État de santé des personnes âgées drépanocytaires suivies en Guadeloupe

Abstract : Introduction : Management improvement of patients with sickle cell disease (SCD) in developed countries has significantly increased the life expectancy of these patients. Elderly patients with SCD are more and more numerous in Guadeloupe and we have little knowledge of their state of health. The objective is to evaluate the complications of SCD and associated pathologies in patients with SCD over 60 years old followed in Guadeloupe. Method : Quantitative, observational, descriptive and cross-sectional study on 72 patients with SCD aged of at least 60 on May 1, 2017 and followed at the Transversal Unit of Sickle Cell Disease at Pointe-à-Pitre University Hospital Center and at the Transversal Unit of Sickle Cell at the Hospital Center of Basse-Terre. Collection and analysis of socio-demographic, clinical and biological data from paper files. Results : The median age was 66 years [62.0 - 70.8]. There were 46 SC patients, 18 SS patients, 7 Sß+ patients and 3 Sß° patients. Since the age of 60, 94.4% of patients had fewer than 5 vaso-occlusive crisis, 22.5% had an acute chest syndrome, 2.7% had cardiomyopathy, 6.9% had pulmonary hypertension, 1.4% had cerebral vasculopathy, 63.8% had a renal dysfunction, 77.5% retinopathy, 16.7% leg ulcers, 51.4% osteonecrosis of the femoral head and 31.9% osteonecrosis of the humeral head. The main associated comorbidities were : hypertension, obstructive sleep apnoea-hypopnoea syndrome (OSAHS), stroke, diabetes mellitus, arrhythmias. Hydroxyurea was found in 81% of the SS and Sβ ° group. Conclusion : Patients with SCD over 60 years old followed in Guadeloupe, are spared from acute or chronic life-threatening complications, but have numerous chronic visceral complications and comorbidities.
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Master Thesis
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Blandine Alavoine. État de santé des personnes âgées drépanocytaires suivies en Guadeloupe. Médecine humaine et pathologie. 2018. ⟨dumas-02044995⟩

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