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, qui permet l'étude de phases très précoces de l'infection et après mise sous traitement antirétroviral, ainsi que l'analyse de tissus non accessibles chez l'homme
, Mon travail dans ce projet a été d'analyser une population cellulaire encore mal caractérisée dans l'infection par le SIV chez le macaque, les cellules myéloïdes suppressives (MDSC)
, auto-immune, et lors de l'infection au VIH. Chez les personnes infectées par le VIH, il a été décrit qu'une augmentation des MDSC était associée à la progression de la maladie
les résultats préliminaires de l'analyse de la dynamique des MDSC suite à l'infection par le SIV chez le macaque montrent une augmentation dans la moelle osseuse et le sang des MDSC d'origine myéloïde 4 semaines après l'infection. De plus, l'absence de traitement antirétroviral montre un épuisement des polynucléaires ,
, MDSC dans la moelle osseuse. La poursuite de cette étude pourrait contribuer à mieux comprendre les mécanismes immunologiques au cours de l'infection VIH