ne semble pas améliorer significativement le pic de dilatation liée au flux chez des étudiants sains. Les résultats sur les fonctions cognitives sont en attentes. 6. Références 1, d'hyperémie réactive, la consommation d'une dose d'EVRP, dans les conditions de cette étude, vol.24, pp.269-84, 2016. ,
Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease, Free Radical Biology and Medicine. 1 janv, vol.52, issue.1, pp.35-45, 2012. ,
Marked antioxidant effect of orange juice intake and its phytomicronutrients in a preliminary randomized cross-over trial on mild hypercholesterolemic men, Clin Nutr. déc, vol.34, issue.6, pp.1093-100, 2015. ,
Pomegranate juice, but not an extract, confers a lower glycemic response on a highglycemic index food: randomized, crossover, controlled trials in healthy subjects, Am J Clin Nutr. 1 déc, vol.106, issue.6, pp.1384-93, 2017. ,
Consumption of a flavonoid-rich açai meal is associated with acute improvements in vascular function and a reduction in total oxidative status in healthy overweight men, Am J Clin Nutr, vol.104, issue.5, pp.1227-1262, 2016. ,
The role of polyphenols in modern nutrition, Nutr Bull. sept, vol.42, issue.3, pp.226-261, 2017. ,
, The Impact of Epicatechin on Human Cognition: The Role of Cerebral Blood Flow, vol.10, p.986, 2018.
Enhancing Human Cognition with Cocoa Flavonoids, Front Nutr, vol.4, p.19, 2017. ,
Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study-a randomized controlled trial1234, Am J Clin Nutr. mars, vol.101, issue.3, pp.538-586, 2015. ,
Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort, J Psychopharmacol, vol.24, issue.10, pp.1505-1519, 2010. ,
Dietary Polyphenol Supplementation Prevents Alterations of Spatial Navigation in MiddleAged Mice, Front Behav Neurosci, vol.10, p.9, 2016. ,
,
, Polyphenol-rich extract from grape and blueberry attenuates cognitive decline and improves neuronal function in aged mice, J Nutr Sci, vol.7, p.19, 2018.
The total flavonoids extracted from Xiaobuxin-Tang up-regulate the decreased hippocampal neurogenesis and neurotrophic molecules expression in chronically stressed rats, Progress in NeuroPsychopharmacology and Biological Psychiatry. 1 août, vol.32, issue.6, pp.1484-90, 2008. ,
The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety, Oxidative Medicine and Cellular Longevity, p.541971, 2012. ,
The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial, Psychopharmacology (Berl), vol.232, issue.17, pp.3227-3261, 2015. ,
The Acute and Chronic Cognitive and Cerebral Blood Flow Effects of a Sideritis scardica (Greek Mountain Tea) Extract: A Double Blind, Randomized, Placebo Controlled, Parallel Groups Study in Healthy Humans, Nutrients. 24 juill, vol.10, issue.8, p.955, 2018. ,
An investigation of cerebral oxygen utilization, blood flow and cognition in healthy aging, PLOS ONE. 22 mai, vol.13, issue.5, p.197055, 2018. ,
,
, Vascular Contributions to Cognitive Impairment and Dementia, Stroke. sept, vol.42, issue.9, pp.2672-713, 2011.
Correlations between endothelial function in the systemic and cerebral circulation and insulin resistance in type 2 diabetes mellitus, Diabetes and Vascular Disease Research. 1 janv, vol.13, issue.1, pp.49-55, 2016. ,
Functional imaging of working memory and peripheral endothelial function in middle-aged adults, Brain Cogn. juill, vol.73, issue.2, pp.146-51, 2010. ,
Flow-Mediated Dilation and Neurocognition: Systematic Review and Future Directions, Psychosom Med. mars, vol.78, issue.2, pp.192-207, 2016. ,
L'endothélium : un nouvel organe, Réanimation. 1 mars, vol.17, issue.2, pp.126-162, 2008. ,
,
, J Mal Vasc. févr, vol.39, issue.1, pp.47-56, 2014.
Nitric oxide: Roles in neurovascular regulation and ischemic brain injury, Nitric Oxide. 15 juill, vol.27, p.3, 2012. ,
Neuronal nitric oxide (NO) contributes to neuroplasticityassociated protein expression through cGMP, protein kinase G (PKG), and ERK, J Neurosci. 11 mai, vol.31, pp.6947-55, 2011. ,
DOI : 10.1523/jneurosci.0374-11.2011
URL : http://www.jneurosci.org/content/jneuro/31/19/6947.full.pdf
The assessment of endothelial function: from research into clinical practice, Circulation. 7 août, vol.126, issue.6, pp.753-67, 2012. ,
Endothelial dysfunction: a pharmacological approach, Sang Thrombose Vaisseaux. mai, issue.5, pp.220-224, 2012. ,
Does a glass of red wine improve endothelial function?, Eur Heart J. janv, vol.21, issue.1, pp.74-82, 2000. ,
The acute effects of grape polyphenols supplementation on endothelial function in adults: meta-analyses of controlled trials, PLoS ONE, vol.8, issue.7, p.69818, 2013. ,
Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic Syndrome, J Nutr. 1 sept, vol.142, issue.9, pp.1626-1658, 2012. ,
Impact of processing on the bioavailability and vascular effects of blueberry (poly)phenols. Mol Nutr Food Res, vol.58, pp.1952-61, 2014. ,
Shortand long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease, Circulation. 10 juill, vol.104, issue.2, pp.151-157, 2001. ,
Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans, J Hypertens. déc, vol.21, issue.12, pp.2281-2287, 2003. ,
,
, Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults, J Am Coll Nutr. juin, vol.23, issue.3, pp.197-204, 2004.
Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans, Proc Natl Acad Sci, vol.103, issue.4, pp.1024-1033, 2006. ,
Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells, Circulation. 24 sept, vol.106, issue.13, pp.1614-1621, 2002. ,
DOI : 10.1161/01.cir.0000034445.31543.43
URL : https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000034445.31543.43
Polyphenols from grape and blueberry improve episodic memory in healthy elderly with lower level of memory performance: a bicentric double-blind, randomized, placebo-controlled clinical study, J Gerontol A Biol Sci Med Sci. 19 juill, 2018. ,
Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization, BMC Cardiovasc Disord. 21 mars, vol.7, p.11, 2007. ,
Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity, The American Journal of Clinical Nutrition, vol.98, issue.5, pp.1179-91, 2013. ,
The impact of acute mental stress on vascular endothelial function: Evidence, mechanisms and importance, International Journal of Psychophysiology. 1 mai, vol.88, issue.2, pp.124-159, 2013. ,
Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research, J Vis Exp, issue.92, p.52070, 2014. ,
Mental stress induces transient endothelial dysfunction in humans, Circulation, vol.102, issue.20, pp.2473-2481, 2000. ,
In: Handbook of Physiological Research Methods in Health Psychology, pp.37-74, 2008. ,
Inhibition of Cortisol Production With Metyrapone Prevents Mental Stress-Induced Endothelial Dysfunction and Baroreflex Impairment, Journal of the American College of Cardiology. 19 juill, vol.46, issue.2, pp.344-50, 2005. ,
Cortisol inhibits cholinergic vasodilatation in the human forearm, American Journal of Hypertension, vol.13, issue.11, pp.1155-60, 2000. ,
,
, Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction, Circ Res. 10 janv, vol.92, issue.1, pp.81-88, 2003.
Mental stress induces prolonged endothelial dysfunction via endothelin-A receptors, Circulation. 18 juin, vol.105, issue.24, pp.2817-2837, 2002. ,
Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation, Journal of the American College of Cardiology. 20 févr, vol.39, issue.4, pp.683-691, 2002. ,
DOI : 10.1016/s0735-1097(01)01786-7
URL : https://doi.org/10.1016/s0735-1097(01)01786-7
Psychosocial stress causes endothelial injury in cynomolgus monkeys via beta1-adrenoceptor activation, Atherosclerosis. janv, vol.136, issue.1, pp.153-61, 1998. ,
Importance of measuring the time course of flow-mediated dilatation in humans, Hypertension. févr, vol.51, issue.2, pp.203-213, 2008. ,
Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease, Eur J Cardiovasc Prev Rehabil. déc, vol.12, issue.6, pp.596-600, 2005. ,
Microvascular Endothelial Function and Neurocognition Among Adults With Major Depressive Disorder. The American Journal of Geriatric Psychiatry, vol.28 ,
DOI : 10.1016/j.jagp.2018.06.011
, Effet aigu d'un Extrait végétal riche en polyphénols (EVRP) sur la fonction endothéliale d'étudiants sains
, De plus en plus d'étudiants cherchent des solutions pour améliorer leurs performances cognitives. Certains polyphénols ont une action dans le maintien de fonctions cognitives optimales
, L'objectif était d'évaluer l'effet en aigu d'un extrait végétal riche en polyphénols (EVRP) sur la fonction endothéliale et sur les fonctions cognitives d'étudiants sains
, Nous avons recruté 30 étudiants volontaires sains âgés de 18 à 25 ans. Le produit à l'étude, l'EVRP, était un mélange d'extraits de raisin et de bleuet sauvage riche et standardisé en polyphénols. La fonction endothéliale a été évaluée par la dilatation médiée par le flux (FMD), 2018.
, Nous avons retrouvé une différence significative entre la 90 ème et la 120 ème seconde post ischémie (t=2,128, p=0,04). Pour le moment
, Dans les conditions de cette étude, la consommation d'une dose d'EVRP n'améliore pas significativement la dilatation médiée par le flux (FMD) d'étudiants sains
fonction endothéliale, dilatation médiée par le flux (FMD), polyphénols, cognition ,