Caractéristiques neuropsychologiques des syndromes parkinsoniens dégénératifs aux Antilles Françaises et apport de l'enregistrement oculomoteur dans l'étude du profil cognitif

Abstract : Introduction : The neuropsychological assessment and the recording of eye movements in Parkinson's patients constitute a diagnostic aid and an evolutionary marker of the disease. We studied the cognitive profile of patients with different West Indian degenerative parkinsonian syndromes and the correlations between neuropsychological test results and oculomotor parameters. Material and Methods : 180 patients, 63 carriers of Parkinson's disease, 117 with atypical parkinsonism, recruited in Guadeloupe and Martinique between 2012 and 2016 as part of a prospective cohort study, were studied. Neuropsychological evaluation included the assessment of cognitive efficiency, memory, executive functions, visuospatial abilities, praxies, mood. Cognitive data and oculomotor parameters recorded by eye tracking were correlated in 117 patients. Results : The cognitive impairment of atypical parkinsonian patients was more severe with a cortico-sub-cortico-frontal profile that differed from the sub-cortico-frontal profile observed in Parkinson's disease. The cortical component was particularly marked in patients with impaired vertical gaze. The latencies of horizontal and vertical oculomotor saccades and the percentage of errors in antisaccades were correlated with pathological neuropsychological scores, particularly in global and executive but also instrumental and visuospatial components. Discussion : Oculomotor and neuropsychological parameters strongly correlated with each other are indicators of frontal and parietal dysfunction in Caribbean atypical Parkinsonism. This study could lead to the development of profiles combining oculomotor parameters and cognition which could contribute to the characterisation and follow-up of parkinsonism.
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Master Thesis
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Aimée Petit. Caractéristiques neuropsychologiques des syndromes parkinsoniens dégénératifs aux Antilles Françaises et apport de l'enregistrement oculomoteur dans l'étude du profil cognitif. Neurosciences [q-bio.NC]. 2018. ⟨dumas-01981140⟩

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