, OMS. Résistance aux antibiotiques, 2018.

C. Bourguignon, Abus, résistance, infection endodontique, Information Dentaire, issue.11, pp.16-25, 2015.

. Inserm, Résistance aux antibiotiques. Un phénomène massif et préoccupant

, Inserm -La science pour la santé, 2018.

D. Sur,

A. J. Karki, G. Holyfield, and D. Thomas, Dental prescribing in Wales and associated public health issues, British Dental Journal, vol.210, issue.21, pp.1-4, 2011.

N. Yingling, B. Ellenbyrne, and G. Hartwell, Antibiotic Use by Members of the American Association of Endodontists in the Year 2000: Report of a National Survey, Journal of Endodontics, vol.28, issue.5, pp.396-404, 2002.

A. , La consommation d'antibiotiques en France en, p.4, 2016.

A. Woda, D. Faulks, and S. Deluzarche, Reflexions sur les critères diagnostiques des maladies pulpaires et parodontales d'origine pulpaire. Information Dentaire, vol.43, pp.3473-3481, 1999.

N. Palmer, R. Pealing, and M. V. Martin, A study of therapeutic antibiotic prescribing in National Health Service general dental practice in England, British Dental Journal, vol.188, issue.10, pp.554-562, 2000.

M. Germack, C. M. Sedgley, and B. Whitten, Antibiotic Use in 2016 by Members of the American Association of Endodontists: Report of a National Survey, Journal of Endodontics, vol.43, issue.10, pp.1615-1637, 2017.

C. Quiñonez, D. Gibson, and D. Locker, Emergency department visits for dental care of nontraumatic origin. Community Dentistry and Oral Epidemiology, vol.37, pp.366-71, 2009.

R. S. Gatewood, V. T. Himel, and S. O. Dorn, Treatment of the endodontic emergency: A decade later, Journal of Endodontics, vol.16, issue.6, pp.284-91, 1990.

A. Cope, N. Francis, and I. G. Chestnutt, Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults, Cochrane Database of Systematic Reviews, pp.1-46, 2014.

P. Carrotte, Endodontics: Part 3 Treatment of endodontic emergencies, British Dental Journal, vol.197, issue.6, pp.299-305, 2004.

J. J. Segura-egea, K. Gould, and P. Dummer, European Society of Endodontology position statement: the use of antibiotics in endodontics, International Endodontic Journal, issue.51, pp.20-25, 2018.

. Afssaps, Prescription des antibiotiques en pratique bucco-dentaire, 2011.

D. Sur,

D. C. Matthews, S. Sutherland, and B. Basrani, Emergency Management of Acute Apical Abscesses in the Permanent Dentition: A Systematic Review of the Literature, Journal of the Canadian Dental Association, vol.69, issue.10, pp.660-660, 2003.

J. Siqueira and I. Rôças, Bacterial pathogenesis and mediators in apical periodontitis, Brazilian Dental Journal, vol.18, issue.4, pp.267-80, 2007.

J. Lasfargues and P. Machtou, Pathogenèse des lésions périapicales. Réalités cliniques, vol.12, pp.139-187, 2001.

P. Nair, Apical periodontitis : a dynamic encounter between root canal infection and host response, Periodontology, vol.13, pp.121-169, 1997.

M. Coli?, D. Gazivoda, and D. Vucevi?, Immunomodulatory Activity of IL-27 in Human Periapical Lesions, Journal of Dental Research, vol.88, issue.12, pp.1142-1149, 2009.

J. F. Siqueira, Endodontic infections: Concepts, paradigms, and perspectives. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol.94, pp.281-93, 2002.

S. Khemaleelakul, J. C. Baumgartner, and S. Pruksakorn, Identification of bacteria in acute endodontic infections and their antimicrobial susceptibility. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol.94, pp.746-55, 2002.

A. R. Özok, I. F. Persoon, and E. Zaura, Ecology of the microbiome of the infected root canal system: a comparison between apical and coronal root segments: Microbiome of infected roots, International Endodontic Journal, vol.45, issue.6, pp.530-571, 2012.

A. Casadevall and L. Pirofski, Host-­--Pathogen Interactions: The Attributes of Virulence, The Journal of Infectious Diseases, vol.184, issue.3, pp.337-381, 2001.

H. Shimauchi, S. Takayama, and H. Okada, Production of Interleukin-8 and Nitric Oxide in Human Periapical Lesions, Journal of Endodontics, vol.27, issue.12, pp.749-52, 2001.

C. Sedgley, Virulence of Endodontic Bacterial Pathogens, Fouad AF, éditeur. Endodontic Microbiology, pp.149-77, 2017.

R. Walton and J. Hunter, Endodontic in emergencies. In principles and practices of endodontics, Saunders Company, 2002.

P. L. Michaelson and G. R. Holland, Is pulpitis painful?, International Endodontic Journal, vol.35, issue.10, pp.829-861, 2002.

M. Lin and . Scribner, Why teeth associated with periapical lesions have a vital response, Clin Prev Dent, vol.12, issue.1, pp.3-4, 1990.

J. Lasfargues, Le diagnostic clinique des parodontites apicales. Réalités cliniques, vol.12, pp.149-62, 2001.

B. Touré, A. Kane, and Y. Boucher, Preoperative pain and medications used in emergency patients with irreversible acute pulpitis or acute apical periodontitis: A prospective comparative study, Journal of orofacial pain, vol.21, pp.303-311, 2007.

H. Segal, Duration and type of pain emergency patients, Gen Dent, issue.32, pp.507-516, 1984.

A. Aminoshariae and J. C. Kulild, Evidence-based recommendations for antibiotic usage to treat endodontic infections and pain, The Journal of the American Dental Association, vol.147, issue.3, pp.186-91, 2016.

G. Habib, B. Hoen, and J. L. Zamorano, Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): The Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC), European Heart Journal, vol.30, pp.2369-413, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00465409

J. J. Segura-egea, K. Gould, and P. Dummer, Antibiotics in Endodontics: a review, International Endodontic Journal, vol.50, issue.12, pp.1169-84, 2017.

J. C. Baumgartner and T. Xia, Antibiotic Susceptibility of Bacteria Associated with Endodontic Abscesses, Journal of Endodontics, vol.29, issue.1, pp.44-51, 2003.

A. Fouad, . Chair, and B. Cha, AAE Guidance on the Use of Systemic Antibiotics in Endodontics, 2017.

, Drug prescribing for dentistry: dental clinical, SDCEP, 2016.

A. F. Disponible-sur-;-fouad, E. M. Rivera, and R. E. Walton, Penicillin as a supplement in resolving the localized acute apical abscess. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol.81, pp.590-595, 1996.

M. Henry, A. Reader, and M. Beck, Effect of Penicillin on Postoperative Endodontic Pain and Swelling in Symptomatic Necrotic Teeth, Journal of Endodontics, vol.27, issue.2, pp.117-140, 2001.

I. Tsesis, V. Faivishevsky, and O. Zukerman, Flare-ups after Endodontic Treatment: A Meta-analysis of Literature, Journal of Endodontics, vol.34, issue.10, pp.1177-81, 2008.

L. Pickenpaugh, A. Reader, and L. Peterson, Effect of Prophylactic Amoxicillin on Endodontic Flare-Up in Asymptomatic, Necrotic Teeth. Journal of Endodontics, vol.27, issue.1, pp.53-59, 2001.

J. Lindeboom, J. Frenken, . Van-den-akker, and . Hp, The role of preoperative prophylactic antibiotic administration in periapical endodontic surgery: a randomized, prospective double-blind placebo-controlled study, International Endodontic Journal, vol.38, issue.12, pp.877-81, 2005.

C. Konig, Bacterial concentrations in pus and infected peritoneal fluid--implications for bactericidal activity of antibiotics, Journal of Antimicrobial Chemotherapy, vol.42, issue.2, pp.227-259, 1998.

G. Vessal, A. Khabiri, and M. Askarian, Study of antibiotic prescribing among dental practitioners in Shiraz, Islamic Republic of Iran, Eastern Mediterranean Health Journal, vol.17, issue.10, p.7, 2011.

D. Finer, First conference on consumer adverse reaction reporting, Essential drugs monitor, issue.28, p.36, 2000.

G. B. Jungermann, K. Burns, and A. F. Fouad, Antibiotic Resistance in Primary and Persistent Endodontic Infections, Journal of Endodontics, vol.37, issue.10, pp.1337-1381, 2011.

T. H. Dellit, R. C. Owens, and T. M. Hooton, Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America Guidelines for Developing an Institutional Program to Enhance Antimicrobial Stewardship, Clinical Infectious Diseases, vol.44, issue.2, pp.159-77, 2007.

A. Mainjot, D. 'hoore, W. Van-nieuwenhuysen, and J. , Antibiotic prescribing in dental practice in Belgium: Antibiotic prescribing, International Endodontic Journal, vol.42, issue.12, pp.1112-1119, 2009.

A. Rodriguez-núñez, R. Cisneros-cabello, and J. J. Segura-egea, Segura-Egea JJ, Velasco-Ortega E, Llamas-Carreras JM. Pattern of antibiotic prescription in the management of endodontic infections amongst Spanish oral surgeons, International Endodontic Journal, vol.35, issue.9, pp.342-50, 2009.

D. Afzalifar, Improving Knowledge of General Dental Practitioners on Antibiotic Prescribing by Raising Awareness of the Faculty of General Dental Practice (UK) Guidelines, Journal of Dentistry, vol.12, issue.3, pp.171-177, 2015.

N. Palmer, Y. M. Dailey, and M. V. Martin, Can audit improve antibiotic prescribing in general dental practice?, British Dental Journal, vol.191, issue.5, 2001.

&. Afzalifar, , 2015.

&. Karki, , 2011.

&. Mainjot,

*. Matériel and . Méthode-questionnaire, adressé'à'1544'praticiens' sur'leurs'habitudes'de'prescriptions' d'antibiotiques

, Analyse'de'55'prescriptions'd'antibiotiques' réalisées'dans'deux'cliniques'du'nord@'Est' de'l'Angleterre'et'comparaison'aux'guides' cliniques'réalisés'par'la'FGDP

, Analyse'des'prescriptions'enregistrées' entre'2007'et, 2008.

, Étude'sur'les'prescriptions'réalisées'lors' des'deux'dernières'semaines'par'des' dentistes'Belges Résultats @Taux'de'réponse, p.60

, @69%'prescrivent'des'antibiotiques'avant' le'drainage'lors'du'traitement'd'abcès' apicaux'et'23%'après'le'drainage

, @72.5'%'prescrivent'des'antibiotiques's'ils' doivent'différer'le'soin'local'et'30%'par' manque'de'temps

, @1/3'prescrivent'des'antibiotiques'lors' d'abcès'avec'gonflement'localisé

&. @'antibiotique'majoritaire, Amoxicilline' @Seulement'30%'des'prescriptions'en' accord'avec'la'FGDP. @Seuls'ATB'prescrits': Amoxicilline'et'Métronidazole

, national'sont'prescrits'par'les'chirurgiens@ dentistes @Augmentation'de'1,3%'des'prescriptions' entre'2007'et'2008 @Pénicilline'(67%)'et'métronidazole' majoritairement'prescrits @Seulement'4,2%'des'patients'vus'les'deux' dernières'semaines'ont'reçu'ATB. @Indication'la'plus'fréquent'de'mise

, péri@ apical'ont'été'mis'sous'ATB'dont'92%'des' prescriptions'faites'en'absence'de'fièvre' et'signes'généraux @54,2%'des'prescriptions'faites'en'absence' de'soin'local @ATB'prescrits':'amoxicilline,'association' amoxicilline'et'acide'clavulanique'et' clindamycine Discussion @Surconsommation'd'antibiotiques

, ATB @Prescriptions'inappropriées':'mauvaise' indication,'posologie'ou'durée':'manque' de'connaissances'concernant'les'ATB @Besoin'de'guides'cliniques'et' d'encourager'les'dentistes'à'se'former'et' prescrire'selon'les'recommandations' établies @Plus'd'un'patient'sur'4'ressort'avec'une' prescription'

, Nombre'de'prescription'par'semaine' plutôt'faible,'semblable'aux'études'faites' en' Angleterre,'mais'mauvaises'indications'de' prescriptions'et'mauvaises'prises'en' charge'des'abcès'péri@apicaux

, Matériel*et*méthode Questionnaire*envoyé*aux*membres*de*la*

*. Spanish and . Endodontic, Society*AEDE*sur*les* habitudes*de*prescription*des*praticiens

, société*espagnole*de*chirurgie*orale* (SECIB)*:*portant*sur*leur*prescription*dans*

, AAE*:*American*Association*of*

. De*palmer*, , 2000.

, *envoyé*à*450*dentistes*des*environs Résultats 6140*réponses*soit*un*taux*de*réponse*de* 31,1% 6Situations*pour*lesquelles*ATB*ont*été* prescrits*: 6Pulpite*irréversibles*>40% 6nécrose*pulpaire,*abcès*apical*sans* gonflement*>52%

, 6ATB*utilisés*:*Amoxicilline*>86%*des*cas

, *questionnaires,*127*réponses*(64%)

. 6>86%*prescrivent*atb*dans*le*cas*de*-pulpites, irréversibles 6>71%*dans*le*cas*de*pulpe*nécrosée*ou* abcès*apical*sans*gonflement 660%*en*cas*de*parodontite*apicale* chronique

, 6>53%*prescrivent*ATB*pour*traiter*des* nécroses*pulpaires*ou*abcès*apicaux*en* l'absence*de*gonflements

, *16%*prescrivent*ATB*pour*traiter*des* pulpites*irréversibles 6>60%*prescrivent*Pénicilline*V

, *là*où*le*soin*local*suffirait 6Un*tiers*des*praticiens*prescrivent*des* ATB*pour*des*infections*péri6apicales* chroniques. 6ATB*le*plus*prescrit*:*Amoxicilline 6Durée,*posologie,*fréquence*variable*:* entre*6*à*10*jours 10%*ont*choisi*une*durée*de*traitement*de* plus*de*4*semaines*d'amoxicilline antibiotiques*là*où*le*traitement*local, 680%*prescrivent*ATB*en*cas*de*signes* généraux 640%*prescrivent*des*antibiotiques*pour* traiter*un*abcès*apical*avec*gonflement* localisé

, Ils*participent*donc*à*la*création*de* résistances*bactériennes 6Manque*de*recommandations*précises* sur*posologie*fréquence*et*durée*de* traitement*lorsqu'il*est*indiqué

. Pas*de*guides*établis*en*république,

. Islamique*d'iran,