Senescence associated secretory phenotype and its possible role in chronic obstructive pulmonary disease, Am J Respir Cell Mol Biol, vol.51, issue.3, pp.323-356, 2014. ,
Recommandation pour la pratique clinique. Prise en charge de la BPCO. Mise à jour 2012. Exploration fonctionnelle respiratoire. Texte long, Rev Mal Respir, vol.2014, issue.31, pp.263-94 ,
Global Strategy for diagnosis, management, and prevention of Chronic Obstructive Lung Disease, 2016. ,
Maladie pulmonaire obstructive chronique/ Bronchopneumopathie chronique obstructive, pp.111-150, 2014. ,
Pathophysiology of the small airways in chronic obstructive pulmonary disease, Respiration, vol.84, issue.2, pp.89-97, 2012. ,
Tiotropium inhibits pulmonary inflammation and remodeling in a guinea pig model of COPD, Eur Respir J, 2011. ,
Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling, Braz J Med Biol Res, vol.44, issue.5, pp.460-468, 2011. ,
Recent advances in COPD: pathophysiology, respiratory physiology and clinical aspects, including comorbidities, Eur Respir Rev, vol.18, issue.114, pp.198-212, 2009. ,
Sénescence cellulaire et pathologies pulmonaires : exemple de la BPCO, Rev Mal Respir, issue.9, pp.893-902, 2014. ,
Telomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential, Pharmacol. Ther, vol.153, pp.125-159, 2015. ,
Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts, J Biol Chem, vol.276, issue.4, pp.2531-2538, 2001. ,
Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward the hematopoietic lineage, Stem cells, vol.23, issue.4, pp.516-545, 2005. ,
Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage, Arterioscler Thromb Vasc Biol, 2009. ,
Telomerase deficiency promotes oxidative stress by reducing catalase activity, Free Radic Biol Med, vol.45, issue.9, pp.1243-51, 2008. ,
Telomeres in lung diseases, Transl Res, vol.162, issue.6, pp.343-52, 2013. ,
TA-65 dans le remodelage des petites voies aériennes de la bronchopneumopathie chronique obstructive induit par la fumée de cigarette, 2016. ,
Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic, Aging Dis, vol.8, issue.6, pp.868-886, 2017. ,
Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia, N Engl J Med, vol.373, issue.10, pp.920-928, 2015. ,
A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis, N Engl J Med, vol.373, issue.10, pp.908-927, 2015. ,
BPCO: définition, prévalence, étiologie et évaluation medico-économique, J Fran Viet Pneu, vol.03, issue.08, pp.1-65, 2012. ,
Broncho-pneumopathies chroniques obstructives (BPCO), pp.640-56, 2009. ,
Données récentes sur la prévalence de la bronchopneumopathie chronique obstructive en France, Bull Epidemiol Hebd, pp.245-253, 2007. ,
Epidémiologie descriptive de la bronchopneumopathie chronique obstructive (BPCO) en France, Rev Mal Respir, issue.27, pp.160-168, 2010. ,
Respiratory symptoms and ilness in older Australians: the Burden of Obstructive Lung Disease (BOLD) study, Med J Aust, vol.198, issue.3, pp.144-152, 2013. ,
Age au moment du diagnostic d'une maladie liée à l'usage du tabac. Rapports sur la santé, vol.14, pp.9-20, 2003. ,
Occupationnal chronic obstructive pulmonary disease: a poorly understood disease), Rev Mal Respir, vol.23, issue.4, pp.13-119, 2006. ,
Occupational exposure: evidence for a causal association with chronic obstructive pulmonary disease, Am Rev Respir Dis, vol.140, issue.3, pp.85-91, 1989. ,
Occupational contribution to the burden of chronic obstructive pulmonary disease, J Occup Environ Med, vol.47, issue.2, pp.154-160, 2005. ,
Facteurs de risques de la BPCO: au-delà de la cigarette, Rev Mal Respir, vol.23, pp.20-24, 2006. ,
Broncho-pneumopathie chronique obstructive (227). Corpus Medical -Faculté de Médecine de, pp.1-25, 2002. ,
COPD 2011: are there other risk factors than tobacco?, Rev Med Suisse, vol.7, issue.317, pp.2232-2237, 2011. ,
Biological dust exposure in the workplace is a risk factor for chronic obstructive pulmonary disease, Thorax, vol.60, issue.8, pp.645-51, 2005. ,
Tobacco Smoking and Environnemental Risk Factors for Chronic Obstructive Pulmonary Disease, Clin Chest Med, vol.2014, issue.35, pp.17-27 ,
Atmospheric air pollution: a risk factor for COPD ?), Rev Mal Respir, vol.27, issue.4, pp.349-63, 2010. ,
Disease progression in young patients with COPD ; rethinking the Fletcher and Peto model, Eur Respir J, vol.44, issue.2, pp.324-355, 2014. ,
BRONCHOPNEUMOPATHIE CHRONIQUE OBSTRUCTIVE (BPCO) Item 205, SPLF, editor. Polycopié National, pp.1-28, 2015. ,
Sex Difference in Chronic Obstructive Lung Disease. Does it Matter? A Concise Review, COPD, vol.13, issue.6, pp.799-806, 2016. ,
An official ,
, public policy statement : Novel risk factors and the global burden of chronic obstructive pulmonary disease, Am J Respir Crit Care Med, vol.182, issue.5, pp.693-718, 2010.
HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism, Thorax, vol.63, issue.5, pp.463-472, 2008. ,
Factors associated with abnormal spirometry among HIV-infected individuals, AIDS, vol.29, issue.13, pp.1691-700, 2015. ,
,
, Antitrypsin Deficiency in COPD Patients: A cross Sectional Study, Arch Bronconeumol, vol.51, issue.11, pp.539-582, 2015.
Genetics of COPD and emphysema, Chest, vol.136, issue.3, pp.859-66, 2009. ,
Association between polymorphisms of microsomal epoxide hydrolase and COPD : results from meta-analyses, Respirology, vol.13, issue.6, pp.837-50, 2008. ,
The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese, Internal medicine, vol.47, issue.15, pp.1387-94, 2008. ,
Tumor Necrosis Factor alpha gene polymorphism in Chronic Bronchitis, Am J Respir Crit Care Med, vol.156, pp.1436-1445, 1997. ,
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease, Am J Hum Genet, vol.70, issue.5, pp.1229-1268, 2002. ,
The nature of smallairway obstruction in chronic obstructive pulmonary disease, New Engl J Med, vol.350, issue.26, pp.2645-53, 2004. ,
Dysfunctional lung anatomy and small airways degeneration in COPD, Int J Chron Obstruct Pulmon Dis, vol.8, pp.7-13, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-01583337
Update on the roles of distal airways in COPD, Eur Respir Rev, vol.20, issue.119, pp.7-22, 2011. ,
Disease of the airways in chronic obstructive pulmonary disease, Eur Respir J Suppl, vol.34, pp.41-50, 2001. ,
Differences in airway remodeling between asthma and chronic obstructive pulmonary disease, Clinical reviews in allergy and immunology, vol.27, issue.1, pp.35-43, 2004. ,
Fibrosis and airay remodeling, Clin Exp Allergy, vol.30, pp.42-47, 2000. ,
The role of small airways in obstructive airway diseases, Eur Respir Rew, vol.20, issue.119, pp.23-33, 2011. ,
Small airways: an important but neglected target in the treatment of obstructive airway diseases, Trends Pharmacol Sci, vol.29, issue.7, pp.340-345, 2008. ,
Remodeling in asthma and COPD-differences and similarities, Clin Respir J, vol.4, issue.1, pp.20-27, 2010. ,
Smoking-related Small airway disease-a review and update, Adv Anat Pathol, vol.17, issue.4, pp.270-276, 2010. ,
Small airway morphology and lung function in the transition from normality to chronic airway obstruction, J Appl Physiol, vol.95, issue.1, pp.441-448, 2003. ,
Remodeling in asthma and chronic obstructive lung disease, Am J Respir Crit Care Med, vol.164, issue.10, pp.28-38, 2001. ,
Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease, Histopathology, vol.45, issue.5, pp.477-84, 2004. ,
Structural abnormalities and inflammation in COPD : a focus on small airways, Rev Mal Respir, vol.28, issue.6, pp.749-60, 2011. ,
Squamous Metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients, J Clin Invest, vol.117, issue.11, pp.3551-62, 2007. ,
Mécanismes de la fibrogenèse pulmonaire, Rev Mal Respir, vol.22, pp.6-101, 2005. ,
Airway remodeling in the smoke exposed guinea pig model, Inhal Toxicol, vol.19, issue.11, pp.915-938, 2007. ,
Integrating mechanisms of pulmonary fibrosis, J. Exp. Med, vol.208, issue.7, pp.1339-50, 2011. ,
Enhanced bronchial expression of extracellular matrix proteins in chronic obstructive pulmonary disease, Am J Clin Pathol, vol.126, issue.5, pp.725-760, 2006. ,
Fibrotic response of tissue remodeling in COPD, Lung, vol.189, issue.2, pp.101-110, 2011. ,
Genesis if the myfibroblast in lung injury and fibrosis, Proc Am Thorac Soc, vol.9, issue.3, pp.148-152, 2012. ,
,
, Myofibroblast expression in airways and alveoli is affected by smoking and COPD, Respir. Res, vol.14, p.84, 2013.
The myofibroblast as an inflammatory cell in pulmonary fibrosis, Curr Top Pathol, vol.93, pp.173-82, 1999. ,
The myofibroblast in pulmonary fibrosis, Chest, vol.122, issue.6, pp.286-295, 2002. ,
Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction, Eur Respir J, vol.31, issue.6, pp.1334-56, 2008. ,
Pathogenesis of chronic obstructive pulmonary disease), Presse Med, vol.38, issue.3, pp.406-418, 2009. ,
Fibrogenic reactions in lung disease, Annu Rev Pathol, vol.5, pp.77-98, 2010. ,
Pulmonary fibrosis: pathogenesis, etiology and regulation, Mucosal Immunol, vol.2, issue.2, pp.103-124, 2009. ,
The Myofibroblast: one function, multiple origins, Am J Pathol, vol.170, issue.6, pp.1807-1823, 2007. ,
New light is she on the enigmatic origin of the lung myfibroblast, Am J Respir Crit Care Med, vol.188, issue.7, pp.765-771, 2013. ,
Cellular players in lung fibrosis, Curr Pharm Des, vol.18, issue.27, pp.4093-102, 2012. ,
Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study, Am J Pathol, vol.145, issue.1, pp.114-139, 1994. ,
Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair, Mol. Med, vol.1, issue.1, pp.71-81, 1994. ,
Fibrogénèse pulmonaire, cellules mésenchymateuses et fibrocytes, Rev Mal Respir, vol.24, pp.75-82, 2007. ,
The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses, Lab Invest, vol.87, issue.9, pp.858-70, 2007. ,
Fibrocytes in pulmonary fibrosis: a brief synopsis, Eur Respir Rev, vol.22, issue.130, pp.552-559, 2013. ,
New mechanisms of pulmonary fibrosis, Chest, vol.136, issue.5, pp.1364-70, 2009. ,
Circulating progenitor cells in chronic lung disease, Expert Rev Respir Med, vol.1, issue.1, pp.157-65, 2007. ,
Fibrocyte are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis, Int J Biochem Cell Biol, vol.40, issue.10, pp.2129-2169, 2008. ,
Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis, Am J Respir Crit Care Med, vol.179, issue.7, pp.588-94, 2009. ,
Bone marrow lacks transplantable progenitor for smooth muscle type alpha-actin-expressing cells, Stem-cells, vol.24, issue.1, pp.13-22, 2006. ,
The basics of epithelial-mesenchymal transition, J Clin Invest, vol.119, issue.6, pp.1420-1428, 2009. ,
TGF-beta signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment, Am J Physiol Lung Cell Mol Physiol, vol.300, issue.6, pp.887-97, 2011. ,
Ligandindependent transforming growth factor-beta type I receptor signaling mediates type I collagen-induced epithelial-mesenchymal transition, J Pathol, vol.226, issue.4, pp.633-677, 2012. ,
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by extracellular matrix, Proc Natl Acad Sci, vol.103, issue.35, pp.13180-13185, 2006. ,
Alveolar epithelial cells express mesenchymal proteins in patients with idiopathic pulmonary fibrosis, Am J Physiol Lung Cell Mol, vol.301, issue.1, p.718, 2011. ,
EMT and interstitial lung disease: a mysterious relationship, Curr Opin Pulm Med, vol.18, issue.5, pp.517-540, 2012. ,
Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition, Proc Natl Acad Sci, vol.108, issue.52, pp.1475-83, 2011. ,
Dualimmunohistochemistry provides little evidence for epithelial-mesenchymal in pulmonary fibrosis, Histochem Cell Biol, vol.129, issue.4, pp.453-62, 2008. ,
Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall, Am J Respir Crit Care Med, vol.174, issue.12, pp.1327-1361, 2006. ,
COPD and inflammation: statement from a French expert group: inflammation and remodeling mechanisms), Rev Mal Respir, vol.27, issue.10, pp.1254-66, 2010. ,
Transforming growth factor-beta: Master regulator of the Respiratory System in Health and Disease, Am J Respir Cell Mol Biol, vol.54, issue.5, pp.647-55, 2016. ,
Cigarette smoke produces airway wall remodeling in rat tracheal explants, Am J Respir Crit Care Med, vol.168, issue.10, pp.1232-1238, 2003. ,
Genealogy, expression, and cellular function of transforming growth factor-beta, Pharmacol. Ther, vol.98, issue.2, pp.257-65, 2003. ,
Transforming growth factor-betas : smad signaling and roles in physiopathology), Pathol Biol, vol.52, issue.1, pp.50-54, 2004. ,
URL : https://hal.archives-ouvertes.fr/inserm-00147403
TGF-beta activation and lung fibrosis, Proc Am Thorac Soc, vol.9, issue.3, pp.130-136, 2012. ,
Non-Smad pathways in TGF-beta signaling, Cell Res, vol.19, issue.1, pp.128-167, 2009. ,
Transforming growth factor-beta 1 drives airway remodeling in cigarette smoke-exposed tracheal explants, Am J Respir Cell Mol Biol, vol.33, issue.4, pp.387-93, 2005. ,
Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD), Am J Respir Crit Care Med, vol.163, issue.6, pp.1476-83, 2001. ,
Connective tissue growth factor is crucial to inducing a profibrotic environment in " fibrosis-resistant" BALB/c mouse lungs, Am J Respir Cell Mol Biol, vol.31, issue.5, pp.510-516, 2004. ,
Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease, Oxid Med Cell Longev, vol.2012, p.458276, 2012. ,
Myofibroblast differentiation: main features, biomedical relevance, and the role of reactive oxygen species, Antioxid Redox Signal, vol.21, issue.5, pp.768-85, 2014. ,
Oxydative stress in pathogenesis of chronic obstructive pulmonary disease: cellular and molecular mechanisms, Cell Biochem Biophys, vol.43, issue.1, pp.167-88, 2005. ,
Telomeres and cellular senescence in respiratory disease, Rev Mal Respir, vol.3, issue.3, pp.202-209, 2011. ,
,
, Rev Mal Respir, vol.31, issue.10, pp.893-902, 2014.
Senescence hypothesis for the pathogenic mechanism of chronic obstructive pulmonary disease, Proc Am Thorac Soc, vol.6, issue.7, pp.596-601, 2009. ,
Roles of apoptosis, cell senescence, and DNA damage in the pathogenetic mechanisms of COPD ,
, Nihon Rinsho, vol.69, issue.10, pp.1754-1761, 2011.
Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema, Transl Res, vol.162, issue.3, pp.156-73, 2013. ,
Free radical generation induces epithelial-to-mesenchymal transition in lung epithelium via a TGF-beta1-dependent mechanism, Free Radic Biol Med, vol.52, issue.6, pp.1024-1056, 2012. ,
TGF-beta1 induces human bronchial epithelial cell-to-mesenchymal transition in vitro, Lung, vol.187, issue.3, pp.187-94, 2009. ,
NADPH Oxidases in Lung Health and Disease, Antioxid Redox Signal, vol.20, issue.17, pp.2838-53, 2014. ,
NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF-?1-induced fibroblast differentiation into myofibroblasts, Thorax, vol.65, issue.8, pp.733-741, 2010. ,
Metformin attenuates lung fibrosis development via NOX4 suppression, Respir. Res, vol.17, issue.1, p.107, 2016. ,
DOI : 10.1186/s12931-016-0420-x
URL : https://respiratory-research.biomedcentral.com/track/pdf/10.1186/s12931-016-0420-x
Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD, Respir. Res, vol.17, issue.1, pp.1-5, 2016. ,
Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke, Thorax, vol.68, issue.5, pp.410-430, 2013. ,
Current smoking of elderly men reduces antioxidants in alveolar macrophages, Am J Respir Crit Care Med, vol.149, issue.1, pp.178-82, 1994. ,
Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice, Am J Physiol Lung Cell Mol Physiol, vol.302, issue.12, pp.1250-61, 2012. ,
Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers, Am J Respir Cell Mol Biol, vol.29, issue.3, pp.331-374, 2003. ,
Bronchiolar epithelial catalase is diminished in smokers with mild COPD, Eur Respir J, vol.42, issue.1, pp.42-53, 2013. ,
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities, Antioxid Redox Signal, vol.15, issue.7, pp.1957-97, 2011. ,
Genetic variation and gene expression in antioxidant related enzymes and risk of COPD: a systematic review, Thorax, vol.63, issue.11, pp.956-61, 2008. ,
Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice, Am J Physiol Lung Cell Mol Physiol, vol.299, issue.3, pp.425-458, 2010. ,
TGF-beta1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells, J Immunol, vol.168, issue.12, pp.6470-6478, 2002. ,
Oxydative stress in chronic obstructive pulmonary disease. Oxydative stress Study Group, Am J Respir Crit Care Med, vol.156, issue.2, pp.341-57, 1997. ,
Antioxidant pharmacological therapies for COPD, Cur Opin Pharmacol, vol.12, issue.3, pp.256-65, 2012. ,
Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease?, Respirology, vol.20, issue.5, pp.722-731, 2015. ,
COPD: balancing oxydants and antioxydants, Int J Chron Obstruct Pulmon Dis, vol.10, pp.261-76, 2015. ,
Myofibroblast differentiation during fibrosis : role of NAD(P)H oxidases, Kidney Int, vol.79, issue.9, pp.944-56, 2011. ,
Recent developments in myofibroblast biology: paradigms for connective tissue remodeling, Am J Pathol, vol.180, issue.4, pp.1340-55, 2012. ,
Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury, Respir. Res, vol.12, p.78, 2011. ,
,
Cigarette smoke induces cellular senescence, Am J Respir Cell Mol Biol, vol.35, issue.6, pp.681-689, 2006. ,
Lymphocyte senescence in COPD is associated with decreased histone deacetylase 2 expression by proinflammatory lymphocytes, Respir. Res, vol.26, p.130, 2015. ,
Les télomères et la télomérase, Rev Med Suisse, 2009. ,
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins, Nat. Rev. Cancer, vol.11, issue.3, pp.161-76, 2011. ,
Telomerase structure function, Curr Opin Struct Biol, vol.21, issue.1, pp.92-100, 2011. ,
Role of Smad3 in th regulation of rat telomerase reverse transcriptase by TGFbeta, Oncogene, vol.25, issue.7, pp.1030-1071, 2006. ,
Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity, PLoS One, vol.8, issue.1, p.53760, 2013. ,
Syndromes of telomere shortening, Annu Rev Genomics Hum Genet, vol.10, pp.45-61, 2009. ,
Evidence of extra-telomerase effects of hTERT and its regulation involving a feedback loop, Exp Cell Res, vol.19, issue.3, pp.322-352, 2003. ,
Telomerase, elixir of life for human cells, Med Sci (Paris), vol.19, issue.3, pp.345-50, 2003. ,
TERT promotes cellular and organismal survival independently of telomerase activity, Oncogene, vol.27, issue.26, pp.3754-3784, 2008. ,
Switching and signalling at the telomere, Cell, vol.106, issue.6, pp.661-73, 2001. ,
Protein composition catalytically active human telomerase from immortal cells, Science, vol.315, issue.5820, pp.1850-1853, 2007. ,
Axtivity, function, and gene regulation of the catalytic subunit of telomerase (hTERT), Gene, vol.269, issue.1-2, pp.1-12, 2001. ,
Replicative senescence and cell immortality : the role of telomeres and telomerase, Proc Soc Exp Biol Med, vol.214, issue.2, pp.99-106, 1997. ,
Telomerase and cancer : revisiting the telomere hypothesis, Trends Biochem Sci, vol.21, issue.10, pp.387-91, 1996. ,
How telomeres are replicated, Nat Rev Mol Cell Biol, vol.8, issue.10, pp.825-863, 2007. ,
Phenotypes in mTERT(+)/(-) and mTERT (-)/(-) mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase, Mol. Cell. Biol, vol.31, issue.12, pp.2369-79, 2011. ,
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDAinduced neurotoxicity, J Neurosci, vol.24, issue.6, pp.1280-1287, 2004. ,
Actions of human telomerase beyond telomeres, Cell research, vol.18, issue.7, pp.725-757, 2008. ,
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses, Proc Natl Acad Sci, vol.102, issue.23, pp.8222-8229, 2005. ,
hTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanisms, Aging cell, vol.11, issue.3, pp.482-90, 2012. ,
Conditional Knockout of Telomerase Reverse Transcriptase in Mesenchymal Cells Impairs Mouse Pulmonary Fibrosis, PLoS One, vol.10, issue.11, p.142547, 2015. ,
Mice with Pulmonary FIbrosis Driven by Telomere Dysfunction, Cells reports, vol.12, issue.2, pp.286-99, 2015. ,
Telomere lengths, pulmonary fibrosis and telomerase (TERT) mutations, PLoS One, vol.5, issue.5, p.10680, 2010. ,
Telomeres in lung diseases, Prog Mol Biol Transl Sci, vol.125, pp.173-83, 2014. ,
I telomeropathy the explanation for combined pulmonary fibrosis and emphysema syndrome?: report of a family with TERT mutation, Am J Respir Crit Care Med, vol.189, issue.6, pp.753-757, 2014. ,
Reply: telomerase makes connections between pulmonary fibrosis and emphysema, Am J Respir Crit Care Med, vol.189, issue.6, pp.754-759, 2014. ,
Telomerase mutations in smokers with severe emphysema, J Clin Invest, vol.125, issue.2, pp.563-70, 2015. ,
Telomere length is a determinant of emphysema susceptibility, Am J Respir Crit Care Med, vol.184, issue.8, pp.904-916, 2011. ,
Telomerase activity in bleomycin-induced epithelial cell apoptosis and lung fibrosis, Eur Respir J, vol.30, issue.2, pp.205-218, 2007. ,
A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis, PLoS One, vol.8, issue.3, p.58423, 2013. ,
Telomerase deficiency does not alter bleomycin-induced fibrosis in mice, Exp Lung Res, vol.38, issue.3, pp.124-158, 2012. ,
Telomerase activity is required for bleomycin-induced pulmonary fibrosis, J Clin Invest, vol.117, issue.12, pp.3800-3809, 2007. ,
Telomerase and telomere length in pulmonary fibrosis, Am J Respir Cell Mol Biol, vol.23, issue.4, pp.460-465, 2000. ,
Induction of telomerase activity in fibroblasts from bleomycin-injured lungs, Am J Respir Cell Mol Biol, vol.23, issue.4, pp.460-465, 2000. ,
Assessing cell and organ senescence biomarkers, Circ Res, vol.111, pp.97-109, 2012. ,
The power and the promise of oncogene-induced senescence markers, Nat Rev Cancer, vol.6, pp.472-476, 2006. ,
Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic, Aging Dis, vol.8, issue.6, pp.868-886, 2017. ,
The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence, Aging Cell, vol.10, pp.604-621, 2011. ,
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes, Am J Hum Genet, vol.52, pp.661-667, 1993. ,
Telomerase activity in human ovarian carcinoma, Proc Natl Acad Sci, vol.91, pp.2900-2904, 1994. ,
Telomeres shorten during ageing of human fibroblasts, Nature, vol.345, pp.458-460, 1990. ,
Extension of life-span by introduction of telomerase into normal human cells, Science, vol.279, pp.349-352, 1998. ,
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice, Nature, vol.469, pp.102-106, 2011. ,
Identification of telomerase-activating blends from naturally occurring compounds, Altern Ther Health Med, vol.22, issue.2, pp.6-14, 2016. ,
Experimental increase in telomere length leads to faster feather regeneration, Exp Gerontol, vol.52, pp.36-38, 2014. ,
URL : https://hal.archives-ouvertes.fr/hal-00955938
A natural product telomerase activator lengthens telomeres in humans: a randomized, double blind, and placebo controlled study, Rejuvenation Res, vol.19, pp.478-484, 2016. ,
A natural product telomerase activator as part of a health maintenance program: metabolic and cardiovascular response, Rejuvenation Res, vol.16, pp.386-395, 2013. ,
A natural product telomerase activator as part of a health maintenance program, Rejuvenation Res, vol.14, pp.45-56, 2011. ,
Functional assessment of pharmacological telomerase activators in human T cells. Cells, vol.2, pp.57-66, 2013. ,
A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer, Ann Oncol, vol.26, issue.2, pp.354-62, 2015. ,
A novel telomerase template antagonist (GRN163) as a potential anticancer agent, Cancer Res, vol.63, pp.3931-3939, 2003. ,
Effects of a novel telomerase inhibitor,GRN163L, in human breast cancer, Breast Cancer Res. Treat, vol.96, pp.73-81, 2006. ,
Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer, Clin. Cancer Res, vol.12, pp.3184-3192, 2006. ,
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death, Proc. Natl. Acad.Sci, vol.96, pp.14276-14281, 1999. ,
Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia, N Engl J Med, vol.353, pp.33-45, 2005. ,
Anagrelide compared with hydroxyurea in WHOclassified essential thrombocythemia: the ANAHYDRET Study, a randomized controlled trial, Blood, vol.121, pp.1720-1728, 2013. ,
Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon a-2a, Blood, vol.122, pp.893-901, 2013. ,
Imetelstat, a potent telomerase inhibitor, inhibits the spontaneous growth of CFU-Meg in vitro from essential thrombocythemia patients but not from healthy individuals, Presented at the 53rd American Society of Hematology Annual Meeting, 2011. ,
Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease, Oxid Med Cell Longev, vol.2018, p.5730395, 2018. ,
A method for the isolation and serial propagation of keratinocytes, endothelial cells, and fibroblasts from a single punch biopsy of human skin, In Vitro Cell Dev Biol Anim, vol.31, issue.6, pp.447-55, 1995. ,
Fibroblasts and myofibroblasts: their source, function and role in disease, Int J Biochem Cell Biol, vol.39, issue.4, pp.666-671, 2007. ,
Cigarette smoke induces cellular senescence, Am J Respir Cell Mol Biol, vol.35, issue.6, pp.681-689, 2006. ,
Telomere length is a determinant of emphysema susceptibility, Am J Respir Crit Care Med, vol.184, issue.8, pp.904-916, 2011. ,
Pharmacological intervention strategies for affecting telomerase activity: future prospects to treat cancer and degenerative disease, Biochimie, vol.90, issue.1, pp.156-72, 2008. ,
Targeting telomerase-expressing cancer cells, J. Cell. Mol. Med, vol.15, issue.7, pp.1433-1475, 2011. ,
In vitro synergistic antioxidant activity and identification of antioxidant components from Astragalus membranaceus and Paeonia lactiflora, PLoS One, vol.9, issue.5, p.96780, 2014. ,
Human telomerase represses ROS dependent cellular responses to Tumor Necrosis Factor-alpha without affecting NF-kappaB activation, Cell Signal, vol.24, issue.3, pp.708-725, 2012. ,
Telomere diseases, N Engl J Med, vol.361, pp.2353-2365, 2009. ,
, Hematology Am Soc Hematol Educ Program, pp.480-486, 2011.
Syndromes of telomere shortening, Annu Rev Genomics Hum Genet, vol.10, pp.45-61, 2009. ,
Telomeric and extra-telomeric roles for telomerase and the telomere binding proteins, Nat Rev Cancer, vol.11, pp.161-176, 2011. ,
Conditional TRF1 knockout in the hematopoietic compartment leads to bone marrow failure and recapitulates clinical features of Dyskeratosis congenita, Blood, vol.120, pp.2990-3000, 2012. ,
Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation, EMBO J, vol.22, pp.131-139, 2003. ,
Expanding the clinical phenotype of autosomal dominant dyskeratosis congenita caused by TERT mutations, Haematologica, vol.93, pp.943-944, 2008. ,
Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer, EMBO Mol Med, vol.4, pp.1-14, 2012. ,
Telomerase reactivation reverses tissue degeneration in aged telomerase deficient mice, Nature, vol.469, pp.102-106, 2011. ,
A survey of telomerase activity in human cancer, Eur J Cancer, vol.33, pp.787-791, 1997. ,
Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis, Oncogene, vol.21, pp.619-626, 2002. ,
Direct activation of TERT transcription by c-MYC, Nat Genet, vol.21, pp.220-224, 1999. ,
Wnt/beta-catenin signaling regulates telomerase in stem cells and cancer cells, Science, vol.336, pp.1549-1554, 2012. ,
Wnt regulates TERT--putting the horse before the cart, Science, vol.336, pp.1519-1520, 2012. ,
Telomerase modulates Wnt signalling by association with target gene chromatin, Nature, vol.460, pp.66-72, 2009. ,
Short telomeres limit tumor progression in vivo by inducing senescence, Cancer Cell, vol.11, pp.461-469, 2007. ,
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis, J Clin Invest, vol.122, pp.2283-2288, 2012. ,
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases, Cell, vol.148, pp.896-907, 2012. ,
Therapeutic Targeting of Telomerase. Genes (Basel), vol.7, p.39, 2016. ,
Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes, J. Immunol, vol.181, pp.7400-7406, 2008. ,
Role of CD8 T Cell Replicative Senescence in Human Aging and in HIVmediated Immunosenescence, Aging Dis, vol.2, pp.382-397, 2011. ,
A natural product telomerase activator as part of a health maintenance program, Rejuven. Res, vol.14, pp.45-56, 2011. ,
Evaluation of an oral telomerase activator for early age-related macular degeneration-a pilot study, Clin Ophthalmol, vol.10, pp.243-249, 2016. ,
A natural product telomerase activator as part of a health maintenance program: Metabolic and cardiovascular response, Rejuven. Res, 2013. ,
A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study, Rejuvenation Res, vol.19, issue.6, pp.478-484, 2016. ,
Inhibition of human telomerase by 2'-O-methyl-RNA, Proc. Natl. Acad. Sci, vol.95, pp.11549-11554, 1988. ,
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death, Proc. Natl. Acad. Sci, vol.96, pp.14276-14281, 1999. ,
Telomerase inhibition, oligonucleotides, and clinical trials, Oncogene, vol.21, issue.4, pp.631-638, 2002. ,
A novel telomerase template antagonist (GRN163) as a potential anticancer agent, Cancer Res, vol.63, pp.3931-3939, 2003. ,
Telomerase and cancer therapeutics, Nat. Rev. Cancer, vol.8, pp.167-179, 2008. ,
The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth, Clin. Cancer Res, vol.16, pp.154-163, 2010. ,
Pharmaceutical regulation of telomerase and its clinical potential, J. Cell. Mol. Med, vol.16, pp.1-7, 2012. ,
The Telomerase Antagonist Imetelstat Efficiently Targets Glioblastoma Tumor-Initiating Cells Leading to Decreased Proliferation and Tumor Growth, Clin Cancer Res, vol.16, issue.1, pp.154-163, 2010. ,