Étude pilote prospective randomisée comparant les différentes voies d’administration et de doses du misoprostol lors de l’interruption volontaire de grossesse médicamenteuse entre 7 et 9 semaines d’aménorrhée

Abstract : Objective - There are many drugs regimens used in medical abortion between 7 and 9 weeks of amenorrhea (WA). The main objective of our study was to compare the efficacy of different routes of administration (oral, sublingual/buccal or vaginal) and doses of misoprostol. Methods - A prospective, randomized, single-center study comparing the efficacy of three routes of administration and two doses of misoprostol in drug-induced medical abortion between 7 and 9WA. Our primary criterion of outcome was defined as complete evacuation of pregnancy on ultrasound at three weeks. Results - 127 patients were included between June 1, 2017 and February 28, 2018. The overall success rate was of 72.6% for a failure rate of 27.4% with a rate of continuing pregnancy of 8.8%. We found no significant difference between the routes of administration (p=0,854) and the dose (p= 0,729). Discussion - Our success rate is low compared to other studies, however the evaluation of uterine vacuity was not always well specified in the literature. In addition, we included more women in the oral route, while a 2011 meta-analysis showed superiority of other routes of administration of misoprostol compared over the oral route. Conclusion - We failed to demonstrate significant difference between the routes of administration and doses of misoprostol, due to lack of potency. Since the withdrawal of Cytotec®, there is the question of health expenses related to abortion and the use of drugs made available.
Complete list of metadatas

Cited literature [56 references]  Display  Hide  Download

https://dumas.ccsd.cnrs.fr/dumas-02059303
Contributor : Philippe Barbey <>
Submitted on : Wednesday, March 6, 2019 - 3:09:26 PM
Last modification on : Saturday, March 9, 2019 - 1:18:19 AM
Long-term archiving on : Friday, June 7, 2019 - 7:17:56 PM

File

Julia Gobert. Thèse d'exercic...
Files produced by the author(s)

Identifiers

  • HAL Id : dumas-02059303, version 1

Collections

Citation

Julia Gobert. Étude pilote prospective randomisée comparant les différentes voies d’administration et de doses du misoprostol lors de l’interruption volontaire de grossesse médicamenteuse entre 7 et 9 semaines d’aménorrhée. Gynécologie et obstétrique. 2018. ⟨dumas-02059303⟩

Share

Metrics

Record views

14

Files downloads

45