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, Amiens Introduction: la Candidose Invasive (CI) est une infection grave dont l'incidence augmente chez les patients immunodéprimés ou en réanimation malgré l'amélioration de leur prise en charge. L'objectif de cette étude était d'abord de comparer les patients présentant une CANDidémie (CAND), une Péritonite à Candida (PC) ou une CI d'Autre Localisation (AL), Résumé Epidémiologie des infections invasives à Candida, la consommation d'antifongiques et son impact sur la résistance au Centre Hospitalier Universitaire d

, Le recueil de données a porté sur la démographie, les scores de gravité, l'évolution clinique, la résistance des germes, les antifongiques et leur consommation annuelle entre, Méthodologie: une étude épidémiologique monocentrique rétrospective a été réalisée pour tous les patients ayant eu un prélèvement profond positif à Candida au CHU d'Amiens de janvier 2010 à décembre 2015, 2012.

, 0%) une AL. 60% des 875 souches étaient des C.Albicans, 14,1% des C.glabrata, 7,9% des C.tropicalis, 5,9% des C.Parapsilosis, 3,3% des C.krusei et 8,8% appartenaient à d'autres espèces. La répartition des germes ne variait pas selon les années (p=0,742). Les CAND étaient associées à 100 (48,1%) décès contre 128 (29,1%) dans les PC et 27 (34,2%) pour les AL (p=0,002). La survie était meilleure avec un traitement adapté (p=0,020), Résultats: 727 patients ont été inclus: 208 (28,6%) avaient une CAND, 440 (60,4%) une PC et 79, vol.3, p.0

, Conclusion: La CI reste associée à un pronostic vital défavorable. La candidémie, l'absence de traitement, la gravité initiale et les comorbidités sont associées à une plus grande mortalité. La consommation croissante d'antifongiques semble associée à une augmentation des résistances

, Abstract Epidemiology of invasive Candida infections, the consumption of antifungals and its impact on resistance at the Amiens University Hospital Center Introduction: Invasive Candidiasis (IC) is a serious infection with on increasing incidence in immunocompromised or intensive care despite improved management. The objective of this study was first to compare patients with CANDidemia (CAND), Candida Peritonitis (CP) or an IC of Other Localization (OL), Mots clés: Epidémiologie, candidémie, péritonite à levures, mortalité, complications, antifongique, résistance

, Methodology: A retrospective monocentric epidemiological study was carried out for all patients who had a deep positive Candida sampling at the CHU Amiens from, 2010.

, 4%) had a CP, and 79 (11.0%) had OL. 60% of the 875 strains were C.Albicans, 14.1% C.Glabrata, 7.9% C.Tropicalis, 5.9% C.Parapsilosis, 3.3% C.Krusei and 8.8 % belonged to other species. Spread distribution did not vary by year (p = 0.742). CANDs were associated with 100 (48.1%) deaths compared to 128 (29.1%) in the CP and 27 (34.2%) for the OL (p = 0.002). Survival was better with appropriate treatment, p.440