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E. , sabine.trellu@gmail.com Phone: +33 1 49, vol.28, p.20

, Results: Base-case scenario: According to the model constructed, at the end of the 5-year period the virtual population contained 9300 patients, as in 700 of the initial 10 000 patients KOA onset could not be estimated (like the loss of follow-up patients in the CHECK cohort), Fax +33 1 49 28 25 13 Word count: 2345 words-The odd-ratio of KOA with a 5% or 5kg weight loss was modified and changed into the confidence interval value (0.3 to 0.9

, If this cohort benefited from management of overweight and obesity for a loss of 2.5 points of BMI, with an acceptance rate of 40%, 1586 people would reach a BMI < 25

, kg/m² at the end of the 5-year period, and 148 KOA would be spared (23.13%) in the target population

, 11? per target patient in direct costs in 5 years: 52.36? in consultation for KOA and medication, 21.14? in arthroplasties, 146.09? for overweight and obesity (complications), and 20.53? for indemnity for sick leave days. The healthcare system would save 150.33? per target patient and indirect costs saved would be 176? for KOA, vol.600, p.605

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