic bleeding, Am J Med, vol.49, issue.3, pp.336-381, 1970.

K. Matsushita, M. Van-der-velde, B. C. Astor, M. Woodward, and A. S. Levey, Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative metaanalysis, Chronic Kidney Disease Prognosis Consortium, vol.375, pp.2073-81, 2010.

A. S. Go, G. M. Chertow, D. Fan, C. E. Mcculloch, and C. Hsu, Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization, N Engl J Med, vol.351, issue.13, pp.1296-305, 200423.

P. Muntner, J. He, B. C. Astor, A. R. Folsom, and J. Coresh, Traditional and nontraditional risk factors predict coronary heart disease in chronic kidney disease: results from the atherosclerosis risk in communities study, J Am Soc Nephrol JASN, vol.16, issue.2, pp.529-567, 2005.

K. L. Cheung, N. A. Zakai, A. R. Folsom, K. Tamura, M. Peralta et al., Measures of Kidney Disease and the Risk of Venous Thromboembolism in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study, Am J Kidney Dis Off J Natl Kidney, 2017.

K. Wattanakit, M. Cushman, C. Stehman-breen, S. R. Heckbert, and A. R. Folsom, Chronic kidney disease increases risk for venous thromboembolism, J Am Soc Nephrol JASN, vol.19, issue.1, pp.135-175, 2008.

H. I. Horowitz, Uremic toxins and platelet function, Arch Intern Med, vol.126, issue.5, pp.823-829, 1970.

P. Boccardo, G. Remuzzi, and M. Galbusera, Platelet dysfunction in renal failure, Semin Thromb Hemost, vol.30, issue.5, pp.579-89, 2004.

G. Escolar, M. Díaz-ricart, and A. Cases, Uremic platelet dysfunction: past and present, Curr Hematol Rep, vol.4, issue.5, pp.359-67, 2005.

G. Glorieux, G. Cohen, J. Jankowski, and R. Vanholder, Platelet/Leukocyte activation, inflammation, and uremia, Semin Dial, vol.22, issue.4, pp.423-430, 2009.

V. Faure, L. Dou, F. Sabatier, C. Cerini, J. Sampol et al., Elevation of circulating endothelial microparticles in patients with chronic renal failure, J Thromb Haemost JTH, vol.4, issue.3, pp.566-73, 2006.
URL : https://hal.archives-ouvertes.fr/hal-01610442

N. Jourde-chiche, L. Dou, F. Sabatier, R. Calaf, C. Cerini et al., Levels of circulating endothelial progenitor cells are related to uremic toxins and vascular injury in hemodialysis patients, J Thromb Haemost JTH, vol.7, issue.9, pp.1576-84, 2009.
URL : https://hal.archives-ouvertes.fr/hal-01610439

N. Jourde-chiche, L. Dou, C. Cerini, F. Dignat-george, and P. Brunet, Vascular incompetence in dialysis patients-protein-bound uremic toxins and endothelial dysfunction, Semin Dial, vol.24, issue.3, pp.327-364, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01610435

M. Sallée, L. Dou, C. Cerini, S. Poitevin, P. Brunet et al., The aryl hydrocarbon receptor-activating effect of uremic toxins from tryptophan metabolism: a new concept to understand cardiovascular complications of chronic kidney disease, Toxins, vol.6, issue.3, pp.934-983, 2014.

B. Gondouin, C. Cerini, L. Dou, M. Sallée, A. Duval-sabatier et al., Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway, Kidney Int, vol.84, issue.4, pp.733-777, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01610430

P. Brunet, B. Gondouin, A. Duval-sabatier, L. Dou, C. Cerini et al., Does Uremia Cause Vascular Dysfunction?, Kidney Blood Press Res, vol.34, issue.4, pp.284-90, 2011.
URL : https://hal.archives-ouvertes.fr/hal-01610434

M. Shashar, M. E. Belghasem, S. Matsuura, J. Walker, S. Richards et al., Targeting STUB1tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk, Sci Transl Med, vol.9, issue.417, 2017.

M. F. Weiss, V. Scivittaro, and J. M. Anderson, Oxidative stress and increased expression of growth factors in lesions of failed hemodialysis access, Am J Kidney Dis Off J Natl Kidney Found, 2001.

T. Ishii, Y. Suzuki, T. Nakayama, M. Ohmori, S. Masai et al., Duplex ultrasound for the prediction of vascular events associated with arteriovenous fistulas in hemodialysis patients, J Vasc Access, vol.17, issue.6, pp.499-505, 2016.

I. Aragoncillo, Y. Amézquita, S. Caldés, S. Abad, A. Vega et al., The impact of access blood flow surveillance on reduction of thrombosis in native arteriovenous fistula: a randomized clinical trial, J Vasc Access, vol.17, issue.1, pp.13-22, 2016.

P. Ravani, R. R. Quinn, M. J. Oliver, D. J. Karsanji, M. T. James et al., Preemptive Correction of Arteriovenous Access Stenosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials, Am J Kidney Dis, vol.67, issue.3, pp.446-60, 2016.

A. B. Irish, A. K. Viecelli, C. M. Hawley, L. Hooi, E. M. Pascoe et al., Effect of Fish Oil Supplementation and Aspirin Use on Arteriovenous Fistula Failure in Patients Requiring Hemodialysis: A Randomized Clinical Trial, JAMA Intern Med, vol.177, issue.2, p.184, 2017.

C. I. Coleman, L. A. Tuttle, C. Teevan, W. L. Baker, C. M. White et al., Antiplatelet agents for the prevention of arteriovenous fistula and graft thrombosis: a meta analysis: Antiplatelet agents and access thrombosis, Int J Clin Pract, vol.64, issue.9, pp.1239-1283, 2010.

N. C. Tanner, D. Silva, and A. , Medical adjuvant treatment to increase patency of arteriovenous fistulae and grafts, Cochrane Database of Systematic Reviews

U. K. Chichester, , 2015.

S. De-marchi, E. Falleti, R. Giacomello, G. Stel, E. Cecchin et al., Risk factors for vascular disease and arteriovenous fistula dysfunction in hemodialysis patients, J Am Soc Nephrol JASN, 1996.

J. Lutz, J. Menke, D. Sollinger, H. Schinzel, and K. Thürmel, Haemostasis in chronic kidney disease, Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc-Eur Ren Assoc, vol.29, issue.1, pp.29-40, 2014.

K. Yang, C. Du, X. Wang, F. Li, Y. Xu et al., Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease-associated thrombosis in mice, vol.129, pp.2667-79, 2017.

L. Dou, N. Jourde-chiche, V. Faure, C. Cerini, Y. Berland et al., The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells, J Thromb Haemost JTH, 2007.
URL : https://hal.archives-ouvertes.fr/hal-01610441

A. Leader, D. Pereg, and M. Lishner, Are platelet volume indices of clinical use? A multidisciplinary review, Ann Med, vol.44, issue.8, pp.805-821, 2012.

A. G. Niethammer and E. N. Forman, Use of the platelet histogram maximum in evaluating thrombocytopenia, Am J Hematol, vol.60, issue.1, pp.19-23, 1999.

K. M. Bowles, L. J. Cooke, E. M. Richards, and T. P. Baglin, Platelet size has diagnostic predictive value in patients with thrombocytopenia, Clin Lab Haematol, vol.27, issue.6, pp.370-373, 2005.

C. B. Thompson, K. A. Eaton, S. M. Princiotta, C. A. Rushin, and C. R. Valeri, Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function, Br J Haematol, vol.50, issue.3, pp.509-528, 1982.

S. Kamath, A. D. Blann, and G. Y. Lip, Platelet activation: assessment and quantification, Eur Heart J, vol.22, issue.17, pp.1561-71, 2001.

C. L. Balduini, P. Noris, P. Spedini, S. Belletti, A. Zambelli et al., Relationship between size and thiazole orange fluorescence of platelets in patients undergoing high-dose chemotherapy, Br J Haematol, vol.106, issue.1, pp.202-209, 1999.

C. B. Thompson, J. A. Jakubowski, P. G. Quinn, D. Deykin, and C. R. Valeri, Platelet size as a determinant of platelet function, J Lab Clin Med, vol.101, issue.2, pp.205-218, 1983.

J. F. Martin, E. A. Trowbridge, G. Salmon, and J. Plumb, The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration, Thromb Res, vol.32, issue.5, pp.443-60, 1983.

S. G. Chu, R. C. Becker, P. B. Berger, D. L. Bhatt, J. W. Eikelboom et al., Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis, J Thromb Haemost JTH, 2010.

P. Noris, F. Melazzini, and C. L. Balduini, New roles for mean platelet volume measurement in the clinical practice? Platelets, vol.27, pp.607-619, 2016.

C. J. Boos, G. D. Beevers, and G. Lip, Assessment of platelet activation indices using the ADVIATM 120 amongst "high-risk" patients with hypertension, Ann Med, vol.39, issue.1, pp.72-80, 2007.

S. K. Nadar, A. D. Blann, S. Kamath, D. G. Beevers, and G. Lip, Platelet indexes in relation to target organ damage in high-risk hypertensive patients: a substudy of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), J Am Coll Cardiol, vol.44, issue.2, pp.415-437, 2004.

Z. Hekimsoy, B. Payzin, T. Ornek, and G. Kando?an, Mean platelet volume in Type 2 diabetic patients, J Diabetes Complications, vol.18, issue.3, pp.173-179, 2004.

Y. Tavil, N. Sen, H. U. Yazici, F. Hizal, A. Abaci et al., Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease, Thromb Res, vol.120, issue.2, pp.245-50, 2007.

E. Varol, O. Ozturk, H. Yucel, T. Gonca, M. Has et al., The effects of continuous positive airway pressure therapy on mean platelet volume in patients with obstructive sleep apnea, Platelets, vol.22, issue.7, pp.552-558, 2011.

G. Vilchez, L. Londra, L. R. Hoyos, R. Sokol, and R. Bahado-singh, Intrapartum mean platelet volume is not a useful predictor of new-onset delayed postpartum pre-eclampsia, Int J Gynecol Obstet, 2015.

A. Y. Gasparyan, L. Ayvazyan, D. P. Mikhailidis, and G. D. Kitas, Mean platelet volume: a link between thrombosis and inflammation?, Curr Pharm Des, vol.17, issue.1, pp.47-58, 2011.

S. Jindal, S. Gupta, R. Gupta, A. Kakkar, H. V. Singh et al., Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications, Hematology, vol.16, issue.2, pp.86-95, 2011.

J. F. Martin, P. M. Bath, and M. L. Burr, Influence of platelet size on outcome after myocardial infarction, Lancet Lond Engl, vol.338, issue.8780, pp.1409-1420, 1991.

N. Sansanayudh, P. Numthavaj, D. Muntham, S. Yamwong, M. Mcevoy et al., Prognostic effect of mean platelet volume in patients with coronary artery disease: A systematic review and metaanalysis, Thromb Haemost, vol.114, issue.6, pp.1299-309, 2015.

S. Pikija, D. Cvetko, M. Hajduk, and V. Trkulja, Higher mean platelet volume determined shortly after the symptom onset in acute ischemic stroke patients is associated with a larger infarct volume on CT brain scans and with worse clinical outcome, Clin Neurol Neurosurg, vol.111, issue.7, pp.568-73, 2009.

M. Asanuma, K. Seino, T. Mizuno, M. Nasu, F. Yamauchi et al., Plasma thrombopoietin level and platelet indices in hemodialysis patients receiving recombinant human erythropoietin, Int J Lab Hematol, vol.32, issue.3, pp.312-321, 2010.

A. Akyüz, D. Ç. Akkoyun, H. De?irmenci, and M. Oran, Rosuvastatin Decreases Mean Platelet Volume in Patients With Diabetes Mellitus, Angiology, vol.67, issue.2, pp.116-136, 2016.

E. Asher, P. Fefer, M. Shechter, R. Beigel, D. Varon et al., Increased mean platelet volume is associated with non-responsiveness to clopidogrel: Thromb Haemost, vol.112, pp.137-178, 2014.

M. Verdoia, L. Barbieri, A. Schaffer, G. Bellomo, P. Marino et al., Impact of renal function on mean platelet volume and its relationship with coronary artery disease: A single-centre cohort study, Thromb Res, vol.141, pp.139-183, 2016.

K. Turgutalp, O. Özhan, E. Akbay, A. Tombak, N. Tiftik et al., Mean Platelet Volume and Related Factors in Patients at Different Stages of Diabetic Nephropathy: A Preliminary Study, Clin Appl Thromb, vol.20, issue.2, pp.190-195, 2014.

M. Schoorl, M. Schoorl, and P. Bartels, Changes in platelet volume, morphology and RNA content in subjects treated with haemodialysis, Scand J Clin Lab Invest, vol.68, issue.4, pp.335-377, 2008.

M. Gritters-van-den-oever, M. Schoorl, M. Schoorl, P. Bartels, M. Grooteman et al.,

, The Role of the Extracorporeal Circuit in the Trapping and Degranulation of Platelets, Blood Purif, vol.28, issue.3, pp.253-262, 2009.

M. Moia, P. M. Mannucci, L. Vizzotto, S. Casati, M. Cattaneo et al., Improvement in the haemostatic defect of uraemia after treatment with recombinant human erythropoietin, Lancet Lond Engl, vol.2, issue.8570, pp.1227-1236, 1987.

R. Evstatiev, A. Bukaty, K. Jimenez, S. Kulnigg-dabsch, L. Surman et al., Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin: Iron and Megakaryopoiesis, Am J Hematol, vol.89, issue.5, pp.524-533, 2014.

B. F. Henning, W. Zidek, B. Linder, and M. Tepel, Mean platelet volume and coronary heart disease in hemodialysis patients, Kidney Blood Press Res, vol.25, issue.2, pp.103-111, 2002.

Z. Bal, U. Bal, K. Okyay, M. Yilmaz, S. Balcioglu et al., Hematological parameters can predict the extent of coronary artery disease in patients with end-stage renal disease, Int Urol Nephrol, vol.47, issue.10, pp.1719-1744, 2015.

S. Kim, M. Z. Molnar, G. C. Fonarow, E. Streja, J. Wang et al., Mean platelet volume and mortality risk in a national incident hemodialysis cohort, Int J Cardiol, vol.220, pp.862-70, 2016.

. R-core-team, R: A language and environment for statistical computing. R Foundation for Statistical Computing, 2018.

P. Roy-chaudhury, V. P. Sukhatme, and A. K. Cheung, Hemodialysis vascular access dysfunction: a cellular and molecular viewpoint, J Am Soc Nephrol JASN, vol.17, issue.4, pp.1112-1139, 2006.

J. Anderson, M. Abbuhl, T. Hering, and K. Johnston, Immunohistochemical identification of components in thehealing response of human vascular grafts, ASAIO J, vol.8, pp.79-85, 1985.

M. Aviram, LDL-platelet interaction under oxidative stress induces macrophage foam cell formation, Thromb Haemost, vol.74, issue.1, pp.560-564, 1995.

S. Badrnya, W. C. Schrottmaier, J. B. Kral, K. Yaiw, I. Volf et al., Platelets mediate oxidized low-density lipoprotein-induced monocyte extravasation and foam cell formation

, Arterioscler Thromb Vasc Biol, vol.34, issue.3, pp.571-80, 2014.

R. H. Alvarez, H. M. Kantarjian, and J. E. Cortes, Biology of platelet-derived growth factor and its involvement in disease, Mayo Clin Proc, vol.81, issue.9, pp.1241-57, 2006.

P. Delafontaine, Growth factors and vascular smooth muscle cell growth responses, Eur Heart J, pp.18-22, 1998.

S. Stracke, K. Konner, I. Köstlin, R. Friedl, P. M. Jehle et al., Increased expression of TGFbeta1 and IGF-I in inflammatory stenotic lesions of hemodialysis fistulas, Kidney Int, 2002.

B. Afsar and R. Elsurer, Mean platelet volume is not a determinant of primary arteriovenous fistula failure in hemodialysis patients, J Vasc Access, vol.12, issue.4, pp.392-392, 2011.

C. Wu, M. Hsieh, S. Hung, K. Kuo, T. Tsai et al., Serum Indoxyl Sulfate Associates with Postangioplasty Thrombosis of Dialysis Grafts, J Am Soc Nephrol JASN, 2016.

S. E. Elchoufani, P. Bolin, S. Waien, C. R. Christiano, D. Holbert et al., ,1) <0, Platelet Adhesion Testing May Predict Early Hemodialysis Arteriovenous Graft and Fistula Failure in End-Stage Renal Disease Patients. Clin Appl Thromb, vol.14, p.62, 2008.