, Annexe 5 | Figure S1 : Représentation IGV des reads amplifiés d'UPN-38 dans KLF2

, Les mutations c. C812T-(p.T271I) en rouge et c.C851G-(p.T284S) en marron ne sont pas retrouvées dans les mêmes reads

, Annexe 6 | Figure S2 : Représentation des CNV de UPN-v3

, Les pertes de copies sont représentées en rouge et orange (Generate report)

G. R. Gosselin, D. G. Hanlon, and G. L. Pease, Leukaemic reticuloendotheliosis, Can Med Assoc J, vol.74, p.886, 1956.

B. A. Bouroncle, B. K. Wiseman, and C. A. Doan, Leukemic Reticuloendotheliosis, Blood, vol.XIII, pp.609-639, 1958.

O. Ewald, Die leukämische reticuloendotheliose, Dtsch Arch Klin Med, vol.142, pp.222-230, 1923.

D. Catovsky, J. E. Pettit, D. Galton, A. Spiers, and C. V. Harrison, Leukaemic Reticuloendotheliosis ('Hairy'Cell Leukaemia): A Distinct Clinico-Pathological Entity, Br J Haematol, vol.26, pp.9-27, 1974.

R. Schrek and W. J. Donnelly, Hairy" cells in blood in lymphoreticular neoplastic disease and" flagellated" cells of normal lymph nodes, Blood, vol.27, pp.199-211, 1966.

L. A. Andritsos and M. R. Grever, Historical overview of hairy cell leukemia, Best Pract Res Clin Haematol, vol.28, pp.166-74, 2015.

L. R. Teras, C. E. Desantis, J. R. Cerhan, L. M. Morton, A. Jemal et al., US lymphoid malignancy statistics by World Health Organization subtypes: 2016 US Lymphoid Malignancy Statistics by World Health Organization Subtypes, CA Cancer J Clin, vol.66, pp.443-59, 2016.

. Orphanet, Prévalence des maladies rares : Données bibliographiques, 2018.

A. Frassoldati, T. Lamparelli, M. Federico, L. Annino, G. Capnist et al.,

E. E. Damasiot and V. Silingardi, Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL), Leuk Lymphoma, vol.13, pp.307-323, 1994.

T. Tadmor and A. Polliack, Epidemiology and environmental risk in hairy cell leukemia, Best Pract Res Clin Haematol, vol.28, pp.175-184, 2015.

L. Hardell, M. Eriksson, and M. Nordström, Exposure to Pesticides as Risk Factor for Non-Hodgkin's

H. Lymphoma and . Leukemia, Pooled Analysis of Two Swedish Case-control Studies, Leuk Lymphoma, vol.43, pp.1043-1052, 2002.

A. Monnereau, S. L. Slager, A. M. Hughes, A. Smith, B. Glimelius et al., Medical History, Lifestyle, and Occupational Risk Factors for Hairy Cell Leukemia: The InterLymph Non-Hodgkin Lymphoma Subtypes Project, JNCI Monogr, vol.2014, pp.115-139, 2014.

A. Dunford, D. M. Weinstock, V. Savova, S. E. Schumacher, J. P. Cleary et al.,

A. A. Gimelbrant, R. Beroukhim, M. S. Lawrence, G. Getz, and A. A. Lane, Tumor-suppressor genes that escape from Xinactivation contribute to cancer sex bias, Nat Genet, vol.49, pp.10-16, 2016.

E. Cornet, C. Tomowiak, A. Tanguy-schmidt, S. Lepretre, J. Dupuis et al., , p.103

V. Leblond, C. Thiéblemont, P. Validire-charpy, L. Sutton, and E. Gyan, Long-term follow-up and second malignancies in 487 patients with hairy cell leukaemia, Br J Haematol, vol.166, pp.390-400, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01690636

. Cladribine, J Clin Oncol, vol.21, pp.891-897, 2003.

E. Cornet, A. Delmer, P. Feugier, F. Garnache-ottou, D. Ghez et al.,

J. Troussard and X. , Recommendations of the SFH (French Society of Haematology) for the diagnosis, treatment and follow-up of hairy cell leukaemia, Ann Hematol, vol.93, pp.1977-83, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01699263

M. Hisada, B. E. Chen, E. S. Jaffe, and L. B. Travis, Second Cancer Incidence and Cause-Specific Mortality Among

, Patients With Hairy Cell Leukemia: A Population-Based Study, JNCI J Natl Cancer Inst, vol.99, pp.215-237, 2007.

A. Saven, C. Burian, J. A. Koziol, and L. D. Piro, Long-term follow-up of patients with hairy cell leukemia after cladribine treatment, Blood, vol.92, pp.1918-1926, 1998.

P. Kampmeier, R. Spielberger, J. Dickstein, R. Mick, H. Golomb et al., Increased incidence of second neoplasms in patients treated with interferon alpha 2b for hairy cell leukemia: a clinicopathologic assessment

, Blood, vol.83, pp.2931-2938, 1994.

E. Spaenij-dekking, E. D. Van-der-meijden, J. Falkenburg, and J. C. Kluin-nelemans, Clonally expanded T cells in hairy cell leukemia patients are not leukemia specific, Leukemia, vol.18, pp.176-184, 2004.

V. Verma, S. Giri, V. R. Bhatt, C. Amador-ortiz, and J. O. Armitage, Synchronous or Metachronous Hairy Cell Leukemia and Chronic Lymphocytic Leukemia: A Case Series and Literature Review. Front Oncol

, , vol.6, 2017.

K. Basso, A. Liso, E. Tiacci, R. Benedetti, A. Pulsoni et al.,

U. Klein, Gene expression profiling of hairy cell leukemia reveals a phenotype related to memory B cells with altered expression of chemokine and adhesion receptors, J Exp Med, vol.199, pp.59-68, 2004.

F. Forconi, D. Raspadori, M. Lenoci, and F. Lauria, Absence of surface CD27 distinguishes hairy cell leukemia from other leukemic B-cell malignancies, Haematologica, vol.90, pp.266-268, 2005.

N. Weston-bell, M. Townsend, D. Genova, G. Forconi, F. Sahota et al., Defining origins of malignant B cells: a new circulating normal human IgM+ D+ B-cell subset lacking CD27 expression and displaying somatically mutated IGHV genes as a relevant memory population, Fecteau JF, Cote G, Neron S. A New Memory CD27-IgG+ B Cell Population in Peripheral Blood, vol.23, pp.2075-2080, 2009.

, Expressing VH Genes with Low Frequency of Somatic Mutation, J Immunol, vol.177, pp.3728-3764, 2006.

S. S. Chung, E. Kim, J. H. Park, Y. R. Chung, P. Lito et al.,

C. and O. , Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia, Sci Transl Med, vol.6, pp.238-71, 2014.

D. Michonneau, S. Kaltenbach, C. Derrieux, A. Trinquand, C. Brouzes et al.,

B. Varet and J. Emile, BRAFV600E mutation in a histiocytic sarcoma arising from hairy cell leukemia, J Clin Oncol, vol.32, pp.117-121, 2014.

F. Nicolaou, CD11c gene expression in hairy cell leukemia is dependent upon activation of the protooncogenes ras and junD, Blood, vol.101, pp.4033-4074, 2003.

A. S. Kamiguti, R. J. Harris, J. R. Slupsky, P. K. Baker, J. C. Cawley et al., Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways, Oncogene, vol.22, pp.2272-84, 2003.

E. Tiacci, V. Trifonov, G. Schiavoni, A. Holmes, W. Kern et al., BRAF mutations in hairy-cell leukemia, N Engl J Med, vol.364, pp.2305-2315, 2011.

P. T. Wan, M. J. Garnett, S. M. Roe, S. Lee, D. Niculescu-duvaz et al.,

C. J. Springer and C. J. , Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF, Cell, vol.116, pp.855-867, 2004.

A. M. Bogusz and A. Bagg, Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets, Leuk Lymphoma, vol.57, pp.1991-2013, 2016.

M. Cargnello and P. P. Roux, Activation and Function of the MAPKs and Their Substrates, the MAPK

, Activated Protein Kinases. Microbiol Mol Biol Rev, vol.75, pp.50-83, 2011.

P. Jain, N. Pemmaraju, and F. Ravandi, Update on the Biology and Treatment Options for Hairy Cell Leukemia

, Curr Treat Options Oncol, vol.15, pp.187-209, 2014.

B. Chaigne-delalande, L. Deuve, E. Reuzeau, C. Basoni, D. Lafarge et al.,

I. Kramer and E. Génot, RhoGTPases and p53 Are Involved in the Morphological Appearance and Interferon-? Response of Hairy Cells, Am J Pathol, vol.168, pp.562-73, 2006.

S. Wong and D. Fulcher, Chemokine Receptor Expression in B-cell Lymphoproliferative Disorders, Leuk Lymphoma, vol.45, pp.2491-2497, 2004.

H. Shibayama, N. Anzai, A. Ritchie, S. Zhang, C. Mantel et al., Interleukin-3 and Flt3-Ligand Induce Adhesion of Baf3/Flt3 Precursor B-Lymphoid Cells to Fibronectin via Activation of VLA-4 and VLA-5

, Cell Immunol, vol.187, pp.27-33, 1998.

J. Burthem, P. K. Baker, J. A. Hunt, and J. C. Cawley, Hairy cell interactions with extracellular matrix: expression of specific integrin receptors and their role in the cell's response to specific adhesive proteins, Blood, vol.84, pp.873-882, 1994.

A. M. Vincent, J. Burthem, R. Brew, and J. C. Cawley, Endothelial interactions of hairy cells: the importance of alpha 4 beta 1 in the unusual tissue distribution of the disorder, Blood, vol.88, pp.3945-3952, 1996.

J. C. Cawley and S. F. Hawkins, The biology of hairy-cell leukaemia, Curr Opin Hematol, vol.17, pp.341-350, 2010.

/. Moh,

M. Sivina, R. J. Kreitman, E. Arons, F. Ravandi, and J. A. Burger, The bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) blocks hairy cell leukaemia survival, proliferation and B cell receptor signalling: a new therapeutic approach, Br J Haematol, vol.166, pp.177-88, 2014.

E. Tiacci, A. Liso, M. Piris, and B. Falini, Evolving concepts in the pathogenesis of hairy-cell leukaemia, Nat Rev Cancer, vol.6, pp.437-485, 2006.

K. A. Aziz, K. J. Till, M. Zuzel, and J. C. Cawley, Involvement of CD44-hyaluronan interaction in malignant cell homing and fibronectin synthesis in hairy cell leukemia, Blood, vol.96, pp.3161-3167, 2000.

M. Shehata, J. D. Schwarzmeier, M. Hilgarth, R. Hubmann, M. Duechler et al., TGF-?1 induces bone marrow reticulin fibrosis in hairy cell leukemia, Garnache Ottou F, Chandesris M, vol.113, pp.676-85, 2004.

C. Villemant, S. Rubio, M. Belanger, C. Suarez, F. Deau et al., Peripheral blood 8 colour flow cytometry monitoring of hairy cell leukaemia allows detection of high-risk patients, Br J Haematol, vol.166, pp.50-59, 2014.

L. Meyaard, The inhibitory collagen receptor LAIR-1 (CD305), J Leukoc Biol, vol.83, pp.799-803, 2008.

J. J. Limon and D. A. Fruman, Akt and mTOR in B Cell Activation and Differentiation. Front Immunol, vol.3, 2012.

T. Weichhart, M. Hengstschläger, M. Linke, S. Nagel, S. Ehrentraut et al., NFkB is activated by multiple mechanisms in hairy cell leukemia: NFkB IS Activated by Multiple Mechanisms, Genes Chromosomes Cancer, vol.15, pp.418-450, 2015.

R. Küppers, Mechanisms of B-cell lymphoma pathogenesis, Nat Rev Cancer, vol.5, pp.251-62, 2005.

F. Forconi, E. Sozzi, E. Cencini, F. Zaja, T. Intermesoli et al.,

A. Baraldi, A. Gallamini, A. Zaccaria, and A. Pulsoni, Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behavior, Blood, vol.114, pp.4696-702, 2009.

C. Sambani, D. T. Trafalis, C. Mitsoulis-mentzikoff, E. Poulakidas, V. Makropoulos et al.,

C. , Clonal chromosome rearrangements in hairy cell leukemia: personal experience and review of literature, Cancer Genet Cytogenet, vol.129, pp.138-144, 2001.

Y. Ueshima, G. Alimena, J. D. Rowley, and H. M. Golomb, Cytogenetic studies in patients with hairy cell leukemia, Hematol Oncol, vol.1, pp.215-226, 1983.

S. L. Hockley, G. J. Morgan, P. E. Leone, B. A. Walker, A. Morilla et al.,

D. Catovsky and D. Gonzalez, High-resolution genomic profiling in hairy cell leukemia-variant compared with typical hairy cell leukemia, Leukemia, vol.25, pp.1189-1192, 2011.

S. H. Swerdlow, E. Campo, L. Harris, N. Jaffe, E. S. Pileri-stefano et al., WHO Classification of tumours of Haematopoietic and Lymphoid Tissues. Lyon, 2008.

E. Tiacci, V. Pettirossi, G. Schiavoni, and B. Falini, Genomics of Hairy Cell Leukemia, J Clin Oncol, vol.35, pp.1002-1012, 2017.

L. Xi, E. Arons, W. Navarro, K. R. Calvo, M. Stetler-stevenson et al., Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation, Waterfall JJ, vol.119, pp.3330-3332, 2012.

P. S. Meltzer, High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias

, Nat Genet, vol.46, pp.8-10, 2013.

N. J. Weston-bell, W. Tapper, J. Gibson, D. Bryant, Y. Moreno et al.,

A. R. Collins and S. S. Sahota, Exome Sequencing in Classic Hairy Cell Leukaemia Reveals Widespread Variation in

, Acquired Somatic Mutations between Individual Tumours Apart from the Signature BRAF V(600)E Lesion

, PLOS ONE, vol.11, 2016.

S. Dietrich, J. Hüllein, S. Lee, B. Hutter, D. Gonzalez et al., Recurrent CDKN1B (p27) mutations in hairy cell leukemia, Blood, vol.126, pp.1005-1008, 2015.

M. S. Lawrence, P. Stojanov, P. Polak, G. V. Kryukov, K. Cibulskis et al.,

C. H. Mermel, S. A. Roberts, A. Kiezun, P. S. Hammerman, and A. Mckenna, XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy, J Hematol OncolJ Hematol Oncol, vol.499, p.2017, 2013.

, , vol.10

L. Jallades, L. Baseggio, P. Sujobert, S. Huet, K. Chabane et al.,

J. Salgado, D. Levy, N. Béroud, C. Felman, and P. , Exome sequencing identifies recurrent BCOR gene alterations and the absence of KLF2, TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma

, Haematologica, pp.1758-66, 2017.

V. Pettirossi, A. Santi, E. Imperi, G. Russo, A. Pucciarini et al.,

A. Rosseto and P. Sportoletti, BRAF inhibitors reverse the unique molecular signature and phenotype of hairy cell leukemia and exert potent antileukemic activity, Blood, vol.125, pp.1207-1216, 2015.

E. Tiacci, J. H. Park, D. Carolis, L. Chung, S. S. Broccoli et al.,

M. Cimminiello, E. Kim, and D. Rossi, Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia

, N Engl J Med, vol.373, pp.1733-1780, 2015.

A. Wotherspoon, A. Attygalle, and L. Sena-teixeira-mendes, Bone marrow and splenic histology in hairy cell leukaemia, Best Pract Res Clin Haematol, vol.28, pp.200-207, 2015.

M. J. Sherman, C. A. Hanson, and J. D. Hoyer, An Assessment of the Usefulness of Immunohistochemical Stains in the Diagnosis of Hairy Cell Leukemia, Am J Clin Pathol, vol.136, pp.390-399, 2011.

R. W. Sharpe and K. J. Bethel, Hairy Cell Leukemia: Diagnostic Pathology, Hematol Oncol Clin North Am, vol.20, pp.1023-1072, 2006.

E. Matutes, R. Morilla, K. Owusu-ankomah, H. Houliham, P. Meeus et al., Proposal for a scoring system to distinguish HCL from B-cell disorders with hairy or villous lymphocytes, Leuk Lymphoma, vol.14, pp.57-61, 1994.

E. Matutes, K. Owusu-ankomah, R. Morilla, J. G. Marco, A. Houliham et al.,

, Immunological Profile of B-Cell Disorders and Proposal of a Scoring System f0r the Diagnosis of CLL, Leukemia, vol.8, pp.1640-1645, 1994.

G. Venkataraman, C. Aguhar, R. J. Kreitman, C. M. Yuan, and M. Stetler-stevenson, Characteristic CD103 and CD123 Expression Pattern Defines Hairy Cell Leukemia: Usefulness of CD123 and CD103 in the Diagnosis of Mature B-Cell Lymphoproliferative Disorders, Am J Clin Pathol, vol.136, 2011.

I. Del-giudice, E. Matutes, R. Morilla, A. Morilla, K. Owusu-ankomah et al.,

M. B. Bazerbashi and D. Catovsky, The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes, haematologica, vol.89, pp.303-308, 2004.

R. Favre, D. Manzoni, A. Traverse-glehen, A. Verney, L. Jallades et al.,

L. Baseggio, Usefulness of CD200 in the differential diagnosis of SDRPL, SMZL, and HCL, Int J Lab Hematol, 2018.

D. Jain, P. Dorwal, S. Gajendra, A. Pande, S. Mehra et al., Diagnostic application of two-color flow cytometry in 161 cases of hairy cell leukemia, Cytometry B Clin Cytom, vol.90, pp.1277-1287, 1993.

T. M. Jasionowski, L. Hartung, J. H. Greenwood, S. L. Perkins, and D. W. Bahler, Analysis of CD10+ Hairy Cell Leukemia, Am J Clin Pathol, vol.120, pp.228-263, 2003.

G. Juliusson, R. Lenkei, and J. Liliemark, Flow cytometry of blood and bone marrow cells from patients with hairy cell leukemia: phenotype of hairy cells and lymphocyte subsets after treatment with 2-chlorodeoxyadenosine, Blood, vol.83, pp.3672-3681, 1994.

N. Poret, Q. Fu, S. Guihard, M. Cheok, K. Miller et al.,

C. S. Shelley, CD38 in Hairy Cell Leukemia Is a Marker of Poor Prognosis and a New Target for Therapy, Cancer Res, vol.75, pp.3902-3913, 2015.

E. Tiacci, G. Schiavoni, F. Forconi, A. Santi, L. Trentin et al.,

P. , D. Bello, C. Pulsoni, A. Foa, R. Inghirami et al., Simple genetic diagnosis of hairy cell leukemia by sensitive detection of the BRAF-V600E mutation, Blood, vol.119, pp.192-197, 2012.

W. O. Greaves, S. Verma, K. P. Patel, M. A. Davies, B. A. Barkoh et al.,

L. J. Medeiros, Frequency and spectrum of BRAF mutations in a retrospective, single-institution study of 1112 cases of melanoma, J Mol Diagn, vol.15, pp.220-226, 2013.

G. Badalian-very, J. Vergilio, B. A. Degar, L. E. Macconaill, B. Brandner et al.,

A. H. Stevenson, K. E. Kehoe, S. M. Garraway, L. A. Hahn, W. C. Meyerson et al., Recurrent BRAF mutations in Langerhans cell histiocytosis, Blood, vol.116, pp.1919-1942, 2010.

M. A. Chapman, M. S. Lawrence, J. J. Keats, K. Cibulskis, C. Sougnez et al.,

G. J. Ahmann, M. Adli, K. C. Anderson, K. G. Ardlie, and D. Auclair, Initial genome sequencing and analysis of multiple myeloma, Nature, vol.471, pp.467-72, 2011.

S. Tschernitz, L. Flossbach, M. Bonengel, S. Roth, A. Rosenwald et al., Alternative <i>BRAF<i> mutations in BRAF V600E-negative hairy cell leukaemias, Br J Haematol, vol.165, pp.529-562, 2014.

E. Arons, L. Roth, J. Sapolsky, T. Suntum, M. Stetler-stevenson et al., Evidence of canonical somatic hypermutation in hairy cell leukemia, Blood, vol.117, pp.4844-4851, 2011.

M. R. Grever, O. Abdel-wahab, L. A. Andritsos, V. Banerji, J. Barrientos et al.,

C. Dearden and J. Demeter, Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia, Blood, vol.129, pp.553-560, 2017.

M. L. Coleman, C. J. Marshall, and M. F. Olson, RAS and RHO GTPases in G1-phase cell-cycle regulation, Nat Rev Mol Cell Biol, vol.5, pp.355-66, 2004.

C. J. Sherr and F. Mccormick, The RB and p53 pathways in cancer, Cancer Cell, vol.2, pp.103-115, 2002.

E. A. König, W. C. Kusser, C. Day, F. Porzsolt, B. W. Glickman et al., p53 mutations in hairy cell leukemia, Leukemia, vol.14, pp.706-717, 2000.

K. Vallianatou, V. Brito-babapulle, E. Matutes, S. Atkinson, and D. Catovsky, p53 gene deletion and trisomy 12 in hairy cell leukemia and its variant, Leuk Res, vol.23, pp.1041-1045, 1999.

T. Zenz, A. Benner, H. Döhner, and S. Stilgenbauer, Chronic lymphocytic leukemia and treatment resistance in cancer: The role of the p53 pathway, Cell Cycle, vol.7, pp.3810-3814, 2008.

B. H. Durham, B. Getta, S. Dietrich, J. Taylor, H. Won et al.,

T. Robak, E. Matutes, D. Catovsky, P. L. Zinzani, and C. Buske, Hairy cell leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Br J Haematol, vol.26, pp.100-107, 2015.

V. Vergote, D. Dierickx, A. Janssens, G. Verhoef, T. Tousseyn et al.,

M. Delforge, K. T. Flaherty, J. R. Infante, A. Daud, R. Gonzalez et al., Rapid and complete hematological response of refractory hairy cell leukemia to the BRAF inhibitor dabrafenib, Ann Hematol, vol.93, pp.2087-2096, 2014.

J. Cebon, N. Ibrahim, R. Kudchadkar, H. A. Burris, and G. Falchook, Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations, N Engl J Med, vol.367, pp.1694-703, 2012.

D. J. Lechleider, R. Pastan, and I. , Phase I Trial of Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (CAT-8015 or HA22) in Patients With Hairy Cell Leukemia, Getta BM, vol.30, pp.269-72, 2012.

S. Dubois, P. Viailly, S. Mareschal, E. Bohers, P. Bertrand et al.,

P. Peyrouze, M. Figeac, T. J. Molina, F. Desmots, and T. Fest, Next Generation Sequencing in Diffuse Large B Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study, Clin Cancer Res, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01343064

D. Colecchia, M. Rossi, F. Sasdelli, S. Sanzone, A. Strambi et al., MAPK15 mediates BCR

A. P. Weng, A. A. Ferrando, W. Lee, J. P. Morris, L. B. Silverman et al., Bigas A, Robert-Moreno lex, Espinosa L. The Notch pathway in the developing hematopoietic system, ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation, vol.11, pp.1175-88, 2004.

E. Manel, Epigenetics in Cancer, N Engl J Med, p.12, 2008.

F. Jardin, A. Pujals, L. Pelletier, E. Bohers, V. Camus et al.,

M. , L. F. Viailly, P. Bertrand, P. Maingonnat, and C. , Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma: XPO1 Mutations in Primary Mediastinal B-Cell Lymphoma, Am J Hematol, vol.91, pp.923-953, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01372756

F. Gabillaud, C. Brunelle-navas, M. Davi, F. , M. -. Béral et al., Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: Analysis of the central role of XPO1, Leukemia, 2017.

C. Albrecht, E. Viturro, R. Piva, S. Deaglio, R. Famà et al., The ABCA subfamily-gene and protein structures, functions and associated hereditary diseases. Pflüg Arch, Eur J Physiol, vol.453, pp.581-590, 2007.

D. Brusa, G. Garaffo, S. Monti, D. Bo, and M. , The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma, Leukemia, vol.29, pp.503-510, 2015.

B. Jebaraj, D. Kienle, A. Bühler, D. Winkler, H. Döhner et al., Factor 2 Is a Transcriptional Regulator of Chronic and Acute Inflammation, Leuk Lymphoma, vol.182, pp.1177-82, 2013.

E. Tiacci, A. Pucciarini, B. Bigerna, V. Pettirossi, F. Strozzini et al., Absence of BRAF-V600E in the human cell lines BONNA-12, ESKOL, HAIR-M, and HC-1 questions their origin from hairy cell leukemia, Blood, vol.119, pp.5332-5333, 2012.

G. Wientjens, J. H. Jansen, H. W. Wessels, R. E. Kibbelaar, G. C. Beverstock et al., Characterization of a new human B cell line (Bonna-12) with trisomy 9 and trisomy 12 chromosomal abnormality, Leuk Lymphoma, vol.5, pp.415-422, 1991.

L. C. Anderson, C. G. Gahmberg, S. E. Jansson, P. Vuopio, and E. Lehtonen, Establishment and characterization of a hairy cell leukemia cell line, JOK-1. Leuk Markers, pp.297-300, 1981.

Z. Yao, N. M. Torres, A. Tao, Y. Gao, L. Luo et al.,

P. I. Poulikakos and N. Rosen, BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition, Cancer Cell, vol.28, pp.370-83, 2015.

G. T. Hart, X. Wang, K. A. Hogquist, J. Sc-;-winkelmann, R. Sandrock et al., Kruppel-like factor 2 (KLF2) regulates B-cell reactivity, subset differentiation, and trafficking molecule expression, Proc Natl Acad Sci, vol.108, pp.716-737, 2011.

W. Schuh and H. Jack, B cell homeostasis and plasma cell homing controlled by Kruppel-like factor 2, Sivina M, Burger JA. The importance of the tissue microenvironment in hairy cell leukemia, vol.108, pp.710-715, 2011.

J. M. Cortazar, D. J. Deangelo, G. S. Pinkus, and E. A. Morgan, Morphological and immunophenotypical features of hairy cell leukaemia involving lymph nodes and extranodal tissues, Bromberg-White JL, Andersen NJ, Duesbery NS. MEK genomics in development and disease, vol.28, pp.112-136, 2015.

C. M. Emery, K. G. Vijayendrana, M. C. Zipserc, A. M. Sawyera, L. Niua et al., Brief Funct Genomics, vol.11, pp.300-310, 2012.

R. Oberholzera, P. A. Karpovac, M. B. Macconailla, L. E. Zhangf, J. Grayf et al., MEK1 mutations confer resistance to MEK and B-RAF inhibition, PNAS, vol.106, pp.20411-20417, 2009.

R. K. , S. D. Levine, R. Michel, K. Thomas, and R. K. , Novel MEK1 Mutation Identified by Mutational Analysis of

G. Van-haaften, G. L. Dalgliesh, H. Davies, L. Chen, G. Bignell et al., Epidermal Growth Factor Receptor Signaling Pathway Genes in Lung Adenocarcinoma, Cancer Res, vol.68, pp.5524-5532, 2008.

O. &apos;meara, S. Teague, J. Butler, A. Hinton, J. Latimer et al., Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer, Sengoku T, Yokoyama S. Structural basis for histone H3 Lys, vol.41, pp.521-524, 2009.

. Utx/kdm6a, Genes Dev, vol.25, pp.2266-77, 2011.

D. Ler, L. Ghosh, S. Chai, X. Thike, A. A. et al., Loss of tumor suppressor KDM6A amplifies PRC2regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2, Sci Transl Med, vol.9, 2017.

M. , P. T. Vandenberghe, P. Schuh, A. Becq, J. Humphray et al., The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia, Blood, vol.125, pp.13-21, 2015.

S. , K. I. Kingsbury, Z. Luo, S. Mcbride, and D. , Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns, Blood, vol.120, pp.4191-4197, 2012.

V. Camus, A. Stamatoullas, S. Mareschal, P. Viailly, N. Sarafan-vasseur et al.,

J. M. Picquenot, P. Ruminy, C. Maingonnat, P. Bertrand, M. Cornic et al., Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma, Haematologica, vol.101, pp.1094-101, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01643995

A. Kohlmann, A. Haferlach, T. Kern, W. Schnittger, S. Tuna et al., SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients, Trends Mol Med, vol.28, pp.120-128, 2009.

B. Cavenagh, J. D. Fitzgibbon, J. Lister, T. A. Young, and B. D. , Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia, Blood, vol.112, pp.814-835, 2008.

J. Lee, J. Kim, K. M. Kim, S. Kim, D. Park et al., Overexpression of MAPK15 in gastric cancer is associated with copy number gain and contributes to the stability of c-Jun, Oncotarget, vol.6, 2015.

M. Chiariello, Activation of the Erk8 Mitogen-activated Protein (MAP) Kinase by RET/PTC3, a Constitutively Active Form of the RET Proto-oncogene, J Biol Chem, vol.281, pp.10567-76, 2006.

Y. Martín, A. Batlle, S. González-de-villambrosía, M. Gut, J. Blanc et al., Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations, Blood, vol.129, pp.1042-1047, 2017.