. .. Introduction,

C. .. Actuel,

C. .. Le-rôle-de-l'activation-de-la-protéine,

.. .. Le-rôle-du-fibrinogène,

L. .. ,

M. .. Et-méthodes,

R. .. ,

.. .. ,

. .. Discussion,

C. .. ,

R. .. Bibliographiques,

L. .. Des-abréviations,

A. .. ,

. , Annexe 1 : La chaîne de soutien médicale du SSA en opération extèrieur

. , Organisation d'un rôle, vol.2

. Publication and . .. Communications,

, Il se reconstitue en moins de 6 minutes, pour un volume de plasma final de 210ml

, Après reconstitution, il doit alors être transfusé immédiatement (14)

, Une des limites de production résulte en son coût de fabrication, 3 fois plus important que celui du PFC, soit environ 400 euros par unité. Cependant son extension à une utilisation civile pourrait s'accompagner d'une baisse de son coût de production

, Propriétés du plasma lyophilisé La préservation de l'activité de coagulation est contrôlée par la mesure de la concentration en facteur VIII (>0,5UI/ml) et du fibrinogène, p.2

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B. H. Tieu, J. B. Holcomb, and M. A. Schreiber, Coagulopathy: Its Pathophysiology and Treatment in the Injured Patient, World J Surg, vol.31, pp.1055-65, 2007.

J. Macleod, M. Lynn, M. G. Mckenney, S. M. Cohn, and M. Murtha, Early coagulopathy predicts mortality in trauma, J Trauma, vol.55, pp.39-44, 2003.

M. Maegele, R. Lefering, N. Yucel, T. Tjardes, D. Rixen et al., Early coagulopathy in multiple injury: An analysis from the German Trauma Registry on 8724 patients, Injury, vol.38, pp.298-304, 2007.

D. S. Kauvar, R. Lefering, and C. E. Wade, Impact of Hemorrhage on Trauma Outcome: An Overview of Epidemiology, Clinical Presentations, and Therapeutic Considerations

, J Trauma Acute Care Surg, vol.60, pp.3-11, 2006.

J. B. Holcomb, D. Jenkins, P. Rhee, J. Johannigman, P. Mahoney et al., Damage control resuscitation: directly addressing the early coagulopathy of trauma, J Trauma, vol.62, pp.307-317, 2007.

R. Rossaint, B. Bouillon, V. Cerny, T. J. Coats, J. Duranteau et al., The European guideline on management of major bleeding and coagulopathy following trauma

, Crit Care, vol.12, p.100, 2016.

J. C. Duchesne, N. Mcswain, B. A. Cotton, J. P. Hunt, J. Dellavolpe et al., Damage Control Resuscitation: The New Face of Damage Control, J Trauma Acute Care Surg, vol.69, pp.976-90, 2010.

D. J. Riskin, T. C. Tsai, L. Riskin, T. Hernandez-boussard, M. Purtill et al., Massive Transfusion Protocols: The Role of Aggressive Resuscitation Versus Product Ratio in Mortality Reduction, J Am Coll Surgeons, vol.209, pp.198-205, 2009.

J. B. Holcomb, B. C. Tilley, S. Baraniuk, E. E. Fox, C. E. Wade et al., PROPPR Study Group: Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial, JAMA, vol.313, pp.471-82, 2015.

D. J. Novak, Y. Bai, R. K. Cooke, M. B. Marques, M. J. Fontaine et al., Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic

, Transfusion, vol.55, issue.6, pp.1331-1339, 2015.

Z. A. Radwan, Y. Bai, N. Matijevic, D. J. Del-junco, J. J. Mccarthy et al., An emergency department thawed plasma protocol for severely injured patients, JAMA Surg, vol.148, pp.170-175, 2013.

S. Beaume, B. Prunet, and J. Cotte, Utilisation du plasma lyophilisé (PLYO) en salle d'accueil des urgences vitales (SAUV) pour l'accueil des traumatisés graves, Ann Fr Anesth, vol.33, p.125, 2014.
DOI : 10.1016/j.annfar.2014.07.207

A. Sailliol, C. Martinaud, A. P. Cap, C. Civadier, B. Clavier et al., The evolving role of lyophilized plasma in remote damage control resuscitation in the French Armed Forces Health Service, Transfusion, vol.53, pp.65-71, 2013.

A. Godier, M. Bacus, E. Kipnis, B. Tavernier, A. Guidat et al., Compliance with evidence-based clinical management guidelines in bleeding trauma patients, Br J Anaesth, vol.117, pp.592-600, 2016.

J. W. Simmons and M. F. Powell, Acute traumatic coagulopathy: pathophysiology and resuscitation, BJA, vol.117, pp.31-43, 2016.
DOI : 10.1093/bja/aew328

, Transfusion de plasma thérapeutique: produits, indications 2012, pp.1-15

V. Vitalis, C. Carfantan, A. Montcriol, S. Peyrefitte, A. Luft et al., Early transfusion on battlefield before admission to role 2: A preliminary observational study during, Barkhane" operation in Sahel. Injury, 2017.

J. Bordes, C. Joubert, P. Esnault, A. Montcriol, C. Nguyen et al., Coagulopathy and transfusion requirements in war related penetrating traumatic brain injury. A single centre study in a French role 3 medical treatment facility in Afghanistan, Injury, 2016.

C. Martinaud, C. Civadier, S. Ausset, C. Verret, A. V. Deshayes et al., Vitro Hemostatic Properties of French Lyophilized Plasma, vol.117, pp.339-385, 2012.

G. A. Sunde, B. Vikenes, G. Strandenes, K. C. Flo, T. A. Hervig et al., Freeze dried plasma and fresh red blood cells for civilian prehospital hemorrhagic shock resuscitation, J Trauma Acute Care Surg, vol.78, issue.6, pp.26-30, 2015.

J. M. Yeguiayan, D. Garrigue, C. Binquet, C. Jacquot, J. Duranteau et al., Prise en charge actuelle du traumatisé grave en France: premier bilan de l'étude FIRST (French Intensive care Recorded in Severe Trauma), Ann Fr Med Urg, vol.2, issue.3, pp.156-63, 2012.

A. B. Nathens, F. P. Brunet, and R. V. Maier, Development of trauma systems and effect on outcomes after injury, Lancet, vol.363, pp.1794-801, 2004.

A. E. Pusateri, M. B. Given, M. A. Schreiber, P. C. Spinella, S. Pati et al., Dried plasma: state of the science and recent developments, Transfusion, vol.56, issue.2, pp.128-167, 2016.

E. Glassberg, R. Nadler, S. Gendler, A. Abramovich, P. C. Spinella et al., Freeze-dried plasma at the point of injury: from concept to doctrine, Shock, vol.40, issue.6, pp.444-50, 2013.