X. Yao, F. Chen, P. Li, L. Quan, J. Chen et al., Natural product Vindoline stimulates insulin secretion

, International Diabetes Federation-Epidemiology & research

. Disponible,

S. H. Tiong, C. Y. Looi, A. Arya, W. F. Wong, H. Hazni et al., Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae), Fitoterapia. avr, vol.102, pp.182-188, 2015.

W. Peter and J. , What is diabetes?, Br Med J, vol.284, pp.1690-1692, 1982.

K. Kohei, Pathophysiology of type 2 diabetes and its treatment policy, JMAJ, vol.53, issue.1, pp.41-46, 2010.

, type-1-diabetes-19063415.jpg (JPEG Image, 1130 × 1300 pixels, p.12, 2017.

. Disponible,

A. Somogyi, C. Mathé, M. Anciaux, A. Endocrinologie, C. Somogyi et al., , pp.2-3, 2006.

L. Grand and N. , Démarche de l'ethnopharmacologie appliquée : plantes antidiabétiques de Madagascar, UNIVERSITÉ RENNES, pp.23-25, 2008.

M. Buysschaert and G. Slama, Diabétologie clinique M.Buysschaert ; préface de G.Slama. 4e édition, pp.2-3, 2011.

J. M. Kim and D. Kim, The Optimal Cutoff Value of Glycated Hemoglobin for Detection of Diabetic Retinopathy, Diabetes Metab J. févr, vol.39, issue.1, pp.16-26, 2015.

C. Beudaert and G. Cavé, Prise en charge du diabète de type 1 et évolution des techniques de traitement par C.Beudaert, pp.11-15, 1983.

A. Grimaldi, Diabète de type 2 coord. par André Grimaldi ; préf. d'A.Grimaldi, pp.170-199, 1944.

A. Grimaldi, Traité de diabétologie coordonné par A.Grimaldi. 2e édition, Flammarion médecinesciences, pp.401-404, 1944.

B. Baz, J. Riveline, J. Gautier, . Endocrinology, and . Pregnancy, Gestational diabetes mellitus: definition, aetiological and clinical aspects, Eur J Endocrinol. 2 janv, vol.174, issue.2, pp.43-51, 2016.

, Type 2 diabetes stock vector. Image of hormone, 2017.

. Disponible,

L. Perlemuter, J. Sélam, C. De-l'hortet, G. Diabète, L. Maladies-métaboliques et al., Collin de l'Hortet, 4e éd, pp.247-248, 1936.

J. Petit and J. Altman, Belon J-P, 1946.

D. Endocrinologie, J. Petit, and J. Altman, JP.Belon. Masson, p.95, 2005.

, VIDAL : Base de données médicamenteuse pour les prescipteurs libéraux

V. ,

. Disponible,

A. A. Tahrani, A. H. Barnett, and C. J. Bailey, Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus, Nat Rev Endocrinol, vol.12, issue.10, pp.566-592, 2016.

K. Alberti, Treating type 2 diabetes-today's targets, tomorrow's goals, Diabetes Obes Metab, vol.3, issue.s1, pp.3-10, 2001.

H. Kourlas and J. Papadopoulas, Clinical Pharmacy Corner: How Do Sulfonylureas Work? | Clinical Correlations, p.12, 2017.

P. M. Ellis and A. T. Dronsfield, Antabuse's diamond anniversary: Still sparkling on?: Antabuse's diamond anniversary, Drug Alcohol Rev. juill, vol.32, issue.4, pp.342-344, 2013.

A. Napolitano, S. Miller, A. W. Nicholls, D. Baker, S. Van-horn et al., Novel Gut-Based Pharmacology of Metformin in Patients with Type 2 Diabetes Mellitus, PLoS ONE. Juill, vol.9, issue.7, pp.1-14, 2014.

E. Jaoued, H. Zidi, and M. Chekir, Les médicaments du diabéte, p.12, 2017.

. Disponible, , 2017.

R. Tundis, M. R. Loizzo, and F. Menichini, Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update, Mini Rev Med Chem. avr, vol.10, issue.4, pp.315-331, 2010.

E. Prevost, Place de l'INSULINOTHERAPIE FONCTIONNELLE dans la prise en charge du diabète de type 1

, UNIVRESITE LILLE 2, pp.78-81, 2015.

W. Werner, . Inuline, and . Insuline, , p.27, 2017.

. Disponible, Bioproductionhome, p.27, 2017.

. Disponible,

, European Medicines Agency-Find medicine-Invokana

. Disponible,

H. P. , Substances naturelles se fixant sur la tubuline-mise en oeuvre d'un criblage par spectrométrie de masse, UNIVERSITÉ NANCY, vol.1, pp.13-21, 2009.

S. Leroux, Synthèse d'alcaloïdes de Vinca et nouvelle approche de la synthèse de la (D)-méquitazine

N. Nejat, A. Valdiani, D. Cahill, Y. Tan, M. Maziah et al., Ornamental Exterior versus Therapeutic Interior of Madagascar Periwinkle ( Catharanthus roseus ): The Two Faces of a Versatile Herb, Sci World J, vol.2015, pp.1-19, 2015.

R. Van-der-heijden, D. I. Jacobs, W. Snoeijer, D. Hallard, and R. Verpoorte, The Catharanthus alkaloids: pharmacognosy and biotechnology, Curr Med Chem. mars, vol.11, issue.5, pp.607-628, 2004.

P. Boiteau and L. Allorge-boiteau, Plantes médicinales de Madagascar:cinquante-huit plantes médicinales utilisées sur le marché de Tananarive (Zoma) à Madagascar /Pierre Boiteau et Lucile Allorge-Boiteau;préface de Jean-Martin Razafinsalama, ACCT Karthala ICSN, pp.28-29, 1993.

J. Aslam, S. H. Khan, Z. H. Siddiqui, Z. Fatima, M. Maqsood et al.,

. Don, An important drug: it's applications and production, Pharm Glob IJCP, vol.4, issue.12, pp.1-16, 2010.

S. Aziz, K. Saha, N. Sultana, H. P. Nur, M. A. Ahsan et al., Comparative studies of elemental composition in leaves and flowers of Catharanthus roseus growing in Bangladesh, Asian Pac J Trop Biomed. janv, vol.6, issue.1, pp.50-54, 2016.

J. Pousset, Plantes médicinales africaines. Utilisation pratique

. Société-française-d'ethnopharmacologie, , 1989.

. Disponible,

Q. Pan, M. Z. Saiman, N. R. Mustafa, R. Verpoorte, and K. Tang, A simple and rapid HPLC-DAD method for simultaneously monitoring the accumulation of alkaloids and precursors in different parts and different developmental stages of Catharanthus roseus plants, J Chromatogr B. 1 mars, vol.1014, pp.10-16, 2016.

T. Miyazaki, S. Yokoshima, S. Simizu, H. Osada, H. Tokuyama et al., Total Synthesis of Vinblastine by Fukuyama, p.13, 2007.

. Disponible,

, Vinorelbine ditartrate salt hydrate ?98% (HPLC), powder | Sigma-Aldrich, p.13, 2017.

. Disponible,

|. Vindesine and . Cas, Product Use Citation | ChemFaces, p.13, 2017.

. Disponible,

N. F. Rizvi, J. D. Weaver, E. J. Cram, and C. Lee-parsons, Silencing the Transcriptional Repressor, ZCT1, Illustrates the Tight Regulation of Terpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus Hairy Roots. Dhaubhadel S, éditeur, PLOS ONE. 28 juill, vol.11, issue.7, pp.1-17, 2016.

S. Besseau, F. Kellner, A. Lanoue, A. Thamm, V. Salim et al., A Pair of Tabersonine 16Hydroxylases Initiates the Synthesis of Vindoline in an Organ-Dependent Manner in Catharanthus roseus, PLANT Physiol. 1 déc, vol.163, issue.4, pp.1792-1803, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01133503

M. Moudi, R. Go, C. Yien, M. Nazre, and . Vinca-alkaloids, Int J Prev Med. nov, vol.4, issue.11, 2013.

. Disponible,

, Accueil-Base de données publique des médicaments

. Disponible,

D. Bates and A. Eastman, Microtubule destabilising agents: far more than just antimitotic anticancer drugs

, Br J Clin Pharmacol. 1 févr, vol.83, issue.2, pp.255-268, 2017.

. Catharanthus_roseus,

S. Sertel, Y. Fu, Y. Zu, B. Rebacz, B. Konkimalla et al., Molecular docking and pharmacogenomics of Vinca alkaloids and their monomeric precursors, Vindoline and catharanthine

, Biochem Pharmacol. 15 mars, vol.81, issue.6, pp.723-735, 2011.

R. L. Noble, The discovery of the vinca alkaloids-chemotherapeutic agents against cancer, Biochem Cell Biol Biochim Biol Cell. déc, vol.68, issue.12, pp.1344-1351, 1990.

R. L. Noble, C. T. Beer, and J. H. Cutts, Role of chance observations in chemotherapy: vinca rosea*, Ann N Y Acad Sci. 22 déc, vol.76, issue.3, pp.882-894, 2006.

X. Wu, S. Tang, Y. Jin, S. Wang, X. Wang et al., Determination of the metabolic profile of gentianine after oral administration to rats by high performance liquid chromatography/electrospray ionization-trap mass spectrometry, J Chromatogr B. 1 mai, vol.989, pp.98-103, 2015.

F. Mirzaee, A. Hosseini, H. B. Jouybari, A. Davoodi, and M. Azadbakht, Medicinal, biological and phytochemical properties of Gentiana species, J Tradit Complement Med, vol.7, issue.4, pp.400-408, 2017.

X. Cao, X. Guo, X. Yang, H. Wang, W. Hua et al., Transcriptional Responses and Gentiopicroside Biosynthesis in Methyl Jasmonate-Treated Gentiana macrophylla Seedlings, PLoS ONE, vol.11, issue.11, pp.1-20, 2016.

C. Zou, Y. Wang, and Z. Shen, 2-NBDG as a fluorescent indicator for direct glucose uptake measurement, J Biochem Biophys Methods. 30 sept, vol.64, issue.3, pp.207-215, 2005.

P. Tolambiya, IdentIfication of cost effective drug through in-silico approach of Catharanthus roseus plant ligand-receptor docking for type 2 diabetes NIDDM, World J Pharm Pharm Sci. 1 avr, pp.1029-1049, 2017.

D. Wei, J. Li, M. Shen, W. Jia, N. Chen et al., Cellular production of n-3 PUFAs and reduction of n6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death, Diabetes. févr, vol.59, issue.2, pp.471-478, 2010.

K. Rasineni, R. Bellamkonda, S. R. Singareddy, and S. Desireddy, Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats, Pharmacogn Res. 5 janv, vol.2, issue.3, p.195, 2010.

G. H. Svoboda, M. Gorman, and M. A. Root, Alkaloids of Vinca rosea (Catharanthus roseus). XXVIII. A preliminary report on hypoglycemic activity, Lloydia. 1 janv, vol.27, pp.361-363, 1964.

A. E. Boyd, The role of ion channels in insulin secretion, J Cell Biochem. mars, vol.48, issue.3, pp.235-241, 1992.

Y. Ihara, Y. Yamada, Y. Fujii, T. Gonoi, H. Yano et al., Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells, Mol Endocrinol Baltim Md. Janv, vol.9, issue.1, pp.121-130, 1995.

F. M. Ashcroft and F. M. Gribble, ATP-sensitive K + channels and insulin secretion: their role in health and disease, Diabetologia. août, vol.42, issue.8, pp.903-919, 1999.

P. E. Macdonald, S. Sewing, J. Wang, J. W. Joseph, S. R. Smukler et al.,

, voltage-dependent K + channels in pancreatic beta-cells enhances glucose-dependent insulin secretion, J Biol Chem, vol.22, issue.47, pp.44938-44945, 2002.

Y. Cui, L. Huang, F. Elefteriou, G. Yang, J. M. Shelton et al., Essential role of STAT3 in body weight and glucose homeostasis, Mol Cell Biol. janv, vol.24, issue.1, pp.258-269, 2004.

C. Xiao, Y. Tian, M. Lei, F. Chen, X. Gan et al., Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of Vindoline derivatives, Bioorg Med Chem Lett. 1 mars, vol.27, issue.5, pp.1316-1318, 2017.