M. E. Marraccini, L. L. Weyandt, J. S. Rossi, and B. G. Gudmundsdottir, ne semble pas améliorer significativement le pic de dilatation liée au flux chez des étudiants sains. Les résultats sur les fonctions cognitives sont en attentes. 6. Références 1, d'hyperémie réactive, la consommation d'une dose d'EVRP, dans les conditions de cette étude, vol.24, pp.269-84, 2016.

R. J. Williams and J. Spencer, Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease, Free Radical Biology and Medicine. 1 janv, vol.52, issue.1, pp.35-45, 2012.

J. Constans, C. Bennetau-pelissero, J. Martin, E. Rock, A. Mazur et al., Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men, Clin Nutr. déc, vol.34, issue.6, pp.1093-100, 2015.

A. Kerimi, H. Nyambe-silavwe, J. S. Gauer, F. A. Tomás-barberán, and G. Williamson, Pomegranate juice, but not an extract, confers a lower glycemic response on a highglycemic index food: randomized, crossover, controlled trials in healthy subjects, Am J Clin Nutr. 1 déc, vol.106, issue.6, pp.1384-93, 2017.

R. M. Alqurashi, L. A. Galante, I. R. Rowland, J. P. Spencer, and D. M. Commane, Consumption of a flavonoid-rich açai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men, Am J Clin Nutr, vol.104, issue.5, pp.1227-1262, 2016.

G. Williamson, The role of polyphenols in modern nutrition, Nutr Bull. sept, vol.42, issue.3, pp.226-261, 2017.

C. F. Haskell-ramsay, J. Schmitt, and L. Actis-goretta, The Impact of Epicatechin on Human Cognition: The Role of Cerebral Blood Flow, vol.10, p.986, 2018.

V. Socci, D. Tempesta, G. Desideri, D. Gennaro, L. Ferrara et al., Enhancing Human Cognition with Cocoa Flavonoids, Front Nutr, vol.4, p.19, 2017.

D. Mastroiacovo, C. Kwik-uribe, D. Grassi, S. Necozione, A. Raffaele et al., Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study-a randomized controlled trial1234, Am J Clin Nutr. mars, vol.101, issue.3, pp.538-586, 2015.

A. B. Scholey, S. J. French, P. J. Morris, D. O. Kennedy, A. L. Milne et al., Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort, J Psychopharmacol, vol.24, issue.10, pp.1505-1519, 2010.

J. Bensalem, L. Servant, S. Alfos, D. Gaudout, S. Layé et al., Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in MiddleAged Mice, Front Behav Neurosci, vol.10, p.9, 2016.

J. Bensalem, S. Dudonné, D. Gaudout, L. Servant, F. Calon et al.,

, Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice, J Nutr Sci, vol.7, p.19, 2018.

L. An, Y. Zhang, Y. Liu, X. Zhao, N. Yuan et al., The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats, Progress in NeuroPsychopharmacology and Biological Psychiatry. 1 août, vol.32, issue.6, pp.1484-90, 2008.

G. P. Dias, N. Cavegn, A. Nix, N. Bevilaqua-do, C. M. Stangl et al., The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety, Oxidative Medicine and Cellular Longevity, p.541971, 2012.

D. J. Lamport, D. Pal, C. Moutsiana, D. T. Field, C. M. Williams et al., The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial, Psychopharmacology (Berl), vol.232, issue.17, pp.3227-3261, 2015.

E. L. Wightman, P. A. Jackson, J. Khan, J. Forster, F. Heiner et al., The Acute and Chronic Cognitive and Cerebral Blood Flow Effects of a Sideritis scardica (Greek Mountain Tea) Extract: A Double Blind, Randomized, Placebo Controlled, Parallel Groups Study in Healthy Humans, Nutrients. 24 juill, vol.10, issue.8, p.955, 2018.

S. J. Catchlove, H. Macpherson, M. E. Hughes, Y. Chen, T. B. Parrish et al., An investigation of cerebral oxygen utilization, blood flow and cognition in healthy aging, PLOS ONE. 22 mai, vol.13, issue.5, p.197055, 2018.

P. B. Gorelick, A. Scuteri, S. E. Black, C. Decarli, S. M. Greenberg et al.,

, Vascular Contributions to Cognitive Impairment and Dementia, Stroke. sept, vol.42, issue.9, pp.2672-713, 2011.

K. Prakash, D. S. Chandran, R. Khadgawat, A. K. Jaryal, and K. K. Deepak, Correlations between endothelial function in the systemic and cerebral circulation and insulin resistance in type 2 diabetes mellitus, Diabetes and Vascular Disease Research. 1 janv, vol.13, issue.1, pp.49-55, 2016.

M. M. Gonzales, T. Tarumi, H. Tanaka, J. Sugawara, T. Swann-sternberg et al., Functional imaging of working memory and peripheral endothelial function in middle-aged adults, Brain Cogn. juill, vol.73, issue.2, pp.146-51, 2010.

M. R. Naiberg, D. F. Newton, and B. I. Goldstein, Flow-Mediated Dilation and Neurocognition: Systematic Review and Future Directions, Psychosom Med. mars, vol.78, issue.2, pp.192-207, 2016.

H. Ait-oufella, M. E. Guidet, B. Offenstadt, and G. , L'endothélium : un nouvel organe, Réanimation. 1 mars, vol.17, issue.2, pp.126-162, 2008.

C. Puissant, P. Abraham, S. Durand, A. Humeau-heurtier, S. Faure et al.,

, J Mal Vasc. févr, vol.39, issue.1, pp.47-56, 2014.

C. Iadecola, Nitric oxide: Roles in neurovascular regulation and ischemic brain injury, Nitric Oxide. 15 juill, vol.27, p.3, 2012.

E. F. Gallo and C. Iadecola, Neuronal nitric oxide (NO) contributes to neuroplasticityassociated protein expression through cGMP, protein kinase G (PKG), and ERK, J Neurosci. 11 mai, vol.31, pp.6947-55, 2011.
DOI : 10.1523/jneurosci.0374-11.2011

URL : http://www.jneurosci.org/content/jneuro/31/19/6947.full.pdf

A. J. Flammer, T. Anderson, D. S. Celermajer, M. A. Creager, J. Deanfield et al., The assessment of endothelial function: from research into clinical practice, Circulation. 7 août, vol.126, issue.6, pp.753-67, 2012.

L. Lucats, M. Bourguignon, M. Feletou, N. Villeneuve, and J. Vilaine, Endothelial dysfunction: a pharmacological approach, Sang Thrombose Vaisseaux. mai, issue.5, pp.220-224, 2012.

S. Agewall, S. Wright, R. N. Doughty, G. A. Whalley, M. Duxbury et al., Does a glass of red wine improve endothelial function?, Eur Heart J. janv, vol.21, issue.1, pp.74-82, 2000.

S. Li, H. Tian, H. Zhao, L. Chen, and L. Cui, The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials, PLoS ONE, vol.8, issue.7, p.69818, 2013.

J. Barona, J. C. Aristizabal, C. N. Blesso, J. S. Volek, and M. L. Fernandez, Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome, J Nutr. 1 sept, vol.142, issue.9, pp.1626-1658, 2012.

A. Rodriguez-mateos, D. Pino-garcía, R. George, T. W. Vidal-diez, A. Heiss et al., Impact of processing on the bioavailability and vascular effects of blueberry (poly)phenols. Mol Nutr Food Res, vol.58, pp.1952-61, 2014.

S. J. Duffy, J. F. Keaney, M. Holbrook, N. Gokce, P. L. Swerdloff et al., Shortand long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease, Circulation. 10 juill, vol.104, issue.2, pp.151-157, 2001.

N. Fisher, M. Hughes, M. Gerhard-herman, and N. K. Hollenberg, Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans, J Hypertens. déc, vol.21, issue.12, pp.2281-2287, 2003.

M. B. Engler, M. M. Engler, C. Y. Chen, M. J. Malloy, A. Browne et al.,

, Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults, J Am Coll Nutr. juin, vol.23, issue.3, pp.197-204, 2004.

H. Schroeter, C. Heiss, J. Balzer, P. Kleinbongard, C. L. Keen et al., Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans, Proc Natl Acad Sci, vol.103, issue.4, pp.1024-1033, 2006.

J. F. Leikert, T. R. Räthel, P. Wohlfart, V. Cheynier, A. M. Vollmar et al., Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells, Circulation. 24 sept, vol.106, issue.13, pp.1614-1621, 2002.
DOI : 10.1161/01.cir.0000034445.31543.43

URL : https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000034445.31543.43

J. Bensalem, S. Dudonné, N. Etchamendy, H. Pellay, C. Amadieu et al., Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study, J Gerontol A Biol Sci Med Sci. 19 juill, 2018.

A. Peretz, D. F. Leotta, J. H. Sullivan, C. A. Trenga, F. N. Sands et al., Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization, BMC Cardiovasc Disord. 21 mars, vol.7, p.11, 2007.

A. Rodriguez-mateos, C. Rendeiro, T. Bergillos-meca, S. Tabatabaee, T. W. George et al., Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity, The American Journal of Clinical Nutrition, vol.98, issue.5, pp.1179-91, 2013.

V. J. Poitras and K. E. Pyke, The impact of acute mental stress on vascular endothelial function: Evidence, mechanisms and importance, International Journal of Psychophysiology. 1 mai, vol.88, issue.2, pp.124-159, 2013.

H. Alley, C. D. Owens, W. J. Gasper, and S. M. Grenon, Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research, J Vis Exp, issue.92, p.52070, 2014.

L. Ghiadoni, A. E. Donald, M. Cropley, M. J. Mullen, G. Oakley et al., Mental stress induces transient endothelial dysfunction in humans, Circulation, vol.102, issue.20, pp.2473-2481, 2000.

N. Nicolson and . Measurement, In: Handbook of Physiological Research Methods in Health Psychology, pp.37-74, 2008.

A. Broadley, A. Korszun, E. Abdelaal, V. Moskvina, C. Jones et al., Inhibition of Cortisol Production With Metyrapone Prevents Mental Stress-Induced Endothelial Dysfunction and Baroreflex Impairment, Journal of the American College of Cardiology. 19 juill, vol.46, issue.2, pp.344-50, 2005.

G. J. Mangos, B. R. Walker, J. J. Kelly, J. A. Lawson, D. J. Webb et al., Cortisol inhibits cholinergic vasodilatation in the human forearm, American Journal of Hypertension, vol.13, issue.11, pp.1155-60, 2000.

T. Iuchi, M. Akaike, T. Mitsui, Y. Ohshima, Y. Shintani et al.,

, Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction, Circ Res. 10 janv, vol.92, issue.1, pp.81-88, 2003.

L. E. Spieker, D. Hürlimann, F. Ruschitzka, R. Corti, F. Enseleit et al., Mental stress induces prolonged endothelial dysfunction via endothelin-A receptors, Circulation. 18 juin, vol.105, issue.24, pp.2817-2837, 2002.

M. L. Hijmering, E. Stroes, J. Olijhoek, B. A. Hutten, P. J. Blankestijn et al., Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation, Journal of the American College of Cardiology. 20 févr, vol.39, issue.4, pp.683-691, 2002.
DOI : 10.1016/s0735-1097(01)01786-7

URL : https://doi.org/10.1016/s0735-1097(01)01786-7

H. B. Skantze, J. Kaplan, K. Pettersson, S. Manuck, N. Blomqvist et al., Psychosocial stress causes endothelial injury in cynomolgus monkeys via beta1-adrenoceptor activation, Atherosclerosis. janv, vol.136, issue.1, pp.153-61, 1998.

M. A. Black, N. T. Cable, D. Thijssen, and D. J. Green, Importance of measuring the time course of flow-mediated dilatation in humans, Hypertension. févr, vol.51, issue.2, pp.203-213, 2008.

J. Lekakis, L. S. Rallidis, I. Andreadou, G. Vamvakou, G. Kazantzoglou et al., Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease, Eur J Cardiovasc Prev Rehabil. déc, vol.12, issue.6, pp.596-600, 2005.

P. J. Smith, J. A. Blumenthal, A. L. Hinderliter, L. L. Watkins, B. M. Hoffman et al., Microvascular Endothelial Function and Neurocognition Among Adults With Major Depressive Disorder. The American Journal of Geriatric Psychiatry, vol.28
DOI : 10.1016/j.jagp.2018.06.011

, Effet aigu d'un Extrait végétal riche en polyphénols (EVRP) sur la fonction endothéliale d'étudiants sains

, De plus en plus d'étudiants cherchent des solutions pour améliorer leurs performances cognitives. Certains polyphénols ont une action dans le maintien de fonctions cognitives optimales

, L'objectif était d'évaluer l'effet en aigu d'un extrait végétal riche en polyphénols (EVRP) sur la fonction endothéliale et sur les fonctions cognitives d'étudiants sains

, Nous avons recruté 30 étudiants volontaires sains âgés de 18 à 25 ans. Le produit à l'étude, l'EVRP, était un mélange d'extraits de raisin et de bleuet sauvage riche et standardisé en polyphénols. La fonction endothéliale a été évaluée par la dilatation médiée par le flux (FMD), 2018.

, Nous avons retrouvé une différence significative entre la 90 ème et la 120 ème seconde post ischémie (t=2,128, p=0,04). Pour le moment

, Dans les conditions de cette étude, la consommation d'une dose d'EVRP n'améliore pas significativement la dilatation médiée par le flux (FMD) d'étudiants sains

. Mots-cles, fonction endothéliale, dilatation médiée par le flux (FMD), polyphénols, cognition